1. Please occupy your seats
1

2. Good Afternoon
2

3. Ayurveda- Compendium of Wisdom
Authentic concepts & theories
3

4. Acquired knowledge
Traditional
Academic- Samhitas,
Commentaries
Practical
4

5. Is this knowledge enough???
Do we have to explore & revive the
intricacies of the basic knowledge we
possess…..
5

6. Do question, even the basics!
You will be a fool for once!
If you don't, you will be, for a lifetime..”
― Himmilicious
6

7. Reviving the concept of
Prabhava
Department of Dravyagunavijnana
VPSV Ayurveda College,Kottakkal
Dr. Praseetha P G Dr.N.Manojkumar
I MD Scholar Reader
7

8. Contents of Discussion
Review of Prabhava
Reanalyzing Prabhava
Reviving Prabhava
8

9. Prabhava- A Review
9

10. 1. Origin of the concept
2. Defining Prabhava
3. Concept in detail
4. Authenticity
5. Importance of Prabhava
10

11. Human-The Supreme Explorer
• First Physician wandered in Jungle
• Critical Observations
11

12. Discovery of Dravya
12

13. 13

14. 14

15. DRAVYA
Rasa
Guna
Veerya
Vipaka
Prabhava
15

16. Prabhava
+ +
“ :”
: I
( )
16

17. More Powerfull
Dominant
Excelling
Distinguished
17

18. Other contexts
Vedas & Puranas
Power
Influence
Manifestation
Of material existence
18

19. Defining Prabhava
 I
: :I I
-

I
( )
19

20. -
20

21. Concept of Prabhava
 :
: : :
( )
21

22. Various terminologies

( )
 :
:
( . - )
22

23. : :
I
I I
-
23

24. Different interpretation
Cakrapani:
Veerya-
Chintya sakthi
Achintya sakthi
Prabhava
24

25. Is it a final word????...
Or a clue to something
more…..
25

26. Passing time & changing theories
Hallmark of many systems of medicine
Certain levels of uncertainty
What to believe? What to forget ?
Approximate or Accurate?
26

27. Ayurveda- The Eternal Science
Time tested science of life
Time-tested theories
Accept defeat rather than fake win
Reasoning beyond one’s logic
Prabhava
27

28. I
II
-
28

29. Importance of Prabhava
Acintya
Daivapratighata
Visapratighata
Darsanat
Sravanat
Tulyarsagunesu Visesata
Adhbuta Karma
Agama
29

30. Prabhava- A Re-analysis
30

31. 1. Re-analysis of the Examples
2. Drug Researches
3. Site specificity of Drugs
4. Yoga Prabhava
31

32. Prabhavaja Karmas
• Aushadikarma - Pharmacological
• Agadiyakarma – Toxic & Antitoxic
• Rakshoghnakarma- Antimicrobial
• Bhautikakarma – Physical
• Manasakarma -
32

33. Virecana karma of Danti
Danti & Chitraka
33

34. Anthraquinines & Carbohydrates
• Pharmacognostic Studies on the Roots of
Baliospermum
Raziana keshav Et Yog. G.V.R. Joseph ,
CCRAS,Kerala
34

35. Virecana karma of Draksha
Draksha & Madhuyashti
35

36. 36

37. Medhya Karma
• Sankhupushpi
• Brahmi
• Guduci
• Madhuyashti
37

38.  Tikta Rasa
T2Rs- T2R4, T2R107 and T2R38 expressed in
multiple regions of the rat brain-brain stem,
cerebellum, cortex and nucleus accumbens.
Functional bitter taste receptors are expressed
in brain cells.
• Singh N, Vrontakis M, Parkinson F, Chelikani P
38

39. Sweet Taste
• The heterodimeric sweet taste receptor has multiple
potential ligand binding sites.
Cui M et.al, Mount Sinai School of
Medicine,Newyork
39

40. Visaghna karma of Sireesa
Universal Antidote
Multitude of Poisons
40

41. Rakshoghna karma
Anti-microbial activity
• Antimicrobial Activity of Clitoria ternatea (L.)
Extracts
L. Kamilla et.al
• In vitro assessment of potenial of Commiphora
whighti(Arn) gum extract
Kalpesh.B et.al
o
• n
41

42. Salyaharana Karma
Magnetism
42

43. Manidharana & Mantras
Psychological
Colour
Vibrations
Asterism & Chatoyancy
• Rendering gems with aterism or
chatoyancy
S Yokoi, K Kurashige, J Toriwaki - The Visual
Computer, 1986 – Springer
43

44. Site Specificity – Is it Prabhava ?
44

45. Asoka- Saraca asoca
45

46. Garbhasaya Rasayana
Active principles-
one stimulating and the other relaxing
Stimulate the uterus, making the
contraction more frequent and
prolonged.
Crystalline glycoside stimulate uterine
contraction
46

47. • Oxytocic activity of a pure phenolic
glycoside (P2) from Saraca indica Linn
(Ashoka): a short communication.
Satyavati GV et al
• Ashoka (Saraca indica) increase estrogen
levels and normalize the endometrium during
menstruation (The Antiseptic, Vol.95,
October 1998, p.329).
47

48. Arjuna- Terminalia arjuna
48

49. • Mechanistic clues in cardioprotective effect of
Terminalia arjuna bark extract in isoprotrenol -
induced chronic heart failure in rats.
Parveen A, Babbar R, Agarwal S, Kotwani A
Department of Physiology, Maulana Azad Medical
College, University of Delhi, India
• Antianginal and cardioprotective effects of
Terminalia arjuna, an indigenous drug, in coronary
artery disease.
Dwivedi S, Agarwal MP.
Department of Medicine, UCMS, Delhi
49

50. Yoga Prabhava
Sahacaradi Kashayam
Prasaranyadi Kashayam
Pathyakshadhatryadi Kashayam
50

51. ?
Deepanakarma of Ghrtha
Pumsavana
Sadya sukrakarana
51

52. Reviving Prabhava
52

53. 1. Proposed Theories
2. Interpreting Prabhava
3. Conclusion
53

54. Isomerism
Active constituents
Receptor-Effector Theory
54

55. Isomerism
55

56. 56

57. Receptor- Effector Theory
• Receptor:
Macromolecule/ Binding site on or inside
effector cell
To recognise the signal molecule/ drug
Initiate response
57

58. Lock & Key mechanism
58

59. 59

60. Types
Type 1 : Channel-linked
Type 2 : G-protien-coupled
Type 3 : Kinase-linked
Type 4 : Gene transcription
60

61. Channel linked
61

62. G-protein-coupled
62

63. Kinase-linked
63

64. Gene transcription regulators
64

65. 65

66. Induced Fit
• A situation where the receptor changes
shape as it binds to a ligand so that its
binding site more closely conforms to
the shape of the ligand.
66

67. Active Chemical Constituents
That performs the intended chemistry or
biochemisrty
Inducing specific response
67

68. Affinity
Potency
Efficacy
68

69. I
( -
69

70. 70

71. Conclusion
Indication for further Research
Substitution
Use of single drugs
Identification of specific chemical
constituents
71

72. What is known is a drop of knowledge
What is unknown is a deep ocean
72

73. Reference
• Rendering gems with aterism or chatoyancy
S Yokoi, K Kurashige, J Toriwaki - The Visual Computer, 1986 –
Springer
73