tuberculosis lecture | pulmonary Tuberculosis
my self ritesh padghan
tuberculosis is infectious disease caused by mycobacterium tuberculosis in active and latent type of tuberculosis .
BRIEF DISCUSSION INCLUDE
:-LEARNING ABOUT
Introduction
Definition
Causative organism
Risk factor
Transmission
Clinical manifestation
Diagnostic evaluation
Medical management
In this lecture the pathophysiology and phathogenesis of tuberculosis has been discussed
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2. INTRODUCTION
Tuberculosis is the respiratory system disorder .The duration of
tuberculosis is very long hence is called as a chronic respiratory
tract disease . tuberculosis is the major problem in developing
countries .
Tuberculosis affects lungs mainly 80% but it can affect other parts
of the body .
4. DEFINITION
“ It is a chronic inflammatory
disease of the lungs and
parenchyma mostly cause due to
the mycobacterium tubercuilosis . “
5. INCIDENCE
Incidence of Tuberculosis among 5 to 11 type more then in
white people .
It has been estimated that about 2 million people are affected
by tuberculosis infection with mycobacterium tuberculosis and
it is second most common cause of death in world rank .
An in every year 2 million people get affected with
mycobacterium tuberculosis .
6. RISK FACTOR
Closed contact with someone having active tuberculosis infection .
HIV infection
Cancer and organ transplant surgery
Diabetic mellitus
Chronic renal Failure
Living in more crowded area
Health care worker
8. PATHOPHYSIOLOGY
DUE TO
ETIOLOGICAL
FACTOR
INDIVIDUAL INHALE
SUFFICIENT NUMBER
OF TUBERCULLI BACILLI
BACILLI
IMPLANT
THEMSELVES
ON
THE
RESPIRATOR
Y
BRONCHIOLE
PASSES LOWER
TO BRONCHIAL
SYSTEM
BASCILLI
MULTIPLY
CELLULAR
REACTION
PRODUCESS
WHITE
NODULE
CALLED
PRIMARY
TUBERCULLI
NECROSIS OF
PARENCHYMAL
CELL
ANTIGEN
ANTIBODY
RECTION
TUBERCULOSIS
9. CLINICAL MANIFESTATION
o LOW GRADE FEVER.
o NIGHT SWEAT
o WEIGHT LOSS
o SEVIORITY OF COUGHING
o ANOREXIA
o CHEST PAIN DUE TO MALASE
o LARGE PRODUCTION OF COUGH
o CHEAST TIGHTNESS
10. DIGANOSTIC EVALUATION
HISTORY COLLECTION
PHYSICAL EXAMINATION
TYBERCULLIN SCREEN TEST
CHEST X –RAY
P.F.T.
MICROSCOPIC EXAMINATION OF SPUTUM
ELISA TEST
MONTOX TEST
11. MEDICAL MANAGEMENT
A ) FRIST LINE DRUG
ISONIAZID ( INH ) 5 mg / kg /day
RIFAMPICIN 10 mg/ kg /day
STREPTOMYCIN 50 mg /kg /day
PYRAZINAMIDE 20 mg /kg /day
ETHAMBUTOL
12. B) SECOND LINE DRUG
ETHAINAMIDE
THIACETAZONE
PARA - AMINO SALICYLIC ACID
AMIKACIN
STREPTOMYCIN
CAPREOMYCIN