Background: To investigate clinic-pathological characteristics, hormonal receptors and HER2 receptor of male breast cancer. Materials and methods: Retrospective study of 10 cases between 2010 and 2013. The studied parameters were: tumor size, histological type, histological grade, lymph node status, hormonal status and overexpression of HER2. Results: The average age of our patients was 60.2 years, in 70% of cases; the histological size that was found was T4; and infiltrating ductal carcinoma was diagnosed in all cases. The grades classification was as follow: grade 2 (30%) and grade 3 (70%). 70% of cases had lymph node metastasis. Estrogen and progesterone receptors (ER,PR) were positive in 60% of tumors. Overexpression of HER2 was positive (Score3) in one case. Luminal B was the most common subtype in our study.

1. Journal of Surgery and
Surgical Research– ISSN: 2455-2968
Peertechz Journals

2. Research Article
HER2 Status in Male Breast Carcinoma: a
Single North African Institution Experience
of 10 Cases and Review of the Literature
 Meriem N Mrabent, Noria Harir, Feriel Sellam*, Soumia Zeggai, Abdenacer Tou,
Mustapha Diaf, Rachida Salah and Soraya Moulesshoul
 *Corresponding author: Feriel Sellam, PhD., Department of Biology, Djillali Liabes
University of Sidi bel Abbes, (Ex ITMA), Algeria candidate in Cellular Biology and
Pathology
 Dates: Received: 12 September, 2015; Accepted: 26 October, 2015; Published: 28
October, 2015
 Citation: Mrabent MN, Harir N, Sellam F, Zeggai S, Tou A, et al. (2015) HER2 Status in
Male Breast Carcinoma: a Single North African Institution Experience of 10 Cases and
Review of the Literature. J Surg Surgical Res 1(3): 049-052. DOI: 10.17352/2454-
2968.000013

3. Abstract
Background: To investigate clinic-pathological characteristics, hormonal receptors
and HER2 receptor of male breast cancer.
Materials and methods: Retrospective study of 10 cases between 2010 and 2013.
The studied parameters were: tumor size, histological type, histological grade,
lymph node status, hormonal status and overexpression of HER2.
Results: The average age of our patients was 60.2 years, in 70% of cases; the
histological size that was found was T4; and infiltrating ductal carcinoma was
diagnosed in all cases. The grades classification was as follow: grade 2 (30%) and
grade 3 (70%). 70% of cases had lymph node metastasis. Estrogen and
progesterone receptors (ER,PR) were positive in 60% of tumors. Overexpression of
HER2 was positive (Score3) in one case. Luminal B was the most common subtype
in our study.

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