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GLOBAL PHARMACEUTICAL MARKET
1. Growing at a CAGR of around 8%, the global pharmaceutical market is
   forecasted to reach US$ 1043.4 Billion in 2012.
2. North America remains the largest pharmaceutical market constituting 42.8% of
   the global sales in 2007. Growth in the region is however expected to slow down
   in near future owing to patent expiration of key drugs and increased prevalence of
   generics.
3. In Europe, growth in the top five markets is expected to remain sluggish in next
   five years. Emerging markets in Central and Eastern Europe is however expected
   to drive growth in future.
4. A large untapped population and strong economic growth in major countries is
                                                                                        “
                                                                                        “The global
                                                                                        pharmaceutical
                                                                                        market value is
                                                                                        expected to expand
   expected to make Asia-Pacific the most lucrative pharmaceutical market in
   future.                                                                              over $1.1 trillion
5. Growth in the Latin American markets is expected to be strong with Brazil and        USD by 2014,”
   Mexico amongst the most emerging pharmaceutical markets in the world.
6. Dwindling drug pipelines and patent expiration of a number of blockbuster drugs
   may challenge the growth of global pharmaceutical market in future.
                                                                                                             ”
Diabetes , is a group of metabolic diseases in which
a person has high blood sugar, either because the body
does
not produce enough insulin, or because cells do not
respond
to the insulin that is produced.
There are three main types of diabetes:

Type 1 diabetes: results from the body's failure to produce
insulin, and presently requires the person to inject insulin. {OR
insulin-dependent diabetes mellitus, (IDDM )} & juvenile
diabetes.)

Type 2 diabetes: results from insulin resistance, a condition in
which cells fail to use insulin properly, sometimes combined
with an absolute insulin deficiency. {OR non-insulin-dependent
diabetes mellitus, NIDDM)} & adult-onset diabetes.)

Gestational diabetes: is when pregnant women, who have
never had diabetes before, have a high blood glucose level
during pregnancy. It may precede development of type 2 DM.
GLOBAL DIABETES
             POPULATION
Globally as of 2010 it is estimated that there are 285
million people diabetes with type 2 making up about 90%
of the cases.



• it is estimated that by 2030, this number will almost
   double.
•It is more common (especially type 2) in the more
 developed countries.
• it is expected that in Asia and Africa, where most
  patients will probably be found by 2030.
•The increase in incidence of diabetes in developing
  countries follows the trend of urbanization and lifestyle
  changes, perhaps most importantly a "Western-style“
  diet.
PREVALENCE OF DIABETES COUNTRY WISE
GLOBAL DIABETES MARKET


 The global market for products in the management of
diabetes currently stands at $41 billion and is on pace to
grow to over $114 billion by 2018.


 Oral anti-diabetics were the leading category of drugs
in 2010 and showed a growth rate of 6.3% from the total
global sales.


The total sales for insulin products increased significantly
as well.
Global Diabetes Market Trends & Future Forecast


 USA controls more than 50% of the total Diabetes Drug market
  share in 2009.
 • Global Insulin Market is estimated to reach around US$ 17 Billion
  by 2013.
 • China will have the second highest Insulin market share by 2012
  replacing Germany.
 • DPP-IV Inhibitors is predicted to be more than US$ 5 Billion
  market by 2015.
 • LP-1 Agonists, market is forecasted to cross US$ 6 Billion mark
  by 2015 .
 • Novorapid is the blockbuster Insulin of Novo Nordisk it is
  expected to cross US$ 3 Billion by 2015.
Global Diabetes Market Trends & Future Forecast

 • Yet to launched Degludec and Degludec Plus is expected to be
  blockbuster Insulin and cross US$ 4 Billion and US$ 6
  Billion respectively by 2030.
 • Januvia is proving a blockbuster of DPP – IV Inhibitors segment
  expected to be more than US$ 4 Billion by 2017 .
 •Last year launched Victoza and yet to be launched Exenatide
  LAR is going to be blockbuster GLP-1 Agonists .
 • China diabetes drug market has crossed the figure of Yuan 10
  Billion by 2009.
 • Japan Insulin market is expected to be more than US$ 1 Billion
  by 2010.
Global DIABETES TOP PLAYERS
PRODUCTS STRONG IN DIABETES
MARKET

Anti-diabetic products include glucose meters, lancets, test strips,
 continuous blood glucose meters, insulin, insulin pumps, syringes
 and other insulin delivery devices and anti-diabetic drugs.


The bulk of product revenues come from three segments - test
 strips, insulin and anti-diabetic drugs - which will remain the
 largest sources of product revenues over the next ten years.


