1) The document discusses sperm function and its contribution to embryo development, including morphology, DNA integrity, and various fertility markers beyond routine semen analysis.
2) Various techniques for improving sperm quality and health are reviewed, such as varicocele repair, antioxidant treatment, lifestyle modifications, and sperm selection methods like hyaluronic acid binding.
3) Studies on the effects of sperm quality on embryo development outcomes like fertilization rate, embryo cleavage and blastulation, as well as pregnancy rates are summarized.
Role of sperm index in embryo quality what to do - 17th iranian congress
1. Sandro Esteves, MD, PhD Director, ANDROFERT Center for Male Reproduction and Infertility Campinas, BRAZIL Esteves, 17 th International Congress of the Iranian Association for Fertility and Reproductive Medicine Tehran– March 2011
14. Sperm DNA Integrity Testing & ART OR 0.07 (0.01-0.48) Esteves Adapted from Bungum et al., Hum Reprod 2007 Adapted from Bungum et al., Hum Reprod 2007 * <.05 *
15. Sperm DFI and Embryo Quality Esteves Reference Assay N ART Findings Larson KL et al (2000) SCSA 24 IVF; ICSI No impact (D3) Gandini et al (2004) SCSA 34 IVF; ICSI No impact (D3) Payne JF et al (2006) SCSA 100 IVF; ICSI No impact (D3) Sun JG et al (1997) TUNEL 236 IVF ↓ Cleavage (D3) Morris ID et al (2002) Comet 60 ICSI ↓ Cleavage; Morphology (D3) Virro MR et al (2004) SCSA 249 IVF; ICSI ↓ Blastulation rate Nasr-Esfahani et al. (2005) Comet, CMA 3 28 ICSI ↓ Blastocyst development
17. Zeta method Modified HOST IMSI PICSI Sperm head birefringence Laser-assisted sperm selection Esteves Magnetic- activated cell sorting Improving Sperm Health What to do ?
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19. Watanabe S et al., J Mamm Ova Res 2008; 25:259-65 Tanaka A et al, ASRM 2009 (P-272) Esteves
23. Microsurgical varicocele repair prior to ICSI (N=80) ICSI in the presence of varicocele (N=162) Clinical Outcome of Intracytoplasmic Sperm Injection in Infertile Men With Treated and Untreated Clinical Varicocele SC Esteves, FV Oliveira, RP Bertolla ANDROFERT, Center for Male Reproduction, Campinas, BRAZIL and Division of Urology, São Paulo Federal University, São Paulo, BRAZIL. The Journal of Urology Vol. 184,1442-6, October 2010 Esteves P<0.01
24. Esteves SC, Oliveira FV, Bertolla RP. Clinical Outcome of ICSI in Infertile Men with Treated and Untreated Clinical Varicocele. J Urol 2010;184:1442-1446 Esteves *P<0.05 Miscarriage (%) Odds ratio 1.87 0.43 95% CI 1.08 - 3.25 0.22 – 0.84 P-value 0.03 0.01