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                                                       Brazilian Science:




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                                                       Riding a Gusher
                                                       A fast-growing economy and oil discoveries are propelling Brazil’s
                                                       research to new heights. But scientific leaders must overcome a
                                                       weak education system and a low-impact track record


   NATAL—Miguel Nicolelis stands with his              Brazil’s poorest regions. Nicolelis, who now place is going to create the next generation
   arms spread, pointing out a rectangular pit         spends part of the year in Brazil, is eager to of Brazilian leaders.”
   carved into dry earth on the outskirts of the       offer a visitor “categorical proof ” of success.        Some continue to think Nicolelis’s idea
   Brazilian beach city of Natal. “That is where       He’s built two hands-on science schools for is eccentric. But his timing couldn’t have
   the supercomputer will go,” he says. And,           children and a maternity clinic,                                  been better. Over the past 8 years,
   pointing to an area still thick with shrubbery,
   “that is the sports complex.”
                                                       and recruited 11 Ph.D. neuro-
                                                       scientists who run labs in a tem-
                                                                                               Online
                                                                                                sciencemag.org
                                                                                                                         Latin America’s largest nation
                                                                                                                         has begun to boom. Its economy
       Nicolelis is Brazil’s best-known scientist. A   porary headquarters. Within a few             Podcast interview
                                                                                                                         is growing fast, and it has become
   neurobiologist at Duke University in Durham,        months, he says, $25 million in               with author         a player in world affairs, reveling
   North Carolina, he is renowned for spectacu-        Brazilian federal money should           Antonio Regalado.        in an unprecedented bout of self-
   lar experiments that use signals tapped from        begin pouring into his sandy acre-                                confidence. It will host the World
   the brains of monkeys to make robots walk.          age, creating the sprawling neuroscience com- Cup in 2014 and the Olympics 2 years later.
   But when Nicolelis launched plans in 2003 for       plex Nicolelis calls his “Campus of the Brain.”         The good times are lifting science, too.
   a neuroscience institute in Brazil’s backward          “In Brazil we need science to build a Between 1997 and 2007 the number of Bra-
   northeast districts, few thought it could work      country,” says Nicolelis, an energetic nation- zilian papers in indexed, peer-reviewed jour-
   (Science, 20 February 2004, p. 1131).               alist whose passions include wearing a nals more than doubled to 19,000 a year. Bra-


                                                                                                                                                                CREDITS (TOP TO BOTTOM): DANNY LEHMAN/CORBIS; A. REGALADO/SCIENCE
       The notion was to pair cutting-edge sci-        green Palmeiras soccer club hat and down- zil now ranks 13th in publications, accord-
   ence with a social mission: developing one of       ing pitchers of yellow maracujá juice. “This ing to Thomson Reuters, having surpassed
                                                                                                           the Netherlands, Israel, and Switzerland.
                                                                                                           Brazil’s universities awarded twice as many
                                                                                                           Ph.D.s this year as they did in 2001, and thou-
                                                                                                           sands of new academic jobs have opened up
                                                                                                           on 134 new federal campuses.
                                                                                                               It’s a reversal of fortune for a nation that
                                                                                                           during the 1990s was beset by dire economic
                                                                                                           problems. Back then, researchers scrounged
                                                                                                           for funds; Brazil even saw its flag removed
                                                                                                           from the logo of the International Space Sta-
                                                                                                           tion after it failed to come up with funding

                                                                                                           Proud moment. Neuroscientist Miguel Nicolelis
                                                                                                           at the foundations of his “Campus of the Brain” in
                                                                                                           northeastern Brazil.


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                                                                       Published by AAAS
SCIENCE IN BRAZIL NEWSFOCUS

                                          Science hub. Brazil’s richest city, São Paulo, and
                                          eponymous state are home to most of the nation’s
                                          research.
                                                                                                                                                                       Manaus
                                          to build six components. “We kept thinking                                                                                    Amazon
                                          smaller and smaller,” says Sérgio Rezende,                                                                                                                                                                                Natal
                                          science minister for the past 5 years. “If we
                                          couldn’t solve small problems, how could we
                                          solve big ones? Now we are in a position to
                                          think big again.”
                                              The fuel that propels science in Brazil is an
                                          R&D tax on big industries; it has swelled the
                                          budget of Rezende’s ministry to $4 billion, up                                                                                                                                                    Brasília
                                          from $600 million a decade ago. The national
                                          oil company, Petrobras, is the largest contrib-
                                          utor (see sidebar, p. 1308). Brazil restarted
                                          its nuclear research program in 2008, after a




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                                          20-year lull, and in October, a delegation trav-                                                                BRAZIL
                                                                                                                                                                                                                           São Paulo
                                          eled to Geneva to negotiate associate mem-                                                                                                                                                                 Rio de Janeiro
                                          bership in CERN. With Brazil’s economy
                                          growing at a pace of 7% this year, the country
                                          can afford the dues of $14 million per year.
                                              Scientists here say their arguments in favor
                                          of more education, innovation, and technol-                                          Highlights
                                          ogy have been heard in Brasília, the capi-
                                          tal, and they expect budgets to keep grow-                                  Amazon: Half as large as Europe, the Brazilian Amazon is home to fewer than 3000
                                          ing under Brazil’s president-elect, Dilma                                   Ph.D. scientists. Government incentives seek to increase Brazil’s scientific presence in
                                          Rousseff, the first woman to hold that post.                                 the forest region.
                                          By 2020, say officials of the Brazilian Soci-
                                          ety for the Advancement of Science, Brazil
                                                                                                                      Brasília: Brazil’s rapid economic growth means rising budgets at the Ministry of
                                          should again redouble or triple output of stu-                              Science and Technology. It now spends about $4 billion a year.
                                          dents, papers, and spending and become a
                                          “formidable” force in science. Government
                                                                                                                      Natal: Construction is beginning on a $25 million “Campus of the Brain” conceived
                                                                                                                      by Miguel Nicolelis, a neuroscientist at Duke University.
                                          officials want to see Brazil among the top 10
                                          science nations.                                                            Rio de Janeiro: A massive new R&D facility built by oil company Petrobras is billed
                                              But Brazil is not formidable yet. Like                                  as the largest laboratory in the Southern Hemisphere. Workers will explore
                                          Nicolelis’s institute—where construction is                                 deep-water oil deposits.
                                          several years behind schedule—Brazil’s sci-
                                          entific output trails its ambitions. The coun-                               São Paulo: The wealthiest state in Brazil is also its science leader.                                                   São Paulo
                                          try produces few high-impact papers and                                     researchers publish half of all Brazilian papers.


                                                                 Brazilian Science Begins to Boom
                                                        Brazilian Papers                                              R&D Spending as % of GDP                                                         U.S. Patents for Selected Countries
                                                        SOURCE: MCT/Thomson Reuters              32,100               SOURCE: IADB                                                                     SOURCE: USPTO
                                                                                                 54.4%
                                                                                                 2.7%                       3.44%                                              JAPAN
                                                        35                                                            3.5
                                                               Number of papers                                                                                                U.S.A.
                                                                                                                                                                                                                                                                    U.S.A.: 82,382
                                                        30     % Brazil of Latin America                              3.0                                                      CHINA
                                                               % Brazil of World                                                    2.68%                                                                                                 JAPAN: 35,501
                                                                                                                                                                                                U.S. Patents, 2009




                                                                                                                                                                               RUSSIA
                                                                                                                      2.5                                                                                                    GERMANY: 9,000
                                          (Thousands)




                                                                                                                                                                               BRAZIL
GRAPHIC CREDIT: N. KEVITIYAGALA/SCIENCE




                                                        25
                                                                                                                                                                               CHILE                                         SOUTH KOREA: 8,762
                                                                             17,714
                                                                                                                (%)




                                                                                                                      2.0                                                                                                CHINA: 1,655
                                                        20                   47.6%                                                                                             MEXICO
                                                                             1.8%                                                       1.49%                                  COSTA RICA                                INDIA: 679
                                                                                                                      1.5
                                                        15                                                                                      1.13% 1.11%                    COLOMBIA                                  RUSSIAN FEDERATION: 196
                                                                6,038                                                 1.0                                                                                                BRAZIL: 103
                                                                39.1%                 10,521                                                                  0.67%
                                                        10      0.8%                                                                                                  0.46%                                              MEXICO: 60
                                                                                      42.9%                           0.5                                                     0.32%                                      ARGENTINA: 45
                                                                                      1.4%                                                                                            0.16%
                                                         5                                                            0.0
                                                        1995          2000          2005         2009                                               2007                                                             0        20,000     40,000      60,000       80,000 100,000
                                           2009 figure elevated due to increase in number of indexed journals                                                                                                             Based on country of residence of first listed inventor