The most significant growth, however, will come from the nascent
 segment of continuous blood glucose monitors, which provide
 significantly added clinical benefit at only a modestly higher cost
 compared to standard blood glucose meters.
NEW MOLECULES DEVELOPING FOR
DIABETES

University of Technology, Sydney. UTS researchers have
 identified molecules secreted by a parasitic worm that prevent
the development of Type 1 diabetes in mice.
A commercial version of the product is currently being
 developed for use in humans.

Researchers at the Stanford University School of Medicine
have identified a key molecular pathway responsible for the
natural decrease in the proliferation of insulin-producing cells
that occurs as a person ages. Artificially activating this
pathway, which is normally not functional in adults, may be a
new way to combat diabetes.
INDIAN DIABETES MARKET

With around 51 million diabetic patients, India promises to be
amongst the most lucrative diabetes markets in the world. In
2009, the total sales of insulin and non-insulin anti-diabetics
reached $424 million, according to the findings of a news report
added to the offering of Research and Markets.


                                         REPORT HIGHLIGHTS

• A growing drug treated population coupled with the launch of
  several new drugs will drive the Indian diabetes market to $1.4
  billion by 2015.
• In 2009, the market for non-insulin anti-diabetics was worth $306
  million. This represented a highly fragmented market with domestic

  diabetes care firm USV being the leading player with a 14% share.
• USV’s Glycomet GP (glimepiride+metformin) was the leading
drug
 in the non-insulin anti-diabetics market with sales worth nearly
INDIAN DIABETES MARKET

•The authors expect around 15 new drugs to be launched in the
 non-insulin anti-diabetics market in the next five years. Seven of
 them are expected to be in the DPP-IV inhibitor and GLP-1 agonist
 classes.

• The insulin market was worth $117 million in 2009. US health care
  major Abbott Laboratories was India's biggest player accounting
  for 61% of the total sales.

• Sanofi-Aventis’ Lantus (insulin glargine) represented one of the
  fastest growing drugs in the last five year and registered sales worth
  nearly $11 million in 2009

• The total number of diabetes patients in India is expected to reach
  87 million by 2030. Around 56% of these patients will be from
  urban regions of the country.
INDIAN DIABETES TOP PLAYERS
THE INDIAN MARKET
                                 OPPORTUNITY




•World’s largest diabetes patient pool
•Success of newly launched drugs
•Increasing diagnosis and drug treated rates
•A rapidly growing market

In 2010, total sales of insulin and oral anti-diabetics in India
reached INR 28 billion, of which, the market for oral anti-
diabetics was worth INR 17 billion**. With the number of
diabetics increasing, the market, over the next five years, will
be driven by the strong uptake of insulin analogs.

Januvia is proving a blockbuster of DPP – IV Inhibitors segment
 expected to be more than US$ 4 Billion by 2017 (GLOBALLY)

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Pharmaceutical market and Diabetes market worldwide.

