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These are simplified slides discussing the regulation of cardiac output and venous return. Learning objectives: 1. Comprehend the determinants of cardiac output and factors affecting cardiac output 2. Comprehend the factors affecting stroke volume and heart rate and total peripheral resistance 3. Identify the factors regulating venous return 4. Discuss the causes of high and low output cardiac failure 5. Enlist the functions of veins and recognise the significance of venous reservoirs Study Resources: 1. Chapter 20, Guyton and Hall Textbook of Medical Physiology, 14th edition 2. Chapter 30 and 32, Ganong’s Review of Medical Physiology, 26th edition 3. Chapter 10, Human Physiology by Lauralee Sherwood, 9th edition 4. Physiology, Cardiac Output - StatPearls https://www.ncbi.nlm.nih.gov/books/NBK470455/
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In this captivating lecture, Dr. Faiza, an esteemed Assistant Professor of Physiology, embarks on a comprehensive journey into the multifaceted realm of local blood flow regulation. With meticulous detail and clarity, she unravels the intricate mechanisms that govern the dynamic balance between tissue perfusion and vascular resistance, shedding light on both acute and chronic aspects of blood flow control. Beginning with an exploration of acute influences, Dr. Faiza elucidates how physiological factors such as metabolic demand, myogenic responses, and autoregulatory mechanisms orchestrate rapid adjustments in local blood flow. Students gain insight into the vasodilator theory, which elucidates the role of metabolic byproducts and vasoactive metabolites in promoting vasodilation, alongside the oxygen demand theory, which underscores the interplay between tissue oxygenation and nutrient demand. Delving deeper, the lecture delves into the fascinating realm of humoral control, where hormones and vasoactive substances wield significant influence over vascular tone. Dr. Faiza navigates through the intricacies of endothelial-derived factors like nitric oxide (NO) and histamine, alongside hormonal regulators such as angiotensin II and vasopressin. Through vivid explanations and illustrative examples, she unveils the intricate dance of vasodilation and vasoconstriction orchestrated by these biochemical messengers. Moreover, the lecture extends its gaze to the extrinsic control of blood flow, where sympathetic innervation exerts a profound impact on vascular dynamics. Dr. Faiza elucidates the role of sympathetic tone in modulating vascular resistance, highlighting its implications in diverse physiological and pathological scenarios. From skin perfusion to coronary circulation, students gain a nuanced understanding of how neural inputs shape local blood flow patterns. Enriched with clinical insights and contemporary research findings, this lecture equips students with a holistic understanding of blood flow regulation. By exploring concepts like active and reactive hyperemia, vascular remodeling, and collateral circulation, Dr. Faiza fosters a deeper appreciation for the adaptive responses of the cardiovascular system to changing physiological demands and pathological insults.
Control of Local Blood Flow: acute and chronic
Control of Local Blood Flow: acute and chronic
MedicoseAcademics
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Design and synthesis of novel JNK inhibitors targeting liver pyruvate kinase for the treatment of non-alcoholic fatty liver disease and hepatocellular carcinoma.
Shazia Iqbal 2024 - Bioorganic Chemistry.pdf
Shazia Iqbal 2024 - Bioorganic Chemistry.pdf
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Delve into valuable content elucidating the anatomy and physiology of the respiratory system, in line with the PCI syllabus for pharmacy and PharmD students.
ANATOMY AND PHYSIOLOGY OF RESPIRATORY SYSTEM.pptx
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Cardiac Output, Venous Return, and Their Regulation
Cardiac Output, Venous Return, and Their Regulation
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Control of Local Blood Flow: acute and chronic
Control of Local Blood Flow: acute and chronic
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Shazia Iqbal 2024 - Bioorganic Chemistry.pdf
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ANATOMY AND PHYSIOLOGY OF RESPIRATORY SYSTEM.pptx
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Musculo skeletal disorders
1.
MUSCULOSKELETAL DISORDERS SANIL VARGHESE
2.
JOINT DISLOCATION
3.
PATHOPHYSIOLOGY: TRAUMA DISLOCATION OF THE
JOINT JOINT STRUCTURES, BLOOD SUPPLY AND NERVES ARE DISTORTED AND SEVERELY STRESSED AVASCULAR NECROSIS (TISSUE DEATH DUE TO ANOXIA AND DIMINISHED BLOOD SUPPLY) NERVE PALSY
4.
5.
6.
EPICONDYLITIS
7.
8.
9.
LIGAMENT INJURY
10.
11.
ANTERIOR CRUCIATE LIGAMENT
INJURY
12.
POSTERIOR CRUCIATE LIGAMENT INJURY
13.
MENISCAL INJURY
14.
RUPTURED ACHILLES TENDON
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