Part I - How Do They Work

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DIURETICS HOW DO THEY WORK? What do they do? When do I use them? How do I use them?

Na-K-2Cl SYMPORT INHIBITORS ,[object Object],[object Object],[object Object],Ethacrynic Acid Torsemide Bumetanide Furosemide

Na-Cl SYMPORT INHIBITORS ,[object Object],[object Object],[object Object],Chlorthalidone Metolazone Chlorothiazide Hydrochlorothiazide

Na CHANNEL INHIBITORS ,[object Object],[object Object],Amiloride Triamterene

MINERALOCORTICOID RECEPTOR ANTAGONISTS ,[object Object],[object Object],[object Object],Spironolactone Eplerenone

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Diuretics Pharmacology Katzung Abnormalities in fluid volume and electrolyte composition are common and important clinical disorders. Drugs that block specific transport functions of the renal tubules are valuable clinical tools in the treatment of these disorders. Although various agents that increase urine volume (diuretics) have been described since antiquity, it was not until 1937 that carbonic anhydrase inhibitors were first described and not until 1957 that a much more useful and powerful diuretic agent (chlorothiazide) became available. Technically, a “diuretic” is an agent that increases urine volume, whereas a “natriuretic” causes an increase in renal sodium excretion and an “aquaretic” increases excretion of solute-free water. Because natriuretics almost always also increase water excretion, they are usually called diuretics. Osmotic diuretics and antidiuretic hormone antagonists (see Agents That Alter Water Excretion) are aquaretics that are not directly natriuretic.

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