The document describes the design of a pharmaceutical plant to produce the HIV/AIDS drug Stavudine. Key aspects of the design include a three-reactor production process, recycling of solvents to reduce costs and waste, and safety features to protect workers from hazardous chemicals. Economic analysis shows the plant would be profitable, with an internal rate of return of 49.3% and potential to increase annual profits.

1. Design for the Manufacturing of Stavudine Project Leader: Dr. Mahmoud Mirmehrabi April 29, 2008 Esra Altalibi Narjis Al Saleh Peter Winter Nicholas Kuwahara

3. Production Process Overview

4. Overall Synthesis

6. Production Process

9. Overall Plant Layout Tank Farm Office Process Facilities

11. Plant Layout: Synthesis Unit

13. Plant Layout: Temperature Control Unit

14. Temperature Control Unit (TCU)

15. Current Good Manufacturing Practices Copyright: Nanotube (Flickr.com)

18. Safety Safety, it’s what matters most

21. Plant Layout: Storage Tank Farm Warehouse

22. Tank Farm Safety, it’s what matters most

23. Warehouse Safety, it’s what matters most

24. Environmental Considerations Keeping the future in mind Cobalt123 (Flickr.com)

27. Economic Analysis

30. Conclusions

38. Backup Slide: Block Flow Diagram

39. Esra Altalibi

40. Backup Slide: Overview of Stavudine Production

48. Backup Slide: Reaction By-Products Compound Stage N2 1 NaCl 1 H2O 1, 2 Na+[BH2(OCH2CH3)2]- 3 Pyridinium chloride 4 Isobutane 5 Al(OH)4K 5 Sodium Tartrate 5 SO2 6 Compound Stage HCl 6 KCl 6 Tert-butanol 6 C4H4O2N+ 7 TMS-O-TMS 7 NH3 7 Na+ 7 CO2 7 C4H10O 8 KI 8 CH3OCOC(CH3)3 9

51. Backup: Recycle Process