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I. INTRODUCTION
A. OVERVIEW
Dengue is a mosquito-borne disease cause by any one of four closely related
dengue viruses (DENV -1,-2,-3 and -4). Infection with one serotype of DENV provides
immunity to that serotype for life, but provides no long-term immunity to other
serotypes. Thus, a person can be infected as many as four times, once with each
serotype.
Dengue Hemorrhagic Fever, also known as Severe Dengue, was first recognized
in the 1950s during dengue epidemics in the Philippines and Thailand. Today, severe
dengue affects most Asian and Latin American countries and has become a leading
cause of hospitalization and death among children in these regions. Typical cases of
DHF are characterized by four major clinical manifestations: high fever, hemorrhagic
phenomena, and often, hepatomegaly and circulatory failure.
Infected humans are the main carriers and multipliers of the virus, serving as as
source of the virus for uninfected mosquitoes. Patients who are already infected with the
dengue virus can transmit the infection (4-5 days, maximum 12) via Aedes mosquitoes
after their first symptoms appear.
Reference: World Health Organization (WHO) 2011. Retrieved from: http://who.int.com
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Mode of Transmission
1. Bite of an infected mosquito, principally the Aedes Aegypti.
a. Aedes aegypti is a day-biting mosquito (they appear two hours after sunrise
and two hours before sunset).
b. It breeds in an areas of stagnant water.
c. It has limited, low flying movement.
d. It has fine whole dots at the base of the wings and white bands on the legs.
2. Aedes Albopictus may contribute to the transmission of the dengue virus in rural
areas.
3. Other contributory mosquitoes:
a. Aedes polynensis
b. Aedes scutellaris simplex
Incubation Period
The incubation period is 3-14 days; commonly 7-10 days.
Period of Communicability
1. Patients are usually infective to the mosquito from a day before the febrile period
to the end of it.
2. The mosquito becomes infective from day 8 to 12 after the blood meal and
remains infective throughout its life.
Sources of Infection
1. Infected persons- the virus is present in the blood of patients during the acute
phase of the disease and will become a reservoir of the virus, sucked by
mosquitoes, which may then transmit the disease.
2. Standing water- any stagnant water in the household and its premises are usual
breeding places of these mosquitoes.
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Dengue Hemorrhagic Fever (DHF)
This severe form of dengue virus infection id manifested by fever, hemorrhagic,
diathesis, hepatomegaly and hypovolemic shock.
Classification According to Severity
Grade 1
There is fever accompanied with non-specific constitutional symptoms and the
only hemorrhagic manifestations is positive (+) in the tourniquet test.
Grade 2
All signs of Grade 1, plus spontaneous bleeding from the nose, gums,, and GIT,
are present.
Grade 3
There is the presence of circulatory failure, as manifested by a weak pulse, narrow
pulse pressure, hypotension, cold, clammy skin, and restlessness.
Grade 4
There is profound shock, and undetectable blood pressure and pulse.
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Complications
1. Dengue Fever
a. Epistaxis; menorrhagia
b. Gastrointestinal bleeding
c. Concomitant gastrointestinal disorder (peptic ulcer)
2. DHF
a. Metabolic acidosis
b. Hyperkalemia
c. Tissue anoxia
d. Hemorrhage into the CNS or adrenal glands
e. Uterine bleeding may occur
f. Myocarditis
3. Severe manifestations
Dengue encephalopathy is manifested by increasing restlessness, apprehension or
anxiety, disturbed sensorium, convulsions, spacity, and hyporeflexia.
Reference: Handbookof CommonCommunicable andInfectious Disease, 3rd
edition;Dionesia Mondejar-NavalesRN. Maed, p.71-73
Vaccine
Dengvaxia, world’s first dengue vaccine was approved in Mexico. The Federal
Commission for the Protection against Sanitary Risks (COFEPRIS) has approved
Dengvaxia®, tetravalent dengue vaccine, for the prevention of disease caused by all four
dengue virus serotypes in preadolescents, adolescents and adults, 9 to 45 years of age
living in endemic areas.
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It took the multinational pharmaceutical company Sanofi Pasteur more than 20
years to develop the vaccine with clinical trials in five Asian and five Latin American
countries where dengue is endemic.
The vaccine was launched in the Philippines since it was the only country where
all three phases of the clinical development were conducted.
Health authorities said the vaccine will have side effects, including fever,
headache, muscle pain, weakness, redness and swelling.
The DOH also said that the medical breakthrough is no excuse to stop the fight
against dengue. Communities should work towards prevention by cleaning possible
mosquito breeding sites.
Health Secretary Janette Garin said the agency would get a discounted price for
the vaccine that would be used in the vaccination program starting March.
The DOH will begin vaccinating Grade 4 students in public schools in Metro
Manila, and in Southern and Central Luzon. The vaccine will be given in three doses,
with six-month intervals.
It will give the vaccine to over a million students this year but the health
department is planning to hold a nationwide vaccination on 2017.
Reference: http://www.sanofipasteur.com/en/articles/dengvaxia-world-s-first-dengue-vaccine-approved-in-mexico.aspx; Lyon,France
- December 9, 2015
B. STATISTICS
Local
The number of dengue cases in the country spiked from around 120,000 in 2014
to over 200,000 in 2015.
Despite the sharp increase in dengue cases, the Department of Health (DOH) said
there was no corresponding increase in the number of deaths--with 598 in 2015 compared
to 465 in 2014.
The DOH estimated that some 220 Filipinos a day may be infected by the disease.
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Reference: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222740/ Lulu Bravo ,* Vito G. Roque, Jeremy Brett, Ruby
Dizon, and Maïna L'Azou, 2014 Nov 6
International
The incidence of dengue has grown dramatically around the world in recent
decades. The actual numbers of dengue cases are underreported and many cases are
misclassified. One recent estimate indicates 390 million dengue infections per year (95%
credible interval 284–528 million), of which 96 million (67–136 million) manifest
clinically (with any severity of disease). Another study, of the prevalence of dengue,
estimates that 3900 million people, in 128 countries, are at risk of infection with dengue
viruses.
Member States in 3 WHO regions regularly report the annual number of cases. In
2010, nearly 2.4 million cases were reported. Although the full global burden of the
disease is uncertain, the initiation of activities to record all dengue cases partly explains
the sharp increase in the number of cases reported in recent years.
Other features of the disease include its epidemiological patterns, including
hyper-endemicity of multiple dengue virus serotypes in many countries and the alarming
impact on both human health and the global and national economies.
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Cases across the Americas, South-East Asia and Western Pacific exceeded 1.2
million in 2008 and over 3 million in 2013 (based on official data submitted by Member
States). Recently the number of reported cases has continued to increase. In 2013, 2.35
million cases of dengue were reported in the Americas alone, of which 37 687 cases
were of severe dengue.
Reference: http://www.who.int/mediacentre/factsheets/fs117/en/ May, 2015
C. SCOPE AND LIMITATION
We handled our patient last January 30, 2016 on our 6am to 2pm shift, bed #15,
Female-Ward at Laguna Medical Center under the supervision of Gloria Ramos,
Ph.D,MAN, RN.
We received the patient lying on bed with IVF Sodium Chloride 0.9 1 L on right
metacarpal vein. The exposure of our duty comprised Nurse-Patient-Interaction, Head-
to-Toe Assessment, IV regulation, vital signs monitoring and recording, drug
administration via oral route, IV drug medication study and charting.
To have further assessment, our group conducted a home visit on February 25,
2015 in the residence of Patient DLB in Lumban, Laguna. First and foremost, we asked
consent and stated the purpose of the home visit. As we gathered data and information
about the patient and his progress, the patient as well as the family members participated
and cooperated hospitably.
D. OBJECTIVES
General Objective:
At the end of the case study, the Level III nursing students will be able to
expound and incorporate all the ideas and knowledge gained to the nursing approach in
providing valid and outmost care connected with the patient diagnosed of Dengue
Hemorrhagic Fever.
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Specific Objectives:
As supported by our main objective, the level 3 student nurses will be able to:
1. Familiarize with the background of what Dengue Hemorrhagic Fever is all about;
2. Recognize predisposing and precipitating factors that may increase the development
of Dengue Hemorrhagic Fever;
3. Review and understand the Anatomy and Physiology of the Circulatory system and
Lymphatic system.
4. Explain and illustrate the pathophysiology of Dengue Hemorrhagic Fever;
5. Determine what specific laboratory results that may lead to Dengue Hemorrhagic
Fever;
6. Describe the potential complications related to Dengue Hemorrhagic Fever;
7. Develop a comprehensive nursing care plan, with a principle of SMART, that is
applicable to the client diagnosed with Dengue Hemorrhagic Fever;
8. Provide a well-develop Health Teaching using the METHODS formula to
promote positive continuity of care to the patient after discharge which would be in great
help for his continuity of care to the patient after discharge which would be in
great help for his condition.
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II. PATIENT’S PROFILE
Hospital Number: 137170
Patient’s Name: Patient DLB
Address: Segundo Pulo, Lumban, Laguna
Gender: Male
Birthday: 11/22/2001
Age: 14 y/o
Birthplace: Lumban, Laguna
Nationality: Filipino
Civil Status: Single
Religion: Roman Catholic
Educational Level: Grade 8
Allergies: (+) Penicillin
Admitting Time: 6:30am
Admitting Date: 01/29/16
Admitting Diagnosis: Severe Dengue
Admitting Physician: Dra. Abadier
Chief Complaint: Epistaxis, headache, nausea and vomiting
and body malaise
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III. PATIENT’S HISTORY
A. Past History
According to Patient DLB, he had experienced cough, cold, fever and
chicken pox before. He has no history of hospitalization but seeks medical
advice to clinics in their barangay and other clinic to the near towns.
B. Present History
 5 days prior to admission, the patient experienced on and off fever. The
patient drinks tawa-tawa extract and antipyretic medications like biogesic and
tempra to relieve fever.
 After a day, when the patient is still with fever, the patient decided to seek
medical attention in a small Clinic in Unson. They checked the platelet count
which is 187 X10/L and blood pressure of 100/80mmHg. Then he was given a
prescribed medication of Biogesic 500mg for his fever.
 Two days prior to hospitalization, the patient is still with fever. He consults to
his paediatrician, Dra. Aquino and checked again for the platelet count that
has a result of 24 x10/L so he was advised to go to the hospital.
 One day prior to admission, the patient was experiencing fever, loss of
appetite and epistaxis so the family decided to take him to Laguna Medical
Center, Sta. Cruz, Laguna.
 January 29, 2016, at 6:30am he was admitted with a diagnosis of Severe
Dengue by attending physician Dra. Abadier with a blood pressure of
100/78mmHg.
Patient’s vital signs during our shift whereas follows:
Temperature: 38.2 °c
Pulse Rate: 98 bpm
Respiratory Rate: 20 cpm
Blood Pressure: 100/60 mmHg
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C. Psychological
Patient is unable to answer some of the questions properly because he
cannot recall what happened during hospitalization. Nevertheless, the patient
demonstrates an understanding and acceptance concerning on the health teaching
about the health condition he experienced.
D. Family History
There is no history of dengue cases within patient's family members except
with his two cousins who lived in the same Barangay.
E. Spiritual
Patient DLB’s religious affiliation is Roman Catholic. He stated that their
family do not usually go to church but always pray and ask guidance for them.
F. Sociocultural
The patient consults to hilot as one of their health care provider. Prior to
admission, patient DLB sipped tawa-tawa extract and had self-medication of advil,
biogesic, and tempra as a relieved for fever. He also consults in health care clinic
in their town.
G. Exercise
Patient is usually staying in their bedroom after school and during weekends.
But at times he used to walk in going to school that is about 1km away from their
residence.
H. Nutritional
The patient eats vegetables like radish, cabbage and mongo beans more
often than not. He said that he just consumes what is served by his mother and
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does not usually fond of eating junkfoods or processed foods. He drinks 6-8
glasses of water a day.
I. Developmental
Erik Erikson’s stages of psychosocial development are a comprehensive
psychoanalytic theory that identifies a series of eight stages, in which a healthy
developing individual should pass through infancy to late adulthood. All stages are
present at birth but only begin to unfold according to both natural scheme and one’s
cultural and ecological upbringing. Each stages builds upon the successful completion
of earlier stage.
STAGE DESCRIPTION RESULT JUSTIFICATION
Ages 12 to 18 years
old
Identity
Vs.
Role Confusion
The adolescent is
newly concerned
with how they
appear to others.
Superego identity is
the accrued
confidence that the
outer sameness and
continuity prepared
in the future are
matched by the
sameness and
continuity of one’s
meaning for oneself,
as evidenced in the
promise of a career.
It was attained by
the patient.
The patient
accomplished the
ability to settle in the
school. He ponders the
roles he wants to do in
the future. He knows
what he wants to do
and he expresses
himself in the way he is
known to be. He
manages to spend time
with his family and had
good relationship with
his classmates and
knows his priorities.
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J. Hygiene
Before Hospitalization During Hospitalization After Hospitalization
Patient takes a bath every
day before going to school
and brushes his teeth twice
a day. He performs hand
washing before meal and
he usually eat with the use
of spoon and fork instead
of the use of his bare
hands.
The patient is unable to go
to the bathroom by himself
due to muscle weakness so
the family members prefer
to perform sponge bath
when he was in the
hospital. He brushed his
teeth once a day and does
not wash his hands during
hospitalization.
The patient takes a bath
once a day and brushes his
teeth every morning and
before going to bed. He
demonstrates hand
washing with soap and
running water.
K. Elimination
Before Hospitalization During Hospitalization After Hospitalization
Urination
The patient voids 5-6
times a day, yellowish in
color and with moderate
amount.
Defecation
Patient usually defecate
twice a day, light brown in
color and formed in
appearance.
Urination
Patient has no urinary
catheter inserted. He voids
3-4 times per shift,
transparent in color and
with an estimated amount
of 600 ml.
Defecation
During hospitalization, the
patient defecates 5-6 times
a day, black in color.
Urination
Patient voids 5-6 times a
day, approximately 600ml
and yellowish in color.
Defecation
The patient’s stool is light
brown in color and formed
in appearance. He
defecates twice daily.
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L. Sleepand Rest
Before Hospitalization During Hospitalization After Hospitalization
Patient is able to sleep at 9
in the evening and wakes
up 5 in the morning to
prepare for school. He has
adequate rest every day.
The patient sleeps at 7pm,
but wakes up every time
he feels tenderness and has
uncomfortable sensation.
The patient is able to sleep
with his normal sleeping
pattern and has no
difficulty resting.
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IV. NUTRITIONAL ASSESSMENT
24 hour Food Recall
Before Hospitalization After Hospitalization
1. What time did you go to
bed the night before?
Was this the usual time?
“I slept as early as 7pm but
not continuous, sometimes I
woke up when I feel
uncomfortable.”
“No. I usually go to sleep
around 9pm.”
Patient stated that he sleeps
at 9pm in the evening.
“Yes.”
2. What time did you get
up yesterday?
Was this the usual time?
When was the first time
you had anything to eat
or drink?
What did you have and
how much?
“Around 8am.”
“No. I usually wake up
earlier.”
“At lunch time.”
“Just a piece of biscuit and
sipped as small amount of
water.
“I woke up 6 in the
morning.”
“Yes, it is.”
“I had my breakfast at
6:30am.”
“I ate a cup of rice and one
hotdog.”
3. When did you eat again? “The next meal was my
dinner.”
“I ate my snack at 10am.”
4. Where?
What and how much?
“In our house.”
“I drink a half glass of
water and one spoonful of
rice with egg pugo.”
“In our house.”
“I had 3 pieces of bread and
one glass of ice tea.”
5. When did you eat next?
What did you eat and
how much?
“At 10 pm.”
“A piece of tasty.”
“Lunchtime.”
“1 ½ cup of rice and
sinigang.”
6. Did you eat or drink
anything else?
a. Anything from 1st
“I had a glass of water and
half bottle of gatorade.”
“None.”
“Yes. I ate at 6:30 in the
evening.”
“I drink a glass of water
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meal to 2nd meal?
b. Anything from 2nd to
3rd meal?
c. Anything from 3rd
meal to bed time?
“None.”
“None.”
about 150ml.”
“I drink a half glass of
water.”
“I had a glass of water.”
7. Was this day’s food
intake differing from
usual?
If so, why?
“Yes.”
“I lose my appetite and feel
nauseated every time I eat.”
“No.”
8. Is weekend eating
different?
If so, why?
“Sometimes.”
“It depends on what food is
available in our house.”
“At times.”
“It depends on what food is
available in our house.”
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V. PHYSICAL ASSESSMENT
Area Method Findings Post-Findings Interpretation
Hair Inspection Hair is black
and equally
distributed
Hair is black and
equally
distributed
Normal
Palpation No signs of
tenderness and
nodules while
palpating
No signs of
tenderness and
nodules while
palpating
Normal
Skin Inspection Generalized
pallor
Presence of
hematoma on
the upper right
arm
Dengue virus induces bone
marrow suppression. Since bone
marrow is the manufacturing
center of blood cells its
suppression causes deficiency
of blood cells leading to low
hemoglobin count.
Paleness is caused by reduced
blood flow or a decreased
number of red blood cells.
Reference: K. Kafeel (2011). Retrieved from:
http://www.onlymyhealth.com/cause-low-
platelet-count-in-dengue-fever-1301653922
The presence of the virus
(arbovirus) within the blood
vessels, especially those feeding
the skin, causes changes to
these blood vessels. The vessels
swell and leak because of
increase capillary permeability.
As the blood vessels become
more damaged the blood vessels
start to leak. When blood leaves
the circulatory system and
becomes stagnant, there is
almost immediate clotting.
Reference: C. Dewit. Dengue Fever (2006).
Retrieved from:
http://www.encyclopedia.com/topic/dengue_fev
er.aspx
C. Davis. Hematoma (2015). Retrieved from:
http://www.emedicinehealth.com/hematoma/pag
e2_em.htm
Page | 18
Palpation Warm to touch With moist skin
and with good
skin turgor
Warm to touch because of the
body’s compensation to the
virus.
The patient’s body temperature
was 38.2 °c.
Reference: W. Lloyd. (2013). Retrieved from:
http://www.healthgrades.com/symptoms/clamm
y-skin
Nails Inspection Nail surface is
slightly curved
No clubbed
finger
Nail surface is
slightly curved
No clubbed
finger
Normal
Palpation Capillary refill
of more than 3
sec
With pale nail
beds
Capillary refill
of less than 3 sec
With pinkish nail
beds
Damage to an artery or vein
allows blood to escape the
circulatory system. Thus, a low
hemoglobin count cause
alteration in blood flow.
Eyes Inspection With pale
conjunctiva
Pupil Equally
Round Reactive
to Light and
Accommodatio
n
With equally
distributed eye
lid and eye
lashes
With moist and
pinkish
conjunctiva
Pupil Equally
Round Reactive
to Light and
Accommodation
With equally
distributed eye
lid and eye
lashes
Damage to an artery or vein
allows blood to escape the
circulatory system. Thus, a low
hemoglobin count cause
alteration in blood flow.
Palpation No signs
tenderness
when palpating
No signs
tenderness when
palpating
Normal
Ears Inspection Symmetrical,
no presence of
discharge or
redness
Can react to
sound
No presence of
cerumen
Symmetrical, no
presence of
discharge or
redness
Can react to
sound
No presence of
cerumen
Normal
Palpation No tenderness
and nodules
No tenderness
and nodules
Normal
Nose
and
Sinuses
Inspection No nasal
discharge
No redness and
No nasal
discharge
No redness and
Normal
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inflammation
No nasal
deviation
inflammation
No nasal
deviation
Palpation No tenderness
upon palpation
No tenderness
upon palpation
Normal
Mouth Inspection Dry lips
With pale
palate
Can able to
move the
tongue in all
direction
Uvula is at the
midline
No presence of
inflammation in
oral mucosa
Moist and
pinkish mucus
membrane
Can able to
move the tongue
in all direction
Uvula is at the
midline
If the amount of fluid in the
intravascular space is decreased,
the body compensates. (fluid
depletion)
Damage to an artery or vein
allows blood to escape the
circulatory system. Low
hemoglobin count cause
alteration in blood flow.
Palpation No tenderness
when palpating
for the soft and
hard palate
With intact gag
reflex
No presence of
inflammation in
oral mucosa
No tenderness
when palpating
for the soft and
hard palate
With intact gag
reflex
Normal
Neck Inspection No swelling and
no venous
distention
No swelling and
no venous
distention
Normal
Palpation No masses
lymph nodes
and thyroid
gland
enlargement
No masses
lymph nodes and
thyroid gland
enlargement
Normal
Lungs
and
Thorax
Inspection symmetrical
anterior chest
wall
symmetrical
anterior chest
wall
Normal
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With no
difficulty of
breathing
With no signs of
difficulty of
breathing
Normal
Percussion Resonance in
sound
Resonance in
sound
Normal
Auscultation With clear
breath sounds
With clear
breath sounds
Normal
With Systolic of
100 mmHg and
Diastolic of
60mmHg
With systolic of
120 mmHg and
Diastolic of 80
mmHg
Normal
Abdom
en
Inspection No abdominal
distention with
no signs of
tenderness or
masses
No abdominal
distention with
no signs of
tenderness or
masses
Normal
Auscultation Bowel sound
heard
RLQ= 7
RUQ= 6
LUQ= 9
LLQ= 8
Bowel sounds
heard
RLQ= 5
RUQ= 7
LUQ= 5
LLQ= 9
Normal
Percussion With tympanic With tympanic Normal
Palpation Abdomen is
soft
With no signs
of tenderness or
masses
Abdomen is soft
With no signs of
tenderness or
masses
Normal
Muscle Inspection
and Palpation
Able to obey
command
muscle
strength of 4/5
Able to obey
command
muscle strength
of 5/5
The dengue virus causes of
measurable muscle weakness.
The muscle can move the joint
it crosses through a full range of
motion against gravity moderate
resistance.
Extremi
ties
Inspection Presence of
petechiae in
upper and
lower
extremities
Has no signs of
lesions
It caused by capillary fragility.
The blood vessels start to leak
and cause bleeding. Petechiae
(small skin hemorrhages).
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VI. ANATOMY AND PHYSIOLOGY
Blood
Blood is made up of liquid (called plasma) and solid cells. Blood cells are made in
the bone marrow. Bone marrow is the soft, spongy substance in the centre of bones.
Structure
In adults, the most active bone marrow is found in the pelvic bone, shoulder
bones, back bones (vertebra), ribs, breast bone and skull. Immature blood cells in the
bone marrow are called stem cells. Stem cells can also be found in smaller amounts in the
bloodstream. These are called peripheral blood stem cells.
All of our blood cells develop from stem cells. The process of blood cell
development is called hematopoiesis. In the earliest stage of blood cell development,
stem cells begin to develop either along the lymphoid cell line or the myeloid cell line. In
both cell lines, the stem cells become blasts, which are still immature cells.
Lymphoid cell line
Lymphoid stem cells develop into lymphocytes (also called lymphoblasts).
Lymphocytes are another type of white blood cell (also called leukocytes). Lymphocytes
help fight infection and destroy abnormal cells.
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Myeloid cell line
Myeloid stem cells develop into red blood cells, platelets and some types of white
blood cells. Red blood cells carry oxygen to all tissues of the body. Platelets form clots in
damaged blood vessels to stop bleeding.
Myeloid stem cells develop into 2 different types of white blood cells, called
granulocytes and monocytes. These white blood cells destroy bacteria and other foreign
invaders and help to fight infection.
Functions
The main function of blood is to carry nutrients, gases, waste products, cells and
hormones. Each type of blood cell has a specific job.
 Red blood cells carry oxygen from the lungs to the rest of the body. They also
carry carbon dioxide from the body to the lungs so it can be breathed out.
 Platelets form blood clots in damaged vessels to stop bleeding.
 White blood cells help prevent and fight infection by destroying bacteria, viruses
and other foreign cells or substances.
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Types of white blood cells
White blood cells are the cells that help the body fight infection. There are a
number of different types and sub-types of white blood cells which each have different
roles to play.
The three major types of white blood cells are:
 Granulocytes
 Monocytes
 Lymphocytes
Granulocytes
There are three different forms of granulocytes:
 Neutrophils
 Eosinophils
 Basophils
Granulocytes are phagocytes, that is they are able to ingest foreign cells such as
bacteria, viruses and other parasites.
Granulocytes are so called because these cells have granules of enzymes which help to
digest the invading microbes. Granulocytes account for about 60% of our white blood
cells.