                                                                                               www.sciencemag.org SCIENCE VOL 330                                               3 DECEMBER 2010                                                                                1307
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       only a trickle of patents. Its pri-                                                                                    can countries, Brazil’s research
       mary and secondary public edu-                                                                                         base is heavily skewed toward
       cation system is in shambles,                                                                                          agriculture, ecology, and infec-
       leaving the nation of 195 mil-                                                                                         tious diseases—it is first in the
       lion chronically short of tech-                                                                                        world in publications related to
       nical workers. “We need to be                                                                                          sugar, coffee, and orange juice.
       lucid and not fall into a victory                                                                                      Brazil’s cattle industry produces
       discourse,” cautions Sidarta                                                                                           33% of the world’s cow embryos.
       Ribeiro, a neuroscientist trained                                                                                      Once a sideshow, such research
       at Rockefeller University in                                                                                           is increasingly well placed to
       New York City and co-founder                                                                                           address global preoccupations
       of Nicolelis’s brain institute.                                                                                        over food production, climate
       “In terms of impact we are mar-                                                                                        change, and conservation.
       ginal. The external discourse for                                                                                          Nicolelis says he sees an
       the world should be that we are                                                                                        “emerging tropical way of doing
       interested in science and we are                                                                                       science” driven by research on
       growing. The discourse inter-                                                                                          renewable energy, agriculture,




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                                              Tweaking nature. Researcher in a government research lab in Brasília inspects
       nally should be, ‘Let’s improve.       a transgenic cotton plant.                                                     water, and animal and plant
       Let’s focus on merit.’ ”                                                                                              genetics. “These are the issues
                                                            tina took only 3 years ago and which neighbor defining the planet, and, believe it or not,
       Boom times                                           Bolivia is still debating. “Brazil is the only the players are down here,” says Nicolelis.
       Brazil is clearly breaking away from the pack example in Latin America where 1% of GDP                         Biological research is a hot area of growth.
       in Latin America, indicators show. Brazil now goes into R&D and the science minister is a The Empresa Brasileira de Pesquisa Agro-
       accounts for over 60% of all research spend- physicist that still publishes. So Brazil is the pecuária, the government-owned agricul-
       ing in Latin America, and Brazilian scien- beacon,” says Juan Asenjo, president of the tural research company known as Embrapa,
       tists write half of the papers. Brazil’s science Chilean Academy of Sciences.                              plans to hire 700 new researchers this year.
       bureaucracy is influential, too, having had its           Globalization of markets is also working Embrapa is considered one of the world’s
       own ministry since 1985. That’s a step Argen- in Brazil’s favor. Like other Latin Ameri- premier agricultural units, and its budget



                                                                                           October, Petrobras inaugurated a sprawling new $700 million research center
       Tapping a Deep, ‘Pre-Salt’ Bounty                                                   in Rio de Janeiro. At the event, da Silva, a former union leader with a fourth-
       Three years ago, a drill bit struck immense oil deposits deep off the coast of      grade education, left no doubt what the vast R&D complex represents to him:
       Brazil. Petrobras, the national oil company, tapped undersea fields now esti-        “Brazil will never have to lower its head to anyone again,” he roared to a bois-
       mated to hold about 80 billion barrels of oil and natural gas—about three           terous crowd of oil workers.
       times the size of the reservoir under Prudhoe Bay, Alaska. It brought the prom-          Deep-water petroleum exploration is Brazil’s largest technology project,
       ise of new wealth and expectations that Brazil will climb to the world’s top rung   and Petrobras’s money is pouring into research labs throughout the coun-
       of achievement in science and technology.                                           try. In order to retrieve the oil, which lies a daunting 7 kilometers below the
           Brazilian President Luiz Inácio Lula da Silva once termed the oil strike “a     ocean surface, Petrobras has opened a fire hose of funding that is “chang-
       second independence for Brazil” and promised to use the oil revenue for edu-        ing the face of science in Brazil,” says Angela Uller, dean for research at the
       cation and public health. But Brazil’s R&D sector has been first to benefit. This     Federal University of Rio de Janeiro, whose campus on an island outside the
                                                                                                                                city also houses Petrobras’s R&D Center,
                                                                                                                                known as Cenpes.
                                                                                                                                    Petrobras now spends about $1 billion


                                                                                                                                                                                CREDITS (TOP TO BOTTOM): DEVA RODRIGUES/EMBRAPA; PETROBRAS
                                                                                                                                a year on R&D, including some $225 mil-
                                                                                                                                lion that goes directly to universities, for
                                                                                                                                which Petrobras has been rushing to outfit
                                                                                                                                laboratories, erect new geophysics centers,
                                                                                                                                and train a new generation of engineers.
                                                                                                                                “We want to transform the technological
                                                                                                                                capabilities of Brazil and help build univer-
                                                                                                                                sity labs equal to any in the world,” says
                                                                                               Oil money. National              Carlos Tadeu da Costa Fraga, head of Petro-
                                                                                               oil company Petrobras            bras R&D operations.
                                                                                               inaugurated a $700                   Rio’s engineering school, known as
                                                                                               million research center          COPPE, is the biggest single beneficiary of
                                                                                               in Rio de Janeiro                the oil gusher. Petrobras has paid for the
                                                                                               in October.                      construction of numerous laboratories on
                                                                                                                                campus, including the world’s deepest wave



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                                                         of $1 billion is now the same size as that of            unit. Countless shiploads of soybeans that                we needed help, but where could we work
                                                         the U.S. Department of Agriculture’s Agri-               embark for Asia every day from Brazilian                  together,” de França says.
                                                         cultural Research Service. “I’ve never seen              ports could instead, he says, power domestic
                                                         so many resources for science as in the last             industries in lipochemistry and plastics that             Private money
                                                         5 years,” says Maria Fátima Grossi de Sá, a              produce “value-added products.”                           The most important goal right now, by
                                                         plant geneticist who recently received $1.5                  The project represents an important shift             Rezende’s reckoning, “is for science to make
                                                         million to develop a transgenic cotton plant.            in Brazilian thinking: namely, that science               a difference in the productivity of industry.
                                                             De Sá works at Embrapa’s research sta-               can transform the nation’s economy, cur-                  I’d have to say that is our great challenge.”
                                                         tion in Brasília, which is also finishing tests           rently dominated by commodities like soy,                 Other goals are to increase the number of
                                                         on a herbicide-resistant soybean that will be            beef, sugar cane, iron ore, and petroleum.                scientists, invest in strategic areas, and solve
                                                         the first genetically modified crop designed               “The new Brazil will be a natural knowledge               key social problems.
                                                         by Brazilian scientists to reach the market.             economy,” says Gilberto Câmara, head of                       The disconnect between science and busi-
                                                         Demand for Ph.D. scientists is running so                Brazil’s space agency.                                    ness is almost total in Brazil, researchers say.
                                                         high that de Sá says it’s difficult to find people             With more money and an emerging                       In the United States, about 80% of research
                                                         to take postdoc positions. “We’ve gone pretty            green-science mission, Brazilian research-                personnel work in industry, according to
                                                         rapidly from having trouble placing Ph.D.s to            ers say they’re being taken more seriously.               OECD data, whereas in Brazil, that figure
                                                         having stipends that don’t have takers.”                 Most of Embrapa’s senior scientists were                  hovers near 25%. Brazil produces hardly any




                                                                                                                                                                                                                                         Downloaded from www.sciencemag.org on December 2, 2010
                                                             Embrapa has nearly completed a four-                 trained in the United States, like Executive              patents—just 103 U.S. patents were issued to
                                                         story, $15 million agro-energy center that               Director José Geraldo Eugênio de França,                  inventors in Brazil in 2009—and Brazilian
                                                         will employ 100 researchers on the campus in             who in 1987 traveled to Texas A&M Univer-                 companies spend half of what European ones
                                                         Brasília. One goal is to turn Brazil’s 22 mil-           sity to study sorghum genetics. De França                 do on R&D. When they do spend, it’s often
                                                         lion hectares of soybeans into more valuable             says he noticed a change during a mission to              to import technology rather than develop it.
                                                         products, such as biodiesel. “We capture solar           Washington, D.C., last November, where he                     Researchers say Brazil’s 20-year dic-
                                                         energy and turn it into other forms of energy.           met U.S. science adviser John Holdren and                 tatorship, which ended in 1984, is partly
                                                         We think we can move very quickly from                   other officials. “For the first time in history,            to blame for the lag. Universities became
                                                         agriculture for food to agriculture for energy.          we had a recognition that something was                   redoubts of political opposition and Marx-
                                                         We can be a player,” says Frederico Ozanan               changing in Brazil. They didn’t ask us how                ist reading lists, where patents were viewed
                                                         Machado Durães, general director of the new              many postdocs we needed to send, or where                 as oppressive. “We isolated ourselves from



