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True hyponatremia ,[object Object]
True hyponatremia ,[object Object],Negative salt balance  causes hypovolemia
[object Object],Causes of hyponatremia: Increased intake ,[object Object],clearing
Water clearance ,[object Object],[object Object],[object Object],[object Object]
Free water clearance and soup ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],In regards to sodium all that matters is the free water component
Free water clearance 0.5 liter free water Solute component  (plasma osmolality 284 mOsm/kg) Use clearance to calculate the osmolar clearance 1 liter 142 mOsm/Kg 0.5 liter 284 mOsm/Kg
Free water clearance Solute component  (Solute Clearance) ? 0.5 liter Zero mOsm/Kg Free water component  (Free water Clearance) The free water component equals urine volume minus the solute component 1 liter 142 mOsm/Kg 0.5 liter 284 mOsm/Kg
Free water clearance 0.5 liter 568 mOsm/Kg 1 liter 284 mOsm/Kg -0.5 liter 568 mOsm/Kg
Free water clearance Solute component  (plasma osmolality 284 mOsm/kg) Use clearance to calculate the osmolar clearance 1 liter 284 mOsm/Kg 0.5 liter 568 mOsm/Kg
Free water clearance Solute component  (Solute Clearance) ? Free water component  (Free water Clearance) 0.5 liter 568 mOsm/Kg –  0.5 liter Zero mOsm/Kg 1 liter 284 mOsm/Kg
Free water clearance: Implications Dilute urine increases serum osmolality Concentrated urine de-creases serum osmolality Dilute urine Solute free water Concentrated urine Negative free water Na + Na +
Free water clearance: The math
Free water clearance: Math Examples
Electrolyte free water clearance ,[object Object],[object Object]
Electrolyte free water clearance ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Electrolyte free water clearance ,[object Object],[object Object],[object Object],Free water clearance Electrolyte free water clearance
Electrolyte free water clearance: CHF vs. SIADH ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Etiology of hyponatremia ,[object Object],[object Object],Ingestion > EFW clearance

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Electrolyte Free Water Clearance

  • 1.
  • 2.
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  • 4.
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  • 6. Free water clearance 0.5 liter free water Solute component (plasma osmolality 284 mOsm/kg) Use clearance to calculate the osmolar clearance 1 liter 142 mOsm/Kg 0.5 liter 284 mOsm/Kg
  • 7. Free water clearance Solute component (Solute Clearance) ? 0.5 liter Zero mOsm/Kg Free water component (Free water Clearance) The free water component equals urine volume minus the solute component 1 liter 142 mOsm/Kg 0.5 liter 284 mOsm/Kg
  • 8. Free water clearance 0.5 liter 568 mOsm/Kg 1 liter 284 mOsm/Kg -0.5 liter 568 mOsm/Kg
  • 9. Free water clearance Solute component (plasma osmolality 284 mOsm/kg) Use clearance to calculate the osmolar clearance 1 liter 284 mOsm/Kg 0.5 liter 568 mOsm/Kg
  • 10. Free water clearance Solute component (Solute Clearance) ? Free water component (Free water Clearance) 0.5 liter 568 mOsm/Kg – 0.5 liter Zero mOsm/Kg 1 liter 284 mOsm/Kg
  • 11. Free water clearance: Implications Dilute urine increases serum osmolality Concentrated urine de-creases serum osmolality Dilute urine Solute free water Concentrated urine Negative free water Na + Na +
  • 13. Free water clearance: Math Examples
  • 14.
  • 15.
  • 16.
  • 17.
  • 18.