  • 1. GLOBAL PHARMACEUTICAL MARKET 1. Growing at a CAGR of around 8%, the global pharmaceutical market is forecasted to reach US$ 1043.4 Billion in 2012. 2. North America remains the largest pharmaceutical market constituting 42.8% of the global sales in 2007. Growth in the region is however expected to slow down in near future owing to patent expiration of key drugs and increased prevalence of generics. 3. In Europe, growth in the top five markets is expected to remain sluggish in next five years. Emerging markets in Central and Eastern Europe is however expected to drive growth in future. 4. A large untapped population and strong economic growth in major countries is “ “The global pharmaceutical market value is expected to expand expected to make Asia-Pacific the most lucrative pharmaceutical market in future. over $1.1 trillion 5. Growth in the Latin American markets is expected to be strong with Brazil and USD by 2014,” Mexico amongst the most emerging pharmaceutical markets in the world. 6. Dwindling drug pipelines and patent expiration of a number of blockbuster drugs may challenge the growth of global pharmaceutical market in future. ”
  • 2.
  • 3. Diabetes , is a group of metabolic diseases in which a person has high blood sugar, either because the body does not produce enough insulin, or because cells do not respond to the insulin that is produced. There are three main types of diabetes: Type 1 diabetes: results from the body's failure to produce insulin, and presently requires the person to inject insulin. {OR insulin-dependent diabetes mellitus, (IDDM )} & juvenile diabetes.) Type 2 diabetes: results from insulin resistance, a condition in which cells fail to use insulin properly, sometimes combined with an absolute insulin deficiency. {OR non-insulin-dependent diabetes mellitus, NIDDM)} & adult-onset diabetes.) Gestational diabetes: is when pregnant women, who have never had diabetes before, have a high blood glucose level during pregnancy. It may precede development of type 2 DM.
  • 4. GLOBAL DIABETES POPULATION Globally as of 2010 it is estimated that there are 285 million people diabetes with type 2 making up about 90% of the cases. • it is estimated that by 2030, this number will almost double. •It is more common (especially type 2) in the more developed countries. • it is expected that in Asia and Africa, where most patients will probably be found by 2030. •The increase in incidence of diabetes in developing countries follows the trend of urbanization and lifestyle changes, perhaps most importantly a "Western-style“ diet.
  • 5. PREVALENCE OF DIABETES COUNTRY WISE
  • 6. GLOBAL DIABETES MARKET  The global market for products in the management of diabetes currently stands at $41 billion and is on pace to grow to over $114 billion by 2018.  Oral anti-diabetics were the leading category of drugs in 2010 and showed a growth rate of 6.3% from the total global sales. The total sales for insulin products increased significantly as well.
  • 7. Global Diabetes Market Trends & Future Forecast USA controls more than 50% of the total Diabetes Drug market share in 2009. • Global Insulin Market is estimated to reach around US$ 17 Billion by 2013. • China will have the second highest Insulin market share by 2012 replacing Germany. • DPP-IV Inhibitors is predicted to be more than US$ 5 Billion market by 2015. • LP-1 Agonists, market is forecasted to cross US$ 6 Billion mark by 2015 . • Novorapid is the blockbuster Insulin of Novo Nordisk it is expected to cross US$ 3 Billion by 2015.
  • 8. Global Diabetes Market Trends & Future Forecast • Yet to launched Degludec and Degludec Plus is expected to be blockbuster Insulin and cross US$ 4 Billion and US$ 6 Billion respectively by 2030. • Januvia is proving a blockbuster of DPP – IV Inhibitors segment expected to be more than US$ 4 Billion by 2017 . •Last year launched Victoza and yet to be launched Exenatide LAR is going to be blockbuster GLP-1 Agonists . • China diabetes drug market has crossed the figure of Yuan 10 Billion by 2009. • Japan Insulin market is expected to be more than US$ 1 Billion by 2010.
  • 10. PRODUCTS STRONG IN DIABETES MARKET Anti-diabetic products include glucose meters, lancets, test strips, continuous blood glucose meters, insulin, insulin pumps, syringes and other insulin delivery devices and anti-diabetic drugs. The bulk of product revenues come from three segments - test strips, insulin and anti-diabetic drugs - which will remain the largest sources of product revenues over the next ten years. The most significant growth, however, will come from the nascent segment of continuous blood glucose monitors, which provide significantly added clinical benefit at only a modestly higher cost compared to standard blood glucose meters.
  • 11. NEW MOLECULES DEVELOPING FOR DIABETES University of Technology, Sydney. UTS researchers have identified molecules secreted by a parasitic worm that prevent the development of Type 1 diabetes in mice. A commercial version of the product is currently being developed for use in humans. Researchers at the Stanford University School of Medicine have identified a key molecular pathway responsible for the natural decrease in the proliferation of insulin-producing cells that occurs as a person ages. Artificially activating this pathway, which is normally not functional in adults, may be a new way to combat diabetes.
  • 12. INDIAN DIABETES MARKET With around 51 million diabetic patients, India promises to be amongst the most lucrative diabetes markets in the world. In 2009, the total sales of insulin and non-insulin anti-diabetics reached $424 million, according to the findings of a news report added to the offering of Research and Markets. REPORT HIGHLIGHTS • A growing drug treated population coupled with the launch of several new drugs will drive the Indian diabetes market to $1.4 billion by 2015. • In 2009, the market for non-insulin anti-diabetics was worth $306 million. This represented a highly fragmented market with domestic diabetes care firm USV being the leading player with a 14% share. • USV’s Glycomet GP (glimepiride+metformin) was the leading drug in the non-insulin anti-diabetics market with sales worth nearly
  • 13. INDIAN DIABETES MARKET •The authors expect around 15 new drugs to be launched in the non-insulin anti-diabetics market in the next five years. Seven of them are expected to be in the DPP-IV inhibitor and GLP-1 agonist classes. • The insulin market was worth $117 million in 2009. US health care major Abbott Laboratories was India's biggest player accounting for 61% of the total sales. • Sanofi-Aventis’ Lantus (insulin glargine) represented one of the fastest growing drugs in the last five year and registered sales worth nearly $11 million in 2009 • The total number of diabetes patients in India is expected to reach 87 million by 2030. Around 56% of these patients will be from urban regions of the country.
  • 15. THE INDIAN MARKET OPPORTUNITY •World’s largest diabetes patient pool •Success of newly launched drugs •Increasing diagnosis and drug treated rates •A rapidly growing market In 2010, total sales of insulin and oral anti-diabetics in India reached INR 28 billion, of which, the market for oral anti- diabetics was worth INR 17 billion**. With the number of diabetics increasing, the market, over the next five years, will be driven by the strong uptake of insulin analogs. Januvia is proving a blockbuster of DPP – IV Inhibitors segment expected to be more than US$ 4 Billion by 2017 (GLOBALLY)