2. Case Background
• A 7 year old healthy child went camping with
his scouting team at a lake, where he swam
for a long time. 7 days later, he developed a
severe headache, high fever, nausea,
vomiting, photophobia and meningismus.
3. What will be your next step?
A. Empiric broad spectrum antibiotics + Anti
epileptics
B. Acyclovir + Anti epileptics
C. Send for immediate Blood culture
D. Lumbar puncture
E. Wait and watch + Careful Mannitol Infusion
F. Order CT Scan
4. A.
• No response after days 2 and 3, patient
becomes comatose, has seizures, needs
airway protection:
– Continue Antibiotic therapy for days 4 and 5
– Go back to do list and restart!
+ 5
5. B.
• No Response after days 2 and 3, patient
becomes comatose, has seizures, needs
airway protection :
– Continue Anti Virals for Days 4 and 5
– Go back to first step and restart!
- 5
6. C.
• Methicillin Resistant, Coagulase Negative
Staphylococcus cultured.
• Start:
– IV Cefepime
– IV Quinupristine/Dalfopristine
– IV Vancomycin
– IV Linezolid
– Resend blood for culture
- 5
11. Next step
• Start:
– Amphotericin B
– Fluconazole
– Anti TB drugs
– Albendazole + Ivermectin
– Piperacillin/Tazobactam
– Meropenem or Imipenem/Cilastatin
12. Amphotericin B.
• CORRECT drug choice
• Patient becomes comatose
• Respiratory failure
• Intubated and put on ventilator
• No response to empirical
antibiotic/antiviral/antifungal therapy
• Death on day 3!
• Provisional diagnosis? + 10
13. Other Drugs.
• INCORRECT drug choice
• Patient becomes comatose
• Respiratory failure
• Intubated and put on ventilator
• No response to empirical
antibiotic/antiviral/antifungal therapy
• Death on day 3!
• Provisional diagnosis? - 5
14. E.
• Patient becomes comatose
• Respiratory failure
• Intubated and put on ventilator
• No response to empirical
antibiotic/antiviral/antifungal therapy
• Death on day 5!
• Provisional diagnosis?
- 5