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Pharmacology
- 2. MANTLE CELL LYMPHOMA • T (11:14) • CD 23 –VE • CYCLIN D1 • FMC 7
- 3. FOLLICULAR LYMPHOMA • CD 10 • BCL 6 • BCL 2
- 4. BURKITS LYMPHOMA STARRY SKY
- 5. B CLL / SLL SMUDGED CELL PSEUDOFOLLICULAR SMALL CLEAVED LYMPHOCYTE
- 8. CLOSE NEAR INTERMEDIATE DISTANT 8CM 40-50CM HAND GUN 8CM 60-100CM RIFFLE NEAR 15CM 15CM 15CM 60-90CM SHOT GUN30CM SCORTCHING BURNING SINGING SO0T SMOKE TATOOING PEPPERING ABRASSION COLLAR GREASE COLLAR
- 11. HEMICHOLINIUM AcH VESAMICOL SPIDER VENOM CHOLINE BOTULINUM LAMBERT ETON MYETHENIA DALFAMPRIDINE (MS)
- 12. METHYLATION 1.NE TO E 2.HISTAMINE TO METHYL HISTAMINE 3.6 THIOGUANINE METABOLIS M 4.MLS RESISTANCE
- 18. ANTI VAGAL PROPERTY DIGOXIN QUINIDINE PROCANAMIDE DYSOPYRAMIDE IMIPRAMINE (TCA)
- 19. BETHENACHOL PILOCARPINE ECHOTHIAOPHATE CEVEMELINE IPRATROPIUM BROMIDE DORIFENACIN SPOLEFENACIN OXYBUTININ TOLTERODINE FESOTERODINE FLUOXATE TROSPIUM CLORIDE MIRABEGRON OVER ACTIVE B3 SIBUTRAMINE B3 QT PROLONGATION
- 20. OVER ACTIVE BLADDER ONABOTULINUM MIRABEGRON IMIPRAMINE (TCA) NOCTURNAL ENURESIS DESMOPRESSIN (DOC) IMIPRAMINE STRESS INCONTENECE DULOXETINE(SNRI) VENLAFAXIN DESVENLAFAXIN LEVOMILNACIPRAM
- 26. ECHOTHIOPHATE
- 29. INVERSE AGONIST RIMONABANT ------------------CANNABINOID PITOLISANT /TIPROLISANT------------------H3 BENZODIAZEPINE-----------------GABA
- 30. PHYSOSTIGMINE
- 33. IONOCYBE MUSCARANIC TYPE ATROPINE AMANITA MUSCARIA HALUINOGEN NO ANTI DOTE AMANITA PHYLLOIDE PENICILLIN THIOTIC ACID SILIBILLIN
- 34. CACLCINE URIUM Ca NFATC NEUCLEAR FACTOR OF ACTIVATED T CELL LOX ARACHIDONIC ACID COX LTA LTB LTC LTD LTE IL LT RECEPTOR SEROLIMUS EVEROLIMUS ZELUTON PL A2 STEROIDS CYCLOSPORIN TACROLIMUS MONTELEUCAST ZAFIRLEUCAST PRANLUCAST
- 35. A2 ARTERY B2
- 36. CA……
- 39. ALPHA BETA
- 41. OXCARBAZAPINE LAMITROGEN LITHIUM VALPROATE CARBAMAZEPINE OX AND LAMB ARE LIGHT AS VARSHA …..NOT ON CARB MOOD STABILIZER
- 44. SSRI FLUOXATINE FLUOXAMINE CITOLOPRAM ESCITALOPRAM SERTERALINE PAROXETINE PROM NIGHT HALU PERU FLU
- 48. In depression, Tricyclic antidepressants (TCAs) are the drug of choice in severe depression because of their high efficacy while the selective serotonin reuptake inhibitors (SSRIs) are the drug of choice in mild to moderate depression because of their high safety. The side effects of TCAs are: T Tremors C Cardiovascular side effects (arrhythmias esp. in ischemic heart disease, postural hypotension) A Anticholinergic side effects S Sedation and Seizures
- 49. The side effects of SSRIs are: S Serotonin syndrome S Stimulate CNS R Reproductive dysfunctions if male I Insomnia Serotonin syndrome is a very dangerous and fatal situation. It is just like neuroleptic malignant syndrome and results from interaction between serotonin enhancing drugs e.g. SSRIs, MAO-Is, TCAs, etc. Serotonin syndrome is characterized by (causes HARM): H Hyperthermia A Autonomic instability (delirium) R Rigidity M Myoclonus
- 53. 3 As of Buspirone A - partial Agonist A - 5 HT1 type A receptor A - Anxiety disorders ABCD of Sumatriptan A - Acute migraine treatment / Asthenia as a side effect B - Basoconstriction ("v") of cerebral vessels C - Coronary vasospasm D - 5 HT1 type D receptor "SETRON" SE - SEerotonin antagonist T - 5 HT Three receptor TR - TRigger zone O - Ondansetron (MC drug) N - No second messenger (ion channels)
- 58. TCANERI SRI ANTI MANTI H ANTI APLPHA 1
- 59. A1 CLONIDINE METHYLY DOPA GUANAFENSIN DEXMEDITOMIDE CU2+ = TAMBR YOHIMBINE IDAZOXANE
- 64. FENOLDOPAM DOBUTAMINE DOPEXAMINE ISOPRENALINE
- 65. FENOLDOPAM DOBUTAMINE DOPEXAMINE DOPAMINE
- 66. DOBUTAMINE 5-10 micro gram 2 micro gram 2-5 micro gram
- 68. B1 DECREASE CHOLESTEROL HYPOKALEMIA HYPER GLYCEMIA THIAZIDE +B BLOCKER HIGH CHOLESTEROL
- 70. LABETOLOL CARVEIOLOL NEVIBUNOLOL NEPRADIOLOL TISOLOL ADDITIONAL ACTION ALPHA BLOCIN HTN EMG IN PREGNANCE +ANTIOXIDANT -----CHF
