Eicosanoids - power point presentaion

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Namrata Chhabra

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Eicosanoids- Chemistry and
Functions- A Brief Review

5/20/2012 Biochemistry for Medics 1

Eicosanoids

5/20/2012 Biochemistry for Medics 2

Eicosanoids- Classification

5/20/2012 Biochemistry for Medics 3

Prostanoids

5/20/2012 Biochemistry for Medics 4

Characteristic features of
Structure of prostaglandins

5/20/2012 Biochemistry for Medics 5

Series of prostaglandins

5/20/2012 Biochemistry for Medics 6

Characteristic features of
prostaglandins

5/20/2012 Biochemistry for Medics 7

Functions of Prostaglandins

5/20/2012 Biochemistry for Medics 8

Prostacyclins and Thromboxanes-
Chemistry and Functions

5/20/2012 Biochemistry for Medics 9

Functions of Prostcyclins

5/20/2012 Biochemistry for Medics 10

Functions of Thromboxanes

5/20/2012 Biochemistry for Medics 11

Synthesis of Prostaglandins

5/20/2012 Biochemistry for Medics 12

Steps of synthesis of Prostaglandins

5/20/2012 Biochemistry for Medics 13

Steps of synthesis of Prostanoids

5/20/2012 Biochemistry for Medics 14

Steps of synthesis of Prostanoids

5/20/2012 Biochemistry for Medics 15

PGH synthase Isoforms

5/20/2012 Biochemistry for Medics 16

Significance of PGH synthase isoforms

5/20/2012 Biochemistry for Medics 17

Inhibitors of Prostanoid synthesis

5/20/2012 Biochemistry for Medics 18

Selective V/S Non Selective COX
inhibition

5/20/2012 Biochemistry for Medics 19

Catabolism of Prostaglandins

5/20/2012 Biochemistry for Medics 20

Leukotrienes

5/20/2012 Biochemistry for Medics 21

Lipoxins

5/20/2012 Biochemistry for Medics 22

Steps of synthesis of Leukotrienes

5/20/2012 Biochemistry for Medics 23

Steps of synthesis of Leukotrienes

5/20/2012 Biochemistry for Medics 24

Functions of Leukotrienes

5/20/2012 Biochemistry for Medics 25

Steps of synthesis of Lipoxins

5/20/2012 Biochemistry for Medics 26

Steps of Synthesis of Lipoxins

5/20/2012 Biochemistry for Medics 27

Slow-reacting substance of anaphylaxis
(SRS-A)

5/20/2012 Biochemistry for Medics 28

Reason for Aspirin induced Asthma

5/20/2012 Biochemistry for Medics 29

Reason for Aspirin induced Asthma

5/20/2012 Biochemistry for Medics 30

Pharmacological applications of
Eicosanoids

5/20/2012 Biochemistry for Medics 31

Pharmacological applications of
Eicosanoids(Contd.)

5/20/2012 Biochemistry for Medics 32

Pharmacological applications of
Eicosanoids(Contd.)

5/20/2012 Biochemistry for Medics 33

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Diabetes mellitus is an autoimmune disorder which causes impairment in the insulin secretion or resistance. The prevalence of Diabetes is increasing day by day worldwide, also this metabolic disorder diseases is associated with high risk of cardiac problem, obesity and many other diseases. Although, there are different medications and treatments are available but still they have proven to be ineffective and associated with severe adverse effects for long term. Therapeutic compounds based on herbal phytochemicals are considered as the most prominent for the treatments. The computational study helps in finding the structural basis analysis of the compounds by rapid screening tools with rational drug designing. This study aims to identify the natural inhibitor of Rad GTP binding protein to treat Diabetes dysfunctionality.Therefore, by searching the natural compounds against Rad GTPase binding protein with 2DPX structure, all the important data was retrieved by using online webservers followed by computing docking score in AutoDock Vina. Out of three selected compounds, Gedunin was used to dock with the protein 2DAX protein structure, as it follows the both criteria for proceeding further, one is to follow lowest binding criteria then ADME Absorption, Distribution, Metabolism and excretion . The docking score of Gedunin compound shows that, this bioactive agent can go against the Diabetes mellitus and inhibits the expression of Rad GTPase. By result Gedunin has shown its therapeutic role with 7.9 kcal mol value. It has been concluded that in future Gedunin may act as a novel drug target. Chanchal Prajapati | Varsha Prajapati | Mishka Tyagi | Noopur Khare | Abhimanyu Kumar Jha "Study of the Effect of Gedunin against Protein-GTP-Binding Protein RAD to Treat Diabetes: An In-Silico Approach" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd43888.pdf Paper URL: https://www.ijtsrd.com/biological-science/biotechnology/43888/study-of-the-effect-of-gedunin-against-proteingtpbinding-protein-rad-to-treat-diabetes-an-insilico-approach/chanchal-prajapati

