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Addis Ababa University Collage of Health Science Department of Physiology By : Robel Abay September  19 09/30/11 Regulation of cardiac out put
Objectives ,[object Object],[object Object],[object Object],09/30/11
Cardiac output ,[object Object],[object Object],[object Object],09/30/11
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],09/30/11
Normal values cont
 ,[object Object],[object Object],09/30/11
Regulation of cardiac out put ,[object Object],[object Object],09/30/11
Regulation cont
. ,[object Object],[object Object],[object Object],09/30/11
Venous Return ,[object Object],[object Object],09/30/11
Factors aiding venous return ,[object Object],[object Object],[object Object],[object Object],09/30/11
Body position 09/30/11
Factors resisting venous return ,[object Object],[object Object]
[object Object],[object Object],09/30/11
09/30/11
09/30/11
Regulation cont
. ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],09/30/11
Determinants of cardiac output ,[object Object],[object Object],[object Object],[object Object],09/30/11
09/30/11
Cardiac output is controlled by venous return ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],09/30/11
Increase in preload 09/30/11
Increased after load 09/30/11
Factors effecting cardiac performance 09/30/11 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Factors affecting preload   ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],09/30/11
Factors Affecting End-diastolic Volume Ventricular EVD Ventricular performance Total blood volume   Body position  Intrathoracic pressure Atrial contrib. to vent. filling   Pumping action   to skeletal muscle   Venous tone Intrapericardial pressure ventricular compliance  STRETCHING OF MYOCARDIUM   09/30/11
Preload vs Afterload Venules / veins Arterioles Capacitance vessels Resistance vessels Affect preload Affect afterload 09/30/11
09/30/11
09/30/11
Regulation of heart rate ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],09/30/11 +25 0 -25 -50 -75 mV
Regulation of heart rate ,[object Object],[object Object],[object Object],[object Object],[object Object],09/30/11 +25 0 -25 -50 -75 mV
09/30/11
09/30/11
Effect of Bainbridge and Baroreceptor Reflex on HR Intravenous infusion  Increased right atrial pressure   Stimulate atrial receptors Bainbridge reflex  Increased cardiac output  Increased arterial pressure   Baroreceptor reflex  Heart rate  09/30/11
C. Humoral regulation HR/CO INSULIN THYROID GLUCAGON CATECHOLAMINES STEROIDS POTENTIATION
CARDIAC OUTPUT HEART RATE MYOCARDIAL CONTRACTILITY PRELOAD AFTERLOAD CARDIAC FACTORS  COUPLING FACTORS 09/30/11
09/30/11
Reference ,[object Object],[object Object],[object Object],09/30/11
Thank you

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regulation of cardiac out put

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  10. Humoral regulation refers to the effect of hormones in the heart and how hormones that are released into the bloodstream under certain physiological states may regulate cardiac function. Catecholamines released from the adrenal medulla increase the dP/dt of the heart. This effect is potentiated by steroid hormones. Calorigenic hormones like insulin, glucagon and thyroxine also increase cardiac contractility. Thyroxine produces a permissive effect on the action of catecholamines. In hypothyroidism the effect of catecholamines in the heart is depressed by the absence of thyroxine.
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