1. CYCLOTRON Co., Ltd
radioisotope products

2. About the Company
The main sources for radionuclide production are nuclear reactors and charged
particle accelerators which also include cyclotrons. Advantages of cyclotron isotopes
are their high specific activity and radionuclide purity.
Cyclotron Co., Ltd. is a leading Russian producer of cyclotron radioisotopes and
radiation sources.
The enterprise's products are intended for application in scientific researches,
industry and nuclear medicine, and is also in demand in hi-tech space projects.

3. The Company's history
 1958 Construction of a cyclotron U-150 at Institute of Physics and Power
Engineering by the Decree of the USSR Government adopted on the ground of
I.V. Kurchatov's report on development of the work on isotopes production and
application in the country.
 1963 A start of the continuous operation of the cyclotron, development of
technologies and production of radioactive isotopes and radiation sources based
on them.
 1965 The country's needs in cyclotron radioisotopes were satisfied in full.
 1967 The first export product deliveries.
 1981 A start of using enriched stable isotopes as a target material.
 1984 Establishment of the stable isotope regeneration section.
 1991 Establishment of Research-and-Production Lease Enterprise "Cyclotron" on
the base of Cyclotron Isotopes Department of Institute of Physics and Power
Engineering. The enterprise was headed and managed irreplaceably until June 7,
2012, by Nikolay Nikolayevich Krasnov, Doctor of Science (Engineering), Professor.

4. The Company's history
 1992 By the Decree of the RF President the Research-and-Production Lease
Enterprise was transformed to LLP Cyclotron and later to Cyclotron Co., Ltd.
 1993 Putting into operation of the heavy box section in the radiochemical
laboratory for processing of high radioactive targets and organization of
processing of all irradiated targets using.
 1993 Introduction of germanium-68 separation technology based on extraction
of germanium with hexane.
 1994 A technology for separation of strontium-82 radionuclide from a rubidium
target irradiated at an accelerator (Moscow Meson Factory, Troitsk) was developed.
 1995 A technology for separation of thallium-201 radionuclide from an irradiated
thallium target was developed.
 1996 Manufacture and delivery of the first gallium-68 generator.
 1997 A technology for manufacture of germanium-68-based sources for
calibration of PET scanners was developed.
 1998 A start of palladium-103 radionuclide production from an irradiated
rhodium target.

5. The Company's history
 2000 Commissioning of a cyclotron RIC-14.
 2002 Creation of a scanner for control of activity distribution in germanium-68-
based linear sources.
 2005 A new technology for production of the palladium-103 radionuclide from
an irradiated rhodium target was introduced.
 2006 A start of production of gallium-68 generators of a new design.
 2008 A start of the work on development of a scandium-44 generator.
 2009 Researches were carried out which confirmed a possibility of a multiple
recharge of an exhausted gallium-68 generator.
 2010 A new technology for production of sources of PGL-2 type was developed.
 2011 A technology for transfer of the germanum-68 radionuclide to the low-
volatile form with DTPA was developed.
 2013 A new technology for ittrium-88 separation was developed.

6. Products
We produce a wide range of radionuclides
as radiochemicals, gallium-68 generators
and various types of radiation sources.
Products of Cyclotron Co., Ltd. pass rigid
quality and safety control.
All sources are tested after manufacture
for an absence of the radioactive
contamination of the surface and a
leakage of the radioactive substance.
The Company's activities in the field of
industrial safety, labor and environmental
protection are carried out in strict
compliance with the federal legislation
and are an integral part of sustainable
development of the enterprise.
Radiation Control

7. The first cyclotron
The first cyclotron, U-150, accelerates protons to the energy of 20-23 MeV.
Average current of the internal beam on the target during irradiation is up to 1100
µA.
Nuclear reactions (p,2n), (p,pn), (p,2p) are used for the radionuclide production on
this facility.

8. The second cyclotron
The second cyclotron, RIC-14, accelerates protons to the energy of 14 MeV.
Average current of the internal beam on the target during irradiation reaches 2100
µA.
The (p,n)-nuclear reaction is used to produce the radionuclides on this accelerator.

9. The Radiochemical lab
The Radiochemical section has seven heavy boxes (hot cells) with lead shielding
thickness of 50 mm to 150 mm. They are equipped with manipulators for remote
control of operations.