                                                         pool, used to test automobile-sized models of oil platforms. “It’s starting to look
                                                         like Dubai around here,” says Segen Farid Estefen, a director of COPPE, which
                                                         gets about $60 million a year from Petrobras. He says the industry-academic
                                                         complex on the island is the “largest offshore oil research cluster in the world.”
                                                             Petrobras, founded in 1947, began to follow the scent of oil offshore in
                                                         the mid-1970s, investing in R&D to extend its reach. Brazil was importing
                                                         equipment from the North Sea and the Gulf of Mexico and adapting it to
                                                         tropical conditions. But Brazil’s decision to pump its own oil demanded grow-
                                                         ing investment in R&D.
                                                             “You cannot simply cut and paste,” says Martin Landrø, deputy chair
                                                         of petroleum engineering and applied geophysics at the Norges Teknisk-
                                                         Naturvitenskapelige Universitet in Trondheim, Norway. “You have to build
                                                         up competence, and the easiest way to do that is to build up research. You
                                                         have to bite the apple, so to speak.”
                                                             Landrø, who has visited Brazil three times to give courses to Petrobras
                                                                                                                                               Petro power. With workers in 2008, President Luiz Inácio Lula da Silva celebrates
CREDIT: HO NEW/REUTERS; (BACKGROUND IMAGE) GOOGLE MAPS




                                                         geophysicists, says he’s noticed an accelerating change in Brazil. “They have         the “second independence” oil discoveries will give Brazil.
                                                         maneuvered from the position of being not so competent to being on the cut-
                                                         ting edge in 10 years,” says Landrø.                                                  and later encased beneath thick layers of salt. These are “a new kind of geo-
                                                             Petrobras, the world’s largest deep-water oil producer, is reaching               logic play. They are new types of reservoirs and there are lots of things being
                                                         depths where experience is scarce or nonexistent. At the Laboratory for               learned,” says William Fisher, a geologist at the University of Texas, Austin. One
                                                         Non-Destructive Testing, Corrosion and Soldering, for instance, four COPPE            critical difficulty is spotting the oil reservoirs beneath the salt domes, frequently
                                                         professors work alongside 30 Petrobras engineers to submit steel to corro-            over a kilometer thick; seismic signals are hard to interpret. “As far as the poten-
                                                         sive hydrogen sulfide gas at extreme pressures. “At 7000 meters [below sea             tial discoveries—what is the potential volume of oil and gas—well, you can
                                                         level], we don’t have any information about how materials perform, or how             hazard all kinds of guesses, but it’s going to be big,” says Fisher.
                                                         long they can last,” says Oscar Rosa Mattos, director of the lab, which Petro-             Estefen hopes that Brazil’s exploration of the ocean does not stop at oil.
                                                         bras paid $30 million to build in 2008. “My foreign visitors are surprised            He says the country could use its deep-water expertise to be at the forefront
                                                         when they encounter a facility like this in Brazil.”                                  of wave energy and undersea communications, too. “The analogy I use is that
                                                             The superdeep petroleum deposits now being discovered are in the “pre-            deep-sea exploration can do in Brazil what the space race did for the United
                                                         salt” zone, an area where organic matter was deposited 125 million years ago          States,” Estefen says. “If Brazil only pumps oil, it would be a big loss.”     –A.R.



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       the big industries, which supported the mili-                                                            ogy transfer offices, which many are doing
       tary. They couldn’t come in the university.                                                              for the first time. At the Federal University
       The university became closed, hermetic, and                                                              of Minas Gerais, the number of patent appli-
       now we have to change that,” says Maria                                                                  cations has reached 356, including one for a
       Bernardete Cordeiro da Sousa, dean for                                                                   canine vaccine against leishmaniasis, now on
       research at the Federal University of Rio                                                                the market. “All these things are leading to
       Grande do Norte.                                                                                         resonance in the system,” says Ado Jorio, the
           Officials have been trying to close the                                                              professor who coordinates the university’s
       innovation gap. In 2004 and 2005, Bra-                                                                   patent efforts. “There has been an explosion
       zil passed laws giving R&D tax breaks to                                                                 in publications, and this is also going to hap-
       companies and began allowing the Minis-                                                                  pen in innovation.”
       try of Science and Technology to give com-
       panies grants, even pay salaries of indus-                                                               Share the wealth
       trial researchers. In August, the ministry                                                               Brazilian science suffers another imbalance,
       announced a major industrial R&D program,                                                                between the wealthy south and the poor
       offering $294 million in grants to back inno-                                                            northern regions, that officials have put a
       vation projects inside companies in “strate-                                                             priority on trying to correct. Most science




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       gic areas” including electric cars, pacemak-       P.h.D.-in-chief. Physicist Sérgio Rezende has kept    still occurs in just three southern states, with
       ers, and genetically engineered crops.             publishing while running Brazil’s science ministry.   the University of São Paulo alone account-
           It’s too early to say if the government                                                              ing for nearly a quarter of all scientific publi-
       incentives are working; only a small number        he wanted the MIT [Massachusetts Insti-               cations. “One of the great questions we face
       of companies signed up for the tax breaks.         tute of Technology] of Vale,” recalls Mello.          is that Brazilian asymmetry, the inequality
       But U.S.-style, risk-taking innovation, once       “I was being invited to lead something that           of the regions,” says Lucia Melo, head of the
       viewed as alien, is increasingly seen in favor-    would be a new Bell Labs or Xerox PARC.”              Center for Strategic Studies and Manage-
       able terms. Venture capitalists have begun             Mello traveled this fall to Silicon Valley        ment in Science, Technology and Innova-
       setting up shop in Brazil, and in 2010 both        to get ideas. Although Vale’s business is low-        tion, a government science policy think tank
       IBM and General Electric announced plans           tech, the commodity company, which ships              in Brasília.
       for research centers in the country.               vast amounts of ore to China and Europe,                  To push science out into Brazil’s neglected
           “We lack a culture of innovation and           wants to spend heavily on research partly             hinterlands, Brazil’s government has gone on
       entrepreneurship. There is a long path ahead       because it faces a sharp shortage of skilled          a binge of university construction and ear-
       to change that,” says Luiz Mello, a physi-         labor, increasing pressure from environ-              marked 30% of research funds for poor north-
       cian who last year was tapped by Brazil’s          mentalists, and competition from global               ern and western states. Under a 2009 program
       second largest company, the iron-ore miner         companies. Vale’s three labs will work on             called “Stipends for Everyone,” officials in
       Vale S.A., to spend $180 million establishing      biodiversity, renewable energy, and mining            Brasília said they would give study grants
       three new corporate science institutes. Mello      technology. “This is the biggest spontaneous          to all graduate students in distant regions,
       says he was hired after approaching Vale’s         investment in R&D that I know of in Brazil,”          regardless of academic merit.
       CEO, Roger Agnelli, to raise money for an          says Mello.                                               The idea flows from Brazil’s governing
       engineering program. “It turned out to be a            The new laws also encourage Brazilian             Workers’ Party, which has made improving
       meeting for him to say what he wanted. And         universities to file patents and set up technol-       conditions in poor areas a priority. A greatly
                                                                                                                expanded welfare program has helped move
                                                                                                                several million Brazilians out of poverty. It
                                                                                                                has given researchers breathing room, too.
                                                                                                                “Before, we’d face the question, ‘Why are
                                                                                                                you giving a monkey food and milk when
                                                                                                                there is a hungry child next door?’ ” says
                                                                                                                Cordeiro da Sousa, who is also a primate
                                                                                                                researcher. But she sees a tradeoff: Research-
                                                                                                                ers feel increasing pressure to spend time
                                                                                                                solving local problems. She’s considering
                                                                                                                                                                   CREDITS (TOP TO BOTTOM): GE GLOBAL RESEARCH; MCT




                                                                                                                creating a salt institute to support the local
                                                                                                                salt-mining industry. “You have to have a
                                                                                                                vocation, because in the future we could be
                                                                                                                called to answer in a big way.”
                                                                                                                    Nowhere is the dearth of Brazilian-led sci-
                                                                                                                ence of greater concern than in the Amazon,
                                                                                                                the tropical forest that accounts for about 49%
         Tropical innovation. An architect’s rendering                                                          of Brazil’s territory but is home to only about
         of the General Electric global research center                                                         3000 Ph.D. researchers, very few of whom do
         near Rio de Janeiro. The lab, when built, will                                                         bench science. “Imagine what a totally irrele-
         be GE’s fifth international R&D center.
                                                                                                                vant number that represents for this immense
                                                                                                                region,” says Odenildo Teixeira Sena, secre-