Neutrophils are by far the most prevalent of these cells. Each neutrophil cell can
ingest up to between around 5 and 20 bacteria in its lifetime.
Eosinophils are involved in allergic reactions and can attack multicellular
parasites such as worms.
Basophils are also involved in allergic reactions and are able to release histamine,
which helps to trigger inflammation, and heparin, which prevents blood from clotting.
Monocytes
Monocytes can develop into two types of cell:
Dendritic cells are antigen-presenting cells which are able to mark out cells that are
antigens (foreign bodies) that need to be destroyed by lymphocytes.
Macrophages are phagocyte cells which are larger and live longer than neutrophils.
Macrophages are also able to act as antigen-presenting cells.
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Lymphocytes
Lymphocytes are cells which help to regulate the body's immune system.
The main types of lymphocytes are:
 B lymphocytes (B cells)
 T lymphocytes (T cells)
 Natural Killer Cells
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VII. PATHOPHYSIOLOGY
Precipitating Factors
 Environmental conditions (open
spaces with water)
 Presence of 2 Dengue cases in
the community
Predisposing Factors
 Geographical area-tropical island
in the Pacific (Philippines)
Aedes Mosquito
(Carrier of Dengue Virus)
Bite from mosquito to skin
(Portal of Entry)
Virus will circulate in the
blood
Infection primarily targets
the reticulo endothelial
system (blood,bone
marrow, lymph nodes)
Production of immune
mediators
Activation of immune
response
Destructive actions of the virus or
bone marrow precursor cells
Release of cytokines
Stimulate WBC and
Pyrogens
Fever 38.2°C
Viral replication and
Cellular destruction
Page | 26
DENGUE HEMORRHGIC
FEVER
URINARY TRACT INFECTION
Muscle
weakness
4/5
Thrombocytopenia
Platelet Count=38x109
/L
Low
Lymphopenia
Lymphocytes=2.29 %
Low
Leukopenia
WBC=3.83 x 109
/L
Low
Capillary fragility Petechiae
GI
Bleeding
MelenaRelease of Histamine
↑ Capilliary
permeability
Plasma leakage
Epistaxis
↑ Glomerular
Permeabilty
↑ Amount of
plasma protein
Urinalysis Result:
(+) 4 protein
2-4 hpf RBC
Few Bacteria
Hemoglobin=86
g/L
RBC=2.69x 1012
/L
Hematocrit=23.9 %
Page | 27
VIII. MEDICAL MANAGEMENT
Date Doctor’s Order Interpretation
Day 1
January 29, 2016,
6:30 am
Epistaxis
Dengue
Hemorrhagic
fever
Typhoid fever
4:00 pm
(+) epistaxis
 Please admit to
medicine ward
 Secure consent
 TPR every shift
 DAT except dark
colored food
 Hospital policy designates the exact
procedure that should be followed when
admitting the patient to the holding area or
operating room suite. Admission will help
to monitor the client’s condition. The
admitting procedure is continued with
reassessment of the patient and allowance of
time for last minute question. (references:
Medical-Surgical Nursing 5th
edition by Lewis,
Heitkemper &Dirksen Chapter 17, page 380)
 Informed consent is the patient’s
autonomous decision about whether to
undergo a procedure. Before signing the
consent, the risks and benefits of the
procedure must be explained in terms the
patient could easily understand. This is to
prepare patient psychologically and the
health care workers from battery. (references:
Maternal and Child Health Nursing 6th
edition by Adelle
Pilliteri Chapter 24, page 658 and Brunner & Suddarth’s
Textbook of Medical-Surgical Nursing 13th
edition by
Janice L. Hinkle & Kerry H. Cheever Chapter 17 page
406)
 The recording of Temperature, Pulse rate,
and Respiration are part of physical
examination. Acute changes and trends over
time are documented and unexpected
changes and values that deviate significantly
from a patient’s normal values are brought
to the attention of the patient’s primary
health care provider. (references: Brunner &
Suddarth’s Textbook of Medical-Surgical Nursing 13th
edition by Janice L. Hinkle & Kerry H. Cheever Chapter 5
page 67)
 Dark colored foods may alter the color of
the stool of the patient. It is advice to patient
which will undergo fecalysis exam to
determine Blood Occult in the stools.
Highly colored foods, dark green leafy
vegetables and Iron supplements are
avoided as these tend to interfere with the
Page | 28
TVF:
 D5LR 1L × 60
gtts/min × 2
cycles
Laboratories:
 Complete blood
count with PC,
typing
 Urine analysis
 Hematocrit
monitoring at
every 6 hours
test. (reference: Nutrition and Diet Therapy for Nursing
2011 by Adela Jamorabo-Ruiz Chapter 13 page 301-302)
 D5LR is an hypertonic solution that is
given to prevent dehydration. Dengue is a
disease of DEHYDRATION. Much like a
Diarrhea except that the body fluids don’t
come out with the patient’s stool but
through PLASMA LEAKAGE. Imagine
that the arteries and veins of a patient have
thousands of pinpoint holes due to the
body's reaction to the Dengue virus,
causing the fluids inside the blood vessels
to sip out. (reference: Fundamentals of Nursing 8th
edition of 2008 Volume 2 by Snyder, Berman, Kozier
and Erb Chapter 52 Fluid, Electrolyte and Acid – Base
Balance page 1456)
 CBC is done to the patient to test if there is
blood loss. To look for low platelet count
typical of the later stages of the illness and
to detect the decrease in hemoglobin,
hematocrit, and red blood cell (RBC) count
(evidence of anemia) that would occur with
blood loss associated with severe dengue
fever. (references: cell medicine, 24th edition by
Golman and Schater page 345)
 Urinalysis is done to the patient to detect
possible abnormalities in the urinary tract.
It is ordered to determine presence of
bacteria or blood (hematuria) in the urine
of the patient.( reference:Medical Surgical Nursing
8th edition volume 2, Chapter 45 Urinary System page
1150 )
 A blood sample's hematocrit or the red
blood cell volume percentage, and become
a point of reference of its capability of
delivering oxygen. The patient’s
hematology result of Hct: 37.1 % as of 01-
29-2016. (reference: retrieved from
https://en.wikipedia.org/wiki/Hematocrit )
Page | 29
Medications:
 Ascorbic acid 500
mg 1 tab BID
 Tranexamic acid
500 mg TIV
every 8 hours x 3
days
 For transfusion of
platelet 6 units
properly typed
and cross matched
 If platelet
concentrate not
cross matched
may transfused
FFP 4 units
 Supplemental therapy in some GI diseases,
during long term parenteral nutrition.
Increases protection
mechanism of the immune system thus,
resistance to infection. (Reference: Davis’s Drug
Guide for Nurses fifth edition 2010 (ascorbic acid, page
105)
 Inhibits activation of plasminogen thereby
preventing the conversion of plasminogen
to plasmin.
Treatment for bleeding. Patient
experienced epistaxis and melena. Reference:
Davis’s Drug Guide for Nurses fifth edition
2010(tranexamic acid, page 1179)
 Platelet transfusions are used to prevent
spontaneous bleeding or to stop established
bleeding in patients with a deficiency in
platelet number or function. In Dengue
patients, transfusion is done when platelet
count is 10000-20000/ul and
thrombocytopenic bleeding is present. All
the patients of Dengue Shock syndrome
require platelet support. The patient’s
platelet revealed 8x 109
/L as of 01-29-
2016 and positive for epistaxis. Doctors
use blood typing and cross matching to
make sure that the patient receiving a blood
transfusion is getting the correct type of
blood. Crossmatching is used by a doctor
to make sure that the specific donor blood
that will be used during a transfusion does
not react with a patient’s blood.
(reference:http://ijtm.in/view_article.php?id=21)
 Plasma contains all of the coagulation
factors. Fresh frozen plasma (FFP) infusion
can be used for reversal of anticoagulant
effects. Plasma transfusion is
recommended in patients with active
bleeding. The patient experienced nose
bleeding. FFP does not need to be cross-
matched but should be ABO compatible.
(reference:
http://www.aafp.org/afp/2011/0315/p719.html)
Page | 30
 Godex 1 cap 300
mg PO BID
 Omeprazole 40
mg TIV OD
 Ceftriaxone 1g
TIV every 12
hours
 Intake and output
every shift
 To prevent damage to liver, one of the
complication of DHF. Godex acts by
transporting excess, long-chain fatty acids
into the mitochondria to produce high
amounts of energy to produce high
amounts of energy to provide cell
protection and fast treatment of liver
disease.(http://www.mergersdrugfil.com.ph/index.php
/godex-ds )
 Treatment and prevention of
hypersecretions of stomach acid.
Omeprazole is used to prevent upper
gastrointestinal tract bleeding. Due to
patient’s lost appetite with DHF it will
cause abdominal pain. (retrieve from
:http://www.mayoclinic.org/drugs-
supplements/omeprazole-oral-route/description/drg-
2006683)
 To treat infection. Interferes with bacterial
cell wall synthesis by inhibiting cross-
linking of peptidoglycan strands.
Peptidoglycan makes the cell membrane
rigid and protective. Without it, bacterial
cells rupture and die. The patient’s
urinalysis revealed a presence of few
bacteria in urine as of Jan. 31, 2016.
(reference : Jones and Bartlett Nurse’s Drug Handbook
2015 (ceftriaxone page 223)
 Accurate intake and output is necessary for
determining fluid replacement needs and
reducing risk of fluid overload and reflects
circulating fluid shifts, and response to
therapy. Dengue Hemorrhagic Fever can
cause fluid shifting from intracellular spaces
to intravascular space that leads to
dehydration. (references: Nursing Care Plan 8th
edition
of 2010 by Marlynn E. Doenges Capter 10 page 542)
Page | 31
 Vital sign every 1
hour and record
 For close
monitoring
Notify Dra.
Abralzado
Refer
 IVF to following
D5LR 1L x 70
gtts/min x 2 cycles
 Give
Hydrocortisone
250 mg IV now
 The vital signs are body temperature,
pulse, respirations and blood pressure,
which should be looked at in total, are
checked to monitor the function of the
body which may alter the normal function
of the body.(Reference: Fundamentals of Nursing 8th
Edition of 2008 Volume 1 by Berman, Snyder, Kozier
and Erb Chapter 29 Vital signs page. 527)
 The vital signs are body temperature,
pulse, respirations and blood pressure,
which should be looked at in total, are
checked to monitor the function of the
body which may alter the normal function
of the body. Since the patient’s blood count
especially the hemoglobin and platelet is
decreasing he needs more attentive care.
(Reference: Fundamentals of Nursing 8th Edition of 2008
Volume 1 by Berman, Snyder, Kozier and Erb Chapter 29
Vital signs page. 527)
 D5LR is an hypertonic solution that is
given to prevent dehydration. Dengue is a
disease of DEHYDRATION. Much like a
Diarrhea except that the body fluids don’t
come out with the patient’s stool but
through PLASMA LEAKAGE. Imagine
that the arteries and veins of a patient have
thousands of pinpoint holes due to the
body's reaction to the Dengue virus,
causing the fluids inside the blood vessels
to sip out. (reference: Fundamentals of Nursing 8th
edition of 2008 Volume 2 by Snyder, Berman, Kozier
and Erb Chapter 52 Fluid, Electrolyte and Acid – Base
Balance page 1456)
 Management for Dengue shock syndrome.
Corticosteroids are potent anti-
inflammatory agents that have a wide
range of effects on immunological
processes and have found use in a broad
spectrum of diseases (Reference : Jones and
Bartlett Nurse’s Drug Handbook 2015( hydrocortisone
page 256)
Day 2
January 30, 2016
3:00 am
 Diphenhydramine
50 mg TIV now
 To prevent allergic reaction after blood
transfusion. Acts on blood vessels, GI,
respiratory system by competing with
Page | 32
BP 100/70
PR 86
RR 21
(-) PC
10:00 am
(+) black stool
2:00 pm epistaxis
4:00 pm
Severe dengue
Restless
(+) epistaxis
(+) petechia
(+) hematoma
right forearm
Poor pulse
(+) epigastric
tenderness
Clear breath
sounds
6:00 pm
BP 126/79
O2sat 99%
Full pulses
 Hydrocortisone
100 mg TIV now
 Secure and
transfuse 5 units
platelet properly
typed
 Secure and
transfuse either 5
units Platelet
Concentrate or 5
units Fresh Frozen
Plasma
(whichever is
available)
properly typed
and cross
matched)
 Regulate
accurately present
hydration rate
histamine for 𝐻1 –receptor site; decreases
allergic response by blocking histamine.
(Reference : Jones and Bartlett Nurse’s Drug Handbook
2015 ( diphenhydramine page 325)
 Management for Dengue shock syndrome.
Corticosteroids are potent anti-
inflammatory agents that have a wide
range of effects on immunological
processes and have found use in a broad
spectrum of diseases (Reference : Jones and
Bartlett Nurse’s Drug Handbook 2015( hydrocortisone
page 256)
 Platelet transfusions are used to prevent
spontaneous bleeding or to stop established
bleeding in patients with a deficiency in
platelet number or function. In Dengue
patients, transfusion is done when platelet
count is 10000-20000/ul and
thrombocytopenic bleeding is present. All
the patients of Dengue Shock syndrome
require platelet support. Doctors use blood
typing to make sure that the patient
receiving a blood transfusion is getting the
correct type of blood.
(reference:http://ijtm.in/view_article.php?id=21)
 Platelet transfusions are used to prevent
spontaneous bleeding or to stop established
bleeding in patients with a deficiency in
platelet number or function. On the other
hand,. Fresh frozen plasma (FFP) infusion
can be used for reversal of anticoagulant
effects. Plasma transfusion is
recommended in patients with active
bleeding. The patient experienced nose
bleeding and presence of blood in the stool.
(reference:http://ijtm.in/view_article.php?id=21,
http://www.aafp.org/afp/2011/0315/p719.html)
 To prevent dehydration causes by Dengue
virus.
Page | 33
 Facilitate
paracetamol IV
150mg/ml PRN
fever
 Tepid sponge bath
care out
companion
(please facilitate)
 Hook to O2
support via nasal
canulla x 3 cpm
 Transfer to ICU
please
 Appraised mother
 Paracetamol is an antipyretics use to
decreases fever by inhibiting the effects of
pyrogens on the hypothalamus heat
regulating centers & by a hypothalamic
action leading to sweating &
vasodilatation. (reference: retrieved from
https://www.scribd.com/doc/36795690/Drug-Study-
Paracetamol)
 Tepid sponge bath is considered as one of
the best cooling treatments. This method is
recommended for febrile individuals,
especially those with fever ranging from
102.2F or higher. It is effective in relieving
fever by reducing high temperature and
also helpful in alleviating pain
or discomfort. (reference:
https://www.scribd.com/doc/38235959/Tepid-Sponge-
Bath)
 Administration of oxygen helps increase
the percentage of oxygen in inspired air.
The goal of oxygen administration is to
supply the patient with adequate oxygen to
maximize oxygen carrying ability of the
blood. Patient’s hemoglobin revealed 69
g/L (low). References: Medical Surgical Nursing by
LweisHeitkemper Dirksen, Fifth Edition at pages 689)
 Seriously ill patients require close
observation and monitoring. Since the
patient’s blood profile is continuously
decreasing the doctor ordered to transfer
him to ICU.
(reference:http://www.cpmc.org/learning/documents/icu-
ws.html)
 The family should have an accurate
knowledge about the medical condition of
her child to alleviate stress. It allows the
individual to accept and minimize reaction
to difficult situations. (Reference:
http://www.hindawi.com/journals/nrp/2011/392705/)
Page | 34
 IVF to follow
D5LR 1L x 70gtts
2 cycles
 Omeprazole 40
mg IV OD
 Fecalysis with
occult
 Tranexamic acid
500g IV run q 8
 Vitamin K 1 amp
IV every 8 hours
 D5LR is an hypertonic solution that is
given to prevent dehydration. Dengue is a
disease of DEHYDRATION. Much like a
Diarrhea except that the body fluids don’t
come out with the patient’s stool but
through PLASMA LEAKAGE. Imagine
that the arteries and veins of a patient have
thousands of pinpoint holes due to the
body's reaction to the Dengue virus,
causing the fluids inside the blood vessels
to sip out. (reference: Fundamentals of Nursing 8th
edition of 2008 Volume 2 by Snyder, Berman, Kozier
and Erb Chapter 52 Fluid, Electrolyte and Acid – Base
Balance page 1456)
 Treatment and prevention of
hypersecretions of stomach acid.
Omeprazole is used to prevent upper
gastrointestinal tract bleeding. Due to
patient’s lost appetite with DHF it will
cause abdominal pain. (retrieve from
:http://www.mayoclinic.org/drugs-
supplements/omeprazole-oral-route/description/drg-
2006683)
 Since the patient was diagnosed of dengue
hemorrhagic fever, these examination finds
out to see if there was melena in the stool
of the patient. ( reference: Brunner and Suddarth’s
Textbook of Medical Surgical Nursing Twelfth Edition by
Smeltzer, Bare, Hinkle and Cheever page 987)
 Inhibits activation of plasminogen thereby
preventing the conversion of plasminogen
to plasmin.
Treatment for bleeding. Patient
experienced epistaxis and melena.
(Reference: Davis’s Drug Guide for Nurses fifth edition
2010(tranexamic acid, page 1179)
 To treat bleeding.The patient manifested
epistaxis and black tarry stool at 2:00 pm
as of Jan. 30, 2016. Required for hepatic
synthesis of blood coagulation factors II
(prothrombin), VII, IX, and X. An
Page | 35
 Line no 1L PNSS
500cc then
maintain at
55gtts/min (5
cycles)
 Line no 2 D5LR
1L x 55gtts/min
(5)
Refer for next
IVF
 For Fresh Whole
Blood transfusion
properly typed
and crosmatched
x 5 hrs 2 doses,
6hrs
 Furosemide 20mg
PO every after
Blood transfusion
 Please monitor
antihemorrhagic actor that promotes
hepatic formation of active prothrombin.
(Reference: Davis’s Drug Guide for Nurses fifth edition 2010
(vitamin K, page 970)
 Used because it has little to no effect on the
tissues and make the person feel hydrated
preventing hypovolemic shock
or hypotension. (reference:
https://www.scribd.com/doc/109761163/PNSS-drug-
study)
 D5LR is an hypertonic solution that is
given to prevent dehydration. Dengue is a
disease of DEHYDRATION. Much like a
Diarrhea except that the body fluids don’t
come out with the patient’s stool but
through PLASMA LEAKAGE. Imagine
that the arteries and veins of a patient have
thousands of pinpoint holes due to the
body's reaction to the Dengue virus,
causing the fluids inside the blood vessels
to sip out. (reference: Fundamentals of Nursing 8th
edition of 2008 Volume 2 by Snyder, Berman, Kozier
and Erb Chapter 52 Fluid, Electrolyte and Acid – Base
Balance page 1456)
 Plasma contains all of the coagulation
factors. Fresh frozen plasma (FFP) infusion
can be used for reversal of anticoagulant
effects. Plasma transfusion is
recommended in patients with active
bleeding. The patient experienced nose
bleeding. FFP does not need to be cross-
matched but should be ABO compatible.
(reference:
http://www.aafp.org/afp/2011/0315/p719.html)
 To prevent fluid overload that may be
imposed by the additional blood volume
delivered during transfusion. Inhibits the
reabsorption of sodium and chloride from
the loop of Henle and distal renal tubule.
(Reference: Davis’s Drug Guide for Nurses fifth edition
2010(Diuretics (Loop), page 392)
 The vital signs are body temperature,
Page | 36
vital sign blood
pressure every 1
hour and record
Refer
 Hold vitamin K,
and do please PT,
PTT
 Intake and output
every shift
 Complete blood
count every 8
hours
 Please include
SGPT/SGOT (
Serum Glutamic
Pyruvic
Transaminase),
SGOT ( Serum
pulse, respirations and blood pressure,
which should be looked at in total, are
checked to monitor the function of the
body which may alter the normal function
of the body.(Reference: Fundamentals of Nursing 8th
Edition of 2008 Volume 1 by Berman, Snyder, Kozier
and Erb Chapter 29 Vital signs page. 527)
 The PTT is used primarily to investigate
unexplained bleeding or clotting. It may be
ordered along with a prothrombin time
(PT) test to evaluate hemostasis, the
process that the body uses to form blood
clots to help stop bleeding. These tests are
usually the starting points for
investigating excessive bleeding or clotting
disorders. (reference: retrieved from
https://labtestsonline.org/understanding/analytes/aptt/tab/
test/)
 Accurate intake and output is necessary for
determining fluid replacement needs and
reducing risk of fluid overload and reflects
circulating fluid shifts, and response to
therapy. Dengue Hemorrhagic Fever can
cause fluid shifting from intracellular spaces
to intravascular space that leads to
dehydration. (references: Nursing Care Plan 8th
edition
of 2010 by Marlynn E. Doenges Capter 10 page 542)
 CBC is done to the patient to test if there is
blood loss. To look for low platelet count
typical of the later stages of the illness and
to detect the decrease in hemoglobin,
hematocrit, and red blood cell (RBC) count
(evidence of anemia) that would occur with
blood loss associated with severe dengue
fever. (references: cell medicine, 24th edition by
Golman and Schater page 345)
 Liver function tests are one of the blood
tests that are performed to assess the
function of the liver. Liver damage is
detected initially by performing a simple
blood test that determines the level of
various liver enzymes present in the blood.
Liver damage is one of the complication of
Page | 37
Glutamic
Oxaloacetic
Transaminase) on
next CBC
extraction
 O2 at 6 cpm via
face mask
 IVF line no. 1
PNSS at 55
gtts/min (5) x 2
 fused no. 2 D5LR
at 25gtts/min (2)
x 2 hours
Refer
Dengue Hemorrhagic Fever.(reference:
retrieved from http://www.med-health.net/Sgot-Sgpt.html)
 Administration of oxygen helps increase
the percentage of oxygen in inspired air.
The goal of oxygen administration is to
supply the patient with adequate oxygen to
maximize oxygen carrying ability of the
blood. The patient’s hemoglobin revealed
69 g/L (low). (References: Medical Surgical Nursing
by LweisHeitkemper Dirksen, Fifth Edition at pages 689)
 Used because it has little to no effect on the
tissues and make the person feel hydrated
preventing hypovolemic shock
or hypotension. (reference:
https://www.scribd.com/doc/109761163/PNSS-drug-
study)
 D5LR is an hypertonic solution that is
given to prevent dehydration. Dengue is a
disease of DEHYDRATION. Much like a
Diarrhea except that the body fluids don’t
come out with the patient’s stool but
through PLASMA LEAKAGE. Imagine
that the arteries and veins of a patient have
thousands of pinpoint holes due to the
body's reaction to the Dengue virus,
causing the fluids inside the blood vessels
to sip out. (reference: Fundamentals of Nursing 8th
edition of 2008 Volume 2 by Snyder, Berman, Kozier
and Erb Chapter 52 Fluid, Electrolyte and Acid – Base
Balance page 1456)
Day 3
January 31, 2016
12:29 am
BP 113/62
PR 98
T 37.4
O2sat 99%
 IVF line 1 PNSS
at 25gtts/min x
(2) x 4 hours
 Line 2 D5LR at
 Used because it has little to no effect on the
tissues and make the person feel hydrated
preventing hypovolemic shock
or hypotension. (reference:
https://www.scribd.com/doc/109761163/PNSS-drug-
study)
 D5LR is an hypertonic solution that is
Page | 38
(+) mild headache
6:00 am
BP 114/67
(-) Bleeding
8:00 am
(-) melena
(-) epistaxis
Awake
Confused
No epigastric
tenderness
Full pulse
Clear breath sounds
10:00 pm
Coherent
Full pulse
No epistaxis
25gtts/min (2) x 4
hours
Refer
 Paracetamol 1
amp 150mg/ml
IV every 4 hours
 Continue present
management
 Continue
paracetamol PRN
 Facilitate Fresh
Whole Blood
transfuse 2nd dose
given to prevent dehydration. Dengue is a
disease of DEHYDRATION. Much like a
Diarrhea except that the body fluids don’t
come out with the patient’s stool but
through PLASMA LEAKAGE. Imagine
that the arteries and veins of a patient have
thousands of pinpoint holes due to the
body's reaction to the Dengue virus,
causing the fluids inside the blood vessels
to sip out. (reference: Fundamentals of Nursing 8th
edition of 2008 Volume 2 by Snyder, Berman, Kozier
and Erb Chapter 52 Fluid, Electrolyte and Acid – Base
Balance page 1456)
 Paracetamol is an antipyretics use to
decreases fever by inhibiting the effects of
pyrogens on the hypothalamus heat
regulating centers & by a hypothalamic
action leading to sweating &
vasodilatation. (reference: retrieved from
https://www.scribd.com/doc/36795690/Drug-Study-
Paracetamol)
 For supportive Drug; supports body
function until other treatments or the
body’s treatments or body’s response can
take over; because medication is a
substance administered for the diagnosis,
cure treatment or relief of symptoms of for
prevention of disease. (Reference: Fundamentals
of Nursing 8th Edition of 2008 by Berman, Synder,
Kozier and Erb Chapter 35 Medications page 830
 Paracetamol is an antipyretics use to
decreases fever by inhibiting the effects of
pyrogens on the hypothalamus heat
regulating centers & by a hypothalamic
action leading to sweating &
vasodilatation. (reference: retrieved from
https://www.scribd.com/doc/36795690/Drug-Study-
Paracetamol)
 Plasma contains all of the coagulation
factors. Fresh frozen plasma (FFP) infusion
can be used for reversal of anticoagulant
effects. Plasma transfusion is
Page | 39
recommended in patients with active
bleeding. The patient experienced nose
bleeding. FFP does not need to be cross-
matched but should be ABO compatible.
