7. 05/08/14 7
LOGOLOGO
Glycogen Overview (cont):
Storage form of Glucose in
animals so also called as
“animal starch”
Granular form
High in liver (6-8%) and
muscles (1-2%)
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LOGOLOGO
GLYCOGENOLYSIS (cont):
• 2nd
Step: Removal of Branches
General name Of Enzyme: Debranching enzyme
Two enzymatic activities (Bifunctional enzyme)
1.Transferase Activity
2.Glucosidase Activity
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LOGOLOGO
GLYCOGENOLYSIS (cont):
• Transferase activity:
Removes chain of 3 glucose residue from
branch
Transfer them to the non-reducing end of linear
glycogen chain
α-1,4 bond is broken and another α-1,4 bond is
made.
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LOGOLOGO
GLYCOGENOLYSIS (cont):
The third and last stage converts G1P (glucose-1-
phosphate) to G6P (glucose-6-phosphate) through
the enzyme phosphoglucomutase.
G1P ↔ G6P
3rd
step: formation of free glucose
and glucose-6-phosphate
Catalysed By Phosphoglucomutase
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LOGOLOGO
GLYCOGENOLYSIS (cont):
• FATES OF GLUCOSE 6
PHOSPHATE:
IN MUSCLES:
This G6P can enter glycolysis and serve
as an energy source to support muscle
contraction.
IN LIVER:
It releases glucose into blood when blood
glucose level drops.
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LOGOLOGO
GLYCOGENOLYSIS (cont):
• Tissue which has Glucose 6 phosphatase can generate
free glucose.
• LIVER KIDNEY INTESTINE HAVE THE ENZYME:
The end product of glycogenolysis is free glucose
which entors to the blood stream
• MUSCLES BRAIN AND ADIPOSE TISSUES DON'T
HAVE THE ENZYME:
glycogen breakdown leads to the formation of glucose
6 phosphate which is then metabolized via glycolysis and
TCA cycle