1310                                          3 DECEMBER 2010         VOL 330 SCIENCE www.sciencemag.org
                                                                           Published by AAAS
tary of science and technology in the state of
                                                         Amazonas. Although larger than France and
                                                         Spain combined, Amazonas has only a single
                                                         resident Ph.D. archaeologist, and despite its
                                                         vast river systems, no naval engineers, Teix-
                                                         eira says.
                                                             Increasing scientific labor power in the
                                                         region could help find alternatives to slash-
                                                         and-burn agriculture. But national anxiet-
                                                         ies figure into the calculation as well. “The
                                                         majority of publications on the Amazon don’t
                                                         have a Brazilian author. That is a worry for
                                                         us,” says Jorge Guimarães, the Ministry of
                                                         Education official who oversees higher edu-
                                                         cation in Brazil. “We need more Brazilians
                                                         participating.”
                                                             Brazil has never felt secure in its control




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                                                         over the vast region, which Spain ceded to
                                                         Portugal under the 1750 Treaty of Madrid.
                                                         With the Amazon a focus of international          Talented But Underfunded: Brazil’s Future Scientists
                                                         maneuvering on carbon credits, Brazil’s
                                                         dependence on foreign knowledge produc-           It’s an unusual prelab routine. Wake up in a below-ground apartment where five people sleep
                                                         tion has become a “very delicate question,”       (four on the floor), grab your books, then head out past the machine gun–toting gangsters who
                                                         says Adalberto Val, director of the Insti-        guard your street against police vehicles. That’s been reality for 25-year-old Reinaldo Sousa dos
                                                         tuto Nacional de Pesquisas da Amazônia in         Santos, a Ph.D. candidate in biochemistry at the Federal University of Rio de Janeiro (UFRJ) and a
                                                         Manaus. During a national science and tech-       resident of Parque União, a crowded favela where residents live under the thumb of a drug gang.
                                                         nology conference last May, Val called for             Dos Santos owes his journey from shantytown to lab bench to his mentor, Leopoldo de Meis, a
                                                         Brazilian “informational hegemony” over the       72-year-old professor of biochemistry at UFRJ. In 1985, de Meis began offering a hands-on sci-
                                                         forest biome. “There is a question of national    ence course for low-income adolescents called Young Talents. Dos Santos enrolled when he was
                                                         sovereignty,” he says.                            14, a year after his father died, leaving him orphaned.
                                                             Such nationalist tones may sound harsh             “I don’t want people to think I am the poor little kid from the favela,” says Dos Santos, a
                                                         outside Brazil, but they play well at home.       fast, concise talker who is studying the metabolic response of goldfish to low temperatures.
                                                         Physicist Luiz Davidovich, who chaired the        Although he may sleep some nights on the laboratory couch, “intellectually I don’t think I am
                                                         May conference, says Brazil’s scientific com-      below anyone.”
                                                         munity needs to raise “big flags” to rally the          Brazil must write thousands more stories like Dos Santos’s if it is to overcome deep social
                                                         country around. “ ‘The Amazon is Ours’ is         divisions and achieve its dream of becoming a major player in scientific research. Many say the
                                                         one of those,” he says.                           task must begin with improving public schools, where poorly paid teachers offer rote lessons.
                                                             Even some foreign experts have                     Brazil’s math and science scores vie for the worst among 57 countries ranked on the so-called
                                                         responded to the call. Daniel Nepstad, a          PISA scale by OECD, barely edging out Tunisia. College is mainly for the elite. Prestigious federal
                                                         prominent American tropical forest ecolo-         universities in Brazil offer free education, but it’s difficult to pass tough entrance exams unless
                                                         gist, dropped his job in October at Woods         families have paid for private secondary schools. “We have had a perverse system of social apart-
                                                         Hole Research Center in Massachusetts             heid, where the poor don’t have access to higher education,” says Luiz Davidovich, a physicist at
                                                         to become a Brazilian resident and full-          the university who sits on the board of the Brazilian Academy of Sciences. Only 14% of 18- to
                                                         time employee of the Instituto de Pesquisa        24-year-olds are in college, not enough to meet Brazil’s growing demand for researchers and
                                                         Ambiental da Amazônia, a nonprofit he             engineers. “We’re working with just a sliver of the population,” Davidovich says.
                                                         co-founded, based in the city of Belém.                In recent years, the government has tried to broaden access to education. Scores of state
                                                         Nepstad says his U.S. affiliation “was inter-      technical schools have opened; since 1979, Brazil has hosted what is now billed as the world’s
CREDIT: FLÁVIA MARTINS; (BACKGROUND IMAGE) GOOGLE MAPS




                                                         preted that I am less committed to the scien-     largest math olympiad. Another national program, ProUni, since 2005 has paid for 748,000
                                                         tific agenda in Brazil.” Brazil’s forest policy    lower income students who can’t get into federal schools to attend private, for-profit universi-
                                                         is evolving rapidly and, Nepstad says, “as        ties. Davidovich says the efforts fall short: “Brazil needs a revolution in education at all levels,
                                                         long as the science is led by Northerners,        especially at the most basic levels.”
                                                         we are missing the opportunity to get really           Dos Santos recognizes that his life is exceptional. “Most Brazilians don’t know any scientists
                                                         good information into policy decisions.”          and don’t know what a scientist does,” he says. For him, science has proved both an intellectual
                                                                                                           and financial life belt. His state stipend of $1000 a month (he gets another $180 for supplies)
                                                         Making it real                                    makes him his family’s top earner, and this summer he helped his grandmother, uncle, and
                                                         Despite its growing ambitions, Brazil has         cousins move into a larger house. Now that he has his own room, he hopes to decorate it with a
                                                         yet to prove it can do world-class basic          metabolic chart like one he saw at a conference.
                                                         research. The impact scores of its scien-              “I like to see the molecule in vivo doing something,” says Dos Santos of his career choice.
                                                         tific papers are modest, about two-thirds the      “The lab is really a psychological escape from all the situations I live through. It’s my ideal place.”
                                                         world average, and have slid in some areas.                                                                                                       –A.R.
                                                         No Brazilian has won a Nobel Prize in sci-

                                                                                             www.sciencemag.org SCIENCE VOL 330                    3 DECEMBER 2010                                                   1311
                                                                                                                         Published by AAAS
NEWSFOCUS

                                                                                                                   Brazilian officials have instead focused
                                                                                                               on beating another problem: the insecurity
                                                                                                               of research funds. In 2008, in its largest-
                                                                                                               ever funding round for basic research, Bra-
                                                                                                               zil’s Ministry of Science and Technology
                                                                                                               offered $350 million over 3 years to fund 122
                                                                                                               national institutes to tackle subjects from
                                                                                                               quantum computing and stem cells to an
                                                                                                               upgraded Antarctic research station. “They
                                                                                                               saw that we needed long-term programs with
                                                                                                               stability,” says Davidovich, who co-leads the
                                                                                                               program on quantum computing.
                                                                                                                   Other scientists privately express doubts
                                                                                                               about the grandiosely named institutes, not-
                                                                     Missed opportunity? Many                  ing that in reality they are virtual networks
                                                                     researchers have published studies
                                                                                                               with an average of 20 university investigators
                                                                     involving the Amazon region; most
                                                                                                               each and money spread too thin to achieve




