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TUBERCULOSIS
INTRODUCTION
Tuberculosis is the respiratory system disorder .The duration of
tuberculosis is very long hence is called as a chronic respiratory
tract disease . tuberculosis is the major problem in developing
countries .
Tuberculosis affects lungs mainly 80% but it can affect other parts
of the body .
CASUTIVE ORGANISIM
 MYCOBACTERIUM TUBERCULOSIS
DEFINITION
“ It is a chronic inflammatory
disease of the lungs and
parenchyma mostly cause due to
the mycobacterium tubercuilosis . “
INCIDENCE
Incidence of Tuberculosis among 5 to 11 type more then in
white people .
It has been estimated that about 2 million people are affected
by tuberculosis infection with mycobacterium tuberculosis and
it is second most common cause of death in world rank .
An in every year 2 million people get affected with
mycobacterium tuberculosis .
RISK FACTOR
 Closed contact with someone having active tuberculosis infection .
 HIV infection
 Cancer and organ transplant surgery
 Diabetic mellitus
 Chronic renal Failure
 Living in more crowded area
 Health care worker
TRANSMISSION
Tuberculosis spread from person to person by air born
transmission.
By sneezing and speaking that is droplets.
PATHOPHYSIOLOGY
DUE TO
ETIOLOGICAL
FACTOR
INDIVIDUAL INHALE
SUFFICIENT NUMBER
OF TUBERCULLI BACILLI
BACILLI
IMPLANT
THEMSELVES
ON
THE
RESPIRATOR
Y
BRONCHIOLE
PASSES LOWER
TO BRONCHIAL
SYSTEM
BASCILLI
MULTIPLY
CELLULAR
REACTION
PRODUCESS
WHITE
NODULE
CALLED
PRIMARY
TUBERCULLI
NECROSIS OF
PARENCHYMAL
CELL
ANTIGEN
ANTIBODY
RECTION
TUBERCULOSIS
CLINICAL MANIFESTATION
o LOW GRADE FEVER.
o NIGHT SWEAT
o WEIGHT LOSS
o SEVIORITY OF COUGHING
o ANOREXIA
o CHEST PAIN DUE TO MALASE
o LARGE PRODUCTION OF COUGH
o CHEAST TIGHTNESS
DIGANOSTIC EVALUATION
 HISTORY COLLECTION
 PHYSICAL EXAMINATION
 TYBERCULLIN SCREEN TEST
 CHEST X –RAY
 P.F.T.
 MICROSCOPIC EXAMINATION OF SPUTUM
 ELISA TEST
 MONTOX TEST
MEDICAL MANAGEMENT
A ) FRIST LINE DRUG
 ISONIAZID ( INH ) 5 mg / kg /day
 RIFAMPICIN 10 mg/ kg /day
 STREPTOMYCIN 50 mg /kg /day
 PYRAZINAMIDE 20 mg /kg /day
 ETHAMBUTOL
B) SECOND LINE DRUG
 ETHAINAMIDE
 THIACETAZONE
 PARA - AMINO SALICYLIC ACID
 AMIKACIN
 STREPTOMYCIN
 CAPREOMYCIN
DRUG
PROPER
REST
THE BASIC MANAGEMENT OF TUBERCULOSIS
DIET
THANK YOU

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Tuberculosis

  • 2. INTRODUCTION Tuberculosis is the respiratory system disorder .The duration of tuberculosis is very long hence is called as a chronic respiratory tract disease . tuberculosis is the major problem in developing countries . Tuberculosis affects lungs mainly 80% but it can affect other parts of the body .
  • 4. DEFINITION “ It is a chronic inflammatory disease of the lungs and parenchyma mostly cause due to the mycobacterium tubercuilosis . “
  • 5. INCIDENCE Incidence of Tuberculosis among 5 to 11 type more then in white people . It has been estimated that about 2 million people are affected by tuberculosis infection with mycobacterium tuberculosis and it is second most common cause of death in world rank . An in every year 2 million people get affected with mycobacterium tuberculosis .
  • 6. RISK FACTOR  Closed contact with someone having active tuberculosis infection .  HIV infection  Cancer and organ transplant surgery  Diabetic mellitus  Chronic renal Failure  Living in more crowded area  Health care worker
  • 7. TRANSMISSION Tuberculosis spread from person to person by air born transmission. By sneezing and speaking that is droplets.
  • 8. PATHOPHYSIOLOGY DUE TO ETIOLOGICAL FACTOR INDIVIDUAL INHALE SUFFICIENT NUMBER OF TUBERCULLI BACILLI BACILLI IMPLANT THEMSELVES ON THE RESPIRATOR Y BRONCHIOLE PASSES LOWER TO BRONCHIAL SYSTEM BASCILLI MULTIPLY CELLULAR REACTION PRODUCESS WHITE NODULE CALLED PRIMARY TUBERCULLI NECROSIS OF PARENCHYMAL CELL ANTIGEN ANTIBODY RECTION TUBERCULOSIS
  • 9. CLINICAL MANIFESTATION o LOW GRADE FEVER. o NIGHT SWEAT o WEIGHT LOSS o SEVIORITY OF COUGHING o ANOREXIA o CHEST PAIN DUE TO MALASE o LARGE PRODUCTION OF COUGH o CHEAST TIGHTNESS
  • 10. DIGANOSTIC EVALUATION  HISTORY COLLECTION  PHYSICAL EXAMINATION  TYBERCULLIN SCREEN TEST  CHEST X –RAY  P.F.T.  MICROSCOPIC EXAMINATION OF SPUTUM  ELISA TEST  MONTOX TEST
  • 11. MEDICAL MANAGEMENT A ) FRIST LINE DRUG  ISONIAZID ( INH ) 5 mg / kg /day  RIFAMPICIN 10 mg/ kg /day  STREPTOMYCIN 50 mg /kg /day  PYRAZINAMIDE 20 mg /kg /day  ETHAMBUTOL
  • 12. B) SECOND LINE DRUG  ETHAINAMIDE  THIACETAZONE  PARA - AMINO SALICYLIC ACID  AMIKACIN  STREPTOMYCIN  CAPREOMYCIN