1. Published Clinical Studies of Anodyne® Therapy

3. www.rapidhealing.com.au Clinical Studies P < .0001 vs. Before Treatment Improvement in Loss of Protective Sensation (LOPS)

4. www.rapidhealing.com.au Clinical Studies Subjects with diabetic peripheral neuropathy type 1 diabetic patients Quantitative Monofilament LOPS - Insensate to 10 gram filament before MIRE ® 5.07 Monofilament Level sensed after treatment P < .0001 vs. Before Treatment 30 40 50 60 70 80 90 Age 3 4 5 6 7 Improvement in Sensation

5. www.rapidhealing.com.au Clinical Studies Subjects with diabetic peripheral neuropathy type 2 diabetic patients Improvement in Sensation SW Monofilament LOPS - Insensate to 10 gram filament before MIRE ® 5.07 Monofilament Level sensed after treatment P < .0001 vs. Before Treatment 30 40 50 60 70 80 90 Age 3 4 5 6 7

7. www.rapidhealing.com.au Clinical Studies Number of points sensate to 10 Gram (5.07) SWM of 5 tested 106% improvement in sensation with Anodyne® Therapy (placebo NS) P < 0.001 Improvement in Sensation

8. www.rapidhealing.com.au Clinical Studies Neuropathic pain – 45% reduction in pain levels (VAS 10 point pain scale) Neuropathic Pain Reduction P < 0.0001

9. www.rapidhealing.com.au Clinical Studies Balance/fear of falling – 70% reported improved balance Reduction in Fear of Falling/Balance Problems P < 0.0001

11. Patients with the following conditions included in the study: chronic tendonitis, capsulitis, TMJ, myofascial muscle spasm, post-operative pain www.rapidhealing.com.au Clinical Studies Even if placebo effect was 50%, reduction in pain was significant! Pain Reduction Outcomes

13. www.rapidhealing.com.au Clinical Studies *Patients with normal function in all three nerve groups: large and small myelinated and small unmyelinated 59.3% of subjects had normal sensory function after MIRE™ as measured by neurometer CPT sNCT Reduced Sensory Impairment

14. www.rapidhealing.com.au Clinical Studies As determined by neurometer CPT sNCT Changes in Impairment Severity Grade Profound Sensory Loss Moderate Very Mild Normal P < 0.0001

16. www.rapidhealing.com.au Clinical Studies Sensation, Gait and Balance Outcomes Average number sites sensing 5.07 monofilament of 3 sites tested Average gait and balance score (normal = 28) Total falls in 90 days P < .0001 vs. before treatment

17. www.rapidhealing.com.au Clinical Studies Mean Change 11.2 to 21.6 93% Average Tinetti Score Improvement

18. P < .0001 vs. before Tx www.rapidhealing.com.au Clinical Studies Number of Falls By Patient Before & After Treatment

20. www.rapidhealing.com.au Clinical Studies 79.5% reduction in diabetic ulcer incidence in senior DPN patients Reduced Diabetic Ulcer Incidence

21. www.rapidhealing.com.au Clinical Studies 100% reduction in non-healing wounds – previous studies show < 33% of diabetic ulcers heal within 20 weeks Reduced Non-Healing Wounds (Diabetic Ulcers)

23. www.rapidhealing.com.au Clinical Studies 366% improvement in sensation to 10 gram monofilament Improvement in Sensation

24. www.rapidhealing.com.au Clinical Studies Mean sites sensate to 5.07 SWM Improvement in Sensation

25. www.rapidhealing.com.au Clinical Studies Pain Reduction (VAS Scale)

26. www.rapidhealing.com.au Clinical Studies Gait and Balance Improvement (Tinetti Scores) Mod Low >24 <19 High Fall Risk

31. www.rapidhealing.com.au Clinical Studies Outcomes After 90 Days of MIRE™ Use 90 Day Study - Conducted at Joslin Diabetes Center