(reference:
http://www.aafp.org/afp/2011/0315/p719.html)
Day 4
February 01, 2016
8:30 am
Coherent
BP 100/60
PR 99
37
(-) Epistaxis
9:30
(-) bleeding
 PNSS 1L x 15
gtts/min (1)
 D5LR 1L x 15
gtts/min (1)
 Used because it has little to no effect on the
tissues and make the person feel hydrated
preventing hypovolemic shock
or hypotension. (reference:
https://www.scribd.com/doc/109761163/PNSS-drug-
study)
 D5LR is an hypertonic solution that is
given to prevent dehydration. Dengue is a
disease of DEHYDRATION. Much like a
Diarrhea except that the body fluids don’t
come out with the patient’s stool but
through PLASMA LEAKAGE. Imagine
that the arteries and veins of a patient have
thousands of pinpoint holes due to the
body's reaction to the Dengue virus,
causing the fluids inside the blood vessels
to sip out. (reference: Fundamentals of Nursing 8th
edition of 2008 Volume 2 by Snyder, Berman, Kozier
and Erb Chapter 52 Fluid, Electrolyte and Acid – Base
Balance page 1456)
Day 5 February 2,
2016 6:00 am
(-) bleeding
Platelet 198
 May go home
Home Meds:
 Godex 1 cap
300mg BID x 5
days
 Discharge planning is the process of
preparing a client to receive one level of
care for another within or outside of the
current health care agency; usually refers
to the client leaving hospital for home.
( Fundamentals of Nursing 8th Edition of 2008 by
Berman, Synder, Kozier and Erb Chapter 7 Community-
based nursing and care continuity page 113 )
 To prevent damage to liver, one of the
complication of DHF. Godex acts by
transporting excess, long-chain fatty acids
into the mitochondria to produce high
amounts of energy to produce high
amounts of energy to provide cell
protection and fast treatment of liver
disease.(http://www.mergersdrugfil.com.ph/index.php
/godex-ds )
Page | 40
 Cefixime 200mg
cap BID x 7 days
 Omeprazole 20
mg cap OD
 Ascorbic acid 500
mg tab OD
 Cefixime is a cephalosporin antibiotic used
to treat infections such as urinary tract
infections, because the patient’s urinalysis
revealed presence of few bacteria in
urine.(reference: retrieved from
https://www.nlm.nih.gov/medlineplus/druginfo/meds/a69
0007.html)
 Treatment and prevention of
hypersecretions of stomach acid.
Omeprazole is used to prevent upper
gastrointestinal tract bleeding. (retrieve from
:http://www.mayoclinic.org/drugs-
supplements/omeprazole-oral-route/description/drg-
2006683)
 Supplemental therapy in some GI diseases,
during long term parenteral nutrition.
Increases protection
mechanism of the immune system thus,
resistance to infection. (Reference: Davis’s Drug
Guide for Nurses fifth edition 2010 (ascorbic acid, page
105)
Page | 41
VIX. LABORATORY TEST
Urinalysis
Date: Jan. 31, 2016
Provides important clinical information about kidney formation and help diagnose other
diseases.
( Brunner andSuddarth’s Textbook of Medical Surgical Nursing 13th
Edition by Smeltzer, Bare, Hinkle and Cheever chapter 53
Assessment of Kidney and Urinary Function page 1518 )
Test Reference
Value
Result Implication
Physical
Properties
Light
Yellow
Normal
Transparency Slightly
Hazy
Normal
Chemical
Properties
pH 5 – 9 7.0 Normal
Specific Gravity 1.005 -
1.030
1.015 Normal
Sugar Negative Negative Normal
Protein Negative
(<10mg/d
L/100ml)
+4 The glomerulus is the network of capillaries
in the kidneys that filters low molecular
weight solutes such as urea, glucose, and
salts, but normally prevents passage of
protein or cells from blood into filtrate. Due
increased glomerular permeability; this
permeability allows increased amounts of
plasma proteins (sometimes very large
amounts) to pass into the filtrate.
Reference: A.Shah. Proteinuria (2013)
http://www.merckmanuals.com/professional/genitourinary-
disorders/symptoms-of-genitourinary-disorders/proteinuria
Leukocytes Negative Negative Normal
Nitrite Negative Negative Normal
Urobilinogen Normal Normal Normal
Blood Negative Negative Normal
Ketone Negative Negative Normal
Bilirubin Negative Negative Normal
Ascorbic Acid Negative Negative Normal
Microscopic
examination
RBC Negative 2– 4/hpf Due to increase in vascular permeability it
will leads to leakage of RBC.
Reference: National Instituteof Allergy and Infectious Diseases,
NIH: Volume 2
Pus Cells (WBC) Negative 2– 4/hpf Occurrence of pus cells in urine may be
Page | 42
Interpretation Nursing Responsibility
Presence of protein, RBC and WBC in the
urine cause by increase in capillary
permeability thus permitting plasma
protein and blood cells to pass into the
urine.
1. Use clean container.
2. Obtain first morning sample
3. Immediately send specimen to the
laboratory with proper label.
( Medical Surgical Nursing 8th
Edition page 1138 ) ( Medical Surgical Nursing 8th
Edition page 1146 )
taken to be an indicator of an infection,
either on the upper or the lower urinary
tract.
( Retrieved from: http://www.newhealthguide.org/Pus-Cells-in-
Urine.html )
Mucus threads Few If they are present in large amounts then this
means there is some underlying infection in
any part of the urinary tract. If the mucus
threads in urine are associated with red
blood cells (blood), bacteria or yeast then
this indicates to some sort of infection,
irritation or other problems.
(Retrieved from: http://bestwebhealth.org/Mucus-Threads-In-
Urine--What-Does-It-Mean-And-How-To-Treat.html )
Amorphous
Phosphates
- -
Bacteria Negative Few Bacteria in urine can suggest infection due
to vascular permeability.
Page | 43
Complete Blood Count
Date: 01-29-2016
Test Result Normal
Range
Interpretation Implication
WBC 3.83 4.00-10.00 Low WBC is made in the bone
marrow and circulates in the
bloodstream. Dengue virus
induces the suppression of the
bone marrow that results of
producing not enough WBC
to defend against bacterial
infections.
Reference:
http://www.medicinenet.com/script/main/art.
asp?articlekey=6017
Neutrophils 2.52 2.00-7.00 Normal
Lymphocytes 0.83 0.80-4.00 Normal
Monocytes 0.43 0.12-1.20 Normal
Eosinophils 0.04 0.02-0.50 Normal
Basophils 0.01 0.00-0.10 Normal
Neu% 65.7 50.0-70.0 Normal
Lym 21.8 20.0-40.0 Normal
Mon 11.2 3.0-12.0 Normal
Eos 1.1 0.5-5.0 Normal
Bas 0.2 0.0-1.0 Normal
RBC 4.43 4.00-5.50 Normal
HGB 140 120-160 Normal
HCT 40.0 40.0-54.0 Normal
MCV 90.3 80.0-100.0 Normal
MCH 31.6 27.0-34.0 Normal
MCHC 350 320-360 Normal
RDW-CV 10.4 11.0-16.0 Low A low RDW means that the
red blood cells vary very little
in size.
Red cell distribution width
(abbreviated as RDW) and
Coefficient Variation
(abbreviated as CV) is a
measurement of the amount
that red blood cells vary in
size. Red blood cells help
carry oxygen in the blood.
Reference:
http://www.medfriendly.com/red-cell-
distribution-width.html
RDW-SD 34.9 35.0-56.0 Low A low RDW means that the
Page | 44
red blood cells vary very little
in size.
Red cell distribution width
(abbreviated as RDW) and
Standard Variation
(abbreviated as SD) is a
measurement of the amount
that red blood cells vary in
size. Red blood cells help
carry oxygen in the blood.
Reference:
http://www.medfriendly.com/red-cell-
distribution-width.html
PLT 11 170-400 Low Dengue virus induces bone
marrow suppression. Since
bone marrow is the
manufacturing center of blood
cells its suppression causes
deficiency of blood cells
leading to low platelet count.
Reference:
K. Kafeel (2011). Retrieved from:
http://www.onlymyhealth.com/cause-low-
platelet-count-in-dengue-fever-1301653922
MPV 6.2 6.5-12.0 Low Mean platelet volume
(MPV) reflects the average
size of platelets present in a
person's sample of blood.
MPV is low with low platelet
count due to dengue virus
affecting production by the
bone marrow.
Reference:
https://labtestsonline.org/understanding/analy
tes/platelet/tab/faq/
PDW 18.8 9.0-17.0 High Platelet Distribution Width
(PDW) PDW is the variability
in the size of platelets.
Normally PDW increases
with MPV. The patient shows
a low MPV but a high PDW.
Due to the bone marrow
suppression.
Reference:
https://allaboutblood.com/tag/pdw/
PCT 0.007 0.108-
0.282
Low Low PCT (procalcitonin)
values (<0.25 µg/L) in
patients with clinical signs of
infection (CAP, UTI) indicate
a low probability for blood
Page | 45
culture proof of bacterial
infection. One major
advantage of PCT compared
to other parameters is its early
and highly specific increase in
response to bacterial
infections and sepsis.
Reference:
http://www.procalcitonin.com/default.aspx?tr
ee=_2_2
P-LCR 7.6 11.0-45.0 Low P-LCR means Platelet large
cell ratio. It provides
information about the
underlying conditions of
thrombocytopenia.
Reference:
http://www.ehj.eg.net/article.asp?issn=1110-
1067;year=2014;volume=39;issue=3;spage=
134;epage=138;aulast=Elsewefy
Date: 01-30-2016
Test Result Normal
Range
Interpretation Implication
WBC 4.86 4.00-10.00 Normal
Neutrophils 1.65 2.00-7.00 Low Neutrophils are major players
in the body's defense against
bacterial infections.
Neutrophils are made in
the bone marrow and circulate
in the bloodstream. Dengue
virus induces the suppression
of the bone marrow that results
of producing not enough
neutrophils to defend against
bacterial infections.
Reference:
http://www.medicinenet.com/script/main/art.as
p?articlekey=6017
Lymphocytes 2.14 0.80-4.00 Normal
Monocytes 1.05 0.12-1.20 Normal
Eosinophils 0.02 0.02-0.50 Normal
Basophils 0.00 0.00-0.10 Normal
Neu% 33.9 50.0-70.0 Low Neutrophils are manufactured
in bone marrow — the spongy
tissue inside some of our larger
bones. Anything that disrupts
neutrophil production can
Page | 46
result in neutropenia. The
dengue virus induces bone
marrow suppression.
Reference:
http://www.mayoclinic.org/symptoms/neutrope
nia/basics/causes/sym-20050854
Lym 44.0 20.0-40.0 High It is high because of the
bacteria presence in the urine
of the patient. Lymphocytes
provide a means for immunity
against antigens.
Reference:
http://biology.about.com/od/cellbiology/ss/lym
phocytes.htm
Mon 21.6 3.0-12.0 High Monocytes play important
roles in the immune defense,
inflammation and tissue
remodelling and it do so by
phagocytosis, antigen
processing and presentation
and by cytokine production. It
is high because of the bacteria
presence in the urine of the
patient.
Reference:
http://www.monocytes.de
Eos 0.4 0.5-5.0 Low A low eosinophil level is
usually not a cause for concern
and is actually quite
common. They are very helpful
in defending the body
against parasites. Eosinophils
can be too low due to
administration of steroids.
Steroids are any of a large
number of hormone substances
with a similar and basic
chemical structure. Hormones
are natural chemicals produced
by the body and
released into the blood that
have a specific effect on tissues
in the body.
The patient is administered by
Hydrocortisone.
Reference:
http://www.medfriendly.com/eosinophil.html
Bas 0.1 0.0-1.0 Normal
RBC 2.22 4.00-5.50 Low Red blood cells circulate in the
blood and carry oxygen
Page | 47
throughout the body. They are
produced in the bone
marrow and then released into
the bloodstream as they
mature. Dengue virus damage
the bone marrow that results to
low RBC production.
Reference:
https://labtestsonline.org/understanding/analyte
s/rbc/tab/test/
HGB 69 120-160 Low RBCs contain hemoglobin,
which carries oxygen
throughout your body. It is low
because the patient
experienced epistaxis and
melena. It is low because the
patient experienced epistaxis
and melena. Moreover, the
dengue virus induces bone
marrow suppression
HCT 20.0 40.0-54.0 Low The hematocrit is routinely
ordered as a part of
the complete blood count
(CBC). It may also be ordered
by itself or with a hemoglobin
level as part of a general health
examination. It results from
decrease production of
hemoglobin and damage to
bone marrow.
Reference:
https://labtestsonline.org/understanding/analyte
s/hematocrit/tab/test/
MCV 90.0 80.0-100.0 Normal
MCH 31.1 27.0-34.0 Normal
MCHC 345 320-360 Normal
RDW-CV 10.6 11.0-16.0 Low A low RDW means that the red
blood cells vary very little in
size.
Red cell distribution width
(abbreviated as RDW) and
Coefficient Variation
(abbreviated as CV) is a
measurement of the amount
that red blood cells vary in
size. Red blood cells help carry
oxygen in the blood.
Reference: http://www.medfriendly.com/red-
cell-distribution-width.html
Page | 48
RDW-SD 34.8 35.0-56.0 Low A low RDW means that the red
blood cells vary very little in
size.
Red cell distribution width
(abbreviated as RDW) and
Standard Variation
(abbreviated as SD) is a
measurement of the amount
that red blood cells vary in
size. Red blood cells help carry
oxygen in the blood.
Reference: http://www.medfriendly.com/red-
cell-distribution-width.html
PLT 38 170-400 Low Dengue virus induces bone
marrow suppression. Since
bone marrow is the
manufacturing center of blood
cells its suppression causes
deficiency of blood cells
leading to low platelet count.
Reference:
K. Kafeel (2011). Retrieved from:
http://www.onlymyhealth.com/cause-low-
platelet-count-in-dengue-fever-1301653922
MPV 9.2 6.5-12.0 Normal
PDW 18.9 9.0-17.0 High Platelet Distribution Width
(PDW) PDW is the variability
in the size of platelets.
Normally PDW increases with
MPV. The patient shows a low
MPV but a high PDW. Due to
the bone marrow suppression.
Reference:
https://allaboutblood.com/tag/pdw/
PCT 0.035 0.108-
0.282
Low Low PCT (procalcitonin)
values (<0.25 µg/L) in patients
with clinical signs of infection
(CAP, UTI) indicate a low
probability for blood culture
proof of bacterial infection.
One major advantage of PCT
compared to other parameters
is its early and highly specific
increase in response to
bacterial infections and sepsis.
Reference:
http://www.procalcitonin.com/default.aspx?tre
e=_2_2
P-LCR 34.2 11.0-45.0 Normal
Page | 49
Date: 01-31-2016
Test Result Normal
Range
Interpretation Implication
WBC 5.91 4.00-10.00 Normal
Neutrophils 2.92 2.00-7.00 Normal
Lymphocytes 2.00 0.80-4.00 Normal
Monocytes 0.96 0.12-1.20 Normal
Eosinophils 0.02 0.02-0.50 Normal
Basophils 0.01 0.00-0.10 Normal
Neu% 49.5 50.0-70.0 Low Neutrophils are manufactured
in bone marrow — the spongy
tissue inside some of our
larger bones. Anything that
disrupts neutrophil production
can result in neutropenia.
Reference:
http://www.mayoclinic.org/symptoms/neutro
penia/basics/causes/sym-20050854
Lym 33.8 20.0-40.0 Normal
Mon 16.3 3.0-12.0 High Monocytes perform their
functions by surrounding and
engulfing bacteria (a process
known as phagocytosis).
Monocytes can engage in
phagocytosis by coating the
foreign material with
complement or antibodies.
High Monocytes happen for
several reasons such as stress,
inflammation, a fever from a
virus, severe infection
(because more macrophages
are needed to fight it),
premature cell death in living
tissue, diseases that result
from abnormal activity of the
immune system, and
regeneration of red blood
cells.
Reference:
http://www.medfriendly.com/monocyte.html
Eos 0.3 0.5-5.0 Low A low eosinophil level is
usually not a cause for
concern and is actually quite
common. They are very
helpful in defending the body
Page | 50
against parasites. Eosinophils
can be too low due to
administration of steroids.
Steroids are any of a large
number of hormone
substances
with a similar and basic
chemical structure. Hormones
are natural chemicals
produced by the body and
released into the blood that
have a specific effect on
tissues in the body.
The patient is administered by
Hydrocortisone.
Reference:
http://www.medfriendly.com/eosinophil.html
Bas 0.1 0.0-1.0 Normal
RBC 2.69 4.00-5.50 Low Red blood cells circulate in
the blood and carry oxygen
throughout the body. They are
produced in the bone
marrow and then released into
the bloodstream as they
mature. Dengue virus damage
the bone marrow that results
to low RBC production.
Reference:
https://labtestsonline.org/understanding/analy
tes/rbc/tab/test/
HGB 86 120-160 Low RBCs contain hemoglobin,
which carries oxygen
throughout your body. It is
low because the patient
experienced epistaxis and
melena. It is low because the
patient experienced epistaxis
and melena. Moreover, the
dengue virus induces bone
marrow suppression.
HCT 23.9 40.0-54.0 Low The hematocrit is routinely
ordered as a part of
the complete blood count
(CBC). It may also be ordered
by itself or with a hemoglobin
level as part of a general
health examination. It results
from decrease production of
Page | 51
hemoglobin and damage to
bone marrow.
Reference:
https://labtestsonline.org/understanding/analy
tes/hematocrit/tab/test/
MCV 88.9 80.0-100.0 Normal
MCH 32.0 27.0-34.0 Normal
MCHC 360 320-360 Normal
RDW-CV 10.7 11.0-16.0 Low A low RDW means that the
red blood cells vary very little
in size.
Red cell distribution width
(abbreviated as RDW) and
Coefficient Variation
(abbreviated as CV) is a
measurement of the amount
that red blood cells vary in
size. Red blood cells help
carry oxygen in the blood.
Reference:
http://www.medfriendly.com/red-cell-
distribution-width.html
RDW-SD 35.0 35.0-56.0 Normal
PLT 51 170-400 Low Dengue virus induces bone
marrow suppression. Since
bone marrow is the
manufacturing center of blood
cells its suppression causes
deficiency of blood cells
leading to low platelet count.
Reference:
K. Kafeel (2011). Retrieved from:
http://www.onlymyhealth.com/cause-low-
platelet-count-in-dengue-fever-1301653922
MPV 9.1 6.5-12.0 Normal
PDW 18.0 9.0-17.0 High Platelet Distribution Width
(PDW) PDW is the variability
in the size of platelets. Due to
the bone marrow suppression.
Reference:
https://allaboutblood.com/tag/pdw/
PCT 0.046 0.108-
0.282
Low Low PCT (procalcitonin)
values (<0.25 µg/L) in
patients with clinical signs of
infection (CAP, UTI) indicate
a low probability for blood
culture proof of bacterial
infection. One major
advantage of PCT compared
to other parameters is its early
Page | 52
and highly specific increase in
response to bacterial
infections and sepsis.
Reference:
http://www.procalcitonin.com/default.aspx?tr
ee=_2_2
P-LCR 34.7 11.0-45.0 Normal
Date: 01-31-2016
Test Result Normal
Range
Interpretation Implication
WBC 5.79 4.00-10.00 Normal
Neutrophils 2.28 2.00-7.00 Normal
Lymphocytes 2.29 0.80-4.00 Low It is low because the dengue
virus induces the bone
marrow suppression.
Reference:
http://biology.about.com/od/cellbiology/ss/ly
mphocytes.htm
Monocytes 1.17 0.12-1.20 Normal
Eosinophils 0.05 0.02-0.50 Normal
Basophils 0.00 0.00-0.10 Normal
Neu% 39.4 50.0-70.0 Low Neutrophils are manufactured
in bone marrow — the spongy
tissue inside some of our
larger bones. Anything that
disrupts neutrophil production
can result in neutropenia.
Reference:
http://www.mayoclinic.org/symptoms/neutro
penia/basics/causes/sym-20050854
Lym 39.6 20.0-40.0 Normal
Mon 20.2 3.0-12.0 High Monocytes play important
roles in the immune defense,
inflammation and tissue
remodelling and it do so by
phagocytosis, antigen
processing and presentation
and by cytokine production. It
is high because of the bacteria
presence in the urine of the
patient.
Reference:
http://www.monocytes.de
Eos 0.8 0.5-5.0 Normal
Bas 0.0 0.0-1.0 Normal
RBC 3.31 4.00-5.50 Low Red blood cells circulate in
the blood and carry oxygen
Page | 53
throughout the body. They are
produced in the bone
marrow and then released into
the bloodstream as they
mature. Dengue virus damage
the bone marrow that results
to low RBC production.
Reference:
https://labtestsonline.org/understanding/analy
tes/rbc/tab/test/
HGB 102 120-160 Low RBCs contain hemoglobin,
which carries oxygen
throughout your body. It is
low because the patient
experienced epistaxis and
melena. It is low because the
patient experienced epistaxis
and melena. Moreover, the
dengue virus induces bone
marrow suppression
HCT 28.7 40.0-54.0 Low The hematocrit is routinely
ordered as a part of
the complete blood count
(CBC). It may also be ordered
by itself or with a hemoglobin
level as part of a general
health examination. It results
from decrease production of
hemoglobin and damage to
bone marrow.
Reference:
https://labtestsonline.org/understanding/analy
tes/hematocrit/tab/test/
MCV 86.8 80.0-100.0 Normal
MCH 30.8 27.0-34.0 Normal
MCHC 355 320-360 Normal
RDW-CV 10.9 11.0-16.0 Low A low RDW means that the
red blood cells vary very little
in size.
Red cell distribution width
(abbreviated as RDW) and
Coefficient Variation
(abbreviated as CV) is a
measurement of the amount
that red blood cells vary in
size. Red blood cells help
carry oxygen in the blood.
Reference: http://www.medfriendly.com/red-
cell-distribution-width.html
Page | 54
RDW-SD 35.3 35.0-56.0 Normal
PLT 74 170-400 Low Dengue virus induces bone
marrow suppression. Since
bone marrow is the
manufacturing center of blood
cells its suppression causes
deficiency of blood cells
leading to low platelet count.
Reference:
K. Kafeel (2011). Retrieved from:
http://www.onlymyhealth.com/cause-low-
platelet-count-in-dengue-fever-1301653922
MPV 9.6 6.5-12.0 Normal
PDW 18.7 9.0-17.0 High Platelet Distribution Width
(PDW) PDW is the variability
in the size of platelets.
Normally PDW increases
with MPV. Due to the bone
marrow suppression.
Reference:
https://allaboutblood.com/tag/pdw/
PCT 0.071 0.108-
0.282
Low Low PCT (procalcitonin)
values (<0.25 µg/L) in
patients with clinical signs of
infection (CAP, UTI) indicate
a low probability for blood
culture proof of bacterial
infection. One major
advantage of PCT compared
to other parameters is its early
and highly specific increase in
response to bacterial
infections and sepsis.
