Ten percent of all pregnancies are complicated by hypertension (HTN).Eclampsia and preeclampsia account for about half of these cases worldwide.
In 1619, Varandaeus coined the term eclampsia in a treatise on gynecology.
DEFINITION: Eclampsia is defined as the clinical presentation of an unexplained seizure, convulsion, or altered mental status in the setting of the signs and symptoms of preeclampsia. It is considered a complication of severe preeclampsia.
A woman with preeclampsia develops:
--- high blood pressure (>140 mmHg systolic or >90 mmHg diastolic)
--- protein in the urine
--- swelling (edema) of the legs, hands, face or entire body.
21. DRUGS INTERACTIONS MANAGEMENT lactulose ↔ Artesunate ( moderate) Electrolyte loss and increase the risk of torsade de pointes ventricular arrhythmia. Electrolyte disturbances including hypokalemia and hypomagnesemia. The recommended dosage and duration of use should not be exceeded. Electrolye supplements needed to be administered. lumefantrine ↔ food (moderate) Coadministration with grapefruit juice may increase the plasma concentrations of artemethe. The mechanism is decreased clearance due to inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruits. Avoid the consumption of grapefruits and grapefruit juice. To ensure maximal oral absorption, artemether-lumefantrine should be taken with food. Inadequate food intake can increase the risk for recrudescence of malaria.
22. DRUGS INTERACTIONS MANAGEMENT furosemide ↔ lactulose (Moderate) Potentiate the pharmacologic effects of diuretics. Laxatives can cause significant losses of fluid and electrolytes In general, laxatives should only be used on a short-term, intermittent basis in recommended dosages. Contact physician if they experience signs and symptoms of fluid and electrolyte depletion such as dizziness, lightheadedness, dry mouth, thirst, fatigue, weakness, decreased urination, postural hypotension, and tachycardia.