- 76. AMILE NITRITE GTN ISDN ISMN PETN NITRITES MAX SKIN RASH ACUTE ATTACKS LEAST FIRST PASS SHORTEST
- 78. HTN PVD VERAPAMIL DILTIAZEM NIFIDIPINE NICARDIPINE NIMODIPINE FELODIPINE AMLODIPINE NITREDIPINE CLEVIDIPINE CCB DHP ANKLE EDEMA CONSTIPATION ULTRA SHORT ACTING-----ACUTE HTN EMG AVN SAN
- 79. FASUDIL REPASUDIL RHO KINASE INHIBITOR SAH (NIMODIPINE) P HTN ANGINA GLOUCOMA
- 83. PLZ CHECK PFT LFT TFT • PIGMENTATION • PHOTOSENSITIVITY • CORNEAL DEPOSIT (WHORLING) • PULM FIBROSIS • PERIPHERLA NEUROPATHY • PSEUDOALCOHOLIC LIVER INJURY • HYPOTHYROIDISM /HYPERTHYROIDISM
- 86. PURE AS GOLD
- 91. CUT --PYRIMIDINE
- 92. CYTARABINE
- 94. capacitabine
- 95. 5 FLURO URACIL
- 98. Neutrophil chemotactic factors: C - C5a I - IL-8 L - Leukotriene B4
- 99. Oncogenes. Gain of function mutation in one allele --> cancer. K-ras: Kolon, panKreatic H-ras: (Hematuria) - bladder and kidney tumors N-ras: melaNomas
- 100. Tumor suppressor genes: DPC - Deleted in Pancreatic Cancer DCC - Deleted in Colon Cancer
- 101. Psammoma bodies - laminated, concentric, "rings on a tree" spherical calcifications: P - Papillary (adenocarcinoma of thyroid) S - Serous (cystadenoma of ovary) M - Meningioma M - Mesothelioma (asbestos exposure)
- 102. Metastases to brain (# metastases = # primary brain tumors): Lung, Breast, Skin (melanoma), Kidney (RCC), GI Typically, multiple well-circumcribed tumors at gray-white border
- 103. Metastases to liver (metastases >> primary liver tumors): Colon, Stomach, Pancreas, Breast, Lung. *Think breast & lung, plus what is drained by portal venous system to liver.
- 104. Metastases to bone (metastases >> primary): Prostate, Thyroid, Breast, Lung, Kidney Lung = Lytic (IL-1) Prostate = blastic
- 105. Drugs with zero order elimination P - Phenytoin E - Ethanol A - Aspirin (at high or toxic concentrations)
- 106. • Therapeutic Index equation: TI = LD50 / ED50 Safer drugs have higher TI's
- 107. • G-protein linked 2nd messengers: q - alpha 1 - vasoconstriction --> inc BP i - alpha 2 - dec sympathetic outflow s - beta 1 - inc HR, contractility, renin, lipolysis s - beta 2 - vaso-/bronchodilation, inc HR q - M1 - CNS, ENS i - M2 - dec HR, dec contractility of atria q - M3 - peristalsis, gastric acid, bronchoconstriction, miosis, accommodation
- 108. • G-protein linked 2nd messengers: s - D1 - relaxes renal vascular sm muscle i - D2 - modulates NT release, esp in brain q - H1 - (nasal, bronchial mucus production) s - H2 (gastric acid secretion) q - V1 - vasopressin (sm m contraction) s - V2 - vasopressin (inc H2O permeability
- 109. • Receptors that use the Gq pathway: H1, alpha-1, V1, M1, M3 Gq -> phospholipase C -> -> IP3 (-> Ca++ from ER) + DAG (-> Protein Kinase C)
- 110. • Receptors that use the Gi pathway: M2, alpha-2, D2 Gi --> inhibition of Adenylate cyclase --> dec cAMP --> dec protein kinase A
- 111. OP • Hot as a hare (inc body temp) Dry as a bone (dry mouth, skin) Red as a beet (flushed skin) Blind as a bat (cycloplegia, mydriasis) Mad as a hatter (delirium) Bloated as a toad (constipation, urinary retention)
- 112. • low doses of epinephrine are selective for beta-1 receptors -->
- 114. Photo Album by USER1
- 136. AMIODAROJNE
- 224. Photo Album by USER1
- 225. conrady syndrome
- 226. vit a
- 227. lithium
- 228. APLASIA CUTIS
- 229. CHOANAL ATRESIA
- 231. VALPROATE
- 232. TETRACYCLINE
- 233. Phocomelia
- 234. MOBIEUS SYNDROME
- 235. Hypospadias-lg
- 236. GREY BABY SYNDROME
- 238. 734138-fig2
- 239. TB
- 240. TBB
- 241. gr2_lrg
- 242. nrd3975-f1
- 243. download (6)
- 244. fig1 (1)
- 245. 100703_table1
- 246. F1.large (2)
- 247. IBALIZUMAB
- 248. slide_3
- 250. nrendo.2016.51-f1
- 251. slide023
- 253. Slide4
- 254. wilding.fig2
- 260. BULLS EYE RETINOPATY CHLOROQUINE
- 261. BULLS EYE RETINOPATY CHLOROQUINE