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Talk given at the MRC-LMB, Cambridge on 29 Aug 08
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1.
ZRANB2 —
a transcriptional regulator? Richard P. Grant MMB, Sydney Thursday, 11 September 2008 1
2.
Splicing
• Splicing ubiquitous in eukaryotes • ~70% human genes are alternatively spliced • Aberrant splicing causes genetic disease, e.g. - DMD - CF Thursday, 11 September 2008 2
3.
Consensus sequences
direct splicing Exon 1 Intron 1–2 Exon 2 Thursday, 11 September 2008 3