![Ch 5: Membrane Dynamics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]](data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7)
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- 5. Cell Membrane Structure: Fluid Mosaic Model Thickness ~ 8nm PLs Cholesterol Proteins: peripheral (associated) or integral
- 11. Membrane Spanning Protein Fig 5-5
- 12. Cytoskeleton Proteins anchor membrane proteins
- 15. Fick’s law of Diffusion (p 135) surface area x conc. gradient membrane resistance x membrane thickness rate of diffusion = depends on size and lipid-solubility of molecule and composition of lipid bilayer
- 16. Membrane Proteins Fig 5-7
- 26. Mechanism of the Na + /K + -ATPase Fig 5-17 start
- 29. Body Fluid Compartments: Critical Thinking Question What properties should a molecule have to be used as marker for one of the fluid compartments? Do total H 2 O; total EC and plasma. Then, how do you figure out ICF and interstitial fluid? ECF ICF
- 30. Competition and Saturation Glucose and fructose use same transport protein Saturation of carrier mediated transport: Fig 5-18 Fig 20
- 31. Table 5-4
- 35. Receptor Mediated Endocytosis and Membrane Recycling Fig 5-28
- 36. 3. Exocytosis Intracellular vesicle fuses with membrane Requires energy (ATP) and Ca 2+ Examples: large lipophobic molecule secretion; receptor insertion; waste removal
- 41. Distribution of Solutes in Body Fluid Compartments Compare to Fig 5-33
- 47. Osmolarity and Tonicity Comparison Compare to Fig 5-35 A is isosmotic to B A is hypotonic to B
- 49. the end Electrical Disequilibrium and Resting Membrane Potential (pp.156-163) will be covered at the beginning of Ch 8
Hinweis der Redaktion
- Familial Hypercholesterolemia is an autosomal dominate disease which occurs about 1 in every 500 people . The homozygous FH is more rare, occuring with the frequency of about 1 in a million. The statistics for the homozygous FH is not surprising though, since patients suffering from two alleles of this gene usually do not survive pass their teens. The condition of hypercholesterolemia in FH patients are detectable at birth or shortly thereafter. The cholesterol levels in heterozygous patients are between350 to 500 mg/dL, and in homozygous, the levels are between 700 to 1,200 mg/dL (see NCEP table for comparison).
- large lipophobic molecule secretion: mucus and protein hormones
- Ouabain = Na + /K + -ATPase inhibitor – cannot penetrate through cell membrane.
- Is osmosis the same as the diffusion of water? Almost but not exactly. -volume change Force (such as pressure) can oppose osmosis not diffusion
- NaCl is considered to be functionally nonpenetrating, as it gets pumped out of cell as soon as it enters.
- A
- A
- B
- D
- A