Migrane

Serotonin or 5-hydroxytryptamine ,[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

N C N C NH 2 COOH COOH NH 2 OH N C NH 2 OH H Tryptophan 5-Hydroxytryptophan 5-Hydroxytryptamine N C COOH 5-OH Indole Acetaldehyde 5-Hydroxy Indole Acetic Acid Tryptophan hydroxylase 5-OH Tryptophan decarboxylase MAO Aldehyde dehydrogenase (Rate limiting) In diet. Active CNS transport www.freelivedoctor.com

Synthesis and Metabolism ,[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Interference with the system ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Non-selective www.freelivedoctor.com

Serotonin Receptors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Endogenous Function ,[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Serotonin Pharmacological Effects ,[object Object],[object Object],[object Object],www.freelivedoctor.com

[object Object],[object Object],[object Object],[object Object],[object Object],Serotonin Pharmacological Effects -2 www.freelivedoctor.com

[object Object],[object Object],[object Object],[object Object],Serotonin in the Central Nervous System www.freelivedoctor.com

Migraine ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Migraine: Drug Treatment ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Migraine: Prophylaxis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Serotonin in Migraine ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Unknown Trigger Activation antidromic Orthodromic conduction Trigeminal neuron Inhibitory receptor (5-HT1D) Mast cell PAIN Cortex Thalamus Trigem. Nucleus caudalis Blood Vessel nausea autonomic www.freelivedoctor.com

Serotonin Agonists ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Serotonin Antagonists ,[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Migrane

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