Reference:
http://www.procalcitonin.com/default.aspx?tr
ee=_2_2
P-LCR 35.4 11.0-45.0 Normal
Page | 55
Hematology
Date: 01-28-2016
Test Result Normal
Range
Interpreta
tion
Implication
Hemoglobin 16.4 13-17 Normal
Hematocrit 50.2 40-52% Normal
RBC 5.45 4.7-
6.1ml/mm3
Normal
WBC 2500 4800-
10000/mm3
Low WBC is made in the bone
marrow and circulate in the
bloodstream. Dengue virus
induces the suppression of the
bone marrow that results of
producing not enough WBC
to defend against bacterial
infections.
Reference:
http://www.medicinenet.com/script/main/art.
asp?articlekey=6017
DIFFERENTIAL
COUNT
Neutrophils 77 40-74% High Neutrophils are major players
in the body's defense against
bacterial infections.
Neutrophils are made in
the bone marrow and circulate
in the bloodstream. Dengue
virus induces the suppression
of the bone marrow that
results of producing not
enough neutrophils to defend
against bacterial infections.
Reference:
http://www.medicinenet.com/script/main/art.
asp?articlekey=6017
Lymphocytes 21 20-40% Normal
Eosinophils - - -
Monocytes 2 3-7% Low Monocytes are a type of white
blood cell that fight certain
infections and help other
white blood cells which is
also regulate immunity
against foreign substances.
Monocytes are produced in
the bone marrow and then
enter the blood. A low number
Page | 56
of monocytes in the blood
(monocytopenia) can be
caused by anything that
decreases the overall white
blood cell count
(see Neutropenia and see
also Lymphocytopenia), such
as a bloodstream infection or
a bone marrow disorder.
Reference:
https://www.merckmanuals.com/home/blood-
disorders/white-blood-cell-
disorders/monocyte-disorders
Platelet count 24000 130-500000 Low Dengue virus induces bone
marrow suppression. Since
bone marrow is the
manufacturing center of blood
cells its suppression causes
deficiency of blood cells
leading to low platelet count.
Reference:
K. Kafeel (2011). Retrieved from:
http://www.onlymyhealth.com/cause-low-
platelet-count-in-dengue-fever-1301653922
Bleeding time - - -
Clotting time - - -
MCV 92.2 80-96FL Normal
MCH 30.1 27-33PG Normal
MCHC 32.7 32-36% Normal
Date: 01-29-16
Test Result Normal
values
Interpretation Implication
Hemoglobin - 11.5-14.8
Hematocrit 37.1 38-44% Low The hematocrit is routinely
ordered as a part of
the complete blood count
(CBC). It may also be
ordered by itself or with a
hemoglobin level as part of a
general health examination.
It results from decrease
production of hemoglobin
and damage to bone marrow.
Reference:
https://labtestsonline.org/understanding/anal
ytes/hematocrit/tab/test/
Platelet count 18 250- Low Dengue virus induces bone
Page | 57
510x10/L marrow suppression. Since
bone marrow is the
manufacturing center of
blood cells its suppression
causes deficiency of blood
cells leading to low platelet
count.
Reference:
K. Kafeel (2011). Retrieved from:
http://www.onlymyhealth.com/cause-low-
platelet-count-in-dengue-fever-1301653922
Date: 01-29-16
Test Result Normal
values
Interpretation Implication
Hemoglobin - 11.5-14.8 -
Hematocrit 41.6 38-44% Normal
Platelet count 12 250-
510x10/L
Low Dengue virus induces
bone marrow
suppression. Since bone
marrow is the
manufacturing center of
blood cells its
suppression causes
deficiency of blood cells
leading to low platelet
count.
Reference:
K. Kafeel (2011). Retrieved from:
http://www.onlymyhealth.com/cause-
low-platelet-count-in-dengue-fever-
1301653922
Date: 01-30-16
Test Result Normal
values
Interpretation Implication
Hemoglobin - 11.5-14.8 -
Hematocrit 21% 38-44% Low The hematocrit is routinely
ordered as a part of
the complete blood count
(CBC). It may also be
ordered by itself or with a
hemoglobin level as part of
a general health
examination. It results from
damage to bone marrow.
Page | 58
Reference:
https://labtestsonline.org/understanding/a
nalytes/hematocrit/tab/test/
Platelet count 19 250-
510x10/L
Low Dengue virus induces bone
marrow suppression. Since
bone marrow is the
manufacturing center of
blood cells its suppression
causes deficiency of blood
cells leading to low platelet
count.
Reference:
K. Kafeel (2011). Retrieved from:
http://www.onlymyhealth.com/cause-
low-platelet-count-in-dengue-fever-
1301653922
Date: 01-30-16
Test Result Normal
values
Interpretation Implication
Hemoglobin - 11.5-14.8
Hematocrit 35.7% 38-44% Low Hematocrit is the
amount of red blood
cells in your blood. It is
low because the patient
experienced epistaxis
and melena. Moreover,
the dengue virus induces
bone marrow
suppression.
Platelet count 8 250-
510x10/L
Low Dengue virus induces
bone marrow
suppression. Since bone
marrow is the
manufacturing center of
blood cells its
suppression causes
deficiency of blood cells
leading to low platelet
count.
Reference:
K. Kafeel (2011). Retrieved from:
http://www.onlymyhealth.com/cause-
low-platelet-count-in-dengue-fever-
1301653922
Page | 59
Date: 01-30-16
Test Result Normal
values
Interpretation Implication
Hemoglobin - 11.5-14.8 -
Hematocrit 29.7% 38-44% Low The hematocrit is routinely
ordered as a part of
the complete blood count
(CBC). It may also be
ordered by itself or with a
hemoglobin level as part of
a general health
examination. It results from
damage to bone marrow.
Reference:
https://labtestsonline.org/understanding/a
nalytes/hematocrit/tab/test/
Platelet count 16 250-
510x10/L
Low Dengue virus induces bone
marrow suppression. Since
bone marrow is the
manufacturing center of
blood cells its suppression
causes deficiency of blood
cells leading to low platelet
count.
Reference:
K. Kafeel (2011). Retrieved from:
http://www.onlymyhealth.com/cause-
low-platelet-count-in-dengue-fever-
1301653922
Date: 02-01-2016
Test Result Normal
values
Interpretation Implication
Hemoglobin 98 115-148 Low RBCs contain hemoglobin,
which carries oxygen
throughout your body. It is
low because the patient
experienced epistaxis and
melena. It is low because
the patient experienced
epistaxis and melena.
Moreover, the dengue virus
induce bone marrow
suppression.
Hematocrit 29% 38-44 Low The hematocrit is routinely
ordered as a part of
Page | 60
the complete blood count
(CBC). It may also be
ordered by itself or with a
hemoglobin level as part of
a general health
examination. It results from
decrease production of
hemoglobin and damage to
bone marrow.
Reference:
https://labtestsonline.org/understanding/an
alytes/hematocrit/tab/test/
RBC 3.35 38-54 Low RBCs contain hemoglobin,
which carries oxygen
throughout your body. It is
low because the patient
experienced epistaxis and
melena. Moreover, the
dengue virus induces bone
marrow suppression.
Platelet 88 250-510 Low Dengue virus induces bone
marrow suppression. Since
bone marrow is the
manufacturing center of
blood cells its suppression
causes deficiency of blood
cells leading to low platelet
count.
Reference:
K. Kafeel (2011). Retrieved from:
http://www.onlymyhealth.com/cause-low-
platelet-count-in-dengue-fever-
1301653922
WBC 7-9 4-11 Normal
Segmented
neutrophils
52 45-55 Normal
Lymphocytes 40.3 38-45 Normal
Monocytes 7-5 3-6 High Monocytes perform their
functions by surrounding
and engulfing bacteria (a
process known as
phagocytosis). Monocytes
can engage in phagocytosis
by coating the foreign
material with complement
or antibodies.
High Monocytes happen for
several reasons such as
Page | 61
stress, inflammation, a fever
from a virus, severe
infection (because more
macrophages are needed to
fight it), premature cell
death in living tissue,
diseases that result from
abnormal activity of the
immune system, and
regeneration of red blood
cells.
Reference:
http://www.medfriendly.com/monocyte.ht
ml
Date: 02-02-2016
Test Result Normal
Range
Interpretation Implication
Hemoglobin 96 115-148 Low RBCs contain hemoglobin,
which carries oxygen
throughout your body. It is
low because the patient
experienced epistaxis and
melena. It is low because
the patient experienced
epistaxis and melena.
Moreover, the dengue virus
induces bone marrow
suppression.
Hematocrit 26.8 38-44 Normal
RBC 3.14 3.8-5.4 Normal
MCV 85 80-100 Normal
MCH 30.5 27-32 Normal
MCHC 359 320-360 Normal
RDW-CV 13.5 11.0-16.0 Normal
RDW-SD - 37-54 Normal
Platelet 198 250-510 Normal
PCT 0.188 0.15-0.50 Normal
MPV 9.5 6-11 Normal
PDW 18.6 11-18 Normal
WBC 8.0 4-11 Normal
Segmented
neutrophils
54.1 45-55 Normal
lymphocytes 38.3 38-45 Normal
monocytes 7.6 3-6
Page | 62
Date: 02-03-16
Test Result Normal
values
Interpretation Implication
Hemoglobin 9.9 11.5-14.8 Low RBCs contain hemoglobin,
which carries oxygen
throughout your body. It is
low because the patient
experienced epistaxis and
melena. It is low because
the patient experienced
epistaxis and melena.
Moreover, the dengue virus
induces bone marrow
suppression.
Hematocrit 28.0 38-44% Low The hematocrit is routinely
ordered as a part of
the complete blood count
(CBC). It may also be
ordered by itself or with a
hemoglobin level as part of
a general health
examination. It results from
decrease production of
hemoglobin and damage to
bone marrow.
Reference:
https://labtestsonline.org/understanding/an
alytes/hematocrit/tab/test/.
Platelet count 294 250-
510x10/L
Normal
Date: 02-03-16
Test Result Normal
values
Interpretation Implication
Hemoglobin - 11.5-14.8 Low RBCs contain hemoglobin,
which carries oxygen
throughout your body. It is
low because the patient
experienced epistaxis and
melena. It is low because
the patient experienced
epistaxis and melena.
Moreover, the dengue virus
induces bone marrow
suppression.
Page | 63
Hematocrit 26.6 38-44% Low The hematocrit is routinely
ordered as a part of
the complete blood count
(CBC). It may also be
ordered by itself or with a
hemoglobin level as part of
a general health
examination. It results from
decrease production of
hemoglobin and damage to
bone marrow.
Reference:
https://labtestsonline.org/understanding/an
alytes/hematocrit/tab/test/
Platelet count 351 250-
510x10/L
Normal
TyphiDOT
Date: 01-29-16
Test Result
Salmonella IgG Negative
Salmonella IgM Negative
The patient TyphiDOT test is negative to Salmonella IgG and salmonella IgM.
The Typhidot test gave a sensitivity of 100 per cent and specificity of 80 per cent
when bacteraemic patients were analysed.
The TyphiDot is a DOT enzyme immunoassay that detects either IgM or IgG
antibodies against a specific antigen on the outer membrane protein of serotype Typhi.
Reference:
https://www.researchgate.net/publication/10894775_Typhidot_test_to_detect_IgG_IgM_antibodies_in_t yphoid_fever
Page | 64
DENGUE NS1 IgA/IgG/IgM
Date: 01-29-2016
Test Result
Dengue NS1 Positive
Dengue IgA Negative
Dengue IgG Positive
Dengue IgM Negative
The patient’s antibody test revealed positive in Dengue NS1 and Dengue IgG.
The non-structural protein 1 (NS1) of the dengue viral genome has been shown to
be useful as a tool for the diagnosis of acute dengue infections. Dengue NS1 antigen has
been detected in the serum of DENV infected patients as early as 1 day post onset of
symptoms (DPO), and up to 18 DPO.
Antibody tests, IgM and IgG- detect antibodies produced by the immune system
when a person has been exposed to the virus; these tests are most effective when
performed at least 7-10 days after exposure.
Reference:
http://www.cdc.gov/dengue/clinicalLab/laboratory.html
https://labtestsonline.org/understanding/analytes/dengue/tab/sample/
BLOOD TYPE TEST
Date: January 29, 2016
ABO Rhesus D
O (+)
Page | 65
X. PROBLEM PRIORITIZATION
1. Ineffective Tissue Perfusion
2. Hyperthermia
3. Imbalance Nutrition
4. Impaired Tissue Integrity
5. Risk for Injury
Page | 66
XI. NURSING CARE PLAN
Page | 67
Assessment Nursing
Diagnosis
Planning Intervention Rationale Expected Outcome
O:
 Hemoglobin
results
revealed 69
mg/dl as of
01-30-16
 BP: 100/60
mmHg
 RR: 20 cpm
 PR: 98 bpm
 Headache
 Generalized
pallor
 Capillary
refill of
more than 3
sec
 With pale nail
beds
Ineffective
tissue
perfusion
related to
decreased
hemoglobin
concentration
in the blood.
After 8 hours of nursing
intervention, the client
will be able to:
 Demonstrate
different ways to
improve blood
oxygenation and
circulation.
 Verbalize
understanding of
condition and
importance
of treatment
regimen.
 Demonstrate
increased tissue
perfusion.
 Monitor vital
signs.
 Elevate head
of bed to about
10 degrees.
 Discourage
strenuous
activities.
 Provide health
teaching
regarding DHF.
 Provide health
teaching on
drugs being
taken.
Collaborative:
 Administer
Tranexamic
Acid 50mg IV
q8 as ordered.
 Serve as basis for
any alteration in
system functions.
 To promote
circulation and
venous drainage.
 To avoid increasing
oxygen demand.
 To help client
understand his
health condition.
 To maintain
compliance to
meds.
 To control
bleeding.
After 8 hours of nursing
intervention, the
client was be able to:
 Demonstrate different
ways to improve
blood oxygenation
and circulation.
 Verbalize
understanding
of condition and
importance
of treatment
regimen.
 Demonstrate
increased tissue
perfusion.
Page | 68
 With pale
conjunctiva
and palate
 Muscle
strength :
4/5
 Administer and
regulate IVF as
ordered.
 Administer
packed RBC’s
as ordered.
 Monitor lab
studies ( Hb,
Hct, RBC
count).
 Maintain hydration
and help wash
away toxins.
 Packed RBC’s are
adequate for stable
patients with
subacute/chronic
bleeding to
increase oxygen
carrying capability
 Aids in
establishing blood
replacement needs
& monitoring for
effectiveness of
therapy.
Page | 69
Assessment Nursing Diagnosis Planning Intervention Rationale Expected Outcome
O:
 Temp: 38.2 °c
 Warm to touch
 Chills
 Weak in
appearance
 Easy fatigability
 Dry lips
 Pale
Hyperthermia
related to presence
of Arbovirus in
patient’s body
causing release of
pyrogens.
After 2 hours
of nursing
interventions, the
patient will be able
to:
Manifest reduction
of core temperature
from 38.2 to a
normal range of 36.5
C- 37.5 C
 Monitor
patient’s vital
signs.
 Note
chronological an
d developmental
age of client
 Note presence/
absence
of sweating.
 Initiate tepid
sponge bath.
 Promotes surface
cooling through
undressing or
removing extra
linens.
 Encourage
adequate fluid
intake.
 Serves as base
line data for
future
comparison.
 Assess for
causative/
contributing
factor.
 To assess
degree of
hyperthermia.
 Facilitates heat
through
conduction and
evaporation.
 Facilitates heat
loss by
radiation.
 To promote
heat loss and
hydration.
After 2 hours
of nursing
interventions, the
patient will be able
to:
Manifest reduction
of core temperature
from 38.2 to a
normal range of 36.5
C- 37.5 C
Page | 70
 Encourage
adequate
bedrest.
 Instruct patient
and SO to report
signs and
symptoms
of hyperthermia
like flushed skin,
increasing
respiratory rate
and body
temperature.
Collaborative:
 Administer
Paracetamol 1
amp IV, as
ordered.
 To reduce
metabolic
consumption
and oxygen
demands.
 To promote
wellness.
 To relieve high
temperature by
inhibiting the
synthesis of
prostaglandin
Page | 71
Assessment Nursing
Diagnosis
Planning Intervention Rationale Expected Outcome
S: “Wala akong
ganang kumain“ as
verbalized by the
patient.
O:
 Lethargic
 Easy
fatigability
 Weak in
appearance
 Had 2
crackers in
shift
 Pale
 24 hours
dietary recall
Imbalanced
nutrition less than
body
requirements
related to loss of
appetite.
ST: within 4 hours of
giving nursing
intervention patient
will be able to
experience an
increase in the
amount or type of
nutrients ingested.
LT: within 8 hours of
giving nursing
intervention and
medical management
patient will be able to
experience adequate
nutrition through oral
intake.
 Assess and
document
patient’s dietary
history, patters
of ingestion,
intolerance to
foods.
 Auscultate bowel
sounds.
 Instruct
pt. on good oral
hygiene before
and after
feedings.
 Emphasize the
importance of
adequate
 To determine daily
nutrition needs.
 Hypermotility of
intestinal tract is
common and is
associated with
vomiting and
diarrhea, which
may affect choice
of diet/route.
 To promote god
appetite.
 Promotes comfort
to the patient and
encourages a good
After giving
effective nursing
interventions patient
will be able to
partially demonstrate
behavior, lifestyle
changes to regain
appropriate weight.
Page | 72
nutrition.
 Promote pleasant
relieving
environment
including
socialization.
Collaborative:
 Monitor
BUN, protein,
prealbumin, or
albumin, glucose,
nitrogen balance as
indicated.
 Advance diet
as tolerated, avoid
dark colored foods.
eating habit.
 For education of
the patient for
appropriate
recovery from
nutritional
imbalance.
 Reflects organ
function and
nutritional status
and needs.
 Careful
progression of diet
when intake is
resumed reduces
risk of gastric
irritation and to
provide accurate
assessment in
stool.
Page | 73
Assessment Nursing Diagnosis Planning Intervention Rationale Expected Outcome
O:
 Temp: 38.2 °c
 Hematoma on
the upper right
arm
 Capillary refill
of more than 3
sec
 Weak in
appearance
 Dry lips
 Headache-
Pain scale 5/10
 Pale
 Muscle strength :
4/5
Impaired tissue
integrity related to
mechanical and
chemical factor of
skin test and blood
test; secondary to
haematoma as
evidence by
collection of blood
on the upper right
arm.
After 4 hours of
nursing
interventions
patient will
demonstrate
behavior to reduce
the hematoma.
After 2 weeks of
nursing
interventions
presence of
hematoma will be
reduce.
 Provide
comfortable
environment.
 Provide
comfort
measures by
AM care,
changing the
linen and touch
therapy.
 Provide safety
by placing
pillows at the
side of the bed.
 Vital signs
monitor and
record.
 To ease patient’s
anxiety and to
help the patient
recover faster for
proper hygiene of
the patient.
 For proper
hygiene of the
patient.
 To avoid patient
from injury.
 To have baseline
data.
After 4 hours of
nursing interventions
the patient shall have
demonstrate
behavior to reduce
the hematoma.
After 2 weeks of
nursing interventions
the patient shall have
no presence of
hematoma.
Page | 74
 Identify
underlying
condition
involves in
tissue injury.
 Monitor
laboratory
studies.
 Help patient
and family to
identify
effective
successful
coping
mechanism and
to implement
them.
 Suggest treatment
options, desire/
ability to protect
self and potential
self and potential
to recurrence of
tissue damage.
 To changes
indicative of
healing or
infection
complications.
 To reduce
discomfort and
improve quality of
life.
Page | 75
Assessment Nursing
Diagnosis
Planning Intervention Rationale Expected Outcome
O:
 Weak in
appearance
 Capillary refill
of more than 3
sec.
 Easy fatigability
 Hematoma at
the right upper
arm
 Delirium
 Platelet count
results revealed 8
x109
/L as of 01-
30-16
Risk for
injury related
to abnormal
blood profile
as evidenced
by decreased
platelet count.
After 4 hours of
nursing
management, the
patient will
demonstrate
behaviors to
reduce risk factors
and protect self
from injury.
 Establish rapport.
 Monitor and record
vital signs.
 Assess mood, coping
abilities, and
personality styles
(aggression and
impulse behavior).
 Observe for presence
of petechiae,
ecchymosis, bleeding
from one more sites.
 Maintain bed in a
lowest position with
wheels locked.
 Advise SO that those
self inflicting
materials such as
 To gain patient’s
trust and
cooperation.
 For baseline data.
 Aggressive and
impulsive
behavior indicates
self harm to the
patient.
 Observing those
signs will help to
reduce the risk for
injury to the other
parts of the body.
 Ensuring the
patient’s safety.
 To prevent further
injury to the
patient.
After 4 hours of
nursing management
the patient will
demonstrate
behaviors to reduce
risk factors and
protect self from
injury.
Page | 76
(utensils, knife and
syringes) should be
keep.
 Encourage the SO
not to leave the
patient unattended
 Leaving the
patient unattended
may increase
anxiety to the
patient.
Page | 77
XII. DRUGS
Page | 78
Reference : Jones and Bartlett Nurse’s Drug Handbook 2015 ( diphenhydramine page 325)
Name of Drug Dosage and
Frequency
Indications and
Contraindications
Side Effects Mode of
Action
Classification Nursing Responsibilities
Generic Name:
Diphenhydramine
Brand Name:
Benadryl
Date ordered:
01-30-2016
50 mg
PO
TID
Peak: 15-60 min
Onset: 1-4 hr
Duration: 4-8 hr
Indication:
To prevent allergic
reaction after blood
transfusion.
Transfusion reaction
symptoms include:
 back pain
 blood in your urine
 chills
 fainting or dizziness
 fever
 flank pain
 skin flushing
Contraindications:
Hypersensitivity to 𝐻1 –
receptor antagonist,
acute asthma attack,
lower respiratory tract
disease, neonates.
 Dizziness
 Drowsiness
 fatigue
anxiety
 Nausea
Acts on blood
vessels, GI,
respiratory
system by
competing with
histamine for
𝐻1 –receptor
site; decreases
allergic
response by
blocking
histamine.
Antihistamine  Medication may
cause drowsiness.
 Advised the
patient to avoid
activities requiring
alertness until response
of drug is unknown.
 Inform the patient
that this drug may
cause dry mouth.
 Frequent oral
rinses, good oral
hygiene, and candy
that may minimize this
effect.
 Teach patient and
significant other that
this drug may cause
drowsiness.
Page | 79
Name of Drug Dosage and
Frequency
Indications and
Contraindication
s
Side Effects Mode of Action Classification Nursing Responsibilities
Generic Name:
Cefixime
Brand Name:
Suprax
Date ordered:
02- 02- 2016
200 mg
PO
BID
Peak: rapid
Onset: 2-6 hr
Duration: 24 hr
Indication:
Treatment for
infection.
The patient’s
urinalysis revealed
a presence of few
bacteria in urine as
of Jan. 31, 2016.
Contraindication
s:
Hypersensitivity to
cephalosporin or
their
Components.
 Chills
 fever
 headache
 seizures
 Abdominal
cramps
 diarrhea
 elevated
 liver function
test results
 hepatic failure
 hepatitis
 hepatomegaly
 jaundice
 nausea
Interferes with
bacterial cell
wall synthesis
by inhibiting the
final step in the
crosslinking
of peptidoglycan
strands.
Peptidoglycan
makes cell
membranes rigid
and protective.
Without it,
bacterial cells
rupture and die.
Antibiotic  Be aware that an
allergic reaction may
occur a few days after
therapy starts.
 Assess bowel pattern
daily.
 Assess for signs of
superinfection, such as
perineal itching, fever,
malaise, redness, pain,
swelling, drainage,
rash, diarrhea, and
cough or sputum
changes.
 Instruct patient and
significant other to
complete the prescribed
course of therapy.
 Tell patient and S.O. to
report severe diarrhea
to prescriber
immediately.
Reference : Jones and Bartlett Nurse’s Drug Handbook 2015 (cefixime page 205)
Page | 80
Reference : Jones and Bartlett Nurse’s Drug Handbook 2015 (ceftriaxone page 223)
Name of Drug Dosage and
Frequency
Indications and
Contraindications
Side Effects Mode of
Action
Classificatio
n
Nursing
Responsibilities
Generic Name:
Ceftriaxone
Brand Name:
Rocephin
Date ordered:
02-02-16
1 g
IV
every 12 hours
Peak: rapid
Onset: end of
infusion
Duration: 12-24
hr
Indication:
To treat infection.
The patient’s
urinalysis revealed a
presence of few
bacteria in urine as of
Jan. 31, 2016.