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Eicosanoids - power point presentaion

1. Eicosanoids- Chemistry and Functions- A Brief Review 5/20/2012 Biochemistry for Medics 1

2. Eicosanoids 5/20/2012 Biochemistry for Medics 2

3. Eicosanoids- Classification 5/20/2012 Biochemistry for Medics 3

4. Prostanoids 5/20/2012 Biochemistry for Medics 4

5. Characteristic features of Structure of prostaglandins 5/20/2012 Biochemistry for Medics 5

6. Series of prostaglandins 5/20/2012 Biochemistry for Medics 6

7. Characteristic features of prostaglandins 5/20/2012 Biochemistry for Medics 7

8. Functions of Prostaglandins 5/20/2012 Biochemistry for Medics 8

9. Prostacyclins and Thromboxanes- Chemistry and Functions 5/20/2012 Biochemistry for Medics 9

10. Functions of Prostcyclins 5/20/2012 Biochemistry for Medics 10

11. Functions of Thromboxanes 5/20/2012 Biochemistry for Medics 11

12. Synthesis of Prostaglandins 5/20/2012 Biochemistry for Medics 12

13. Steps of synthesis of Prostaglandins 5/20/2012 Biochemistry for Medics 13

14. Steps of synthesis of Prostanoids 5/20/2012 Biochemistry for Medics 14

15. Steps of synthesis of Prostanoids 5/20/2012 Biochemistry for Medics 15

16. PGH synthase Isoforms 5/20/2012 Biochemistry for Medics 16

17. Significance of PGH synthase isoforms 5/20/2012 Biochemistry for Medics 17

18. Inhibitors of Prostanoid synthesis 5/20/2012 Biochemistry for Medics 18

19. Selective V/S Non Selective COX inhibition 5/20/2012 Biochemistry for Medics 19

20. Catabolism of Prostaglandins 5/20/2012 Biochemistry for Medics 20

21. Leukotrienes 5/20/2012 Biochemistry for Medics 21

22. Lipoxins 5/20/2012 Biochemistry for Medics 22

23. Steps of synthesis of Leukotrienes 5/20/2012 Biochemistry for Medics 23

24. Steps of synthesis of Leukotrienes 5/20/2012 Biochemistry for Medics 24

25. Functions of Leukotrienes 5/20/2012 Biochemistry for Medics 25

26. Steps of synthesis of Lipoxins 5/20/2012 Biochemistry for Medics 26

27. Steps of Synthesis of Lipoxins 5/20/2012 Biochemistry for Medics 27

28. Slow-reacting substance of anaphylaxis (SRS-A) 5/20/2012 Biochemistry for Medics 28

29. Reason for Aspirin induced Asthma 5/20/2012 Biochemistry for Medics 29

30. Reason for Aspirin induced Asthma 5/20/2012 Biochemistry for Medics 30

31. Pharmacological applications of Eicosanoids 5/20/2012 Biochemistry for Medics 31

32. Pharmacological applications of Eicosanoids(Contd.) 5/20/2012 Biochemistry for Medics 32

33. Pharmacological applications of Eicosanoids(Contd.) 5/20/2012 Biochemistry for Medics 33

Eicosanoids - power point presentaion

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