                                                                                                                                                                                                                              Downloaded from www.sciencemag.org on December 2, 2010
                                                                     are not Brazilian.
                                                                                                               much. In position papers, the Brazilian Soci-
                                                                                                               ety for the Advancement of Science has said
       ence or medicine, whereas regional rival           has been trapped in customs for 4 months.            that Brazil needs to focus on creating more
       Argentina has three. Researchers blame             “You can have the best head in the world             pure research jobs outside of the university
       structural problems at Brazil’s state-run          and you will never be competitive because            system. It wants a new, heavily staffed state
       universities. Critics say they discourage          the government works against us,” says               institute to study the oceans, and another for
       competition, for example, with automatic           Bertolini. “When we begin thinking that way,         the Amazon, modeled on the agricultural
       tenure after 3 years on the job and evalu-         we want to go back.”                                 agency Embrapa—in this case with funding
       ations that reward Portuguese-language                 Some say the prospects will remain bleak         to match the grandiose vision.
       publication. “The attitude for many years          until such problems are solved. “I know of               In the city of Natal, Nicolelis’s neuro-
       was to avoid competition, keep your head           no extraordinary science in Brazil,” says            science institute, currently housed in a con-
       low, and choose a marginal subject,” says          Andrew J. G. Simpson, scientific director of          verted hotel, has also yet to produce a Bra-
       Ribeiro. Instead of competing head-to-head         the Ludwig Institute for Cancer Research in          zilian breakthrough. But it’s increasingly
       on hot topics with big labs overseas, he           New York City. A naturalized Brazilian cit-          well-positioned to do so. It has reasonably
       says, Brazilian researchers have sometimes         izen, he lived in São Paulo for 7 years and          equipped laboratories, a primate facility, and
       been content to study local questions. “The        coordinated one of Brazil’s memorable tri-           a crowd of young professors with promising
       thinking was, ‘The anteater is yours so don’t      umphs, the sequencing of the plant patho-            track records who have signed on, includ-
       worry about the gringos.’ ”                        gen Xylella fastidiosa, which landed on the          ing two recruited from a Max Planck center
           Brazilian researchers returning from over-     cover of Nature in 2000. But when Simpson            in Germany. In August, the École Polytech-
       seas, drawn by jobs and start-up funds, com-       returned this year for a 10th-year celebration       nique Fédérale de Lausanne in Switzerland
       plain that there are still many obstacles that     of the feat, he noticed that, at least in the field   donated an IBM Blue Gene/L supercom-
       make producing world-class science nearly          of genomics, “there was never again a big            puter, which Nicolelis says will be the fastest
       impossible. After 11 years in the United           impact paper. There was no upwards process.          in South America.
       States, biologist Luciana Relly Bertolini          It was a blip.”                                          Ribeiro, the Brazilian who returned from
       returned to Brazil in 2006 with her                                                                     a postdoc at Rockefeller to be the institute’s
       husband, Marcelo, to start a labo-                                                                      scientific director, says the year of science
       ratory that aims to clone trans-                                                                        he expected to lose while organizing the
       genic goats. Although the effort                                                                        center has dragged into three, as he faced
       is adequately funded, Relly Ber-                                                                        down customs officials and coped with
       tolini says a heavy teaching load                                                                       large numbers of poorly trained students.         CREDIT (TOP TO BOTTOM): WORLD WIND/NASA; PAULO BRANDO/IPAM
       required of professors and lack of                                                                      “Now I’m finally starting to fight reviewers
       trained staff means “it’s science by                                                                    again instead of bureaucrats, which is a sign
       persistence here.”                                                                                      the plan worked,” says Ribeiro, whose work
           Also notorious are Brazil’s                                                                         includes experiments to look at the effect of
       Kafkaesque importation regula-                                                                          sleep and dreaming on motor and percep-
       tions. Even simple reagents can                                                                         tual skill retention.
       take months to arrive, with radio-                                                                          The dirt road outside his building that
       active or biological samples often                                                                      leads to a nearby shantytown, he says,
       in doubtful condition. Relly Ber-                                                                       reminds him of a photograph he saw of Rock-
       tolini says a cell-fusion instru-                                                                       efeller’s Founder’s Hall after it was built in
       ment she ordered from Hungary                                                                           1906 and still surrounded by muddy fields
       Returnee. Tropical ecologist Dan Neps-                                                                  and horse-drawn carriages: “They didn’t start
       tad studies a controlled fire in Tanguro                                                                 as the best place to do science either.”
       Forest, Mato Grosso, Brazil, in August.                                                                                        –ANTONIO REGALADO


1312                                             3 DECEMBER 2010     VOL 330 SCIENCE www.sciencemag.org
                                                                          Published by AAAS

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Ciencia Brasileira na Science