Contraindications:
Hypersensitivity to
ceftriaxone, other
cephalosporins, or
their components
 Abdominal
cramps
 elevated
liver
function test
results
 Edema
 Arthralgia
 Allergic
pneumonitis
,
 dyspnea
Interferes with
bacterial cell
wall synthesis
by inhibiting
cross-linking of
peptidoglycan
strands.
Peptidoglycan
makes the cell
membrane rigid
and protective.
Without it,
bacterial cells
rupture and die.
Antibiotic  Assess bowel
pattern daily.
 Assess for
pharyngitis,
ecchymosis,
bleeding, and
arthralgia; they
may indicate a
blood dyscrasia.
 Advise patient and
S.O. to report any
hypersensitivity
reactions, such as
a rash, itching
skin, or hives, to
prescriber
immediately and
to stop taking the
drug.
Page | 81
Name of
Drug
Dosage and
Frequency
Indications and
Contraindications
Side effects Mode of Action Classification Nursing
Responsibilities
Generic
Name:
Vitamin K
Brand
name:
Phytonadione
Date
ordered:
01-30-16
1 amp
10mg/ml
IV
every 8 hours
Peak: 1-2 hr
Onset: unknown
Duration:
unknown
Indication:
To treat bleeding.
The patient
manifested
epistaxis and black
tarry stool at 2:00
pm as of Jan. 30,
2016.
Contraindications:
Hypersensitivity to
benzyl alcohol
(Aquamephyton
only)
 Gastric upset
 Unusual taste
 Rash
 Urticaria
 Flushing
 Erythema
 Allergic
reactions
Required for
hepatic synthesis
of blood
coagulation
factors II
(prothrombin),
VII, IX, and X.
An
antihemorrhagic
actor that
promotes hepatic
formation of
active
prothrombin.
Fat soluble
vitamins  Monitor the
patient for
gastric upset.
 Monitor
patient for the
possible side
effects that
may occur.
 To report any
signs and
symptoms of
allergic
reactions.
Reference: Davis’s Drug Guide for Nurses fifth edition 2010 (vitamin K, page 970)
Page | 82
Name of
Drug
Dosage and
Frequency
Indications and
Contraindicatio
ns
Side effects Mode of Action Classification Nursing
Responsibilities
Generic
Name:
Omeprazole
Brand
Name:
Losec
Ordered at:
01-29-16
6:30 am
01-30-16
10:00 am
02-01-16
6:00 am
40 mg
IV
OD
Peak: unknown
Onset: 10-90
min
Duration:
unknown
Indication:
Treatment and
prevention of
hypersecretions
of stomach acid.
Due to patient’s
lost appetite with
DHF it will
cause abdominal
pain.
Contraindicatio
ns:
Hypersensitivity
 Weakness
 Dizziness
 Headache
 Fatigue
 Abdominal
pain
 Acid
regurgitatio
n
 Constipatio
n
 Diarrhea
 Flatulence
 Nausea
 Vomiting
 Rash
 Itching
Suppresses gastric
secretion by
inhibiting
hydrogen;
characterized as
gastric pump
inhibitor
Anti-ulcer,
proton pump
inhibitor
 Inform the patient
and significant other
about the reason why
drug is given and how it
is process inside the
patient's body.
 Monitor for diarrhea
and abdominal pain.
 Take the drug before
meals.
 Report severe
headache, worsening
of symptoms, fever,
chills. Swallow the
capsules whole; do not
chew, open, or crush
them.
 Inform patient and
S.O. that he/she may
experience these side
effects: Dizziness;
headache; nausea,
vomiting, diarrhea;
symptoms of URI,
cough.
Reference: Davis’s Drug Guide for Nurses fifth edition 2010 (omeprazole, page 878)
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Dengue Hemorrhagic Fever- Case Study

  • 1. Page | 1 I. INTRODUCTION A. OVERVIEW Dengue is a mosquito-borne disease cause by any one of four closely related dengue viruses (DENV -1,-2,-3 and -4). Infection with one serotype of DENV provides immunity to that serotype for life, but provides no long-term immunity to other serotypes. Thus, a person can be infected as many as four times, once with each serotype. Dengue Hemorrhagic Fever, also known as Severe Dengue, was first recognized in the 1950s during dengue epidemics in the Philippines and Thailand. Today, severe dengue affects most Asian and Latin American countries and has become a leading cause of hospitalization and death among children in these regions. Typical cases of DHF are characterized by four major clinical manifestations: high fever, hemorrhagic phenomena, and often, hepatomegaly and circulatory failure. Infected humans are the main carriers and multipliers of the virus, serving as as source of the virus for uninfected mosquitoes. Patients who are already infected with the dengue virus can transmit the infection (4-5 days, maximum 12) via Aedes mosquitoes after their first symptoms appear. Reference: World Health Organization (WHO) 2011. Retrieved from: http://who.int.com
  • 2. Page | 2 Mode of Transmission 1. Bite of an infected mosquito, principally the Aedes Aegypti. a. Aedes aegypti is a day-biting mosquito (they appear two hours after sunrise and two hours before sunset). b. It breeds in an areas of stagnant water. c. It has limited, low flying movement. d. It has fine whole dots at the base of the wings and white bands on the legs. 2. Aedes Albopictus may contribute to the transmission of the dengue virus in rural areas. 3. Other contributory mosquitoes: a. Aedes polynensis b. Aedes scutellaris simplex Incubation Period The incubation period is 3-14 days; commonly 7-10 days. Period of Communicability 1. Patients are usually infective to the mosquito from a day before the febrile period to the end of it. 2. The mosquito becomes infective from day 8 to 12 after the blood meal and remains infective throughout its life. Sources of Infection 1. Infected persons- the virus is present in the blood of patients during the acute phase of the disease and will become a reservoir of the virus, sucked by mosquitoes, which may then transmit the disease. 2. Standing water- any stagnant water in the household and its premises are usual breeding places of these mosquitoes.
  • 3. Page | 3 Dengue Hemorrhagic Fever (DHF) This severe form of dengue virus infection id manifested by fever, hemorrhagic, diathesis, hepatomegaly and hypovolemic shock. Classification According to Severity Grade 1 There is fever accompanied with non-specific constitutional symptoms and the only hemorrhagic manifestations is positive (+) in the tourniquet test. Grade 2 All signs of Grade 1, plus spontaneous bleeding from the nose, gums,, and GIT, are present. Grade 3 There is the presence of circulatory failure, as manifested by a weak pulse, narrow pulse pressure, hypotension, cold, clammy skin, and restlessness. Grade 4 There is profound shock, and undetectable blood pressure and pulse.
  • 4. Page | 4 Complications 1. Dengue Fever a. Epistaxis; menorrhagia b. Gastrointestinal bleeding c. Concomitant gastrointestinal disorder (peptic ulcer) 2. DHF a. Metabolic acidosis b. Hyperkalemia c. Tissue anoxia d. Hemorrhage into the CNS or adrenal glands e. Uterine bleeding may occur f. Myocarditis 3. Severe manifestations Dengue encephalopathy is manifested by increasing restlessness, apprehension or anxiety, disturbed sensorium, convulsions, spacity, and hyporeflexia. Reference: Handbookof CommonCommunicable andInfectious Disease, 3rd edition;Dionesia Mondejar-NavalesRN. Maed, p.71-73 Vaccine Dengvaxia, world’s first dengue vaccine was approved in Mexico. The Federal Commission for the Protection against Sanitary Risks (COFEPRIS) has approved Dengvaxia®, tetravalent dengue vaccine, for the prevention of disease caused by all four dengue virus serotypes in preadolescents, adolescents and adults, 9 to 45 years of age living in endemic areas.
  • 5. Page | 5 It took the multinational pharmaceutical company Sanofi Pasteur more than 20 years to develop the vaccine with clinical trials in five Asian and five Latin American countries where dengue is endemic. The vaccine was launched in the Philippines since it was the only country where all three phases of the clinical development were conducted. Health authorities said the vaccine will have side effects, including fever, headache, muscle pain, weakness, redness and swelling. The DOH also said that the medical breakthrough is no excuse to stop the fight against dengue. Communities should work towards prevention by cleaning possible mosquito breeding sites. Health Secretary Janette Garin said the agency would get a discounted price for the vaccine that would be used in the vaccination program starting March. The DOH will begin vaccinating Grade 4 students in public schools in Metro Manila, and in Southern and Central Luzon. The vaccine will be given in three doses, with six-month intervals. It will give the vaccine to over a million students this year but the health department is planning to hold a nationwide vaccination on 2017. Reference: http://www.sanofipasteur.com/en/articles/dengvaxia-world-s-first-dengue-vaccine-approved-in-mexico.aspx; Lyon,France - December 9, 2015 B. STATISTICS Local The number of dengue cases in the country spiked from around 120,000 in 2014 to over 200,000 in 2015. Despite the sharp increase in dengue cases, the Department of Health (DOH) said there was no corresponding increase in the number of deaths--with 598 in 2015 compared to 465 in 2014. The DOH estimated that some 220 Filipinos a day may be infected by the disease.
  • 6. Page | 6 Reference: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222740/ Lulu Bravo ,* Vito G. Roque, Jeremy Brett, Ruby Dizon, and Maïna L'Azou, 2014 Nov 6 International The incidence of dengue has grown dramatically around the world in recent decades. The actual numbers of dengue cases are underreported and many cases are misclassified. One recent estimate indicates 390 million dengue infections per year (95% credible interval 284–528 million), of which 96 million (67–136 million) manifest clinically (with any severity of disease). Another study, of the prevalence of dengue, estimates that 3900 million people, in 128 countries, are at risk of infection with dengue viruses. Member States in 3 WHO regions regularly report the annual number of cases. In 2010, nearly 2.4 million cases were reported. Although the full global burden of the disease is uncertain, the initiation of activities to record all dengue cases partly explains the sharp increase in the number of cases reported in recent years. Other features of the disease include its epidemiological patterns, including hyper-endemicity of multiple dengue virus serotypes in many countries and the alarming impact on both human health and the global and national economies.
  • 7. Page | 7 Cases across the Americas, South-East Asia and Western Pacific exceeded 1.2 million in 2008 and over 3 million in 2013 (based on official data submitted by Member States). Recently the number of reported cases has continued to increase. In 2013, 2.35 million cases of dengue were reported in the Americas alone, of which 37 687 cases were of severe dengue. Reference: http://www.who.int/mediacentre/factsheets/fs117/en/ May, 2015 C. SCOPE AND LIMITATION We handled our patient last January 30, 2016 on our 6am to 2pm shift, bed #15, Female-Ward at Laguna Medical Center under the supervision of Gloria Ramos, Ph.D,MAN, RN. We received the patient lying on bed with IVF Sodium Chloride 0.9 1 L on right metacarpal vein. The exposure of our duty comprised Nurse-Patient-Interaction, Head- to-Toe Assessment, IV regulation, vital signs monitoring and recording, drug administration via oral route, IV drug medication study and charting. To have further assessment, our group conducted a home visit on February 25, 2015 in the residence of Patient DLB in Lumban, Laguna. First and foremost, we asked consent and stated the purpose of the home visit. As we gathered data and information about the patient and his progress, the patient as well as the family members participated and cooperated hospitably. D. OBJECTIVES General Objective: At the end of the case study, the Level III nursing students will be able to expound and incorporate all the ideas and knowledge gained to the nursing approach in providing valid and outmost care connected with the patient diagnosed of Dengue Hemorrhagic Fever.
  • 8. Page | 8 Specific Objectives: As supported by our main objective, the level 3 student nurses will be able to: 1. Familiarize with the background of what Dengue Hemorrhagic Fever is all about; 2. Recognize predisposing and precipitating factors that may increase the development of Dengue Hemorrhagic Fever; 3. Review and understand the Anatomy and Physiology of the Circulatory system and Lymphatic system. 4. Explain and illustrate the pathophysiology of Dengue Hemorrhagic Fever; 5. Determine what specific laboratory results that may lead to Dengue Hemorrhagic Fever; 6. Describe the potential complications related to Dengue Hemorrhagic Fever; 7. Develop a comprehensive nursing care plan, with a principle of SMART, that is applicable to the client diagnosed with Dengue Hemorrhagic Fever; 8. Provide a well-develop Health Teaching using the METHODS formula to promote positive continuity of care to the patient after discharge which would be in great help for his continuity of care to the patient after discharge which would be in great help for his condition.
  • 9. Page | 9 II. PATIENT’S PROFILE Hospital Number: 137170 Patient’s Name: Patient DLB Address: Segundo Pulo, Lumban, Laguna Gender: Male Birthday: 11/22/2001 Age: 14 y/o Birthplace: Lumban, Laguna Nationality: Filipino Civil Status: Single Religion: Roman Catholic Educational Level: Grade 8 Allergies: (+) Penicillin Admitting Time: 6:30am Admitting Date: 01/29/16 Admitting Diagnosis: Severe Dengue Admitting Physician: Dra. Abadier Chief Complaint: Epistaxis, headache, nausea and vomiting and body malaise
  • 10. Page | 10 III. PATIENT’S HISTORY A. Past History According to Patient DLB, he had experienced cough, cold, fever and chicken pox before. He has no history of hospitalization but seeks medical advice to clinics in their barangay and other clinic to the near towns. B. Present History  5 days prior to admission, the patient experienced on and off fever. The patient drinks tawa-tawa extract and antipyretic medications like biogesic and tempra to relieve fever.  After a day, when the patient is still with fever, the patient decided to seek medical attention in a small Clinic in Unson. They checked the platelet count which is 187 X10/L and blood pressure of 100/80mmHg. Then he was given a prescribed medication of Biogesic 500mg for his fever.  Two days prior to hospitalization, the patient is still with fever. He consults to his paediatrician, Dra. Aquino and checked again for the platelet count that has a result of 24 x10/L so he was advised to go to the hospital.  One day prior to admission, the patient was experiencing fever, loss of appetite and epistaxis so the family decided to take him to Laguna Medical Center, Sta. Cruz, Laguna.  January 29, 2016, at 6:30am he was admitted with a diagnosis of Severe Dengue by attending physician Dra. Abadier with a blood pressure of 100/78mmHg. Patient’s vital signs during our shift whereas follows: Temperature: 38.2 °c Pulse Rate: 98 bpm Respiratory Rate: 20 cpm Blood Pressure: 100/60 mmHg
  • 11. Page | 11 C. Psychological Patient is unable to answer some of the questions properly because he cannot recall what happened during hospitalization. Nevertheless, the patient demonstrates an understanding and acceptance concerning on the health teaching about the health condition he experienced. D. Family History There is no history of dengue cases within patient's family members except with his two cousins who lived in the same Barangay. E. Spiritual Patient DLB’s religious affiliation is Roman Catholic. He stated that their family do not usually go to church but always pray and ask guidance for them. F. Sociocultural The patient consults to hilot as one of their health care provider. Prior to admission, patient DLB sipped tawa-tawa extract and had self-medication of advil, biogesic, and tempra as a relieved for fever. He also consults in health care clinic in their town. G. Exercise Patient is usually staying in their bedroom after school and during weekends. But at times he used to walk in going to school that is about 1km away from their residence. H. Nutritional The patient eats vegetables like radish, cabbage and mongo beans more often than not. He said that he just consumes what is served by his mother and
  • 12. Page | 12 does not usually fond of eating junkfoods or processed foods. He drinks 6-8 glasses of water a day. I. Developmental Erik Erikson’s stages of psychosocial development are a comprehensive psychoanalytic theory that identifies a series of eight stages, in which a healthy developing individual should pass through infancy to late adulthood. All stages are present at birth but only begin to unfold according to both natural scheme and one’s cultural and ecological upbringing. Each stages builds upon the successful completion of earlier stage. STAGE DESCRIPTION RESULT JUSTIFICATION Ages 12 to 18 years old Identity Vs. Role Confusion The adolescent is newly concerned with how they appear to others. Superego identity is the accrued confidence that the outer sameness and continuity prepared in the future are matched by the sameness and continuity of one’s meaning for oneself, as evidenced in the promise of a career. It was attained by the patient. The patient accomplished the ability to settle in the school. He ponders the roles he wants to do in the future. He knows what he wants to do and he expresses himself in the way he is known to be. He manages to spend time with his family and had good relationship with his classmates and knows his priorities.
  • 13. Page | 13 J. Hygiene Before Hospitalization During Hospitalization After Hospitalization Patient takes a bath every day before going to school and brushes his teeth twice a day. He performs hand washing before meal and he usually eat with the use of spoon and fork instead of the use of his bare hands. The patient is unable to go to the bathroom by himself due to muscle weakness so the family members prefer to perform sponge bath when he was in the hospital. He brushed his teeth once a day and does not wash his hands during hospitalization. The patient takes a bath once a day and brushes his teeth every morning and before going to bed. He demonstrates hand washing with soap and running water. K. Elimination Before Hospitalization During Hospitalization After Hospitalization Urination The patient voids 5-6 times a day, yellowish in color and with moderate amount. Defecation Patient usually defecate twice a day, light brown in color and formed in appearance. Urination Patient has no urinary catheter inserted. He voids 3-4 times per shift, transparent in color and with an estimated amount of 600 ml. Defecation During hospitalization, the patient defecates 5-6 times a day, black in color. Urination Patient voids 5-6 times a day, approximately 600ml and yellowish in color. Defecation The patient’s stool is light brown in color and formed in appearance. He defecates twice daily.
  • 14. Page | 14 L. Sleepand Rest Before Hospitalization During Hospitalization After Hospitalization Patient is able to sleep at 9 in the evening and wakes up 5 in the morning to prepare for school. He has adequate rest every day. The patient sleeps at 7pm, but wakes up every time he feels tenderness and has uncomfortable sensation. The patient is able to sleep with his normal sleeping pattern and has no difficulty resting.
  • 15. Page | 15 IV. NUTRITIONAL ASSESSMENT 24 hour Food Recall Before Hospitalization After Hospitalization 1. What time did you go to bed the night before? Was this the usual time? “I slept as early as 7pm but not continuous, sometimes I woke up when I feel uncomfortable.” “No. I usually go to sleep around 9pm.” Patient stated that he sleeps at 9pm in the evening. “Yes.” 2. What time did you get up yesterday? Was this the usual time? When was the first time you had anything to eat or drink? What did you have and how much? “Around 8am.” “No. I usually wake up earlier.” “At lunch time.” “Just a piece of biscuit and sipped as small amount of water. “I woke up 6 in the morning.” “Yes, it is.” “I had my breakfast at 6:30am.” “I ate a cup of rice and one hotdog.” 3. When did you eat again? “The next meal was my dinner.” “I ate my snack at 10am.” 4. Where? What and how much? “In our house.” “I drink a half glass of water and one spoonful of rice with egg pugo.” “In our house.” “I had 3 pieces of bread and one glass of ice tea.” 5. When did you eat next? What did you eat and how much? “At 10 pm.” “A piece of tasty.” “Lunchtime.” “1 ½ cup of rice and sinigang.” 6. Did you eat or drink anything else? a. Anything from 1st “I had a glass of water and half bottle of gatorade.” “None.” “Yes. I ate at 6:30 in the evening.” “I drink a glass of water
  • 16. Page | 16 meal to 2nd meal? b. Anything from 2nd to 3rd meal? c. Anything from 3rd meal to bed time? “None.” “None.” about 150ml.” “I drink a half glass of water.” “I had a glass of water.” 7. Was this day’s food intake differing from usual? If so, why? “Yes.” “I lose my appetite and feel nauseated every time I eat.” “No.” 8. Is weekend eating different? If so, why? “Sometimes.” “It depends on what food is available in our house.” “At times.” “It depends on what food is available in our house.”
  • 17. Page | 17 V. PHYSICAL ASSESSMENT Area Method Findings Post-Findings Interpretation Hair Inspection Hair is black and equally distributed Hair is black and equally distributed Normal Palpation No signs of tenderness and nodules while palpating No signs of tenderness and nodules while palpating Normal Skin Inspection Generalized pallor Presence of hematoma on the upper right arm Dengue virus induces bone marrow suppression. Since bone marrow is the manufacturing center of blood cells its suppression causes deficiency of blood cells leading to low hemoglobin count. Paleness is caused by reduced blood flow or a decreased number of red blood cells. Reference: K. Kafeel (2011). Retrieved from: http://www.onlymyhealth.com/cause-low- platelet-count-in-dengue-fever-1301653922 The presence of the virus (arbovirus) within the blood vessels, especially those feeding the skin, causes changes to these blood vessels. The vessels swell and leak because of increase capillary permeability. As the blood vessels become more damaged the blood vessels start to leak. When blood leaves the circulatory system and becomes stagnant, there is almost immediate clotting. Reference: C. Dewit. Dengue Fever (2006). Retrieved from: http://www.encyclopedia.com/topic/dengue_fev er.aspx C. Davis. Hematoma (2015). Retrieved from: http://www.emedicinehealth.com/hematoma/pag e2_em.htm
  • 18. Page | 18 Palpation Warm to touch With moist skin and with good skin turgor Warm to touch because of the body’s compensation to the virus. The patient’s body temperature was 38.2 °c. Reference: W. Lloyd. (2013). Retrieved from: http://www.healthgrades.com/symptoms/clamm y-skin Nails Inspection Nail surface is slightly curved No clubbed finger Nail surface is slightly curved No clubbed finger Normal Palpation Capillary refill of more than 3 sec With pale nail beds Capillary refill of less than 3 sec With pinkish nail beds Damage to an artery or vein allows blood to escape the circulatory system. Thus, a low hemoglobin count cause alteration in blood flow. Eyes Inspection With pale conjunctiva Pupil Equally Round Reactive to Light and Accommodatio n With equally distributed eye lid and eye lashes With moist and pinkish conjunctiva Pupil Equally Round Reactive to Light and Accommodation With equally distributed eye lid and eye lashes Damage to an artery or vein allows blood to escape the circulatory system. Thus, a low hemoglobin count cause alteration in blood flow. Palpation No signs tenderness when palpating No signs tenderness when palpating Normal Ears Inspection Symmetrical, no presence of discharge or redness Can react to sound No presence of cerumen Symmetrical, no presence of discharge or redness Can react to sound No presence of cerumen Normal Palpation No tenderness and nodules No tenderness and nodules Normal Nose and Sinuses Inspection No nasal discharge No redness and No nasal discharge No redness and Normal
  • 19. Page | 19 inflammation No nasal deviation inflammation No nasal deviation Palpation No tenderness upon palpation No tenderness upon palpation Normal Mouth Inspection Dry lips With pale palate Can able to move the tongue in all direction Uvula is at the midline No presence of inflammation in oral mucosa Moist and pinkish mucus membrane Can able to move the tongue in all direction Uvula is at the midline If the amount of fluid in the intravascular space is decreased, the body compensates. (fluid depletion) Damage to an artery or vein allows blood to escape the circulatory system. Low hemoglobin count cause alteration in blood flow. Palpation No tenderness when palpating for the soft and hard palate With intact gag reflex No presence of inflammation in oral mucosa No tenderness when palpating for the soft and hard palate With intact gag reflex Normal Neck Inspection No swelling and no venous distention No swelling and no venous distention Normal Palpation No masses lymph nodes and thyroid gland enlargement No masses lymph nodes and thyroid gland enlargement Normal Lungs and Thorax Inspection symmetrical anterior chest wall symmetrical anterior chest wall Normal
  • 20. Page | 20 With no difficulty of breathing With no signs of difficulty of breathing Normal Percussion Resonance in sound Resonance in sound Normal Auscultation With clear breath sounds With clear breath sounds Normal With Systolic of 100 mmHg and Diastolic of 60mmHg With systolic of 120 mmHg and Diastolic of 80 mmHg Normal Abdom en Inspection No abdominal distention with no signs of tenderness or masses No abdominal distention with no signs of tenderness or masses Normal Auscultation Bowel sound heard RLQ= 7 RUQ= 6 LUQ= 9 LLQ= 8 Bowel sounds heard RLQ= 5 RUQ= 7 LUQ= 5 LLQ= 9 Normal Percussion With tympanic With tympanic Normal Palpation Abdomen is soft With no signs of tenderness or masses Abdomen is soft With no signs of tenderness or masses Normal Muscle Inspection and Palpation Able to obey command muscle strength of 4/5 Able to obey command muscle strength of 5/5 The dengue virus causes of measurable muscle weakness. The muscle can move the joint it crosses through a full range of motion against gravity moderate resistance. Extremi ties Inspection Presence of petechiae in upper and lower extremities Has no signs of lesions It caused by capillary fragility. The blood vessels start to leak and cause bleeding. Petechiae (small skin hemorrhages).