10. Separated cyclotron radionuclides
The enterprise "Cyclotron" has developed technologies for production of more than
20 radionuclides as radiochemicals. These technologies are constantly improved.
Besides, technologies for regeneration of enriched stable isotopes used in
radionuclide production are developed and improved. Manufacturing application of
innovative technologies for production of radioactive nuclides and recovery of raw
materials makes it possible to increase production volumes, to improve production
efficiency and to increase the quality of manufactured products.
Radionuclide:
Beryllium-7
Titanium-44
Iron-55
Cobalt-56
Cobalt-57
Zinc-65
Gallium-67
Germanium-68
Strontium-85
Yttrium-88
Palladium-103
Cadmium-109
Indium-111
Cerium-139
Bismuth-207

11. Mössbauer sources with 57Co
A standard source has a capsule from Al with an output window of 40 µm Al foil.
57Co is incorporated into Rh foil matrix (7 µm thick) by annealing. The Rh foil with
57Co is sealed hermetically in the capsule by laser welding. The source has ISO
classification C 32231 in accordance with international standard ISO 2919.
OPTIONS
The capsule can be fabricated upon
request as follows:
• Ti and 0.5 mm Be window
(ISO classification C 54334) or
• Al and capton window
(ISO classification C 22221).
The matrix material can be Cr, Pd, Pt and Cu.
The capsule dimensions and active diameter can be modified as specified by the
customer.

12. IRIK-D type X-ray Sources
Scope of application: X-ray
fluorescent analysis, nuclear
medicine and technology
control.
Radionuclides 55Fe, 57Co or 109Cd
are electroplated on a metal
foil. The foil with radionuclide is
hermetically sealed in the
capsule. The hermetization of
the capsule is provided by laser
welding or by adhesive epoxy
resin.

13. Sources for PET checking with Ge-68
Scope of application: positron emission tomography (PET) systems
Line Source of PGL.1 type
Line source PGL.1 has a capsule made from Ti alloy (or stainless steel) tube 3 mm in
diameter and maximum length of 202 mm. 68Ge is uniformly electroplated on Cu
wire. The Cu wire with 68Ge is hermetically sealed in the capsule by laser welding.
Plug 2 has internal M2 thread.

14. Phantom Source of PGL.2 type
Phantom source PGL.2 has a hermetically sealed plastic capsule with active part in
the form of cylinder. 68Ge is uniformly distributed in the active part. Material of the
active part is epoxy resin.

15. Gallium-68 generator
Scope of application: equipment calibration at positron emission tomography
centers; development of methods of synthesis of gallium-68 labeled compounds.
The gallium-68 generator is intended for multiple production of a gallium-68
solution.

16. Transport packing set
The cyclotron products are shipped in the packing sets of UKT1A-1C and UKT1A-2C
types manufactured and marked in accordance with rules and regulations for safe
transportation of radioactive materials, stated in NP-053-04 (a standard of RF), No
TS-R-1 (IAEA-2005), ICAO and the UN regulations. The packing sets have certificates-
authorizations for the design issued by the State Corporation for Atomic Energy
“Rosatom”.

17. The Company's research and engineering potential
Within the last 30 years employees of Cyclotron Co., Ltd.
implemented more than 50 inventions, published over
260 research papers, and prepared and defended
7 Associate’s theses and 1 Doctor’s thesis.
Products of Cyclotron Co., Ltd. were awarded golden and
silver medals of the Exhibition of National Economy
Achievements, the High-Quality Mark and other awards.

18. Licenses and certificates

19. Cyclotron Co., Ltd.
Bondarenko Sq., 1, Obninsk, Kaluga Region, 249033
General Director: Dr. Anatolii Razbash
Phone: +7 48439 9-86-36, 9-80-34; +7 495 956-91-57
Fax: +7 48439 9-53-78, 9-70-48, 9-42-73
Е-mail: info@cyclotronzao.ru, cyclotron@obninsk.com
Web site: www.cyclotronzao.ru
Delivery of the required
goods of the required
quality, in the required
quantity, at the required
time and to the required
place to a consumer on
favorable terms.
Obninsk