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Presented by
Anirudh Padiyar
INNOVATOR COMPANY
 Indena Phytosome® U.S. Patent # 4,764,508
world's leading company in the identification,
development and production of active principles
derived from plants, for use in pharmaceutical, health-
food and personal care industy.
Phytosome vs Liposome.
Advantages of phytosome
 Better bioavailability.
 Reduced dose.
 Hepatoprotective synergistic effect.
 Better stability profile.
 Nutritional benefit.
Formulation
Patented Procedure.
Phytosome® U.S. Patent # 4,764,508
Siliphos® Bioavailable silybin
 Plasma levels of total silybin after oral Silipide® and silybin in rats, where Silipide® (200
mg/kg as silybin) and silybin (200 mg/kg) were administered by gavage as aqueous
suspensions to 6 male rats.
Ginkgoselect® Phytosome vs Ginkgo biloba
extract
Fifteen healthy volunteers two groups and administered
respectively 160 mg of free formulation of GBE and
160 mg of Ginkgoselect® Phytosome®
Meriva® vs Curcumin
 In comparative study in humans the overall curcuminoid absorption was about 29-fold higher.
Greenselect® Phytosome vs green tea extract
Tablet formulation with Phytosome® complex
 Leucoselect® Phytosome® 100.0 mg
 Soy polysaccharides 138.0 mg
 Corn starch 100.0 mg
 Silicon dioxide 6.0 mg
 Talc 3.0 mg
 Magnesium stearate 3.0 mg
Hard gelatin capsule formulation with
Phytosome® complex
 Ginkgoselect® Phytosome® 180.0 mg
 Dicalcium phosphate dihydrate 196.0 mg
 microcrystalline cellulose 47.0 mg
 Croscarmellose sodium 23.0 mg
 Talc 2.0 mg
 Magnesium stearate 2.0 mg
Conclusion
 All that man needs for health and healing has
been provided by God in nature, the challenge of
science is to find it.
 Novel drug delivery systems of herbal drugs have a
potential future for enhancing the activity and
overcoming problems associated with plant
medicines.
THANK YOU

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Phytosome® a novel drug delivery system based herbal formulation

  • 2. INNOVATOR COMPANY  Indena Phytosome® U.S. Patent # 4,764,508 world's leading company in the identification, development and production of active principles derived from plants, for use in pharmaceutical, health- food and personal care industy.
  • 4. Advantages of phytosome  Better bioavailability.  Reduced dose.  Hepatoprotective synergistic effect.  Better stability profile.  Nutritional benefit.
  • 6. Siliphos® Bioavailable silybin  Plasma levels of total silybin after oral Silipide® and silybin in rats, where Silipide® (200 mg/kg as silybin) and silybin (200 mg/kg) were administered by gavage as aqueous suspensions to 6 male rats.
  • 7. Ginkgoselect® Phytosome vs Ginkgo biloba extract Fifteen healthy volunteers two groups and administered respectively 160 mg of free formulation of GBE and 160 mg of Ginkgoselect® Phytosome®
  • 8. Meriva® vs Curcumin  In comparative study in humans the overall curcuminoid absorption was about 29-fold higher.
  • 9. Greenselect® Phytosome vs green tea extract
  • 10. Tablet formulation with Phytosome® complex  Leucoselect® Phytosome® 100.0 mg  Soy polysaccharides 138.0 mg  Corn starch 100.0 mg  Silicon dioxide 6.0 mg  Talc 3.0 mg  Magnesium stearate 3.0 mg
  • 11. Hard gelatin capsule formulation with Phytosome® complex  Ginkgoselect® Phytosome® 180.0 mg  Dicalcium phosphate dihydrate 196.0 mg  microcrystalline cellulose 47.0 mg  Croscarmellose sodium 23.0 mg  Talc 2.0 mg  Magnesium stearate 2.0 mg
  • 12. Conclusion  All that man needs for health and healing has been provided by God in nature, the challenge of science is to find it.  Novel drug delivery systems of herbal drugs have a potential future for enhancing the activity and overcoming problems associated with plant medicines.