  • 21. Page | 21 VI. ANATOMY AND PHYSIOLOGY Blood Blood is made up of liquid (called plasma) and solid cells. Blood cells are made in the bone marrow. Bone marrow is the soft, spongy substance in the centre of bones. Structure In adults, the most active bone marrow is found in the pelvic bone, shoulder bones, back bones (vertebra), ribs, breast bone and skull. Immature blood cells in the bone marrow are called stem cells. Stem cells can also be found in smaller amounts in the bloodstream. These are called peripheral blood stem cells. All of our blood cells develop from stem cells. The process of blood cell development is called hematopoiesis. In the earliest stage of blood cell development, stem cells begin to develop either along the lymphoid cell line or the myeloid cell line. In both cell lines, the stem cells become blasts, which are still immature cells. Lymphoid cell line Lymphoid stem cells develop into lymphocytes (also called lymphoblasts). Lymphocytes are another type of white blood cell (also called leukocytes). Lymphocytes help fight infection and destroy abnormal cells.
  • 22. Page | 22 Myeloid cell line Myeloid stem cells develop into red blood cells, platelets and some types of white blood cells. Red blood cells carry oxygen to all tissues of the body. Platelets form clots in damaged blood vessels to stop bleeding. Myeloid stem cells develop into 2 different types of white blood cells, called granulocytes and monocytes. These white blood cells destroy bacteria and other foreign invaders and help to fight infection. Functions The main function of blood is to carry nutrients, gases, waste products, cells and hormones. Each type of blood cell has a specific job.  Red blood cells carry oxygen from the lungs to the rest of the body. They also carry carbon dioxide from the body to the lungs so it can be breathed out.  Platelets form blood clots in damaged vessels to stop bleeding.  White blood cells help prevent and fight infection by destroying bacteria, viruses and other foreign cells or substances.
  • 23. Page | 23 Types of white blood cells White blood cells are the cells that help the body fight infection. There are a number of different types and sub-types of white blood cells which each have different roles to play. The three major types of white blood cells are:  Granulocytes  Monocytes  Lymphocytes Granulocytes There are three different forms of granulocytes:  Neutrophils  Eosinophils  Basophils Granulocytes are phagocytes, that is they are able to ingest foreign cells such as bacteria, viruses and other parasites. Granulocytes are so called because these cells have granules of enzymes which help to digest the invading microbes. Granulocytes account for about 60% of our white blood cells. Neutrophils are by far the most prevalent of these cells. Each neutrophil cell can ingest up to between around 5 and 20 bacteria in its lifetime. Eosinophils are involved in allergic reactions and can attack multicellular parasites such as worms. Basophils are also involved in allergic reactions and are able to release histamine, which helps to trigger inflammation, and heparin, which prevents blood from clotting. Monocytes Monocytes can develop into two types of cell: Dendritic cells are antigen-presenting cells which are able to mark out cells that are antigens (foreign bodies) that need to be destroyed by lymphocytes. Macrophages are phagocyte cells which are larger and live longer than neutrophils. Macrophages are also able to act as antigen-presenting cells.
  • 24. Page | 24 Lymphocytes Lymphocytes are cells which help to regulate the body's immune system. The main types of lymphocytes are:  B lymphocytes (B cells)  T lymphocytes (T cells)  Natural Killer Cells
  • 25. Page | 25 VII. PATHOPHYSIOLOGY Precipitating Factors  Environmental conditions (open spaces with water)  Presence of 2 Dengue cases in the community Predisposing Factors  Geographical area-tropical island in the Pacific (Philippines) Aedes Mosquito (Carrier of Dengue Virus) Bite from mosquito to skin (Portal of Entry) Virus will circulate in the blood Infection primarily targets the reticulo endothelial system (blood,bone marrow, lymph nodes) Production of immune mediators Activation of immune response Destructive actions of the virus or bone marrow precursor cells Release of cytokines Stimulate WBC and Pyrogens Fever 38.2°C Viral replication and Cellular destruction
  • 26. Page | 26 DENGUE HEMORRHGIC FEVER URINARY TRACT INFECTION Muscle weakness 4/5 Thrombocytopenia Platelet Count=38x109 /L Low Lymphopenia Lymphocytes=2.29 % Low Leukopenia WBC=3.83 x 109 /L Low Capillary fragility Petechiae GI Bleeding MelenaRelease of Histamine ↑ Capilliary permeability Plasma leakage Epistaxis ↑ Glomerular Permeabilty ↑ Amount of plasma protein Urinalysis Result: (+) 4 protein 2-4 hpf RBC Few Bacteria Hemoglobin=86 g/L RBC=2.69x 1012 /L Hematocrit=23.9 %
  • 27. Page | 27 VIII. MEDICAL MANAGEMENT Date Doctor’s Order Interpretation Day 1 January 29, 2016, 6:30 am Epistaxis Dengue Hemorrhagic fever Typhoid fever 4:00 pm (+) epistaxis  Please admit to medicine ward  Secure consent  TPR every shift  DAT except dark colored food  Hospital policy designates the exact procedure that should be followed when admitting the patient to the holding area or operating room suite. Admission will help to monitor the client’s condition. The admitting procedure is continued with reassessment of the patient and allowance of time for last minute question. (references: Medical-Surgical Nursing 5th edition by Lewis, Heitkemper &Dirksen Chapter 17, page 380)  Informed consent is the patient’s autonomous decision about whether to undergo a procedure. Before signing the consent, the risks and benefits of the procedure must be explained in terms the patient could easily understand. This is to prepare patient psychologically and the health care workers from battery. (references: Maternal and Child Health Nursing 6th edition by Adelle Pilliteri Chapter 24, page 658 and Brunner & Suddarth’s Textbook of Medical-Surgical Nursing 13th edition by Janice L. Hinkle & Kerry H. Cheever Chapter 17 page 406)  The recording of Temperature, Pulse rate, and Respiration are part of physical examination. Acute changes and trends over time are documented and unexpected changes and values that deviate significantly from a patient’s normal values are brought to the attention of the patient’s primary health care provider. (references: Brunner & Suddarth’s Textbook of Medical-Surgical Nursing 13th edition by Janice L. Hinkle & Kerry H. Cheever Chapter 5 page 67)  Dark colored foods may alter the color of the stool of the patient. It is advice to patient which will undergo fecalysis exam to determine Blood Occult in the stools. Highly colored foods, dark green leafy vegetables and Iron supplements are avoided as these tend to interfere with the
  • 28. Page | 28 TVF:  D5LR 1L × 60 gtts/min × 2 cycles Laboratories:  Complete blood count with PC, typing  Urine analysis  Hematocrit monitoring at every 6 hours test. (reference: Nutrition and Diet Therapy for Nursing 2011 by Adela Jamorabo-Ruiz Chapter 13 page 301-302)  D5LR is an hypertonic solution that is given to prevent dehydration. Dengue is a disease of DEHYDRATION. Much like a Diarrhea except that the body fluids don’t come out with the patient’s stool but through PLASMA LEAKAGE. Imagine that the arteries and veins of a patient have thousands of pinpoint holes due to the body's reaction to the Dengue virus, causing the fluids inside the blood vessels to sip out. (reference: Fundamentals of Nursing 8th edition of 2008 Volume 2 by Snyder, Berman, Kozier and Erb Chapter 52 Fluid, Electrolyte and Acid – Base Balance page 1456)  CBC is done to the patient to test if there is blood loss. To look for low platelet count typical of the later stages of the illness and to detect the decrease in hemoglobin, hematocrit, and red blood cell (RBC) count (evidence of anemia) that would occur with blood loss associated with severe dengue fever. (references: cell medicine, 24th edition by Golman and Schater page 345)  Urinalysis is done to the patient to detect possible abnormalities in the urinary tract. It is ordered to determine presence of bacteria or blood (hematuria) in the urine of the patient.( reference:Medical Surgical Nursing 8th edition volume 2, Chapter 45 Urinary System page 1150 )  A blood sample's hematocrit or the red blood cell volume percentage, and become a point of reference of its capability of delivering oxygen. The patient’s hematology result of Hct: 37.1 % as of 01- 29-2016. (reference: retrieved from https://en.wikipedia.org/wiki/Hematocrit )
  • 29. Page | 29 Medications:  Ascorbic acid 500 mg 1 tab BID  Tranexamic acid 500 mg TIV every 8 hours x 3 days  For transfusion of platelet 6 units properly typed and cross matched  If platelet concentrate not cross matched may transfused FFP 4 units  Supplemental therapy in some GI diseases, during long term parenteral nutrition. Increases protection mechanism of the immune system thus, resistance to infection. (Reference: Davis’s Drug Guide for Nurses fifth edition 2010 (ascorbic acid, page 105)  Inhibits activation of plasminogen thereby preventing the conversion of plasminogen to plasmin. Treatment for bleeding. Patient experienced epistaxis and melena. Reference: Davis’s Drug Guide for Nurses fifth edition 2010(tranexamic acid, page 1179)  Platelet transfusions are used to prevent spontaneous bleeding or to stop established bleeding in patients with a deficiency in platelet number or function. In Dengue patients, transfusion is done when platelet count is 10000-20000/ul and thrombocytopenic bleeding is present. All the patients of Dengue Shock syndrome require platelet support. The patient’s platelet revealed 8x 109 /L as of 01-29- 2016 and positive for epistaxis. Doctors use blood typing and cross matching to make sure that the patient receiving a blood transfusion is getting the correct type of blood. Crossmatching is used by a doctor to make sure that the specific donor blood that will be used during a transfusion does not react with a patient’s blood. (reference:http://ijtm.in/view_article.php?id=21)  Plasma contains all of the coagulation factors. Fresh frozen plasma (FFP) infusion can be used for reversal of anticoagulant effects. Plasma transfusion is recommended in patients with active bleeding. The patient experienced nose bleeding. FFP does not need to be cross- matched but should be ABO compatible. (reference: http://www.aafp.org/afp/2011/0315/p719.html)
  • 30. Page | 30  Godex 1 cap 300 mg PO BID  Omeprazole 40 mg TIV OD  Ceftriaxone 1g TIV every 12 hours  Intake and output every shift  To prevent damage to liver, one of the complication of DHF. Godex acts by transporting excess, long-chain fatty acids into the mitochondria to produce high amounts of energy to produce high amounts of energy to provide cell protection and fast treatment of liver disease.(http://www.mergersdrugfil.com.ph/index.php /godex-ds )  Treatment and prevention of hypersecretions of stomach acid. Omeprazole is used to prevent upper gastrointestinal tract bleeding. Due to patient’s lost appetite with DHF it will cause abdominal pain. (retrieve from :http://www.mayoclinic.org/drugs- supplements/omeprazole-oral-route/description/drg- 2006683)  To treat infection. Interferes with bacterial cell wall synthesis by inhibiting cross- linking of peptidoglycan strands. Peptidoglycan makes the cell membrane rigid and protective. Without it, bacterial cells rupture and die. The patient’s urinalysis revealed a presence of few bacteria in urine as of Jan. 31, 2016. (reference : Jones and Bartlett Nurse’s Drug Handbook 2015 (ceftriaxone page 223)  Accurate intake and output is necessary for determining fluid replacement needs and reducing risk of fluid overload and reflects circulating fluid shifts, and response to therapy. Dengue Hemorrhagic Fever can cause fluid shifting from intracellular spaces to intravascular space that leads to dehydration. (references: Nursing Care Plan 8th edition of 2010 by Marlynn E. Doenges Capter 10 page 542)
  • 31. Page | 31  Vital sign every 1 hour and record  For close monitoring Notify Dra. Abralzado Refer  IVF to following D5LR 1L x 70 gtts/min x 2 cycles  Give Hydrocortisone 250 mg IV now  The vital signs are body temperature, pulse, respirations and blood pressure, which should be looked at in total, are checked to monitor the function of the body which may alter the normal function of the body.(Reference: Fundamentals of Nursing 8th Edition of 2008 Volume 1 by Berman, Snyder, Kozier and Erb Chapter 29 Vital signs page. 527)  The vital signs are body temperature, pulse, respirations and blood pressure, which should be looked at in total, are checked to monitor the function of the body which may alter the normal function of the body. Since the patient’s blood count especially the hemoglobin and platelet is decreasing he needs more attentive care. (Reference: Fundamentals of Nursing 8th Edition of 2008 Volume 1 by Berman, Snyder, Kozier and Erb Chapter 29 Vital signs page. 527)  D5LR is an hypertonic solution that is given to prevent dehydration. Dengue is a disease of DEHYDRATION. Much like a Diarrhea except that the body fluids don’t come out with the patient’s stool but through PLASMA LEAKAGE. Imagine that the arteries and veins of a patient have thousands of pinpoint holes due to the body's reaction to the Dengue virus, causing the fluids inside the blood vessels to sip out. (reference: Fundamentals of Nursing 8th edition of 2008 Volume 2 by Snyder, Berman, Kozier and Erb Chapter 52 Fluid, Electrolyte and Acid – Base Balance page 1456)  Management for Dengue shock syndrome. Corticosteroids are potent anti- inflammatory agents that have a wide range of effects on immunological processes and have found use in a broad spectrum of diseases (Reference : Jones and Bartlett Nurse’s Drug Handbook 2015( hydrocortisone page 256) Day 2 January 30, 2016 3:00 am  Diphenhydramine 50 mg TIV now  To prevent allergic reaction after blood transfusion. Acts on blood vessels, GI, respiratory system by competing with
  • 32. Page | 32 BP 100/70 PR 86 RR 21 (-) PC 10:00 am (+) black stool 2:00 pm epistaxis 4:00 pm Severe dengue Restless (+) epistaxis (+) petechia (+) hematoma right forearm Poor pulse (+) epigastric tenderness Clear breath sounds 6:00 pm BP 126/79 O2sat 99% Full pulses  Hydrocortisone 100 mg TIV now  Secure and transfuse 5 units platelet properly typed  Secure and transfuse either 5 units Platelet Concentrate or 5 units Fresh Frozen Plasma (whichever is available) properly typed and cross matched)  Regulate accurately present hydration rate histamine for 𝐻1 –receptor site; decreases allergic response by blocking histamine. (Reference : Jones and Bartlett Nurse’s Drug Handbook 2015 ( diphenhydramine page 325)  Management for Dengue shock syndrome. Corticosteroids are potent anti- inflammatory agents that have a wide range of effects on immunological processes and have found use in a broad spectrum of diseases (Reference : Jones and Bartlett Nurse’s Drug Handbook 2015( hydrocortisone page 256)  Platelet transfusions are used to prevent spontaneous bleeding or to stop established bleeding in patients with a deficiency in platelet number or function. In Dengue patients, transfusion is done when platelet count is 10000-20000/ul and thrombocytopenic bleeding is present. All the patients of Dengue Shock syndrome require platelet support. Doctors use blood typing to make sure that the patient receiving a blood transfusion is getting the correct type of blood. (reference:http://ijtm.in/view_article.php?id=21)  Platelet transfusions are used to prevent spontaneous bleeding or to stop established bleeding in patients with a deficiency in platelet number or function. On the other hand,. Fresh frozen plasma (FFP) infusion can be used for reversal of anticoagulant effects. Plasma transfusion is recommended in patients with active bleeding. The patient experienced nose bleeding and presence of blood in the stool. (reference:http://ijtm.in/view_article.php?id=21, http://www.aafp.org/afp/2011/0315/p719.html)  To prevent dehydration causes by Dengue virus.
  • 33. Page | 33  Facilitate paracetamol IV 150mg/ml PRN fever  Tepid sponge bath care out companion (please facilitate)  Hook to O2 support via nasal canulla x 3 cpm  Transfer to ICU please  Appraised mother  Paracetamol is an antipyretics use to decreases fever by inhibiting the effects of pyrogens on the hypothalamus heat regulating centers & by a hypothalamic action leading to sweating & vasodilatation. (reference: retrieved from https://www.scribd.com/doc/36795690/Drug-Study- Paracetamol)  Tepid sponge bath is considered as one of the best cooling treatments. This method is recommended for febrile individuals, especially those with fever ranging from 102.2F or higher. It is effective in relieving fever by reducing high temperature and also helpful in alleviating pain or discomfort. (reference: https://www.scribd.com/doc/38235959/Tepid-Sponge- Bath)  Administration of oxygen helps increase the percentage of oxygen in inspired air. The goal of oxygen administration is to supply the patient with adequate oxygen to maximize oxygen carrying ability of the blood. Patient’s hemoglobin revealed 69 g/L (low). References: Medical Surgical Nursing by LweisHeitkemper Dirksen, Fifth Edition at pages 689)  Seriously ill patients require close observation and monitoring. Since the patient’s blood profile is continuously decreasing the doctor ordered to transfer him to ICU. (reference:http://www.cpmc.org/learning/documents/icu- ws.html)  The family should have an accurate knowledge about the medical condition of her child to alleviate stress. It allows the individual to accept and minimize reaction to difficult situations. (Reference: http://www.hindawi.com/journals/nrp/2011/392705/)
  • 34. Page | 34  IVF to follow D5LR 1L x 70gtts 2 cycles  Omeprazole 40 mg IV OD  Fecalysis with occult  Tranexamic acid 500g IV run q 8  Vitamin K 1 amp IV every 8 hours  D5LR is an hypertonic solution that is given to prevent dehydration. Dengue is a disease of DEHYDRATION. Much like a Diarrhea except that the body fluids don’t come out with the patient’s stool but through PLASMA LEAKAGE. Imagine that the arteries and veins of a patient have thousands of pinpoint holes due to the body's reaction to the Dengue virus, causing the fluids inside the blood vessels to sip out. (reference: Fundamentals of Nursing 8th edition of 2008 Volume 2 by Snyder, Berman, Kozier and Erb Chapter 52 Fluid, Electrolyte and Acid – Base Balance page 1456)  Treatment and prevention of hypersecretions of stomach acid. Omeprazole is used to prevent upper gastrointestinal tract bleeding. Due to patient’s lost appetite with DHF it will cause abdominal pain. (retrieve from :http://www.mayoclinic.org/drugs- supplements/omeprazole-oral-route/description/drg- 2006683)  Since the patient was diagnosed of dengue hemorrhagic fever, these examination finds out to see if there was melena in the stool of the patient. ( reference: Brunner and Suddarth’s Textbook of Medical Surgical Nursing Twelfth Edition by Smeltzer, Bare, Hinkle and Cheever page 987)  Inhibits activation of plasminogen thereby preventing the conversion of plasminogen to plasmin. Treatment for bleeding. Patient experienced epistaxis and melena. (Reference: Davis’s Drug Guide for Nurses fifth edition 2010(tranexamic acid, page 1179)  To treat bleeding.The patient manifested epistaxis and black tarry stool at 2:00 pm as of Jan. 30, 2016. Required for hepatic synthesis of blood coagulation factors II (prothrombin), VII, IX, and X. An
  • 35. Page | 35  Line no 1L PNSS 500cc then maintain at 55gtts/min (5 cycles)  Line no 2 D5LR 1L x 55gtts/min (5) Refer for next IVF  For Fresh Whole Blood transfusion properly typed and crosmatched x 5 hrs 2 doses, 6hrs  Furosemide 20mg PO every after Blood transfusion  Please monitor antihemorrhagic actor that promotes hepatic formation of active prothrombin. (Reference: Davis’s Drug Guide for Nurses fifth edition 2010 (vitamin K, page 970)  Used because it has little to no effect on the tissues and make the person feel hydrated preventing hypovolemic shock or hypotension. (reference: https://www.scribd.com/doc/109761163/PNSS-drug- study)  D5LR is an hypertonic solution that is given to prevent dehydration. Dengue is a disease of DEHYDRATION. Much like a Diarrhea except that the body fluids don’t come out with the patient’s stool but through PLASMA LEAKAGE. Imagine that the arteries and veins of a patient have thousands of pinpoint holes due to the body's reaction to the Dengue virus, causing the fluids inside the blood vessels to sip out. (reference: Fundamentals of Nursing 8th edition of 2008 Volume 2 by Snyder, Berman, Kozier and Erb Chapter 52 Fluid, Electrolyte and Acid – Base Balance page 1456)  Plasma contains all of the coagulation factors. Fresh frozen plasma (FFP) infusion can be used for reversal of anticoagulant effects. Plasma transfusion is recommended in patients with active bleeding. The patient experienced nose bleeding. FFP does not need to be cross- matched but should be ABO compatible. (reference: http://www.aafp.org/afp/2011/0315/p719.html)  To prevent fluid overload that may be imposed by the additional blood volume delivered during transfusion. Inhibits the reabsorption of sodium and chloride from the loop of Henle and distal renal tubule. (Reference: Davis’s Drug Guide for Nurses fifth edition 2010(Diuretics (Loop), page 392)  The vital signs are body temperature,
  • 36. Page | 36 vital sign blood pressure every 1 hour and record Refer  Hold vitamin K, and do please PT, PTT  Intake and output every shift  Complete blood count every 8 hours  Please include SGPT/SGOT ( Serum Glutamic Pyruvic Transaminase), SGOT ( Serum pulse, respirations and blood pressure, which should be looked at in total, are checked to monitor the function of the body which may alter the normal function of the body.(Reference: Fundamentals of Nursing 8th Edition of 2008 Volume 1 by Berman, Snyder, Kozier and Erb Chapter 29 Vital signs page. 527)  The PTT is used primarily to investigate unexplained bleeding or clotting. It may be ordered along with a prothrombin time (PT) test to evaluate hemostasis, the process that the body uses to form blood clots to help stop bleeding. These tests are usually the starting points for investigating excessive bleeding or clotting disorders. (reference: retrieved from https://labtestsonline.org/understanding/analytes/aptt/tab/ test/)  Accurate intake and output is necessary for determining fluid replacement needs and reducing risk of fluid overload and reflects circulating fluid shifts, and response to therapy. Dengue Hemorrhagic Fever can cause fluid shifting from intracellular spaces to intravascular space that leads to dehydration. (references: Nursing Care Plan 8th edition of 2010 by Marlynn E. Doenges Capter 10 page 542)  CBC is done to the patient to test if there is blood loss. To look for low platelet count typical of the later stages of the illness and to detect the decrease in hemoglobin, hematocrit, and red blood cell (RBC) count (evidence of anemia) that would occur with blood loss associated with severe dengue fever. (references: cell medicine, 24th edition by Golman and Schater page 345)  Liver function tests are one of the blood tests that are performed to assess the function of the liver. Liver damage is detected initially by performing a simple blood test that determines the level of various liver enzymes present in the blood. Liver damage is one of the complication of
  • 37. Page | 37 Glutamic Oxaloacetic Transaminase) on next CBC extraction  O2 at 6 cpm via face mask  IVF line no. 1 PNSS at 55 gtts/min (5) x 2  fused no. 2 D5LR at 25gtts/min (2) x 2 hours Refer Dengue Hemorrhagic Fever.(reference: retrieved from http://www.med-health.net/Sgot-Sgpt.html)  Administration of oxygen helps increase the percentage of oxygen in inspired air. The goal of oxygen administration is to supply the patient with adequate oxygen to maximize oxygen carrying ability of the blood. The patient’s hemoglobin revealed 69 g/L (low). (References: Medical Surgical Nursing by LweisHeitkemper Dirksen, Fifth Edition at pages 689)  Used because it has little to no effect on the tissues and make the person feel hydrated preventing hypovolemic shock or hypotension. (reference: https://www.scribd.com/doc/109761163/PNSS-drug- study)  D5LR is an hypertonic solution that is given to prevent dehydration. Dengue is a disease of DEHYDRATION. Much like a Diarrhea except that the body fluids don’t come out with the patient’s stool but through PLASMA LEAKAGE. Imagine that the arteries and veins of a patient have thousands of pinpoint holes due to the body's reaction to the Dengue virus, causing the fluids inside the blood vessels to sip out. (reference: Fundamentals of Nursing 8th edition of 2008 Volume 2 by Snyder, Berman, Kozier and Erb Chapter 52 Fluid, Electrolyte and Acid – Base Balance page 1456) Day 3 January 31, 2016 12:29 am BP 113/62 PR 98 T 37.4 O2sat 99%  IVF line 1 PNSS at 25gtts/min x (2) x 4 hours  Line 2 D5LR at  Used because it has little to no effect on the tissues and make the person feel hydrated preventing hypovolemic shock or hypotension. (reference: https://www.scribd.com/doc/109761163/PNSS-drug- study)  D5LR is an hypertonic solution that is
