Three technological changes are transforming manufacturing: 1) 3D printing is achieving production-ready performance levels, 2) Intelligent robotics are becoming cheaper and easier to use, and 3) Open-source electronics are enabling general purpose computing anywhere. These changes will rewrite the rules of product design and manufacturing by enabling more customized, flexible production driven by software. Enterprises must rethink strategies like supply chains, design processes, and business models to leverage these new technologies and stay competitive.