1. Development of
GENITAL SYSTEM
Dr mohan angadi

2. Development of
•
Gonads (testis / ovary)
•
Genital ducts and glands
•
Uterus and vagina
•
External genitalia(male & female)

3. Introduction

2 embryonic structures that play an imp
role in dev of UG system
1. Intermediate mesoderm &
2. Primitive Urogenital Sinus(UGS)-a part of
cloaca.

4. Intermediate mesoderm
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6. Cloaca

7. Development of gonads(testis/ovary)

9. Development of genital ducts

10. •
In males- mesonephric duct

11. Paramesonephric(mullarian)
derivatives in males

12. Prostate
Inner glandular zone-meso
Outer glandular zone-endo
Female homologues of
prostate
-Urethral glands &
-Paraurethral glands of
Skene

13. •
In females

14. mesonephric(wolffian)derivative
s in females

15. Paramesonephric(mullarian)
derivatives in females

16. Development of uterus &
vagina

17. Female homologues of
prostate
-urethral glands &
-
peneffdjhfgdhgffaraurethral
glands of Sk

18. Dev. of vagina

19. Development of ext genitalia

21. Male urethra

22. Development of inguinal
canal/Descent of testis

23. Factors responsible for descent
•
Initiated by-androgens
•
Prompted by-differential growth
•
Permitted by-lengthening of ductus
•
Fascilitated by-gubernaculum

24. Control of differentiation of
genital organs
1. Cromosomal sex of individual-at fertilization
2. SRY gene on short arm- production of TDF
3. Testosterone –interstitial Leydig cells
4. MIS – Sertoli cells

25. Applied aspects

26. Anomalies of testis
-undescended testis/ ectopic testis
- crptorchidism

27. Anomalies of processus vaginalis
•
Congenital hernia/hydrocoele
•
Vaginal hydrocoele
•
Infantile hydrocoele
•
Hydrocoele of cord
•
Interstitial hernia

28. Hermaphroditism
•
True
•
Pseudo
–
Female
–
Male
•
Androgen insensitivity syndrome/testicular
feminization syndrome

29. Anomalies of Uterine
tube,uterus and vagina

30. Anomalies of female ext genitalia
•
Clitoris - absent/bifid or double or
enlarged(heramaphroditism)
•
Fusion of labia minora
•
Ectopic urethra in ant wall of vagina
•
Anomalies of hymen

31. •
Vaginal fistulas
–
Rectovaginal fistula
–
Vesico vaginal fistula
–
Urethrovaginal fistula
•
Vagina duplicated/ absent/ septum

32. Anomalies of male ext genitalia
•
Phimosis
•
Hypospadias
•
Epispadias

33. Epispadias
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35. Thank you