Cancerul de prostata1 boala de nutritie

CANCERUL DE PROSTATA Boala de nutritie ? Coordonator stintific :Dr Bogdan Streza medic primar chirurg urolog

Analiza statistica a Sectiei de Urologie Spitalul Clinic CF 2 Bucuresti ,[object Object],[object Object],[object Object],[object Object]

Elemente comune in epicriza bolnavilor ,[object Object],[object Object],[object Object],[object Object]

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Cercetari recente arata ca…. ,[object Object]

Acestea sunt si concluziile prezentarii noastre fundamentate pe cateva cercetari ,[object Object],[object Object],[object Object]

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Factorii de risc Factorul rasial Deosebirea intre tari

Factori de risc Inflamatia cronica/recurenta Vasectomia Metale toxice

Factorii de risc Varsta inaintata Factorul genetic Factorul hormonal Hormonii androgeni Factorul de crestere IGF1

IGF-1 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

IGF-1 ,[object Object],[object Object]

IGF-1 ,[object Object],[object Object],[object Object]

FACTORI ALIMENTARI GRASIMILE PROTEINELE

Factori alimentari in exces ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Factori alimentari FACTORI ALIMENTARI CALCIUL PREPARAREA TERMICA VITAMINA D

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[object Object],[object Object],[object Object],SUBSTANTE REZULTANTE IN URMA PROCESULUI TERMIC AL CARNII: amine de 2-amino-1-metil-6-phenylimidazo [4,5-b] piridina (PhIP)

Factorii cancerigeni pot produce modificari la nivelul ADN

FACTORI ALIMENTARI CONSUMUL TOTAL DE CALORII SURPLUSUL PONDERAL SI OBEZITATEA HIPERCOLESTEROLEMIE

SURPLUSUL PONDERAL SI OBEZITATEA CRESTERISCUL DE CANCER DE PROSTATA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

HIPERCOLESTEROLEMIE ,[object Object],[object Object]

Studiu realizat de Hasings si colaboratorii in 1990 pe un lot de 250 000 veterani americani ,[object Object],[object Object],FACTORI DE RISC FUMATUL

ALTI FACTORI DE RISC INACTIVITATEA FIZICA LUCRUL IN TURE PROFESIA INALTIMEA

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PREVENIREA CANCERULUI DE PROSTATA PRIN ALIMENTATIE ,[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],PREVENIREA CANCERULUI DE PROSTATA PRIN ALIMENTATIE

EVITAREA SI COMBATEREA OBEZITATII ,[object Object],[object Object],[object Object],[object Object]

EVITAREA PROTEINELOR DE ORIGINE A N IMALA

SCADEREA CONSUMULUI DE GRASIMI ANIMALE

MECANISME ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Jerome D Amico-Urologic Oncology 2005 ,Elsevier Saunders

EVITAREA PRODUSELOR LACTATE ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Jerome D Amico-Urologic Oncology 2005 ,Elsevier Saunders

ATENTIE!......... HIDROCARBURI POLICICLICE AROMATE ,[object Object]

AMINE HETEROCICLICE ,[object Object],[object Object],[object Object],[object Object]

ACIDUL ARAHIDONIC SI PROCESELE INFLAMATORII DIN ORGANISM ,[object Object],[object Object]

CRESTEREA CONSUMULUI DE ALIMENTE VEGETALE PRINCIPII ACTIVE: RESVERATROL SOIA POLIFENOLII GLUTATION S-TRANSFERAZA VITAMINA E SELENIUL LICOPENUL FLAVONELE IZOFLAVONELE ANTOCIANINELE ADKP

SOIA IZOFLAVONELE(fitoestrogene) Se fixează pe receptorii de estrogen din prostata împiedicând fixarea estrogenului adevărat care stimulează cresterea prostatei ,[object Object],[object Object],[object Object],INHIBA AROMATAZA Aromataza desface testosteronul in estradiol estron

Izoflavonele ,[object Object],[object Object],[object Object]

IZOFLAVONELE IMPIEDICAREA ANGIOGENEZEI (genisteina) INHIBAREA UNEI PROTEINKINAZE SPECIFICE se induce apoptoza celulelor tumorale (genisteina) CRESTEREA SINTEZEI HEPATICE DE GLOBULINA=scad niv. hormonilor androgeni din sânge

LICOPENUL ,[object Object],[object Object],[object Object]

LICOPENUL ,[object Object],[object Object]

Journal National of Cancer Institute (2005;97:396-399) cereale integrale zarzavaturi fructe ,legume(soia) VITAMINA E(tocoferol) ,[object Object],[object Object],Inhiba cresterea celulelor canceroase din prostata in fazele initiale prin cresterea raspunsului imun concentratiile crescute de alfa –tocoferol =risc mai mic de cancer de prostata

CRUCIFERELE SULFORAN INDOL-3 CARBINOL SCADE RISCUL CANCERULUI DE PROSTATA CU 20% DISTRUGE SUBSTANTELE CANCERIGENE DN ALIMENTELE CONSUMATE (AMINE HETEROCICLICE DIN GRATAR ,CARNE FRIPTA) FAVORIZEAZA ACT. GLUTATION S-TRANSFERAZA IN ADKP GLUTATION S-TRANSFERAZA ESTE ABSENTA IN 95%

CRUCIFERELE CONSUMUL DE 5 PORTII DE CRUCIFERE SCADE RISCUL CANCERULUI DE PROSTATA CU 20% (INT. Journal Oncology 2003;20:631-636) NY Medical College SULFORANUL INDUCE APOPTOZA CELULELOR CANCEROASE

SOIA POT INTRERUPE CAILE DE CRESTERE CELULARA POT INTRERUPE INFLUENTEAZA PRODUCTIA NEOGENEZA POT INFLUENTA PRODUCTIA ,METABOLISMUL ,EXCRETIA TESTOSTERONULUI IZOFLAVONE GENISTEINA DAIZDEINA EQUOL

SELENIUL ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],British Journal of Cancer 2004;91:195-199

ROLUL FRUCTELOR SI LEGUMELOR IN PREVENTIA CANCERULUI DE PROSTATA “CITOCROMUL P450 CYP1B1 “ William R. Ware, PhD Faculty of Science, University of Western Ontario, London, Ontario, Canada, [email_address] ,[object Object]

Vitamina E ,[object Object],[object Object],[object Object],[object Object],[object Object],Author: Stanley A Brosman, MD, Clinical Professor, Department of Urology, University of California at Los Angeles Medical School Coauthor(s): Mark A Moyad, MD, MPH, ND, Phil F Jenkins Director of Complementary and Alternative Medicine, Department of Urology, University of Michigan Medical Center

[object Object],[object Object],Author: Stanley A Brosman, MD, Clinical Professor, Department of Urology, University of California at Los Angeles Medical School Coauthor(s): Mark A Moyad, MD, MPH, ND, Phil F Jenkins Director of Complementary and Alternative Medicine, Department of Urology, University of Michigan Medical Center

BIBLIOGRAFIE ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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Cancerul de prostata1 boala de nutritie

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