1. Peripheral Neuropathy

2. Peripheral Neuropathy
 DEFINITION:
It is inflammation and degeneration of
the peripheral nerves and/or the
cranial nerves resulting in
impairment of the conductivity of
these nerves

3. Classification of Neuropathy
1- Mononeuropathy:
2- Mononeuropathy multiplex:
3- Polyneuropathy:

4.  CAUSES OF MONONEUROPATHY:
1- Trauma: wrong injection into a nerve,
callus compression.
2- Infective: leprosy, herpes zoster.
3- Vascular: polyarteritis nodosa.
4- Metabolic: diabetes mellilus.

5. CAUSES OF POLYNEUROPATHY
I-Heridofamilial:
1- Hypertrophic interstitial polyneuropathy.
2- Peroneal muscle atrophy.
3- Refsum's disease.

6. Clinical Picture of polyneuropathy
A- Motor:

7. B- Sensory:

8. Glove
Hypothesia
Stock

9. C-Autonomic:
 Vasomotor: coldness and cyanosis of
the limbs.
 Cutaneous: loss of hair, brittle nails,
trophic ulcers.

10. Specific Types of Polyneuropathy
I- PERONEAL MUSCLE ATROPHY

11. Peroneal muscle Atrophy
Inverted Champagne-bottle appearance

12. Diabetic Neuropathy
 Pathogenesis:
 Diabetic microangiopathy of the vasa
nervosa.
 Ischaemia of the nerves, 2ry to
atherosclerosis of the vasa nervosa.

13. Treatment of Diabetic Neuropathy
 Proper management of diabetes: diet,
oral hypoglycaemic drugs or insulin.
 VilaminsB1 100 mg daily, B6 200 mg
daily, B12 1000 mg daily.

14. Acute Infective Polyneuropathy
Landary-Guillan-Barre Syndrome
 Aetiology:
It is due to an allergic or auto-immune
reaction secondary to a previous non-
specific virus infection.

15. Clinical Picture
1-Febrile stage:
2-Latent stage:

16. 3-Paralytic stage:

17. PN Testing for
diagnosis
The EMG test itself:
 Nerve Conduction Studies (NCS)
 EMG (Needle portion)

20. Treatment of Guillain Barre Syndrome

21. Thank you