  • 38. Page | 38 (+) mild headache 6:00 am BP 114/67 (-) Bleeding 8:00 am (-) melena (-) epistaxis Awake Confused No epigastric tenderness Full pulse Clear breath sounds 10:00 pm Coherent Full pulse No epistaxis 25gtts/min (2) x 4 hours Refer  Paracetamol 1 amp 150mg/ml IV every 4 hours  Continue present management  Continue paracetamol PRN  Facilitate Fresh Whole Blood transfuse 2nd dose given to prevent dehydration. Dengue is a disease of DEHYDRATION. Much like a Diarrhea except that the body fluids don’t come out with the patient’s stool but through PLASMA LEAKAGE. Imagine that the arteries and veins of a patient have thousands of pinpoint holes due to the body's reaction to the Dengue virus, causing the fluids inside the blood vessels to sip out. (reference: Fundamentals of Nursing 8th edition of 2008 Volume 2 by Snyder, Berman, Kozier and Erb Chapter 52 Fluid, Electrolyte and Acid – Base Balance page 1456)  Paracetamol is an antipyretics use to decreases fever by inhibiting the effects of pyrogens on the hypothalamus heat regulating centers & by a hypothalamic action leading to sweating & vasodilatation. (reference: retrieved from https://www.scribd.com/doc/36795690/Drug-Study- Paracetamol)  For supportive Drug; supports body function until other treatments or the body’s treatments or body’s response can take over; because medication is a substance administered for the diagnosis, cure treatment or relief of symptoms of for prevention of disease. (Reference: Fundamentals of Nursing 8th Edition of 2008 by Berman, Synder, Kozier and Erb Chapter 35 Medications page 830  Paracetamol is an antipyretics use to decreases fever by inhibiting the effects of pyrogens on the hypothalamus heat regulating centers & by a hypothalamic action leading to sweating & vasodilatation. (reference: retrieved from https://www.scribd.com/doc/36795690/Drug-Study- Paracetamol)  Plasma contains all of the coagulation factors. Fresh frozen plasma (FFP) infusion can be used for reversal of anticoagulant effects. Plasma transfusion is
  • 39. Page | 39 recommended in patients with active bleeding. The patient experienced nose bleeding. FFP does not need to be cross- matched but should be ABO compatible. (reference: http://www.aafp.org/afp/2011/0315/p719.html) Day 4 February 01, 2016 8:30 am Coherent BP 100/60 PR 99 37 (-) Epistaxis 9:30 (-) bleeding  PNSS 1L x 15 gtts/min (1)  D5LR 1L x 15 gtts/min (1)  Used because it has little to no effect on the tissues and make the person feel hydrated preventing hypovolemic shock or hypotension. (reference: https://www.scribd.com/doc/109761163/PNSS-drug- study)  D5LR is an hypertonic solution that is given to prevent dehydration. Dengue is a disease of DEHYDRATION. Much like a Diarrhea except that the body fluids don’t come out with the patient’s stool but through PLASMA LEAKAGE. Imagine that the arteries and veins of a patient have thousands of pinpoint holes due to the body's reaction to the Dengue virus, causing the fluids inside the blood vessels to sip out. (reference: Fundamentals of Nursing 8th edition of 2008 Volume 2 by Snyder, Berman, Kozier and Erb Chapter 52 Fluid, Electrolyte and Acid – Base Balance page 1456) Day 5 February 2, 2016 6:00 am (-) bleeding Platelet 198  May go home Home Meds:  Godex 1 cap 300mg BID x 5 days  Discharge planning is the process of preparing a client to receive one level of care for another within or outside of the current health care agency; usually refers to the client leaving hospital for home. ( Fundamentals of Nursing 8th Edition of 2008 by Berman, Synder, Kozier and Erb Chapter 7 Community- based nursing and care continuity page 113 )  To prevent damage to liver, one of the complication of DHF. Godex acts by transporting excess, long-chain fatty acids into the mitochondria to produce high amounts of energy to produce high amounts of energy to provide cell protection and fast treatment of liver disease.(http://www.mergersdrugfil.com.ph/index.php /godex-ds )
  • 40. Page | 40  Cefixime 200mg cap BID x 7 days  Omeprazole 20 mg cap OD  Ascorbic acid 500 mg tab OD  Cefixime is a cephalosporin antibiotic used to treat infections such as urinary tract infections, because the patient’s urinalysis revealed presence of few bacteria in urine.(reference: retrieved from https://www.nlm.nih.gov/medlineplus/druginfo/meds/a69 0007.html)  Treatment and prevention of hypersecretions of stomach acid. Omeprazole is used to prevent upper gastrointestinal tract bleeding. (retrieve from :http://www.mayoclinic.org/drugs- supplements/omeprazole-oral-route/description/drg- 2006683)  Supplemental therapy in some GI diseases, during long term parenteral nutrition. Increases protection mechanism of the immune system thus, resistance to infection. (Reference: Davis’s Drug Guide for Nurses fifth edition 2010 (ascorbic acid, page 105)
  • 41. Page | 41 VIX. LABORATORY TEST Urinalysis Date: Jan. 31, 2016 Provides important clinical information about kidney formation and help diagnose other diseases. ( Brunner andSuddarth’s Textbook of Medical Surgical Nursing 13th Edition by Smeltzer, Bare, Hinkle and Cheever chapter 53 Assessment of Kidney and Urinary Function page 1518 ) Test Reference Value Result Implication Physical Properties Light Yellow Normal Transparency Slightly Hazy Normal Chemical Properties pH 5 – 9 7.0 Normal Specific Gravity 1.005 - 1.030 1.015 Normal Sugar Negative Negative Normal Protein Negative (<10mg/d L/100ml) +4 The glomerulus is the network of capillaries in the kidneys that filters low molecular weight solutes such as urea, glucose, and salts, but normally prevents passage of protein or cells from blood into filtrate. Due increased glomerular permeability; this permeability allows increased amounts of plasma proteins (sometimes very large amounts) to pass into the filtrate. Reference: A.Shah. Proteinuria (2013) http://www.merckmanuals.com/professional/genitourinary- disorders/symptoms-of-genitourinary-disorders/proteinuria Leukocytes Negative Negative Normal Nitrite Negative Negative Normal Urobilinogen Normal Normal Normal Blood Negative Negative Normal Ketone Negative Negative Normal Bilirubin Negative Negative Normal Ascorbic Acid Negative Negative Normal Microscopic examination RBC Negative 2– 4/hpf Due to increase in vascular permeability it will leads to leakage of RBC. Reference: National Instituteof Allergy and Infectious Diseases, NIH: Volume 2 Pus Cells (WBC) Negative 2– 4/hpf Occurrence of pus cells in urine may be
  • 42. Page | 42 Interpretation Nursing Responsibility Presence of protein, RBC and WBC in the urine cause by increase in capillary permeability thus permitting plasma protein and blood cells to pass into the urine. 1. Use clean container. 2. Obtain first morning sample 3. Immediately send specimen to the laboratory with proper label. ( Medical Surgical Nursing 8th Edition page 1138 ) ( Medical Surgical Nursing 8th Edition page 1146 ) taken to be an indicator of an infection, either on the upper or the lower urinary tract. ( Retrieved from: http://www.newhealthguide.org/Pus-Cells-in- Urine.html ) Mucus threads Few If they are present in large amounts then this means there is some underlying infection in any part of the urinary tract. If the mucus threads in urine are associated with red blood cells (blood), bacteria or yeast then this indicates to some sort of infection, irritation or other problems. (Retrieved from: http://bestwebhealth.org/Mucus-Threads-In- Urine--What-Does-It-Mean-And-How-To-Treat.html ) Amorphous Phosphates - - Bacteria Negative Few Bacteria in urine can suggest infection due to vascular permeability.
  • 43. Page | 43 Complete Blood Count Date: 01-29-2016 Test Result Normal Range Interpretation Implication WBC 3.83 4.00-10.00 Low WBC is made in the bone marrow and circulates in the bloodstream. Dengue virus induces the suppression of the bone marrow that results of producing not enough WBC to defend against bacterial infections. Reference: http://www.medicinenet.com/script/main/art. asp?articlekey=6017 Neutrophils 2.52 2.00-7.00 Normal Lymphocytes 0.83 0.80-4.00 Normal Monocytes 0.43 0.12-1.20 Normal Eosinophils 0.04 0.02-0.50 Normal Basophils 0.01 0.00-0.10 Normal Neu% 65.7 50.0-70.0 Normal Lym 21.8 20.0-40.0 Normal Mon 11.2 3.0-12.0 Normal Eos 1.1 0.5-5.0 Normal Bas 0.2 0.0-1.0 Normal RBC 4.43 4.00-5.50 Normal HGB 140 120-160 Normal HCT 40.0 40.0-54.0 Normal MCV 90.3 80.0-100.0 Normal MCH 31.6 27.0-34.0 Normal MCHC 350 320-360 Normal RDW-CV 10.4 11.0-16.0 Low A low RDW means that the red blood cells vary very little in size. Red cell distribution width (abbreviated as RDW) and Coefficient Variation (abbreviated as CV) is a measurement of the amount that red blood cells vary in size. Red blood cells help carry oxygen in the blood. Reference: http://www.medfriendly.com/red-cell- distribution-width.html RDW-SD 34.9 35.0-56.0 Low A low RDW means that the
  • 44. Page | 44 red blood cells vary very little in size. Red cell distribution width (abbreviated as RDW) and Standard Variation (abbreviated as SD) is a measurement of the amount that red blood cells vary in size. Red blood cells help carry oxygen in the blood. Reference: http://www.medfriendly.com/red-cell- distribution-width.html PLT 11 170-400 Low Dengue virus induces bone marrow suppression. Since bone marrow is the manufacturing center of blood cells its suppression causes deficiency of blood cells leading to low platelet count. Reference: K. Kafeel (2011). Retrieved from: http://www.onlymyhealth.com/cause-low- platelet-count-in-dengue-fever-1301653922 MPV 6.2 6.5-12.0 Low Mean platelet volume (MPV) reflects the average size of platelets present in a person's sample of blood. MPV is low with low platelet count due to dengue virus affecting production by the bone marrow. Reference: https://labtestsonline.org/understanding/analy tes/platelet/tab/faq/ PDW 18.8 9.0-17.0 High Platelet Distribution Width (PDW) PDW is the variability in the size of platelets. Normally PDW increases with MPV. The patient shows a low MPV but a high PDW. Due to the bone marrow suppression. Reference: https://allaboutblood.com/tag/pdw/ PCT 0.007 0.108- 0.282 Low Low PCT (procalcitonin) values (<0.25 µg/L) in patients with clinical signs of infection (CAP, UTI) indicate a low probability for blood
  • 45. Page | 45 culture proof of bacterial infection. One major advantage of PCT compared to other parameters is its early and highly specific increase in response to bacterial infections and sepsis. Reference: http://www.procalcitonin.com/default.aspx?tr ee=_2_2 P-LCR 7.6 11.0-45.0 Low P-LCR means Platelet large cell ratio. It provides information about the underlying conditions of thrombocytopenia. Reference: http://www.ehj.eg.net/article.asp?issn=1110- 1067;year=2014;volume=39;issue=3;spage= 134;epage=138;aulast=Elsewefy Date: 01-30-2016 Test Result Normal Range Interpretation Implication WBC 4.86 4.00-10.00 Normal Neutrophils 1.65 2.00-7.00 Low Neutrophils are major players in the body's defense against bacterial infections. Neutrophils are made in the bone marrow and circulate in the bloodstream. Dengue virus induces the suppression of the bone marrow that results of producing not enough neutrophils to defend against bacterial infections. Reference: http://www.medicinenet.com/script/main/art.as p?articlekey=6017 Lymphocytes 2.14 0.80-4.00 Normal Monocytes 1.05 0.12-1.20 Normal Eosinophils 0.02 0.02-0.50 Normal Basophils 0.00 0.00-0.10 Normal Neu% 33.9 50.0-70.0 Low Neutrophils are manufactured in bone marrow — the spongy tissue inside some of our larger bones. Anything that disrupts neutrophil production can
  • 46. Page | 46 result in neutropenia. The dengue virus induces bone marrow suppression. Reference: http://www.mayoclinic.org/symptoms/neutrope nia/basics/causes/sym-20050854 Lym 44.0 20.0-40.0 High It is high because of the bacteria presence in the urine of the patient. Lymphocytes provide a means for immunity against antigens. Reference: http://biology.about.com/od/cellbiology/ss/lym phocytes.htm Mon 21.6 3.0-12.0 High Monocytes play important roles in the immune defense, inflammation and tissue remodelling and it do so by phagocytosis, antigen processing and presentation and by cytokine production. It is high because of the bacteria presence in the urine of the patient. Reference: http://www.monocytes.de Eos 0.4 0.5-5.0 Low A low eosinophil level is usually not a cause for concern and is actually quite common. They are very helpful in defending the body against parasites. Eosinophils can be too low due to administration of steroids. Steroids are any of a large number of hormone substances with a similar and basic chemical structure. Hormones are natural chemicals produced by the body and released into the blood that have a specific effect on tissues in the body. The patient is administered by Hydrocortisone. Reference: http://www.medfriendly.com/eosinophil.html Bas 0.1 0.0-1.0 Normal RBC 2.22 4.00-5.50 Low Red blood cells circulate in the blood and carry oxygen
  • 47. Page | 47 throughout the body. They are produced in the bone marrow and then released into the bloodstream as they mature. Dengue virus damage the bone marrow that results to low RBC production. Reference: https://labtestsonline.org/understanding/analyte s/rbc/tab/test/ HGB 69 120-160 Low RBCs contain hemoglobin, which carries oxygen throughout your body. It is low because the patient experienced epistaxis and melena. It is low because the patient experienced epistaxis and melena. Moreover, the dengue virus induces bone marrow suppression HCT 20.0 40.0-54.0 Low The hematocrit is routinely ordered as a part of the complete blood count (CBC). It may also be ordered by itself or with a hemoglobin level as part of a general health examination. It results from decrease production of hemoglobin and damage to bone marrow. Reference: https://labtestsonline.org/understanding/analyte s/hematocrit/tab/test/ MCV 90.0 80.0-100.0 Normal MCH 31.1 27.0-34.0 Normal MCHC 345 320-360 Normal RDW-CV 10.6 11.0-16.0 Low A low RDW means that the red blood cells vary very little in size. Red cell distribution width (abbreviated as RDW) and Coefficient Variation (abbreviated as CV) is a measurement of the amount that red blood cells vary in size. Red blood cells help carry oxygen in the blood. Reference: http://www.medfriendly.com/red- cell-distribution-width.html
  • 48. Page | 48 RDW-SD 34.8 35.0-56.0 Low A low RDW means that the red blood cells vary very little in size. Red cell distribution width (abbreviated as RDW) and Standard Variation (abbreviated as SD) is a measurement of the amount that red blood cells vary in size. Red blood cells help carry oxygen in the blood. Reference: http://www.medfriendly.com/red- cell-distribution-width.html PLT 38 170-400 Low Dengue virus induces bone marrow suppression. Since bone marrow is the manufacturing center of blood cells its suppression causes deficiency of blood cells leading to low platelet count. Reference: K. Kafeel (2011). Retrieved from: http://www.onlymyhealth.com/cause-low- platelet-count-in-dengue-fever-1301653922 MPV 9.2 6.5-12.0 Normal PDW 18.9 9.0-17.0 High Platelet Distribution Width (PDW) PDW is the variability in the size of platelets. Normally PDW increases with MPV. The patient shows a low MPV but a high PDW. Due to the bone marrow suppression. Reference: https://allaboutblood.com/tag/pdw/ PCT 0.035 0.108- 0.282 Low Low PCT (procalcitonin) values (<0.25 µg/L) in patients with clinical signs of infection (CAP, UTI) indicate a low probability for blood culture proof of bacterial infection. One major advantage of PCT compared to other parameters is its early and highly specific increase in response to bacterial infections and sepsis. Reference: http://www.procalcitonin.com/default.aspx?tre e=_2_2 P-LCR 34.2 11.0-45.0 Normal
  • 49. Page | 49 Date: 01-31-2016 Test Result Normal Range Interpretation Implication WBC 5.91 4.00-10.00 Normal Neutrophils 2.92 2.00-7.00 Normal Lymphocytes 2.00 0.80-4.00 Normal Monocytes 0.96 0.12-1.20 Normal Eosinophils 0.02 0.02-0.50 Normal Basophils 0.01 0.00-0.10 Normal Neu% 49.5 50.0-70.0 Low Neutrophils are manufactured in bone marrow — the spongy tissue inside some of our larger bones. Anything that disrupts neutrophil production can result in neutropenia. Reference: http://www.mayoclinic.org/symptoms/neutro penia/basics/causes/sym-20050854 Lym 33.8 20.0-40.0 Normal Mon 16.3 3.0-12.0 High Monocytes perform their functions by surrounding and engulfing bacteria (a process known as phagocytosis). Monocytes can engage in phagocytosis by coating the foreign material with complement or antibodies. High Monocytes happen for several reasons such as stress, inflammation, a fever from a virus, severe infection (because more macrophages are needed to fight it), premature cell death in living tissue, diseases that result from abnormal activity of the immune system, and regeneration of red blood cells. Reference: http://www.medfriendly.com/monocyte.html Eos 0.3 0.5-5.0 Low A low eosinophil level is usually not a cause for concern and is actually quite common. They are very helpful in defending the body
  • 50. Page | 50 against parasites. Eosinophils can be too low due to administration of steroids. Steroids are any of a large number of hormone substances with a similar and basic chemical structure. Hormones are natural chemicals produced by the body and released into the blood that have a specific effect on tissues in the body. The patient is administered by Hydrocortisone. Reference: http://www.medfriendly.com/eosinophil.html Bas 0.1 0.0-1.0 Normal RBC 2.69 4.00-5.50 Low Red blood cells circulate in the blood and carry oxygen throughout the body. They are produced in the bone marrow and then released into the bloodstream as they mature. Dengue virus damage the bone marrow that results to low RBC production. Reference: https://labtestsonline.org/understanding/analy tes/rbc/tab/test/ HGB 86 120-160 Low RBCs contain hemoglobin, which carries oxygen throughout your body. It is low because the patient experienced epistaxis and melena. It is low because the patient experienced epistaxis and melena. Moreover, the dengue virus induces bone marrow suppression. HCT 23.9 40.0-54.0 Low The hematocrit is routinely ordered as a part of the complete blood count (CBC). It may also be ordered by itself or with a hemoglobin level as part of a general health examination. It results from decrease production of
  • 51. Page | 51 hemoglobin and damage to bone marrow. Reference: https://labtestsonline.org/understanding/analy tes/hematocrit/tab/test/ MCV 88.9 80.0-100.0 Normal MCH 32.0 27.0-34.0 Normal MCHC 360 320-360 Normal RDW-CV 10.7 11.0-16.0 Low A low RDW means that the red blood cells vary very little in size. Red cell distribution width (abbreviated as RDW) and Coefficient Variation (abbreviated as CV) is a measurement of the amount that red blood cells vary in size. Red blood cells help carry oxygen in the blood. Reference: http://www.medfriendly.com/red-cell- distribution-width.html RDW-SD 35.0 35.0-56.0 Normal PLT 51 170-400 Low Dengue virus induces bone marrow suppression. Since bone marrow is the manufacturing center of blood cells its suppression causes deficiency of blood cells leading to low platelet count. Reference: K. Kafeel (2011). Retrieved from: http://www.onlymyhealth.com/cause-low- platelet-count-in-dengue-fever-1301653922 MPV 9.1 6.5-12.0 Normal PDW 18.0 9.0-17.0 High Platelet Distribution Width (PDW) PDW is the variability in the size of platelets. Due to the bone marrow suppression. Reference: https://allaboutblood.com/tag/pdw/ PCT 0.046 0.108- 0.282 Low Low PCT (procalcitonin) values (<0.25 µg/L) in patients with clinical signs of infection (CAP, UTI) indicate a low probability for blood culture proof of bacterial infection. One major advantage of PCT compared to other parameters is its early
  • 52. Page | 52 and highly specific increase in response to bacterial infections and sepsis. Reference: http://www.procalcitonin.com/default.aspx?tr ee=_2_2 P-LCR 34.7 11.0-45.0 Normal Date: 01-31-2016 Test Result Normal Range Interpretation Implication WBC 5.79 4.00-10.00 Normal Neutrophils 2.28 2.00-7.00 Normal Lymphocytes 2.29 0.80-4.00 Low It is low because the dengue virus induces the bone marrow suppression. Reference: http://biology.about.com/od/cellbiology/ss/ly mphocytes.htm Monocytes 1.17 0.12-1.20 Normal Eosinophils 0.05 0.02-0.50 Normal Basophils 0.00 0.00-0.10 Normal Neu% 39.4 50.0-70.0 Low Neutrophils are manufactured in bone marrow — the spongy tissue inside some of our larger bones. Anything that disrupts neutrophil production can result in neutropenia. Reference: http://www.mayoclinic.org/symptoms/neutro penia/basics/causes/sym-20050854 Lym 39.6 20.0-40.0 Normal Mon 20.2 3.0-12.0 High Monocytes play important roles in the immune defense, inflammation and tissue remodelling and it do so by phagocytosis, antigen processing and presentation and by cytokine production. It is high because of the bacteria presence in the urine of the patient. Reference: http://www.monocytes.de Eos 0.8 0.5-5.0 Normal Bas 0.0 0.0-1.0 Normal RBC 3.31 4.00-5.50 Low Red blood cells circulate in the blood and carry oxygen
  • 53. Page | 53 throughout the body. They are produced in the bone marrow and then released into the bloodstream as they mature. Dengue virus damage the bone marrow that results to low RBC production. Reference: https://labtestsonline.org/understanding/analy tes/rbc/tab/test/ HGB 102 120-160 Low RBCs contain hemoglobin, which carries oxygen throughout your body. It is low because the patient experienced epistaxis and melena. It is low because the patient experienced epistaxis and melena. Moreover, the dengue virus induces bone marrow suppression HCT 28.7 40.0-54.0 Low The hematocrit is routinely ordered as a part of the complete blood count (CBC). It may also be ordered by itself or with a hemoglobin level as part of a general health examination. It results from decrease production of hemoglobin and damage to bone marrow. Reference: https://labtestsonline.org/understanding/analy tes/hematocrit/tab/test/ MCV 86.8 80.0-100.0 Normal MCH 30.8 27.0-34.0 Normal MCHC 355 320-360 Normal RDW-CV 10.9 11.0-16.0 Low A low RDW means that the red blood cells vary very little in size. Red cell distribution width (abbreviated as RDW) and Coefficient Variation (abbreviated as CV) is a measurement of the amount that red blood cells vary in size. Red blood cells help carry oxygen in the blood. Reference: http://www.medfriendly.com/red- cell-distribution-width.html
  • 54. Page | 54 RDW-SD 35.3 35.0-56.0 Normal PLT 74 170-400 Low Dengue virus induces bone marrow suppression. Since bone marrow is the manufacturing center of blood cells its suppression causes deficiency of blood cells leading to low platelet count. Reference: K. Kafeel (2011). Retrieved from: http://www.onlymyhealth.com/cause-low- platelet-count-in-dengue-fever-1301653922 MPV 9.6 6.5-12.0 Normal PDW 18.7 9.0-17.0 High Platelet Distribution Width (PDW) PDW is the variability in the size of platelets. Normally PDW increases with MPV. Due to the bone marrow suppression. Reference: https://allaboutblood.com/tag/pdw/ PCT 0.071 0.108- 0.282 Low Low PCT (procalcitonin) values (<0.25 µg/L) in patients with clinical signs of infection (CAP, UTI) indicate a low probability for blood culture proof of bacterial infection. One major advantage of PCT compared to other parameters is its early and highly specific increase in response to bacterial infections and sepsis. Reference: http://www.procalcitonin.com/default.aspx?tr ee=_2_2 P-LCR 35.4 11.0-45.0 Normal
  • 55. Page | 55 Hematology Date: 01-28-2016 Test Result Normal Range Interpreta tion Implication Hemoglobin 16.4 13-17 Normal Hematocrit 50.2 40-52% Normal RBC 5.45 4.7- 6.1ml/mm3 Normal WBC 2500 4800- 10000/mm3 Low WBC is made in the bone marrow and circulate in the bloodstream. Dengue virus induces the suppression of the bone marrow that results of producing not enough WBC to defend against bacterial infections. Reference: http://www.medicinenet.com/script/main/art. asp?articlekey=6017 DIFFERENTIAL COUNT Neutrophils 77 40-74% High Neutrophils are major players in the body's defense against bacterial infections. Neutrophils are made in the bone marrow and circulate in the bloodstream. Dengue virus induces the suppression of the bone marrow that results of producing not enough neutrophils to defend against bacterial infections. Reference: http://www.medicinenet.com/script/main/art. asp?articlekey=6017 Lymphocytes 21 20-40% Normal Eosinophils - - - Monocytes 2 3-7% Low Monocytes are a type of white blood cell that fight certain infections and help other white blood cells which is also regulate immunity against foreign substances. Monocytes are produced in the bone marrow and then enter the blood. A low number
  • 56. Page | 56 of monocytes in the blood (monocytopenia) can be caused by anything that decreases the overall white blood cell count (see Neutropenia and see also Lymphocytopenia), such as a bloodstream infection or a bone marrow disorder. Reference: https://www.merckmanuals.com/home/blood- disorders/white-blood-cell- disorders/monocyte-disorders Platelet count 24000 130-500000 Low Dengue virus induces bone marrow suppression. Since bone marrow is the manufacturing center of blood cells its suppression causes deficiency of blood cells leading to low platelet count. Reference: K. Kafeel (2011). Retrieved from: http://www.onlymyhealth.com/cause-low- platelet-count-in-dengue-fever-1301653922 Bleeding time - - - Clotting time - - - MCV 92.2 80-96FL Normal MCH 30.1 27-33PG Normal MCHC 32.7 32-36% Normal Date: 01-29-16 Test Result Normal values Interpretation Implication Hemoglobin - 11.5-14.8 Hematocrit 37.1 38-44% Low The hematocrit is routinely ordered as a part of the complete blood count (CBC). It may also be ordered by itself or with a hemoglobin level as part of a general health examination. It results from decrease production of hemoglobin and damage to bone marrow. Reference: https://labtestsonline.org/understanding/anal ytes/hematocrit/tab/test/ Platelet count 18 250- Low Dengue virus induces bone
  • 57. Page | 57 510x10/L marrow suppression. Since bone marrow is the manufacturing center of blood cells its suppression causes deficiency of blood cells leading to low platelet count. Reference: K. Kafeel (2011). Retrieved from: http://www.onlymyhealth.com/cause-low- platelet-count-in-dengue-fever-1301653922 Date: 01-29-16 Test Result Normal values Interpretation Implication Hemoglobin - 11.5-14.8 - Hematocrit 41.6 38-44% Normal Platelet count 12 250- 510x10/L Low Dengue virus induces bone marrow suppression. Since bone marrow is the manufacturing center of blood cells its suppression causes deficiency of blood cells leading to low platelet count. Reference: K. Kafeel (2011). Retrieved from: http://www.onlymyhealth.com/cause- low-platelet-count-in-dengue-fever- 1301653922 Date: 01-30-16 Test Result Normal values Interpretation Implication Hemoglobin - 11.5-14.8 - Hematocrit 21% 38-44% Low The hematocrit is routinely ordered as a part of the complete blood count (CBC). It may also be ordered by itself or with a hemoglobin level as part of a general health examination. It results from damage to bone marrow.
