2. Executive Summary
The raw material for blood plasma industry is the straw colored liquid that is a component of blood called blood plasma. It consists mostly of
water and a small amount of proteins and antibodies. Those proteins are used to produce medicines, which are extracted to produce the end
products for treatment that helps people with a variety of life-threatening diseases, illnesses and conditions. These plasma-derived
medications are the standard course of treatment for thousands of people, in more than 100 countries across the globe, who need the
treatment to improve their health and lead productive lives.
The global blood plasma market has historically grown at a mid-single digit rate up till now. Currently the US is the largest market, and the
most profitable, as prices enjoy a significant premium over the other countries compared to Europe. China is now the largest consumer of
albumin globally and continues to grow rapidly.
The key trends observed in the market include strong and stable pricing power in immunoglobulin market, rapidly growing SCIG market and
capacity expansion by commercial fractionators. But there are certain challenges too which include competition from recombinant FVIII and
pricing pressure in tenders in plasma-derived FVIII market as well as potential threats to immunoglobulin market. The market’s main growth
drivers include immunoglobulin segment, albumin market growth in China, new indications, an ageing population as well as growth in plasma
collections in the US.
The report provides a comprehensive study of blood plasma market globally. The industry is quite concentrated with a few large players such
as Baxter, Grifols, CSL and Octapharma. All these companies have been profiled in the present report highlighting their key financials and
business strategies for growth.
By combining SPSS Inc.’s data integration and analysis capabilities with our relevant findings, we have predicted the future growth of the
industry. We employed various significant variables that have an impact on this industry and created regression models with SPSS Base to
determine the future direction of the industry. Before deploying the regression model, the relationship between several independent or
predictor variables and the dependent variable was analyzed using standard SPSS output, including charts, tables and tests.
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3. The big three of global plasma market, Baxter, Grifols and CSL.
Demand for plasma derived products is driven by new indications,
higher penetration of existing indications and better access to
medicines in emerging markets, an ageing population and new
plasma derived therapies. The blood plasma market is estimated
to be US$... billion in 2014, a growth of US$... million from
previous year.
From product point of view, the main products are immunoglobulin
(IG) with estimated …% of market share, followed by albumin and
factor VIII (FVIII) with …% and …% of global blood plasma market
share in 2014. Rest …% of the market share includes proteins like
factor IX, hyper immunoglobulin and fibrin glue among others.
In accordance with 2014 estimates, CSL has the ideal profile
among plasma firms hence lead the industry with global blood
plasma market share of …% immediately followed by Baxter with
…% of the market share. Grifols and Octapharma are estimated
to have ..% and …% of the market share respectively in 2014.
Global Blood Plasma Market by Product Type (2014E)
Global Blood Plasma Market Value (2010-2014E)
Global Blood Plasma Market Share by Company (2014)
2010 2011 2012 2013 2014E
US$Billion
Immunoglobulin Albumin Factor VIII A1PI Others
CSL Baxter Grifols Octapharma Biotest
Kedrion Sanquin BPL Others
4. The US market is estimated to account for 51% of the global immunoglobulin market.
The global immunoglobulin market is estimated to be
US$... billion in 2014, with growth of …% from previous
year, primarily due to improved diagnosis and more off-
label indications. Immunoglobulin market growth is
expected at a CAGR of …% from 2013 to 2018.
By region, the largest share of immunoglobulin market
volume of …% is in North America, US in particular, as
per 2014 estimates immediately followed by Europe with
…% of market volume share.
In 2014, global immunoglobulin market was dominated
by CSL and Grifols with …% and …% of market share
respectively due to each ones higher capacity to serve
the increased demand for immunoglobulin products. In
contrast, Baxter has market share of …% due to weak
2014 year and lower ability to expand capacity as per the
requirement.
Global Immunoglobulin Market Volume Share by Region (2014E)
Global Immunoglobulin Market Value (2013-2018E)
Global Immunoglobulin Market Share by Company (2014)
0%
1%
2%
3%
4%
5%
6%
7%
8%
9%
10%
0
2
4
6
8
10
12
2013 2014E 2015E 2016E 2017E 2018E
US$Billion
Market Size Growth (%)
North America Europe R.O.W
CSL Grifols Baxter Octapharma Biotest LFP Others
5. Albumin is the only plasma-derived protein that international producers are allowed to import into China.
The albumin market is estimated to be of worth US$...
million in 2014, a growth of …% form previous year. The
market is estimated to grow at a CAGR of …% from 2013
to 2018 due to steady and strong demand in Asia,
developed markets and double-digit growth in China, even
if prices remain flat.
The US and European demand for albumin is robust as its
consumption continues to grow at a solid pace in these
regions supported by the on-going trend away from
hydroxethyl starches (HES), following the revised safety
warnings.
CSL, largely due to entering the Chinese market before its
competitors, has the largest share of the international
fractionators i.e. …% coupled with accelerated albumin
sales, particularly in China in 2014. However, Grifols and
Baxter manage to capture …% and …% of market share
respectively as per 2014 estimates.
Global Albumin Market Volume Share by Region (2014E)
Global Albumin Market Value (2013-2018E)
Global Albumin Market Share by Company (2014E)
0%
2%
4%
6%
8%
10%
12%
14%
16%
18%
20%
0
500
1,000
1,500
2,000
2,500
3,000
3,500
4,000
4,500
5,000
2013 2014E 2015E 2016E 2017E 2018E
US$Million
Albumin Market Growth (%)
Europe North America R.O.W
CSL Grifols Baxter Others
6. Major players in this industry are increasing capacity to meet future demands of blood plasma product.
• The global blood plasma market is forecasted to reach value of US$... billion by 2015, an increase of …% versus prior year. For the next four years,
the market is forecasted to grow at CAGR of …% from 2015 to 2018. It is expected that continued strong demand for albumin in Asia and higher
volume immunoglobulin use in developed countries will drive plasma market growth.
• Albumin has been a key driver of the plasma market over the last two years for two key reasons. Firstly, strong demand from China (at nearly a 100%
price premium over European prices), and secondly, security warnings in Europe related to solutions containing HES (also used to expand plasma
volumes, one of the indications of albumin). It is estimated that China buys about half of its albumin needs abroad, and the Chinese albumin market is
growing at a rate of …%, making it the second-largest market in the world after the US, with … tons. Thus, China acts as a future growth driver for the
albumin market.
• The US is the largest market of plasma collection, with three big players CSL, Grifols and Baxter, acting as growth driver of the blood plasma industry.
Plasma collections growth confirms limited supply risk with significant fractionation capacity expansion under way. The US plasma collection reported
until 2013 was … million liters and is estimated to have reached … million liters in 2014. The donors are paid for their time in plasma collection for
US$30 on an average for 75 minutes.
Global Blood Plasma Market Forecast (2013-2018F)
0%
2%
4%
6%
8%
10%
12%
0
5
10
15
20
25
2013 2014 2015F 2016F 2017F 2018F
US$Billion
Market Size Growth (%)
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