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Why Infant Mental Health?
Neil W. Boris, MD
Tulane Institute of Infant and Early Childhood Mental Health
Reason 1:
      Fetal Programming
      2)   Attachment
      3)   Therapy
Fetal or Developmental Programming:
“…biological systems adapt to input from the
 environment during especially sensitive
 periods of development; furthermore, the
 malleability of biological systems to adjust to
 environmental input is developmentally
 constrained, so that systems that adapt to
 environments early in life do not readapt to
 subsequent changes in the environment…”
                           p. 674, O’Connor, 2003
Consider the nightmare of the
                      “Hungerwinter” of 1944
                •    Dutch under German occupation
                •    Sudden starvation
                •    20,000 people die
                •    What happens to pregnant
                     women?




http://www.pnas.org/content/107/39/16757.full.pdf+html
Dutch Famine Study 1944-5
Periconception    1st Trimester   3rd Trimester




  Schizophrenia
Dutch Famine Study 1944-5
Periconception    1st Trimester       3rd Trimester




  Schizophrenia


                  Increased Obesity
Dutch Famine Study 1944-5
Periconception    1st Trimester        3rd Trimester




                                          Birth weight
                                      incl. 2nd Generation



  Schizophrenia


                  Increased Obesity
Dutch Famine Study 1944-5
Periconception              1st Trimester           3rd Trimester

      Fertility         Gestation length-preterm    Maternal Weight



                                                       Birth weight
Organic Brain Defects          Stillbirths
                                                   incl. 2nd Generation



   Schizophrenia           Neonatal Mortality      Mortality Months


 Antisocial Behavior       Increased Obesity       Decreased Obesity


                                                           Nutr Rev 1994, 52: 84
Fetal Nutrient demand


   Maternoplacental nutrient supply
   • Nutrient availability
   • Placental function and transfer
   • Uteroplacental blood flow



Fetal adaptations (e.g., re-programming)
   If demand is > maternoplacental supply
  Then alterations how key organs function



    Disease and Disability—YEARS later!
Anne Murphy Paul @ TED
                   What we learn before we’re born




http://www.ted.com/talks/annie_murphy_paul_what_we_learn_before_we_re_born.html
The Adverse Childhood Experiences (ACEs)
                        Study


            • The largest study of its kind ever done: ~18,000
              participants.

            • Examined the health and social effects of adverse
              childhood experiences over the lifespan.

            • Conducted by a group at Kaiser Permanente, a large
              HMO



For more on the Adverse Childhood Experiences Study, see:
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=DetailsSearch&term=adverse+childhood+experiences+study
Abuse
  Physical    10.6%
  Sexual      28.3%
  Emotional   20.7%
Abuse
   Physical    10.6%
   Sexual      28.3%
   Emotional   20.7%
Neglect
   Physical     9.9%
   Emotional   14.8%
Abuse
   Physical                        10.6%
   Sexual                          28.3%
   Emotional                       20.7%
Neglect
   Physical                         9.9%
   Emotional                       14.8%
Household Dysfunction
   Mother treated violently        12.7%
   Household substance abuse       26.9%
   Household mental illness        19.4%
   Parental separation/divorce     23.3%
   Incarcerated household member    4.4%
Adverse Childhood Experiences and
         Adult Depression
  Odds Ratio




               Adverse Events
                                Chapman et al, 2004
Adverse Childhood Events and
   Adult Substance Abuse




  Self-Report: Alcoholism   Self-Report: Illicit Drug Use


                                Dube et al, 2002, 2005
Cumulative ACEs Increase the Risk of
       Negative Outcomes
 14
                               Attempted
                               suicide
 12                            Injected drug
                               use
                               Alcohol problem

 10                            Illicit drug use

                               Depressed

  8                            Chronic
                               bronchitis
                               50+ sex
                               partners
  6                            STDs

                               Poor Self-rated
                               health
  4                            Current Smoker

                               Cancer

  2                            Severe obesity



  0
      0   1    2    3     4+
ACE Studies Summary of Findings
• Adverse Childhood Experiences are very
  common.
• ACEs are strong predictors of later health risks.
ACE Studies Summary of Findings
This combination makes ACEs one of the

leading, if not the leading, determinant of the
health and social well-being of our nation.
Felitti’s General Model-Trauma Effects

                    Early
                    Death
                  Disease &
                  Disability

              Adoption of Health
                 Risk Behavior

             Social, Emotional, &
            Cognitive Impairment

             Adverse Childhood
               Experienced
James Heckman and the Question of
        When to Intervene….

