2. STRUCTURE
hCG is a glycoprotein Molecular weight is 36000-40000 daltons.
The HCG is produced by the placental trophoblastic cells made of two
subunits, alpha, and beta.
α-HCG, produced by cytotrophoblasts, structurally resembles
follicle-stimulating hormone, leutinizing hormone, and thyroid-
stimulating hormone.
β-HCG, made by syncitiotrophoblasts, has a unique structure,
making it the earliest characteristic clinical marker of pregnancy.
3.
4. Function HCG
1. rescue and maintenance of corpus luteum till 6-8 weeks of pregnancy.
2. stimulus for the secretion of progesteron by the corpus luteum.
3. It stimulate Leyding cells of the male fetus to produce testosterone
4. inhibit the maternal process of immunorejection of the fetus as a homograft.
5. Stimulates both adrenal and placental steroidogenesis.
6. Stimulates maternal thyroid because of its thyrotrophic activity.
5. NORMAL LEVEL HCG
Men = < 5.0 mIU/mL
Non Pregnant women = < 5.0
mIU/ mL
1. HCG is detectable after 6 to 8
days.
2. The HCG doubles every two
days until 10 weeks.
3. By second trimester the peak
level is 10,000 (800 ng/mL)
6.
7. High levels of hCG
Multiple Fetuses
Molar pregnancy.
Choriocarcinoma.
Germ cell tumors of ovary and testes
HCG may be produced in primary liver cell carcinoma
Medication
8. Low HCG level
In an early pregnancy as estimated by the last menstrual period.
An ectopic pregnancy
Death of the baby
Miscarriage (spontaneous abortion)