4. WHAT CONTROLS YOUR BLOOD SUGAR?
When we eat …blood sugar (Glucose)
increases
This stimulates insulin secretion
Insulin moves the glucose out of the
Blood Cells
5. GLUCOSE :FACTS
Carbohydrates (Glucose) are the main
calorie source for our body
Extra CHO are stored as:
Glycogen (liver and muscles)
OR
Fat (Adipose tissue)
6. GLUCOSE :FACTS
The brain relies almost exclusively on
glucose as a fuel, but cannot synthesize or
store it
Adequate uptake of glucose from the
plasma is essential for normal brain function
and survival
8. GLUCOSE :FACTS
In case of CHO shortage ( ex: Starvation)
OR
Unable to use CHO ( ex: No insulin as in
DKA)
Body shifts gear to other sources of energy
9. GLUCOSE :FACTS
Other sources of energy …
Protein breakdown to amino acids
and glucose synthesis
Fat breakdown into FFA and
ketones formation (with acidosis)..
Minimal amount of Insulin can prevent Ketogenesis
10. WHAT CONTROLS YOUR BLOOD SUGAR?
-Insulin …Lowers
-Glucagon…Increases
-Other hormones
Amount of CHO load
Physical activity
Stress factors
Counter Regulatory Hormones
11. HYPERGLYCEMIA
Hyperglycemia basic processes are :
1-Impaired/decreased glucose use
2-Increased gluconeogenesis
(Make up of glucose from other sources)
3-Increased glycogenolysis
(breakdown of Glycogen to Glucose )
12. HYPERGLYCEMIA
Due to variable reasons…
Insulin deficiency (Absolute / Relative)
Insulin Resistance
Excess counter regulatory hormones
(Glucagon, Cortisol…)
Defected secretion of GLP-1…
14. VS
Type 1DM
Immune system stops
insulin from being made
All ages :
More in younger
age groups
Type 2 DM
-Not enough insulin
-Insulin resistance)
Combination of the two
Alpha cell defect
Others: GLP-1 , SGLT2
Affects older age group
Can affect children
15. VS
Treatment ?
Type 1 DM
The insulin must be replaced
By injection or continuous infusion
Type 2 DM
Lifestyle changes (TLC)
Medications : tablets and/or Insulin
16. DIABETIC HYPERGLYCEMIC CRISES
Diabetic Ketoacidosis
(DKA)
Hyperglycemic
Hyperosmolar State (HHS)
Younger, type 1 diabetes Older, type 2 diabetes
No hyperosmolality Hyperosmolality
Volume depletion Volume depletion
Electrolyte disturbances Electrolyte disturbances
Acidosis No acidosis
17. DIABETIC KETOACIDOSIS (DKA)
PATHOPHYSIOLOGY
Unchecked gluconeogenesis Hyperglycemia
Osmotic diuresis Dehydration
Unchecked ketogenesis Ketosis
Dissociation of ketone bodies
into hydrogen ion and anions
Acidosis
Anion-gap metabolic
17
Often a precipitating event is identified
(infection, lack of insulin administration)
18. HYPEROSMOLAR HYPERGLYCEMIC STATE
(HHS) PATHOPHYSIOLOGY
Unchecked gluconeogenesis Hyperglycemia
Osmotic diuresis Dehydration
• Presents commonly with renal failure
• Insufficient insulin for prevention of hyperglycemia but
sufficient insulin for suppression of lipolysis and ketogenesis
• Absence of significant acidosis
• Often identifiable precipitating event (infection, MI)
Major body water loss
DKA 5-7 L
HHS 8- 10 L
23. HYPERGLYCEMIA
WHAT IS DKA?
Severe hyperglycemia ; 250-300 mg/dl
Ketonemia : ketone bodies in the blood
(β-OH-butyric acid, Acetoacetic acid and Acetone)
Acidosis: PH <7.3
= Lack of insulin
24. Hyperglycemia
Ketosis
Acidosis
Adapted from Kitabchi AE, Fisher JN. Diabetes Mellitus. In: Glew RA, Peters SP, ed. Clinical
Studies in Medical Biochemistry. New York, NY: Oxford University Press; 1987:105.
DKA : DEFINITION
27. HYPERGLYCEMIA
DKA
Signs of DKA include:
Kussmaul respirations : Heavy, deep breathing
Fruity breath – the smell of ketoacid
Tachycardia
Supine hypotension,
Orthostatic drop of BP (feel dizzy when standing)
Dry mucous membranes Poor skin turgor
Confusion /Unconsciousness
28. HYPERGLYCEMIA
DKA
Inadequate insulin …
Fat comes out of fat cells (Free Fatty Acids)….
Free Fatty Acids >> Liver (Mitochondria/ Glucagon)
Used as an alternative energy source
Makes ketoacids ( ketones) out of the fat
33. HYPERGLYCEMIC CRISIS
DKA & HHS
• LIFE THREATENING EMERGENCIES
• DKA …MOSTLY TYPE 1 –YOUNG
INSULIN DEFICIENCY -ACIDOSIS
• HHS….TYPE 2 DM –OLDER
WORSE DEGREE OF DEHYDRATION
• BOTH: SIMILAR PRECIPITATING FACTORS
ELECTROLYTES DISTURBANCES
34. DKA VS HHS
Diabetic Ketoacidosis
(DKA)
Hyperglycemic
Hyperosmolar State (HHS)
Absolute (or near-absolute)
insulin deficiency, resulting in
• Severe hyperglycemia
• Ketone body production
• Systemic acidosis
Severe relative insulin deficiency,
resulting in
• Profound hyperglycemia and
hyperosmolality (from urinary
free water losses)
• No significant ketone
production or acidosis
Develops over hours to 1-2 days Develops over days to weeks
Most common in type 1 diabetes,
but increasingly seen in type 2
diabetes
Typically presents in type 2 or
previously unrecognized
diabetes
Higher mortality rate
35. DKA & HHS
• EARLY AGGRESSIVE MANAGEMENT
• HYDRATION
• INSULIN
• ELECTROLYTES DISTURBANCES RX
• LOOK FOR PRECIPITATING FACTORS :
TREAT AND TEACH TO AVOID ..IF POSSIBLE
35
36. PREDISCHARGE CHECKLIST
• EDUCATION
• DIET INFORMATION
• TREATMENT GOALS
• “SURVIVAL SKILLS” TRAINING
• “MEDIC-ALERT” BRACELET
• PROVIDE :
GLUCOSE MONITOR AND STRIPS
MEDICATIONS, INSULIN, NEEDLES
• CONTACT PHONE NUMBERS