  • 1. NEWSFOCUS Brazilian Science: Downloaded from www.sciencemag.org on December 2, 2010 Riding a Gusher A fast-growing economy and oil discoveries are propelling Brazil’s research to new heights. But scientific leaders must overcome a weak education system and a low-impact track record NATAL—Miguel Nicolelis stands with his Brazil’s poorest regions. Nicolelis, who now place is going to create the next generation arms spread, pointing out a rectangular pit spends part of the year in Brazil, is eager to of Brazilian leaders.” carved into dry earth on the outskirts of the offer a visitor “categorical proof ” of success. Some continue to think Nicolelis’s idea Brazilian beach city of Natal. “That is where He’s built two hands-on science schools for is eccentric. But his timing couldn’t have the supercomputer will go,” he says. And, children and a maternity clinic, been better. Over the past 8 years, pointing to an area still thick with shrubbery, “that is the sports complex.” and recruited 11 Ph.D. neuro- scientists who run labs in a tem- Online sciencemag.org Latin America’s largest nation has begun to boom. Its economy Nicolelis is Brazil’s best-known scientist. A porary headquarters. Within a few Podcast interview is growing fast, and it has become neurobiologist at Duke University in Durham, months, he says, $25 million in with author a player in world affairs, reveling North Carolina, he is renowned for spectacu- Brazilian federal money should Antonio Regalado. in an unprecedented bout of self- lar experiments that use signals tapped from begin pouring into his sandy acre- confidence. It will host the World the brains of monkeys to make robots walk. age, creating the sprawling neuroscience com- Cup in 2014 and the Olympics 2 years later. But when Nicolelis launched plans in 2003 for plex Nicolelis calls his “Campus of the Brain.” The good times are lifting science, too. a neuroscience institute in Brazil’s backward “In Brazil we need science to build a Between 1997 and 2007 the number of Bra- northeast districts, few thought it could work country,” says Nicolelis, an energetic nation- zilian papers in indexed, peer-reviewed jour- (Science, 20 February 2004, p. 1131). alist whose passions include wearing a nals more than doubled to 19,000 a year. Bra- CREDITS (TOP TO BOTTOM): DANNY LEHMAN/CORBIS; A. REGALADO/SCIENCE The notion was to pair cutting-edge sci- green Palmeiras soccer club hat and down- zil now ranks 13th in publications, accord- ence with a social mission: developing one of ing pitchers of yellow maracujá juice. “This ing to Thomson Reuters, having surpassed the Netherlands, Israel, and Switzerland. Brazil’s universities awarded twice as many Ph.D.s this year as they did in 2001, and thou- sands of new academic jobs have opened up on 134 new federal campuses. It’s a reversal of fortune for a nation that during the 1990s was beset by dire economic problems. Back then, researchers scrounged for funds; Brazil even saw its flag removed from the logo of the International Space Sta- tion after it failed to come up with funding Proud moment. Neuroscientist Miguel Nicolelis at the foundations of his “Campus of the Brain” in northeastern Brazil. 1306 3 DECEMBER 2010 VOL 330 SCIENCE www.sciencemag.org Published by AAAS
  • 2. SCIENCE IN BRAZIL NEWSFOCUS Science hub. Brazil’s richest city, São Paulo, and eponymous state are home to most of the nation’s research. Manaus to build six components. “We kept thinking Amazon smaller and smaller,” says Sérgio Rezende, Natal science minister for the past 5 years. “If we couldn’t solve small problems, how could we solve big ones? Now we are in a position to think big again.” The fuel that propels science in Brazil is an R&D tax on big industries; it has swelled the budget of Rezende’s ministry to $4 billion, up Brasília from $600 million a decade ago. The national oil company, Petrobras, is the largest contrib- utor (see sidebar, p. 1308). Brazil restarted its nuclear research program in 2008, after a Downloaded from www.sciencemag.org on December 2, 2010 20-year lull, and in October, a delegation trav- BRAZIL São Paulo eled to Geneva to negotiate associate mem- Rio de Janeiro bership in CERN. With Brazil’s economy growing at a pace of 7% this year, the country can afford the dues of $14 million per year. Scientists here say their arguments in favor of more education, innovation, and technol- Highlights ogy have been heard in Brasília, the capi- tal, and they expect budgets to keep grow- Amazon: Half as large as Europe, the Brazilian Amazon is home to fewer than 3000 ing under Brazil’s president-elect, Dilma Ph.D. scientists. Government incentives seek to increase Brazil’s scientific presence in Rousseff, the first woman to hold that post. the forest region. By 2020, say officials of the Brazilian Soci- ety for the Advancement of Science, Brazil Brasília: Brazil’s rapid economic growth means rising budgets at the Ministry of should again redouble or triple output of stu- Science and Technology. It now spends about $4 billion a year. dents, papers, and spending and become a “formidable” force in science. Government Natal: Construction is beginning on a $25 million “Campus of the Brain” conceived by Miguel Nicolelis, a neuroscientist at Duke University. officials want to see Brazil among the top 10 science nations. Rio de Janeiro: A massive new R&D facility built by oil company Petrobras is billed But Brazil is not formidable yet. Like as the largest laboratory in the Southern Hemisphere. Workers will explore Nicolelis’s institute—where construction is deep-water oil deposits. several years behind schedule—Brazil’s sci- entific output trails its ambitions. The coun- São Paulo: The wealthiest state in Brazil is also its science leader. São Paulo try produces few high-impact papers and researchers publish half of all Brazilian papers. Brazilian Science Begins to Boom Brazilian Papers R&D Spending as % of GDP U.S. Patents for Selected Countries SOURCE: MCT/Thomson Reuters 32,100 SOURCE: IADB SOURCE: USPTO 54.4% 2.7% 3.44% JAPAN 35 3.5 Number of papers U.S.A. U.S.A.: 82,382 30 % Brazil of Latin America 3.0 CHINA % Brazil of World 2.68% JAPAN: 35,501 U.S. Patents, 2009 RUSSIA 2.5 GERMANY: 9,000 (Thousands) BRAZIL GRAPHIC CREDIT: N. KEVITIYAGALA/SCIENCE 25 CHILE SOUTH KOREA: 8,762 17,714 (%) 2.0 CHINA: 1,655 20 47.6% MEXICO 1.8% 1.49% COSTA RICA INDIA: 679 1.5 15 1.13% 1.11% COLOMBIA RUSSIAN FEDERATION: 196 6,038 1.0 BRAZIL: 103 39.1% 10,521 0.67% 10 0.8% 0.46% MEXICO: 60 42.9% 0.5 0.32% ARGENTINA: 45 1.4% 0.16% 5 0.0 1995 2000 2005 2009 2007 0 20,000 40,000 60,000 80,000 100,000 2009 figure elevated due to increase in number of indexed journals Based on country of residence of first listed inventor www.sciencemag.org SCIENCE VOL 330 3 DECEMBER 2010 1307 Published by AAAS
  • 3. NEWSFOCUS only a trickle of patents. Its pri- can countries, Brazil’s research mary and secondary public edu- base is heavily skewed toward cation system is in shambles, agriculture, ecology, and infec- leaving the nation of 195 mil- tious diseases—it is first in the lion chronically short of tech- world in publications related to nical workers. “We need to be sugar, coffee, and orange juice. lucid and not fall into a victory Brazil’s cattle industry produces discourse,” cautions Sidarta 33% of the world’s cow embryos. Ribeiro, a neuroscientist trained Once a sideshow, such research at Rockefeller University in is increasingly well placed to New York City and co-founder address global preoccupations of Nicolelis’s brain institute. over food production, climate “In terms of impact we are mar- change, and conservation. ginal. The external discourse for Nicolelis says he sees an the world should be that we are “emerging tropical way of doing interested in science and we are science” driven by research on growing. The discourse inter- renewable energy, agriculture, Downloaded from www.sciencemag.org on December 2, 2010 Tweaking nature. Researcher in a government research lab in Brasília inspects nally should be, ‘Let’s improve. a transgenic cotton plant. water, and animal and plant Let’s focus on merit.’ ” genetics. “These are the issues tina took only 3 years ago and which neighbor defining the planet, and, believe it or not, Boom times Bolivia is still debating. “Brazil is the only the players are down here,” says Nicolelis. Brazil is clearly breaking away from the pack example in Latin America where 1% of GDP Biological research is a hot area of growth. in Latin America, indicators show. Brazil now goes into R&D and the science minister is a The Empresa Brasileira de Pesquisa Agro- accounts for over 60% of all research spend- physicist that still publishes. So Brazil is the pecuária, the government-owned agricul- ing in Latin America, and Brazilian scien- beacon,” says Juan Asenjo, president of the tural research company known as Embrapa, tists write half of the papers. Brazil’s science Chilean Academy of Sciences. plans to hire 700 new researchers this year. bureaucracy is influential, too, having had its Globalization of markets is also working Embrapa is considered one of the world’s own ministry since 1985. That’s a step Argen- in Brazil’s favor. Like other Latin Ameri- premier agricultural units, and its budget October, Petrobras inaugurated a sprawling new $700 million research center Tapping a Deep, ‘Pre-Salt’ Bounty in Rio de Janeiro. At the event, da Silva, a former union leader with a fourth- Three years ago, a drill bit struck immense oil deposits deep off the coast of grade education, left no doubt what the vast R&D complex represents to him: Brazil. Petrobras, the national oil company, tapped undersea fields now esti- “Brazil will never have to lower its head to anyone again,” he roared to a bois- mated to hold about 80 billion barrels of oil and natural gas—about three terous crowd of oil workers. times the size of the reservoir under Prudhoe Bay, Alaska. It brought the prom- Deep-water petroleum exploration is Brazil’s largest technology project, ise of new wealth and expectations that Brazil will climb to the world’s top rung and Petrobras’s money is pouring into research labs throughout the coun- of achievement in science and technology. try. In order to retrieve the oil, which lies a daunting 7 kilometers below the Brazilian President Luiz Inácio Lula da Silva once termed the oil strike “a ocean surface, Petrobras has opened a fire hose of funding that is “chang- second independence for Brazil” and promised to use the oil revenue for edu- ing the face of science in Brazil,” says Angela Uller, dean for research at the cation and public health. But Brazil’s R&D sector has been first to benefit. This Federal University of Rio de Janeiro, whose campus on an island outside the city also houses Petrobras’s R&D Center, known as Cenpes. Petrobras now spends about $1 billion CREDITS (TOP TO BOTTOM): DEVA RODRIGUES/EMBRAPA; PETROBRAS a year on R&D, including some $225 mil- lion that goes directly to universities, for which Petrobras has been rushing to outfit laboratories, erect new geophysics centers, and train a new generation of engineers. “We want to transform the technological capabilities of Brazil and help build univer- sity labs equal to any in the world,” says Oil money. National Carlos Tadeu da Costa Fraga, head of Petro- oil company Petrobras bras R&D operations. inaugurated a $700 Rio’s engineering school, known as million research center COPPE, is the biggest single beneficiary of in Rio de Janeiro the oil gusher. Petrobras has paid for the in October. construction of numerous laboratories on campus, including the world’s deepest wave 1308 3 DECEMBER 2010 VOL 330 SCIENCE www.sciencemag.org Published by AAAS
