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Case 1
Case Background
• A 7 year old healthy child went camping with
  his scouting team at a lake, where he swam
  for a long time. 7 days later, he developed a
  severe headache, high fever, nausea,
  vomiting, photophobia and meningismus.
What will be your next step?
A. Empiric broad spectrum antibiotics + Anti
   epileptics
B. Acyclovir + Anti epileptics
C. Send for immediate Blood culture
D. Lumbar puncture
E. Wait and watch + Careful Mannitol Infusion
F. Order CT Scan
A.
• No response after days 2 and 3, patient
  becomes comatose, has seizures, needs
  airway protection:
  – Continue Antibiotic therapy for days 4 and 5
  – Go back to do list and restart!




                                          + 5
B.
• No Response after days 2 and 3, patient
  becomes comatose, has seizures, needs
  airway protection :
  – Continue Anti Virals for Days 4 and 5
  – Go back to first step and restart!




                                            - 5
C.
• Methicillin Resistant, Coagulase Negative
  Staphylococcus cultured.
• Start:
  – IV Cefepime
  – IV Quinupristine/Dalfopristine
  – IV Vancomycin
  – IV Linezolid
  – Resend blood for culture
                                      - 5
Resend Culture
• No growth
• Go back to starting list




                               +5
IV Drugs.
• No response after days 2 and 3:
  – Continue Antibiotic therapy for days 4 and 5
  – Go back to do list and restart!




                                          - 5
D.
• High intracranial
  pressure observed
  during LP
• WBC = 15,000/microlit
• Protein = (very high)
• Glucose = (very low)
• More Slides
• Provisional Diagnosis
• Next step
                          + 10
More Slides
Next step
• Start:
  – Amphotericin B
  – Fluconazole
  – Anti TB drugs
  – Albendazole + Ivermectin
  – Piperacillin/Tazobactam
  – Meropenem or Imipenem/Cilastatin
Amphotericin B.
• CORRECT drug choice
• Patient becomes comatose
• Respiratory failure
• Intubated and put on ventilator
• No response to empirical
  antibiotic/antiviral/antifungal therapy
• Death on day 3!

• Provisional diagnosis?                    + 10
Other Drugs.
• INCORRECT drug choice
• Patient becomes comatose
• Respiratory failure
• Intubated and put on ventilator
• No response to empirical
  antibiotic/antiviral/antifungal therapy
• Death on day 3!

• Provisional diagnosis?                    - 5
E.
• Patient becomes comatose
• Respiratory failure
• Intubated and put on ventilator
• No response to empirical
  antibiotic/antiviral/antifungal therapy
• Death on day 5!

• Provisional diagnosis?
                                       - 5
F.




• Back to List of options

                +5
Continuing Drugs
• On Day 6 patient has severe seizures, becomes
  comatose.
• Transferred to ICU.
• Further deterioration  Death!




                                    - 5
Provisional Diagnosis
• Correct

• Incorrect

• Back to work up
Incorrect
• Incorrect Diagnosis: You missed, he hit!




                                       - 10
Correct
• Early Diagnosis! Patient may have a chance if
  properly treated!
• Choose treatment




                                      + 15

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A Novel Method for Medical Quizzing!

  • 2. Case Background • A 7 year old healthy child went camping with his scouting team at a lake, where he swam for a long time. 7 days later, he developed a severe headache, high fever, nausea, vomiting, photophobia and meningismus.
  • 3. What will be your next step? A. Empiric broad spectrum antibiotics + Anti epileptics B. Acyclovir + Anti epileptics C. Send for immediate Blood culture D. Lumbar puncture E. Wait and watch + Careful Mannitol Infusion F. Order CT Scan
  • 4. A. • No response after days 2 and 3, patient becomes comatose, has seizures, needs airway protection: – Continue Antibiotic therapy for days 4 and 5 – Go back to do list and restart! + 5
  • 5. B. • No Response after days 2 and 3, patient becomes comatose, has seizures, needs airway protection : – Continue Anti Virals for Days 4 and 5 – Go back to first step and restart! - 5
  • 6. C. • Methicillin Resistant, Coagulase Negative Staphylococcus cultured. • Start: – IV Cefepime – IV Quinupristine/Dalfopristine – IV Vancomycin – IV Linezolid – Resend blood for culture - 5
  • 7. Resend Culture • No growth • Go back to starting list +5
  • 8. IV Drugs. • No response after days 2 and 3: – Continue Antibiotic therapy for days 4 and 5 – Go back to do list and restart! - 5
  • 9. D. • High intracranial pressure observed during LP • WBC = 15,000/microlit • Protein = (very high) • Glucose = (very low) • More Slides • Provisional Diagnosis • Next step + 10
  • 11. Next step • Start: – Amphotericin B – Fluconazole – Anti TB drugs – Albendazole + Ivermectin – Piperacillin/Tazobactam – Meropenem or Imipenem/Cilastatin
  • 12. Amphotericin B. • CORRECT drug choice • Patient becomes comatose • Respiratory failure • Intubated and put on ventilator • No response to empirical antibiotic/antiviral/antifungal therapy • Death on day 3! • Provisional diagnosis? + 10
  • 13. Other Drugs. • INCORRECT drug choice • Patient becomes comatose • Respiratory failure • Intubated and put on ventilator • No response to empirical antibiotic/antiviral/antifungal therapy • Death on day 3! • Provisional diagnosis? - 5
  • 14. E. • Patient becomes comatose • Respiratory failure • Intubated and put on ventilator • No response to empirical antibiotic/antiviral/antifungal therapy • Death on day 5! • Provisional diagnosis? - 5
  • 15. F. • Back to List of options +5
  • 16. Continuing Drugs • On Day 6 patient has severe seizures, becomes comatose. • Transferred to ICU. • Further deterioration  Death! - 5
  • 17. Provisional Diagnosis • Correct • Incorrect • Back to work up
  • 18. Incorrect • Incorrect Diagnosis: You missed, he hit! - 10
  • 19. Correct • Early Diagnosis! Patient may have a chance if properly treated! • Choose treatment + 15