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Signal Transduction Powerpoint
1.
My Dog is
Broken! A Case Study in Cell Signaling. By: Philip Wang and Emad Madha
2.
3.
Guanylyl Cyclase is
activated and GTP produces cGMP.
4.
cGMP binds to
a regulatory subunit (PKG) and activates it.
5.
The activated PKG
uses ATP and proteins to create phospho-proteins.
6.
The phospho-proteins help
lower the concentration of calcium ions in the cell.
7.
This decrease of
calcium ions causes the smooth muscle cells in the penis to relax, letting blood flow into the penis.
8.
9.
Since nitric oxide
is the first messenger, having ginseng would help increase the nitric oxide available for use.
10.
This would lead
to an increase of cGMP being activated, which would lead to an increase of PKG being activated.
11.
The increase of
active PKG would decrease even more calcium ions, which would lead to relaxation of the smooth muscle cells.
12.
13.
Phosphodiesterase normally accepts
cGMP and breaks it down as a regulator for this pathway.
14.
PDE5 inhibitors prevent
phosphodiesterase from breaking down cGMP
15.
This results in
an increase in cGMP, which would result in an increase of PKG
16.
Calcium ion levels
would decrease and the smooth muscle cells would relax.
17.
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