  • 4. SCIENCE IN BRAZIL NEWSFOCUS of $1 billion is now the same size as that of unit. Countless shiploads of soybeans that we needed help, but where could we work the U.S. Department of Agriculture’s Agri- embark for Asia every day from Brazilian together,” de França says. cultural Research Service. “I’ve never seen ports could instead, he says, power domestic so many resources for science as in the last industries in lipochemistry and plastics that Private money 5 years,” says Maria Fátima Grossi de Sá, a produce “value-added products.” The most important goal right now, by plant geneticist who recently received $1.5 The project represents an important shift Rezende’s reckoning, “is for science to make million to develop a transgenic cotton plant. in Brazilian thinking: namely, that science a difference in the productivity of industry. De Sá works at Embrapa’s research sta- can transform the nation’s economy, cur- I’d have to say that is our great challenge.” tion in Brasília, which is also finishing tests rently dominated by commodities like soy, Other goals are to increase the number of on a herbicide-resistant soybean that will be beef, sugar cane, iron ore, and petroleum. scientists, invest in strategic areas, and solve the first genetically modified crop designed “The new Brazil will be a natural knowledge key social problems. by Brazilian scientists to reach the market. economy,” says Gilberto Câmara, head of The disconnect between science and busi- Demand for Ph.D. scientists is running so Brazil’s space agency. ness is almost total in Brazil, researchers say. high that de Sá says it’s difficult to find people With more money and an emerging In the United States, about 80% of research to take postdoc positions. “We’ve gone pretty green-science mission, Brazilian research- personnel work in industry, according to rapidly from having trouble placing Ph.D.s to ers say they’re being taken more seriously. OECD data, whereas in Brazil, that figure having stipends that don’t have takers.” Most of Embrapa’s senior scientists were hovers near 25%. Brazil produces hardly any Downloaded from www.sciencemag.org on December 2, 2010 Embrapa has nearly completed a four- trained in the United States, like Executive patents—just 103 U.S. patents were issued to story, $15 million agro-energy center that Director José Geraldo Eugênio de França, inventors in Brazil in 2009—and Brazilian will employ 100 researchers on the campus in who in 1987 traveled to Texas A&M Univer- companies spend half of what European ones Brasília. One goal is to turn Brazil’s 22 mil- sity to study sorghum genetics. De França do on R&D. When they do spend, it’s often lion hectares of soybeans into more valuable says he noticed a change during a mission to to import technology rather than develop it. products, such as biodiesel. “We capture solar Washington, D.C., last November, where he Researchers say Brazil’s 20-year dic- energy and turn it into other forms of energy. met U.S. science adviser John Holdren and tatorship, which ended in 1984, is partly We think we can move very quickly from other officials. “For the first time in history, to blame for the lag. Universities became agriculture for food to agriculture for energy. we had a recognition that something was redoubts of political opposition and Marx- We can be a player,” says Frederico Ozanan changing in Brazil. They didn’t ask us how ist reading lists, where patents were viewed Machado Durães, general director of the new many postdocs we needed to send, or where as oppressive. “We isolated ourselves from pool, used to test automobile-sized models of oil platforms. “It’s starting to look like Dubai around here,” says Segen Farid Estefen, a director of COPPE, which gets about $60 million a year from Petrobras. He says the industry-academic complex on the island is the “largest offshore oil research cluster in the world.” Petrobras, founded in 1947, began to follow the scent of oil offshore in the mid-1970s, investing in R&D to extend its reach. Brazil was importing equipment from the North Sea and the Gulf of Mexico and adapting it to tropical conditions. But Brazil’s decision to pump its own oil demanded grow- ing investment in R&D. “You cannot simply cut and paste,” says Martin Landrø, deputy chair of petroleum engineering and applied geophysics at the Norges Teknisk- Naturvitenskapelige Universitet in Trondheim, Norway. “You have to build up competence, and the easiest way to do that is to build up research. You have to bite the apple, so to speak.” Landrø, who has visited Brazil three times to give courses to Petrobras Petro power. With workers in 2008, President Luiz Inácio Lula da Silva celebrates CREDIT: HO NEW/REUTERS; (BACKGROUND IMAGE) GOOGLE MAPS geophysicists, says he’s noticed an accelerating change in Brazil. “They have the “second independence” oil discoveries will give Brazil. maneuvered from the position of being not so competent to being on the cut- ting edge in 10 years,” says Landrø. and later encased beneath thick layers of salt. These are “a new kind of geo- Petrobras, the world’s largest deep-water oil producer, is reaching logic play. They are new types of reservoirs and there are lots of things being depths where experience is scarce or nonexistent. At the Laboratory for learned,” says William Fisher, a geologist at the University of Texas, Austin. One Non-Destructive Testing, Corrosion and Soldering, for instance, four COPPE critical difficulty is spotting the oil reservoirs beneath the salt domes, frequently professors work alongside 30 Petrobras engineers to submit steel to corro- over a kilometer thick; seismic signals are hard to interpret. “As far as the poten- sive hydrogen sulfide gas at extreme pressures. “At 7000 meters [below sea tial discoveries—what is the potential volume of oil and gas—well, you can level], we don’t have any information about how materials perform, or how hazard all kinds of guesses, but it’s going to be big,” says Fisher. long they can last,” says Oscar Rosa Mattos, director of the lab, which Petro- Estefen hopes that Brazil’s exploration of the ocean does not stop at oil. bras paid $30 million to build in 2008. “My foreign visitors are surprised He says the country could use its deep-water expertise to be at the forefront when they encounter a facility like this in Brazil.” of wave energy and undersea communications, too. “The analogy I use is that The superdeep petroleum deposits now being discovered are in the “pre- deep-sea exploration can do in Brazil what the space race did for the United salt” zone, an area where organic matter was deposited 125 million years ago States,” Estefen says. “If Brazil only pumps oil, it would be a big loss.” –A.R. www.sciencemag.org SCIENCE VOL 330 3 DECEMBER 2010 1309 Published by AAAS
  • 5. NEWSFOCUS the big industries, which supported the mili- ogy transfer offices, which many are doing tary. They couldn’t come in the university. for the first time. At the Federal University The university became closed, hermetic, and of Minas Gerais, the number of patent appli- now we have to change that,” says Maria cations has reached 356, including one for a Bernardete Cordeiro da Sousa, dean for canine vaccine against leishmaniasis, now on research at the Federal University of Rio the market. “All these things are leading to Grande do Norte. resonance in the system,” says Ado Jorio, the Officials have been trying to close the professor who coordinates the university’s innovation gap. In 2004 and 2005, Bra- patent efforts. “There has been an explosion zil passed laws giving R&D tax breaks to in publications, and this is also going to hap- companies and began allowing the Minis- pen in innovation.” try of Science and Technology to give com- panies grants, even pay salaries of indus- Share the wealth trial researchers. In August, the ministry Brazilian science suffers another imbalance, announced a major industrial R&D program, between the wealthy south and the poor offering $294 million in grants to back inno- northern regions, that officials have put a vation projects inside companies in “strate- priority on trying to correct. Most science Downloaded from www.sciencemag.org on December 2, 2010 gic areas” including electric cars, pacemak- P.h.D.-in-chief. Physicist Sérgio Rezende has kept still occurs in just three southern states, with ers, and genetically engineered crops. publishing while running Brazil’s science ministry. the University of São Paulo alone account- It’s too early to say if the government ing for nearly a quarter of all scientific publi- incentives are working; only a small number he wanted the MIT [Massachusetts Insti- cations. “One of the great questions we face of companies signed up for the tax breaks. tute of Technology] of Vale,” recalls Mello. is that Brazilian asymmetry, the inequality But U.S.-style, risk-taking innovation, once “I was being invited to lead something that of the regions,” says Lucia Melo, head of the viewed as alien, is increasingly seen in favor- would be a new Bell Labs or Xerox PARC.” Center for Strategic Studies and Manage- able terms. Venture capitalists have begun Mello traveled this fall to Silicon Valley ment in Science, Technology and Innova- setting up shop in Brazil, and in 2010 both to get ideas. Although Vale’s business is low- tion, a government science policy think tank IBM and General Electric announced plans tech, the commodity company, which ships in Brasília. for research centers in the country. vast amounts of ore to China and Europe, To push science out into Brazil’s neglected “We lack a culture of innovation and wants to spend heavily on research partly hinterlands, Brazil’s government has gone on entrepreneurship. There is a long path ahead because it faces a sharp shortage of skilled a binge of university construction and ear- to change that,” says Luiz Mello, a physi- labor, increasing pressure from environ- marked 30% of research funds for poor north- cian who last year was tapped by Brazil’s mentalists, and competition from global ern and western states. Under a 2009 program second largest company, the iron-ore miner companies. Vale’s three labs will work on called “Stipends for Everyone,” officials in Vale S.A., to spend $180 million establishing biodiversity, renewable energy, and mining Brasília said they would give study grants three new corporate science institutes. Mello technology. “This is the biggest spontaneous to all graduate students in distant regions, says he was hired after approaching Vale’s investment in R&D that I know of in Brazil,” regardless of academic merit. CEO, Roger Agnelli, to raise money for an says Mello. The idea flows from Brazil’s governing engineering program. “It turned out to be a The new laws also encourage Brazilian Workers’ Party, which has made improving meeting for him to say what he wanted. And universities to file patents and set up technol- conditions in poor areas a priority. A greatly expanded welfare program has helped move several million Brazilians out of poverty. It has given researchers breathing room, too. “Before, we’d face the question, ‘Why are you giving a monkey food and milk when there is a hungry child next door?’ ” says Cordeiro da Sousa, who is also a primate researcher. But she sees a tradeoff: Research- ers feel increasing pressure to spend time solving local problems. She’s considering CREDITS (TOP TO BOTTOM): GE GLOBAL RESEARCH; MCT creating a salt institute to support the local salt-mining industry. “You have to have a vocation, because in the future we could be called to answer in a big way.” Nowhere is the dearth of Brazilian-led sci- ence of greater concern than in the Amazon, the tropical forest that accounts for about 49% Tropical innovation. An architect’s rendering of Brazil’s territory but is home to only about of the General Electric global research center 3000 Ph.D. researchers, very few of whom do near Rio de Janeiro. The lab, when built, will bench science. “Imagine what a totally irrele- be GE’s fifth international R&D center. vant number that represents for this immense region,” says Odenildo Teixeira Sena, secre- 1310 3 DECEMBER 2010 VOL 330 SCIENCE www.sciencemag.org Published by AAAS
