Your microbiome your health
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Your body is home to three pounds of germs, a rich microbiome that weighs as much as your brain! Thanks to the recent plummeting cost of gene sequencing, scientists are just now discovering how important these microbes are to health and wellness, with surprising links to conditions ranging from obesity, autism, allergies, depression, and much more. We’ll discuss the latest developments, and show how new, low-cost testing kits can help you learn more about — and reshape — your own unique microbiome.
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Your microbiome your health
- 1. Your Microbiome, Your Health Richard Sprague April 29, 2015
- 2. Hello, I’m Richard Sprague
- 3. What is a human?
- 5. You Weight Human Non-Human Cells Human Non-Human Genes Human Non-Human 3 pounds
- 10. What they want
- 13. Who’s in charge?
- 14. Find which microbes you have
- 15. For hardcore experimenters • 25-35 week program • Weekly+ sampling • Detailed analysis • 16S (like uBiome) • Metagenomics (very expensive) Dynamics of the Human Microbiota
- 16. What’s in my microbiome?
- 22. 0 10000 20000 30000 40000 50000 60000 70000 May Jun Oct Jan Feb Bifidobacterium
- 23. Did it help my sleep?
- 25. Microbiome changes over time David et al: Host lifestyle affects human microbiota on daily timescales Genome Biology 2014, 15:R8
- 26. My microbiome through time 0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100% May-14 Jun-14 Oct-14 Jan-15 Feb-15 Actinobacteria Verrucomicrobia Proteobacteria Bacteroidetes Firmicutes 0% 10% 20% 30% 40% 50% 60% 70% May Jun Oct Jan Feb Bacteroidetes/Firmicutes
- 27. My Microbiome after travel
- 28. Microbiome of the mouth “treads the fine line between commensal and pathogen” Sophie C.H. Wen et al
- 29. “Good” or “Bad” ? Helicobacter pylori
- 30. Good or Bad? Streptococcus viridans
- 31. Obesity
- 32. Germophobia
- 33. Microbiome mania
Hinweis der Redaktion
- Ways to measure yourself
- http://creationrevolution.com/wp-content/uploads/2013/05/Charles-Darwin-tree-of-life-poster.jpg
- http://en.wikipedia.org/wiki/File:Tree_of_life_1500px_coloured.png
- Amato Pierre, et al http://femsec.oxfordjournals.org/content/59/2/242.long Deinococcus radiodurans http://en.wikipedia.org/wiki/Deinococcus_radiodurans Desulforudis audaxviator found 3 kilometers below the ground in South Africa http://www.newscientist.com/article/dn22612-worlds-loneliest-bug-turns-up-in-death-valley.html
- Dinan TG, et al., Collective unconscious: How gut microbes shape human behavior, Journal of Psychiatric Research (2015), http://dx.doi.org/10.1016/j.jpsychires.2015.02.021 80% of your receptors go to the gut Hungry? Who’s hungry?
- Toxoplasma gondii
- https://neurophilosophy.wordpress.com/2007/04/09/parasite-hijacks-the-mind-of-its-host/ http://aboutthebrain.tumblr.com/post/42010562290/you-may-have-it-and-not-even-know-a-parasite-that It’s not just a rat/cat thing. There is some evidence that infected humans tend to be sexually active.
- Each costs about $100 uBiome gives you results now in a few weeks (used to be months) uBiome gives you details about your own data, downloadable as JSON.
- uBiome helpfully offers this top-level summary of your test results.
- http://news.sciencemag.org/biology/2010/04/japanese-guts-are-made-sushi My gut has reasonably high numbers of this species, usually only found in Japanese, that lets me metabolize seaweed.
- http://blogs.scientificamerican.com/a-blog-around-the-clock/myths-about-myths-about-thanksgiving-turkey-making-you-sleepy/
- http://genomebiology.com/2014/15/7/R89#sec2
- But at least I have no streptococcus mutans, the one that causes tooth decay. People without H Pylori are far more likely to have had asthma as children.
- Causes ulcers, cancer But extremely common in humans, and appears to have co-evolved with us. Much more common in people without allergies.
- http://en.wikipedia.org/wiki/Viridans_streptococci [see Blaser p119] "live peacefully in everyone's mouth...a leading cause of heart valve infections...normal residents of the mouth, only occasionally entering the bloodstream and landing on a previously damaged valve....if we mix harmless Viridans with pathogenic Group A strep, viridans always win out. They knock back the strep."
- Methylisothiazolinone Sodium Lauryl Sulfate Triclosan Flouride
- http://i.imgur.com/WNkmN.jpg