• Nobel prize winning economist who teaches at
  U-Chicago
• Focus is on human capital and on policy that
  promotes this commodity
• See: www.heckmanequation.org
Early Intervention Pays
Thank you for your attention!

 Neil W. Boris, MD
 Tulane Institute of Infant and Early Childhood Mental Health

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Reason 1: Fetal Programming

  • 1. Why Infant Mental Health? Neil W. Boris, MD Tulane Institute of Infant and Early Childhood Mental Health
  • 2. Reason 1: Fetal Programming 2) Attachment 3) Therapy
  • 3. Fetal or Developmental Programming: “…biological systems adapt to input from the environment during especially sensitive periods of development; furthermore, the malleability of biological systems to adjust to environmental input is developmentally constrained, so that systems that adapt to environments early in life do not readapt to subsequent changes in the environment…” p. 674, O’Connor, 2003
  • 4. Consider the nightmare of the “Hungerwinter” of 1944 • Dutch under German occupation • Sudden starvation • 20,000 people die • What happens to pregnant women? http://www.pnas.org/content/107/39/16757.full.pdf+html
  • 5. Dutch Famine Study 1944-5 Periconception 1st Trimester 3rd Trimester Schizophrenia
  • 6. Dutch Famine Study 1944-5 Periconception 1st Trimester 3rd Trimester Schizophrenia Increased Obesity
  • 7. Dutch Famine Study 1944-5 Periconception 1st Trimester 3rd Trimester Birth weight incl. 2nd Generation Schizophrenia Increased Obesity
  • 8. Dutch Famine Study 1944-5 Periconception 1st Trimester 3rd Trimester Fertility Gestation length-preterm Maternal Weight Birth weight Organic Brain Defects Stillbirths incl. 2nd Generation Schizophrenia Neonatal Mortality Mortality Months Antisocial Behavior Increased Obesity Decreased Obesity Nutr Rev 1994, 52: 84
  • 9. Fetal Nutrient demand Maternoplacental nutrient supply • Nutrient availability • Placental function and transfer • Uteroplacental blood flow Fetal adaptations (e.g., re-programming) If demand is > maternoplacental supply Then alterations how key organs function Disease and Disability—YEARS later!
  • 10. Anne Murphy Paul @ TED What we learn before we’re born http://www.ted.com/talks/annie_murphy_paul_what_we_learn_before_we_re_born.html
  • 11. The Adverse Childhood Experiences (ACEs) Study • The largest study of its kind ever done: ~18,000 participants. • Examined the health and social effects of adverse childhood experiences over the lifespan. • Conducted by a group at Kaiser Permanente, a large HMO For more on the Adverse Childhood Experiences Study, see: http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=DetailsSearch&term=adverse+childhood+experiences+study
  • 12. Abuse Physical 10.6% Sexual 28.3% Emotional 20.7%
  • 13. Abuse Physical 10.6% Sexual 28.3% Emotional 20.7% Neglect Physical 9.9% Emotional 14.8%
  • 14. Abuse Physical 10.6% Sexual 28.3% Emotional 20.7% Neglect Physical 9.9% Emotional 14.8% Household Dysfunction Mother treated violently 12.7% Household substance abuse 26.9% Household mental illness 19.4% Parental separation/divorce 23.3% Incarcerated household member 4.4%
  • 15. Adverse Childhood Experiences and Adult Depression Odds Ratio Adverse Events Chapman et al, 2004
  • 16. Adverse Childhood Events and Adult Substance Abuse Self-Report: Alcoholism Self-Report: Illicit Drug Use Dube et al, 2002, 2005
  • 17. Cumulative ACEs Increase the Risk of Negative Outcomes 14 Attempted suicide 12 Injected drug use Alcohol problem 10 Illicit drug use Depressed 8 Chronic bronchitis 50+ sex partners 6 STDs Poor Self-rated health 4 Current Smoker Cancer 2 Severe obesity 0 0 1 2 3 4+
  • 18. ACE Studies Summary of Findings • Adverse Childhood Experiences are very common. • ACEs are strong predictors of later health risks.
  • 19. ACE Studies Summary of Findings This combination makes ACEs one of the leading, if not the leading, determinant of the health and social well-being of our nation.
  • 20. Felitti’s General Model-Trauma Effects Early Death Disease & Disability Adoption of Health Risk Behavior Social, Emotional, & Cognitive Impairment Adverse Childhood Experienced
  • 21. James Heckman and the Question of When to Intervene…. • Nobel prize winning economist who teaches at U-Chicago • Focus is on human capital and on policy that promotes this commodity • See: www.heckmanequation.org
  • 23. Thank you for your attention! Neil W. Boris, MD Tulane Institute of Infant and Early Childhood Mental Health