  • 58. Page | 58 Reference: https://labtestsonline.org/understanding/a nalytes/hematocrit/tab/test/ Platelet count 19 250- 510x10/L Low Dengue virus induces bone marrow suppression. Since bone marrow is the manufacturing center of blood cells its suppression causes deficiency of blood cells leading to low platelet count. Reference: K. Kafeel (2011). Retrieved from: http://www.onlymyhealth.com/cause- low-platelet-count-in-dengue-fever- 1301653922 Date: 01-30-16 Test Result Normal values Interpretation Implication Hemoglobin - 11.5-14.8 Hematocrit 35.7% 38-44% Low Hematocrit is the amount of red blood cells in your blood. It is low because the patient experienced epistaxis and melena. Moreover, the dengue virus induces bone marrow suppression. Platelet count 8 250- 510x10/L Low Dengue virus induces bone marrow suppression. Since bone marrow is the manufacturing center of blood cells its suppression causes deficiency of blood cells leading to low platelet count. Reference: K. Kafeel (2011). Retrieved from: http://www.onlymyhealth.com/cause- low-platelet-count-in-dengue-fever- 1301653922
  • 59. Page | 59 Date: 01-30-16 Test Result Normal values Interpretation Implication Hemoglobin - 11.5-14.8 - Hematocrit 29.7% 38-44% Low The hematocrit is routinely ordered as a part of the complete blood count (CBC). It may also be ordered by itself or with a hemoglobin level as part of a general health examination. It results from damage to bone marrow. Reference: https://labtestsonline.org/understanding/a nalytes/hematocrit/tab/test/ Platelet count 16 250- 510x10/L Low Dengue virus induces bone marrow suppression. Since bone marrow is the manufacturing center of blood cells its suppression causes deficiency of blood cells leading to low platelet count. Reference: K. Kafeel (2011). Retrieved from: http://www.onlymyhealth.com/cause- low-platelet-count-in-dengue-fever- 1301653922 Date: 02-01-2016 Test Result Normal values Interpretation Implication Hemoglobin 98 115-148 Low RBCs contain hemoglobin, which carries oxygen throughout your body. It is low because the patient experienced epistaxis and melena. It is low because the patient experienced epistaxis and melena. Moreover, the dengue virus induce bone marrow suppression. Hematocrit 29% 38-44 Low The hematocrit is routinely ordered as a part of
  • 60. Page | 60 the complete blood count (CBC). It may also be ordered by itself or with a hemoglobin level as part of a general health examination. It results from decrease production of hemoglobin and damage to bone marrow. Reference: https://labtestsonline.org/understanding/an alytes/hematocrit/tab/test/ RBC 3.35 38-54 Low RBCs contain hemoglobin, which carries oxygen throughout your body. It is low because the patient experienced epistaxis and melena. Moreover, the dengue virus induces bone marrow suppression. Platelet 88 250-510 Low Dengue virus induces bone marrow suppression. Since bone marrow is the manufacturing center of blood cells its suppression causes deficiency of blood cells leading to low platelet count. Reference: K. Kafeel (2011). Retrieved from: http://www.onlymyhealth.com/cause-low- platelet-count-in-dengue-fever- 1301653922 WBC 7-9 4-11 Normal Segmented neutrophils 52 45-55 Normal Lymphocytes 40.3 38-45 Normal Monocytes 7-5 3-6 High Monocytes perform their functions by surrounding and engulfing bacteria (a process known as phagocytosis). Monocytes can engage in phagocytosis by coating the foreign material with complement or antibodies. High Monocytes happen for several reasons such as
  • 61. Page | 61 stress, inflammation, a fever from a virus, severe infection (because more macrophages are needed to fight it), premature cell death in living tissue, diseases that result from abnormal activity of the immune system, and regeneration of red blood cells. Reference: http://www.medfriendly.com/monocyte.ht ml Date: 02-02-2016 Test Result Normal Range Interpretation Implication Hemoglobin 96 115-148 Low RBCs contain hemoglobin, which carries oxygen throughout your body. It is low because the patient experienced epistaxis and melena. It is low because the patient experienced epistaxis and melena. Moreover, the dengue virus induces bone marrow suppression. Hematocrit 26.8 38-44 Normal RBC 3.14 3.8-5.4 Normal MCV 85 80-100 Normal MCH 30.5 27-32 Normal MCHC 359 320-360 Normal RDW-CV 13.5 11.0-16.0 Normal RDW-SD - 37-54 Normal Platelet 198 250-510 Normal PCT 0.188 0.15-0.50 Normal MPV 9.5 6-11 Normal PDW 18.6 11-18 Normal WBC 8.0 4-11 Normal Segmented neutrophils 54.1 45-55 Normal lymphocytes 38.3 38-45 Normal monocytes 7.6 3-6
  • 62. Page | 62 Date: 02-03-16 Test Result Normal values Interpretation Implication Hemoglobin 9.9 11.5-14.8 Low RBCs contain hemoglobin, which carries oxygen throughout your body. It is low because the patient experienced epistaxis and melena. It is low because the patient experienced epistaxis and melena. Moreover, the dengue virus induces bone marrow suppression. Hematocrit 28.0 38-44% Low The hematocrit is routinely ordered as a part of the complete blood count (CBC). It may also be ordered by itself or with a hemoglobin level as part of a general health examination. It results from decrease production of hemoglobin and damage to bone marrow. Reference: https://labtestsonline.org/understanding/an alytes/hematocrit/tab/test/. Platelet count 294 250- 510x10/L Normal Date: 02-03-16 Test Result Normal values Interpretation Implication Hemoglobin - 11.5-14.8 Low RBCs contain hemoglobin, which carries oxygen throughout your body. It is low because the patient experienced epistaxis and melena. It is low because the patient experienced epistaxis and melena. Moreover, the dengue virus induces bone marrow suppression.
  • 63. Page | 63 Hematocrit 26.6 38-44% Low The hematocrit is routinely ordered as a part of the complete blood count (CBC). It may also be ordered by itself or with a hemoglobin level as part of a general health examination. It results from decrease production of hemoglobin and damage to bone marrow. Reference: https://labtestsonline.org/understanding/an alytes/hematocrit/tab/test/ Platelet count 351 250- 510x10/L Normal TyphiDOT Date: 01-29-16 Test Result Salmonella IgG Negative Salmonella IgM Negative The patient TyphiDOT test is negative to Salmonella IgG and salmonella IgM. The Typhidot test gave a sensitivity of 100 per cent and specificity of 80 per cent when bacteraemic patients were analysed. The TyphiDot is a DOT enzyme immunoassay that detects either IgM or IgG antibodies against a specific antigen on the outer membrane protein of serotype Typhi. Reference: https://www.researchgate.net/publication/10894775_Typhidot_test_to_detect_IgG_IgM_antibodies_in_t yphoid_fever
  • 64. Page | 64 DENGUE NS1 IgA/IgG/IgM Date: 01-29-2016 Test Result Dengue NS1 Positive Dengue IgA Negative Dengue IgG Positive Dengue IgM Negative The patient’s antibody test revealed positive in Dengue NS1 and Dengue IgG. The non-structural protein 1 (NS1) of the dengue viral genome has been shown to be useful as a tool for the diagnosis of acute dengue infections. Dengue NS1 antigen has been detected in the serum of DENV infected patients as early as 1 day post onset of symptoms (DPO), and up to 18 DPO. Antibody tests, IgM and IgG- detect antibodies produced by the immune system when a person has been exposed to the virus; these tests are most effective when performed at least 7-10 days after exposure. Reference: http://www.cdc.gov/dengue/clinicalLab/laboratory.html https://labtestsonline.org/understanding/analytes/dengue/tab/sample/ BLOOD TYPE TEST Date: January 29, 2016 ABO Rhesus D O (+)
  • 65. Page | 65 X. PROBLEM PRIORITIZATION 1. Ineffective Tissue Perfusion 2. Hyperthermia 3. Imbalance Nutrition 4. Impaired Tissue Integrity 5. Risk for Injury
  • 66. Page | 66 XI. NURSING CARE PLAN
  • 67. Page | 67 Assessment Nursing Diagnosis Planning Intervention Rationale Expected Outcome O:  Hemoglobin results revealed 69 mg/dl as of 01-30-16  BP: 100/60 mmHg  RR: 20 cpm  PR: 98 bpm  Headache  Generalized pallor  Capillary refill of more than 3 sec  With pale nail beds Ineffective tissue perfusion related to decreased hemoglobin concentration in the blood. After 8 hours of nursing intervention, the client will be able to:  Demonstrate different ways to improve blood oxygenation and circulation.  Verbalize understanding of condition and importance of treatment regimen.  Demonstrate increased tissue perfusion.  Monitor vital signs.  Elevate head of bed to about 10 degrees.  Discourage strenuous activities.  Provide health teaching regarding DHF.  Provide health teaching on drugs being taken. Collaborative:  Administer Tranexamic Acid 50mg IV q8 as ordered.  Serve as basis for any alteration in system functions.  To promote circulation and venous drainage.  To avoid increasing oxygen demand.  To help client understand his health condition.  To maintain compliance to meds.  To control bleeding. After 8 hours of nursing intervention, the client was be able to:  Demonstrate different ways to improve blood oxygenation and circulation.  Verbalize understanding of condition and importance of treatment regimen.  Demonstrate increased tissue perfusion.
  • 68. Page | 68  With pale conjunctiva and palate  Muscle strength : 4/5  Administer and regulate IVF as ordered.  Administer packed RBC’s as ordered.  Monitor lab studies ( Hb, Hct, RBC count).  Maintain hydration and help wash away toxins.  Packed RBC’s are adequate for stable patients with subacute/chronic bleeding to increase oxygen carrying capability  Aids in establishing blood replacement needs & monitoring for effectiveness of therapy.
  • 69. Page | 69 Assessment Nursing Diagnosis Planning Intervention Rationale Expected Outcome O:  Temp: 38.2 °c  Warm to touch  Chills  Weak in appearance  Easy fatigability  Dry lips  Pale Hyperthermia related to presence of Arbovirus in patient’s body causing release of pyrogens. After 2 hours of nursing interventions, the patient will be able to: Manifest reduction of core temperature from 38.2 to a normal range of 36.5 C- 37.5 C  Monitor patient’s vital signs.  Note chronological an d developmental age of client  Note presence/ absence of sweating.  Initiate tepid sponge bath.  Promotes surface cooling through undressing or removing extra linens.  Encourage adequate fluid intake.  Serves as base line data for future comparison.  Assess for causative/ contributing factor.  To assess degree of hyperthermia.  Facilitates heat through conduction and evaporation.  Facilitates heat loss by radiation.  To promote heat loss and hydration. After 2 hours of nursing interventions, the patient will be able to: Manifest reduction of core temperature from 38.2 to a normal range of 36.5 C- 37.5 C
  • 70. Page | 70  Encourage adequate bedrest.  Instruct patient and SO to report signs and symptoms of hyperthermia like flushed skin, increasing respiratory rate and body temperature. Collaborative:  Administer Paracetamol 1 amp IV, as ordered.  To reduce metabolic consumption and oxygen demands.  To promote wellness.  To relieve high temperature by inhibiting the synthesis of prostaglandin
  • 71. Page | 71 Assessment Nursing Diagnosis Planning Intervention Rationale Expected Outcome S: “Wala akong ganang kumain“ as verbalized by the patient. O:  Lethargic  Easy fatigability  Weak in appearance  Had 2 crackers in shift  Pale  24 hours dietary recall Imbalanced nutrition less than body requirements related to loss of appetite. ST: within 4 hours of giving nursing intervention patient will be able to experience an increase in the amount or type of nutrients ingested. LT: within 8 hours of giving nursing intervention and medical management patient will be able to experience adequate nutrition through oral intake.  Assess and document patient’s dietary history, patters of ingestion, intolerance to foods.  Auscultate bowel sounds.  Instruct pt. on good oral hygiene before and after feedings.  Emphasize the importance of adequate  To determine daily nutrition needs.  Hypermotility of intestinal tract is common and is associated with vomiting and diarrhea, which may affect choice of diet/route.  To promote god appetite.  Promotes comfort to the patient and encourages a good After giving effective nursing interventions patient will be able to partially demonstrate behavior, lifestyle changes to regain appropriate weight.
  • 72. Page | 72 nutrition.  Promote pleasant relieving environment including socialization. Collaborative:  Monitor BUN, protein, prealbumin, or albumin, glucose, nitrogen balance as indicated.  Advance diet as tolerated, avoid dark colored foods. eating habit.  For education of the patient for appropriate recovery from nutritional imbalance.  Reflects organ function and nutritional status and needs.  Careful progression of diet when intake is resumed reduces risk of gastric irritation and to provide accurate assessment in stool.
  • 73. Page | 73 Assessment Nursing Diagnosis Planning Intervention Rationale Expected Outcome O:  Temp: 38.2 °c  Hematoma on the upper right arm  Capillary refill of more than 3 sec  Weak in appearance  Dry lips  Headache- Pain scale 5/10  Pale  Muscle strength : 4/5 Impaired tissue integrity related to mechanical and chemical factor of skin test and blood test; secondary to haematoma as evidence by collection of blood on the upper right arm. After 4 hours of nursing interventions patient will demonstrate behavior to reduce the hematoma. After 2 weeks of nursing interventions presence of hematoma will be reduce.  Provide comfortable environment.  Provide comfort measures by AM care, changing the linen and touch therapy.  Provide safety by placing pillows at the side of the bed.  Vital signs monitor and record.  To ease patient’s anxiety and to help the patient recover faster for proper hygiene of the patient.  For proper hygiene of the patient.  To avoid patient from injury.  To have baseline data. After 4 hours of nursing interventions the patient shall have demonstrate behavior to reduce the hematoma. After 2 weeks of nursing interventions the patient shall have no presence of hematoma.
  • 74. Page | 74  Identify underlying condition involves in tissue injury.  Monitor laboratory studies.  Help patient and family to identify effective successful coping mechanism and to implement them.  Suggest treatment options, desire/ ability to protect self and potential self and potential to recurrence of tissue damage.  To changes indicative of healing or infection complications.  To reduce discomfort and improve quality of life.
  • 75. Page | 75 Assessment Nursing Diagnosis Planning Intervention Rationale Expected Outcome O:  Weak in appearance  Capillary refill of more than 3 sec.  Easy fatigability  Hematoma at the right upper arm  Delirium  Platelet count results revealed 8 x109 /L as of 01- 30-16 Risk for injury related to abnormal blood profile as evidenced by decreased platelet count. After 4 hours of nursing management, the patient will demonstrate behaviors to reduce risk factors and protect self from injury.  Establish rapport.  Monitor and record vital signs.  Assess mood, coping abilities, and personality styles (aggression and impulse behavior).  Observe for presence of petechiae, ecchymosis, bleeding from one more sites.  Maintain bed in a lowest position with wheels locked.  Advise SO that those self inflicting materials such as  To gain patient’s trust and cooperation.  For baseline data.  Aggressive and impulsive behavior indicates self harm to the patient.  Observing those signs will help to reduce the risk for injury to the other parts of the body.  Ensuring the patient’s safety.  To prevent further injury to the patient. After 4 hours of nursing management the patient will demonstrate behaviors to reduce risk factors and protect self from injury.
  • 76. Page | 76 (utensils, knife and syringes) should be keep.  Encourage the SO not to leave the patient unattended  Leaving the patient unattended may increase anxiety to the patient.
  • 77. Page | 77 XII. DRUGS
  • 78. Page | 78 Reference : Jones and Bartlett Nurse’s Drug Handbook 2015 ( diphenhydramine page 325) Name of Drug Dosage and Frequency Indications and Contraindications Side Effects Mode of Action Classification Nursing Responsibilities Generic Name: Diphenhydramine Brand Name: Benadryl Date ordered: 01-30-2016 50 mg PO TID Peak: 15-60 min Onset: 1-4 hr Duration: 4-8 hr Indication: To prevent allergic reaction after blood transfusion. Transfusion reaction symptoms include:  back pain  blood in your urine  chills  fainting or dizziness  fever  flank pain  skin flushing Contraindications: Hypersensitivity to 𝐻1 – receptor antagonist, acute asthma attack, lower respiratory tract disease, neonates.  Dizziness  Drowsiness  fatigue anxiety  Nausea Acts on blood vessels, GI, respiratory system by competing with histamine for 𝐻1 –receptor site; decreases allergic response by blocking histamine. Antihistamine  Medication may cause drowsiness.  Advised the patient to avoid activities requiring alertness until response of drug is unknown.  Inform the patient that this drug may cause dry mouth.  Frequent oral rinses, good oral hygiene, and candy that may minimize this effect.  Teach patient and significant other that this drug may cause drowsiness.
  • 79. Page | 79 Name of Drug Dosage and Frequency Indications and Contraindication s Side Effects Mode of Action Classification Nursing Responsibilities Generic Name: Cefixime Brand Name: Suprax Date ordered: 02- 02- 2016 200 mg PO BID Peak: rapid Onset: 2-6 hr Duration: 24 hr Indication: Treatment for infection. The patient’s urinalysis revealed a presence of few bacteria in urine as of Jan. 31, 2016. Contraindication s: Hypersensitivity to cephalosporin or their Components.  Chills  fever  headache  seizures  Abdominal cramps  diarrhea  elevated  liver function test results  hepatic failure  hepatitis  hepatomegaly  jaundice  nausea Interferes with bacterial cell wall synthesis by inhibiting the final step in the crosslinking of peptidoglycan strands. Peptidoglycan makes cell membranes rigid and protective. Without it, bacterial cells rupture and die. Antibiotic  Be aware that an allergic reaction may occur a few days after therapy starts.  Assess bowel pattern daily.  Assess for signs of superinfection, such as perineal itching, fever, malaise, redness, pain, swelling, drainage, rash, diarrhea, and cough or sputum changes.  Instruct patient and significant other to complete the prescribed course of therapy.  Tell patient and S.O. to report severe diarrhea to prescriber immediately. Reference : Jones and Bartlett Nurse’s Drug Handbook 2015 (cefixime page 205)
  • 80. Page | 80 Reference : Jones and Bartlett Nurse’s Drug Handbook 2015 (ceftriaxone page 223) Name of Drug Dosage and Frequency Indications and Contraindications Side Effects Mode of Action Classificatio n Nursing Responsibilities Generic Name: Ceftriaxone Brand Name: Rocephin Date ordered: 02-02-16 1 g IV every 12 hours Peak: rapid Onset: end of infusion Duration: 12-24 hr Indication: To treat infection. The patient’s urinalysis revealed a presence of few bacteria in urine as of Jan. 31, 2016. Contraindications: Hypersensitivity to ceftriaxone, other cephalosporins, or their components  Abdominal cramps  elevated liver function test results  Edema  Arthralgia  Allergic pneumonitis ,  dyspnea Interferes with bacterial cell wall synthesis by inhibiting cross-linking of peptidoglycan strands. Peptidoglycan makes the cell membrane rigid and protective. Without it, bacterial cells rupture and die. Antibiotic  Assess bowel pattern daily.  Assess for pharyngitis, ecchymosis, bleeding, and arthralgia; they may indicate a blood dyscrasia.  Advise patient and S.O. to report any hypersensitivity reactions, such as a rash, itching skin, or hives, to prescriber immediately and to stop taking the drug.
  • 81. Page | 81 Name of Drug Dosage and Frequency Indications and Contraindications Side effects Mode of Action Classification Nursing Responsibilities Generic Name: Vitamin K Brand name: Phytonadione Date ordered: 01-30-16 1 amp 10mg/ml IV every 8 hours Peak: 1-2 hr Onset: unknown Duration: unknown Indication: To treat bleeding. The patient manifested epistaxis and black tarry stool at 2:00 pm as of Jan. 30, 2016. Contraindications: Hypersensitivity to benzyl alcohol (Aquamephyton only)  Gastric upset  Unusual taste  Rash  Urticaria  Flushing  Erythema  Allergic reactions Required for hepatic synthesis of blood coagulation factors II (prothrombin), VII, IX, and X. An antihemorrhagic actor that promotes hepatic formation of active prothrombin. Fat soluble vitamins  Monitor the patient for gastric upset.  Monitor patient for the possible side effects that may occur.  To report any signs and symptoms of allergic reactions. Reference: Davis’s Drug Guide for Nurses fifth edition 2010 (vitamin K, page 970)
  • 82. Page | 82 Name of Drug Dosage and Frequency Indications and Contraindicatio ns Side effects Mode of Action Classification Nursing Responsibilities Generic Name: Omeprazole Brand Name: Losec Ordered at: 01-29-16 6:30 am 01-30-16 10:00 am 02-01-16 6:00 am 40 mg IV OD Peak: unknown Onset: 10-90 min Duration: unknown Indication: Treatment and prevention of hypersecretions of stomach acid. Due to patient’s lost appetite with DHF it will cause abdominal pain. Contraindicatio ns: Hypersensitivity  Weakness  Dizziness  Headache  Fatigue  Abdominal pain  Acid regurgitatio n  Constipatio n  Diarrhea  Flatulence  Nausea  Vomiting  Rash  Itching Suppresses gastric secretion by inhibiting hydrogen; characterized as gastric pump inhibitor Anti-ulcer, proton pump inhibitor  Inform the patient and significant other about the reason why drug is given and how it is process inside the patient's body.  Monitor for diarrhea and abdominal pain.  Take the drug before meals.  Report severe headache, worsening of symptoms, fever, chills. Swallow the capsules whole; do not chew, open, or crush them.  Inform patient and S.O. that he/she may experience these side effects: Dizziness; headache; nausea, vomiting, diarrhea; symptoms of URI, cough. Reference: Davis’s Drug Guide for Nurses fifth edition 2010 (omeprazole, page 878)