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10 Things you Need to Know about TBI by Knight
1. Next Level Neuro Resus
26 June 2015
WilliamA Knight IV, MD, FACEP
University of Cincinnati
Traumatic Brain Injury – 10Things you Need to Know
William.Knight@uc.edu
@waknight4
2.
3.
4.
5.
6.
7. Epidemiology:TBI in the US
50,000
Deaths
100,000
Hospitalizations
1,111,000
Emergency DepartmentVisits
?? Receiving Other Medical Care or No Care
* Average annual numbers, 1995-2001
2004 CDC Report: TBI in the United States: ED Visits, Hospitalizations, and Deaths
1.5 – 2.0 million
TBIs occur each year.*
40.  DECRA
ProTECT
 Disease definition
 Can what we see contributing to poor or good
outcome be as wrong as these trials suggest or
do we need to define the disease and patients
better?
 Multicenter RCTs can be successfully performed
41. Adeoye O & Shutter L. Neurotrauma & Critical Care of
the Brain. JalloJ, ed. Thieme; 2009.
CPP?
42.
43.
44.  Target normal physiologic goals
 Research
 We know how to study
â–Ş Do we know what to study?
 Early aggressive care is the future
 24 hours of resuscitation prior to prognosis
45. “It’s not an exceptional case. We
just don’t know how many
exceptions to the rule there are.
So.
I don’t believe in the rule anymore.”
- Joseph Giacino, PhD
http://nymag.com/scienceofus/2015/06/dylan-rizzo-coma.html