The document discusses neural correlates of empathy, trust, and bonding. It explains that the "resonance circuitry" in the medial frontal cortex is involved in these processes. It also describes how the principle of "what fires together, wires together" explains how new neural connections are formed through coactivation of cells. Dopamine is discussed as playing a key role by modulating attention and memory through expectations and context, and by regulating synaptic strengthening according to Hebb's principle. Dopamine levels rise when expectations are exceeded and fall when expectations are not met.

1. Empathy, trust, bonding, etc. Neural correlates ? -”Resonance” circuitry (Siegel et al.)‏ Why does it seem to be essential to recovery ? -”What fires together, wires together” How does it work ? -expectations modulate dopamine which modulates attention -role of context on memory retrieval & consolidation http://brainsci-rehab-discussion.net

3. Daniel J. Siegel M.D. http://www.jibc.ca/cccs/video/danSiegal.htm “ Resonance Circuits” involving medial frontal cortex

4. According to the principle “ what fires together, wires together " Hebb (1949) postulated a simple synaptic mechanism how new cell assemblies can be formed by groups of cells that are often coactivated: Hebb's synaptic learning rule prescribes a strengthening of synapses between coactivated cells (by some metabolic or structural changes). Why is empathy (attunement etc.) so important for recovery ?

5. Dopamine = “synaptic juice” = “social juice” = “rehabilitative juice” Evidence from Hyperscanning

8. What is TRUST ? If I repeatedly give you more than you expect, then Dopamine levels RISE If I repeatedly give you less than you expect, then Dopamine levels FALL Dopamine is also a key regulator of synaptic strengthening (Hebb's principle)‏ Dopamine = “synaptic juice” = “social juice” = “rehabilitative juice” DOPAMINE

9. DA serves as ‘gain’ control to support its role in learning and inhibition -80 -50 DRD2 activation suppresses Cells in the resting state DRD1 activation excites Cells in the -50 mV state Coincident inputs Will drive a cell from -50 - -80 mV ACTION POTENTIALS & SYNAPTIC PLASTICITY MS spine Glu- PFC DA