  • 6. tary of science and technology in the state of Amazonas. Although larger than France and Spain combined, Amazonas has only a single resident Ph.D. archaeologist, and despite its vast river systems, no naval engineers, Teix- eira says. Increasing scientific labor power in the region could help find alternatives to slash- and-burn agriculture. But national anxiet- ies figure into the calculation as well. “The majority of publications on the Amazon don’t have a Brazilian author. That is a worry for us,” says Jorge Guimarães, the Ministry of Education official who oversees higher edu- cation in Brazil. “We need more Brazilians participating.” Brazil has never felt secure in its control Downloaded from www.sciencemag.org on December 2, 2010 over the vast region, which Spain ceded to Portugal under the 1750 Treaty of Madrid. With the Amazon a focus of international Talented But Underfunded: Brazil’s Future Scientists maneuvering on carbon credits, Brazil’s dependence on foreign knowledge produc- It’s an unusual prelab routine. Wake up in a below-ground apartment where five people sleep tion has become a “very delicate question,” (four on the floor), grab your books, then head out past the machine gun–toting gangsters who says Adalberto Val, director of the Insti- guard your street against police vehicles. That’s been reality for 25-year-old Reinaldo Sousa dos tuto Nacional de Pesquisas da Amazônia in Santos, a Ph.D. candidate in biochemistry at the Federal University of Rio de Janeiro (UFRJ) and a Manaus. During a national science and tech- resident of Parque União, a crowded favela where residents live under the thumb of a drug gang. nology conference last May, Val called for Dos Santos owes his journey from shantytown to lab bench to his mentor, Leopoldo de Meis, a Brazilian “informational hegemony” over the 72-year-old professor of biochemistry at UFRJ. In 1985, de Meis began offering a hands-on sci- forest biome. “There is a question of national ence course for low-income adolescents called Young Talents. Dos Santos enrolled when he was sovereignty,” he says. 14, a year after his father died, leaving him orphaned. Such nationalist tones may sound harsh “I don’t want people to think I am the poor little kid from the favela,” says Dos Santos, a outside Brazil, but they play well at home. fast, concise talker who is studying the metabolic response of goldfish to low temperatures. Physicist Luiz Davidovich, who chaired the Although he may sleep some nights on the laboratory couch, “intellectually I don’t think I am May conference, says Brazil’s scientific com- below anyone.” munity needs to raise “big flags” to rally the Brazil must write thousands more stories like Dos Santos’s if it is to overcome deep social country around. “ ‘The Amazon is Ours’ is divisions and achieve its dream of becoming a major player in scientific research. Many say the one of those,” he says. task must begin with improving public schools, where poorly paid teachers offer rote lessons. Even some foreign experts have Brazil’s math and science scores vie for the worst among 57 countries ranked on the so-called responded to the call. Daniel Nepstad, a PISA scale by OECD, barely edging out Tunisia. College is mainly for the elite. Prestigious federal prominent American tropical forest ecolo- universities in Brazil offer free education, but it’s difficult to pass tough entrance exams unless gist, dropped his job in October at Woods families have paid for private secondary schools. “We have had a perverse system of social apart- Hole Research Center in Massachusetts heid, where the poor don’t have access to higher education,” says Luiz Davidovich, a physicist at to become a Brazilian resident and full- the university who sits on the board of the Brazilian Academy of Sciences. Only 14% of 18- to time employee of the Instituto de Pesquisa 24-year-olds are in college, not enough to meet Brazil’s growing demand for researchers and Ambiental da Amazônia, a nonprofit he engineers. “We’re working with just a sliver of the population,” Davidovich says. co-founded, based in the city of Belém. In recent years, the government has tried to broaden access to education. Scores of state Nepstad says his U.S. affiliation “was inter- technical schools have opened; since 1979, Brazil has hosted what is now billed as the world’s CREDIT: FLÁVIA MARTINS; (BACKGROUND IMAGE) GOOGLE MAPS preted that I am less committed to the scien- largest math olympiad. Another national program, ProUni, since 2005 has paid for 748,000 tific agenda in Brazil.” Brazil’s forest policy lower income students who can’t get into federal schools to attend private, for-profit universi- is evolving rapidly and, Nepstad says, “as ties. Davidovich says the efforts fall short: “Brazil needs a revolution in education at all levels, long as the science is led by Northerners, especially at the most basic levels.” we are missing the opportunity to get really Dos Santos recognizes that his life is exceptional. “Most Brazilians don’t know any scientists good information into policy decisions.” and don’t know what a scientist does,” he says. For him, science has proved both an intellectual and financial life belt. His state stipend of $1000 a month (he gets another $180 for supplies) Making it real makes him his family’s top earner, and this summer he helped his grandmother, uncle, and Despite its growing ambitions, Brazil has cousins move into a larger house. Now that he has his own room, he hopes to decorate it with a yet to prove it can do world-class basic metabolic chart like one he saw at a conference. research. The impact scores of its scien- “I like to see the molecule in vivo doing something,” says Dos Santos of his career choice. tific papers are modest, about two-thirds the “The lab is really a psychological escape from all the situations I live through. It’s my ideal place.” world average, and have slid in some areas. –A.R. No Brazilian has won a Nobel Prize in sci- www.sciencemag.org SCIENCE VOL 330 3 DECEMBER 2010 1311 Published by AAAS
  • 7. NEWSFOCUS Brazilian officials have instead focused on beating another problem: the insecurity of research funds. In 2008, in its largest- ever funding round for basic research, Bra- zil’s Ministry of Science and Technology offered $350 million over 3 years to fund 122 national institutes to tackle subjects from quantum computing and stem cells to an upgraded Antarctic research station. “They saw that we needed long-term programs with stability,” says Davidovich, who co-leads the program on quantum computing. Other scientists privately express doubts about the grandiosely named institutes, not- Missed opportunity? Many ing that in reality they are virtual networks researchers have published studies with an average of 20 university investigators involving the Amazon region; most each and money spread too thin to achieve Downloaded from www.sciencemag.org on December 2, 2010 are not Brazilian. much. In position papers, the Brazilian Soci- ety for the Advancement of Science has said ence or medicine, whereas regional rival has been trapped in customs for 4 months. that Brazil needs to focus on creating more Argentina has three. Researchers blame “You can have the best head in the world pure research jobs outside of the university structural problems at Brazil’s state-run and you will never be competitive because system. It wants a new, heavily staffed state universities. Critics say they discourage the government works against us,” says institute to study the oceans, and another for competition, for example, with automatic Bertolini. “When we begin thinking that way, the Amazon, modeled on the agricultural tenure after 3 years on the job and evalu- we want to go back.” agency Embrapa—in this case with funding ations that reward Portuguese-language Some say the prospects will remain bleak to match the grandiose vision. publication. “The attitude for many years until such problems are solved. “I know of In the city of Natal, Nicolelis’s neuro- was to avoid competition, keep your head no extraordinary science in Brazil,” says science institute, currently housed in a con- low, and choose a marginal subject,” says Andrew J. G. Simpson, scientific director of verted hotel, has also yet to produce a Bra- Ribeiro. Instead of competing head-to-head the Ludwig Institute for Cancer Research in zilian breakthrough. But it’s increasingly on hot topics with big labs overseas, he New York City. A naturalized Brazilian cit- well-positioned to do so. It has reasonably says, Brazilian researchers have sometimes izen, he lived in São Paulo for 7 years and equipped laboratories, a primate facility, and been content to study local questions. “The coordinated one of Brazil’s memorable tri- a crowd of young professors with promising thinking was, ‘The anteater is yours so don’t umphs, the sequencing of the plant patho- track records who have signed on, includ- worry about the gringos.’ ” gen Xylella fastidiosa, which landed on the ing two recruited from a Max Planck center Brazilian researchers returning from over- cover of Nature in 2000. But when Simpson in Germany. In August, the École Polytech- seas, drawn by jobs and start-up funds, com- returned this year for a 10th-year celebration nique Fédérale de Lausanne in Switzerland plain that there are still many obstacles that of the feat, he noticed that, at least in the field donated an IBM Blue Gene/L supercom- make producing world-class science nearly of genomics, “there was never again a big puter, which Nicolelis says will be the fastest impossible. After 11 years in the United impact paper. There was no upwards process. in South America. States, biologist Luciana Relly Bertolini It was a blip.” Ribeiro, the Brazilian who returned from returned to Brazil in 2006 with her a postdoc at Rockefeller to be the institute’s husband, Marcelo, to start a labo- scientific director, says the year of science ratory that aims to clone trans- he expected to lose while organizing the genic goats. Although the effort center has dragged into three, as he faced is adequately funded, Relly Ber- down customs officials and coped with tolini says a heavy teaching load large numbers of poorly trained students. CREDIT (TOP TO BOTTOM): WORLD WIND/NASA; PAULO BRANDO/IPAM required of professors and lack of “Now I’m finally starting to fight reviewers trained staff means “it’s science by again instead of bureaucrats, which is a sign persistence here.” the plan worked,” says Ribeiro, whose work Also notorious are Brazil’s includes experiments to look at the effect of Kafkaesque importation regula- sleep and dreaming on motor and percep- tions. Even simple reagents can tual skill retention. take months to arrive, with radio- The dirt road outside his building that active or biological samples often leads to a nearby shantytown, he says, in doubtful condition. Relly Ber- reminds him of a photograph he saw of Rock- tolini says a cell-fusion instru- efeller’s Founder’s Hall after it was built in ment she ordered from Hungary 1906 and still surrounded by muddy fields Returnee. Tropical ecologist Dan Neps- and horse-drawn carriages: “They didn’t start tad studies a controlled fire in Tanguro as the best place to do science either.” Forest, Mato Grosso, Brazil, in August. –ANTONIO REGALADO 1312 3 DECEMBER 2010 VOL 330 SCIENCE www.sciencemag.org Published by AAAS