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AIDS IssuesAIDS Issues
ByBy
Dr Mona AbosereaDr Mona Aboserea
Prof. of Public HealthProf. of Public Health
Zagazig universi...
HIVHIV
Human Immunodeficiency VirusHuman Immunodeficiency Virus
H = Infects onlyH = Infects only HHuman beingsuman beings
...
AIDSAIDS
AAcquiredcquired IImmunemmune DDeficiencyeficiency SSyndromeyndrome
AA == AAcquired, not inheritedcquired, not in...
DR. S.K CHATURVEDIDR. S.K CHATURVEDI
Transmission of HIVTransmission of HIV
HIV is not transmitted byHIV is not transmitte...
Stages of HIV infectionStages of HIV infection
HIV infection occurs in 4 stages:HIV infection occurs in 4 stages:
primary infection, clinicallyprimary infection, clinica...
Case Surveillance DefinitionsCase Surveillance Definitions
The WHO system also is based onThe WHO system also is based on
...
In addition, for children aged youngerIn addition, for children aged younger
than 5 years, WHO suggests using thethan 5 ye...
What is HIV Incidence SurveillanceWhat is HIV Incidence Surveillance
(HIS)?(HIS)?
HIV incidence measures the number of new...
HIV and AIDSHIV and AIDS
• When the immune system becomesWhen the immune system becomes
weakened by HIV, the illnessweaken...
Period of communicability:Period of communicability:
So long the infected person is aliveSo long the infected person is al...
Clinical picture of AIDS:Clinical picture of AIDS:
11 -- Non-specific manifestations:Non-specific manifestations: e.g.e.g....
Diagnosis of AIDS:Diagnosis of AIDS:
1 - Clinical picture.1 - Clinical picture.
2 - Laboratory diagnosis:2 - Laboratory di...
Desired Outcome of Routine HIVDesired Outcome of Routine HIV
ScreeningScreening
1616
Health Consequences ofHealth Consequences of
AIDS-related StigmaAIDS-related Stigma
What is Stigma?What is Stigma?
1)1) It's a mark of anIt's a mark of an enduringenduring condition orcondition or
attribute...
StigmaStigma , prejudice, prejudice &&
discriminationdiscrimination
Related but not synonymous:Related but not synonymous:...
Why is AIDS so highlyWhy is AIDS so highly
stigmatized?stigmatized?
Stigma is more intense when the conditionStigma is mor...
Effects of stigmaEffects of stigma
Social isolationSocial isolation
Limited rights and reduced access toLimited rights a...
Consequences of AIDS-relatedConsequences of AIDS-related
stigma and discriminationstigma and discrimination
It causes huma...
Stigma in service deliveryStigma in service delivery
• Discourages access to ANC servicesDiscourages access to ANC service...
Health Consequences of AIDS StigmaHealth Consequences of AIDS Stigma
 PreventionPrevention - afraid to access prevention ...
Addressing stigmaAddressing stigma
• Interventions addressing HIV-relatedInterventions addressing HIV-related
stigma can t...
Stigma avoidance strategies included:Stigma avoidance strategies included:
1) stating or implying that they had a1) statin...
Interviewed at baseline, six-Interviewed at baseline, six-
month follow-up, and twelve-month follow-up, and twelve-
month ...
So what can we do to reduceSo what can we do to reduce
AIDS-related stigma?AIDS-related stigma?
Reducing AIDS stigmaReducing AIDS stigma
Targeting at multiple levelsTargeting at multiple levels
PolicyPolicy:: Law and p...
FamiliesFamilies - provide support and education in whatever- provide support and education in whatever
venue that is poss...
Reducing stigmaReducing stigma
Content of messagesContent of messages
Content needs to be tailored, based on:Content needs...
Prevention of HIV TransmissionPrevention of HIV Transmission
Strategies to prevent HIV transmissionStrategies to prevent ...
a) Measures for casesa) Measures for cases
1 -1 - Case findingCase finding: screening of high risk: screening of high risk...
44 - Concurrent disinfection- Concurrent disinfection: of equipment: of equipment
contaminated with blood or body fluids a...
b) Measures for contacts:b) Measures for contacts:
1 - Notification of contacts and source1 - Notification of contacts and...
Prevention of HIV TransmissionPrevention of HIV Transmission
Public health strategies to prevent HIVPublic health strategi...
We should stress onWe should stress on
HIV patients Health care providers
Improve their awareness &
KNOWELEDGE about AIDS
GOOD COMMUNICATION
WITH these patient...
Vaccine DevelopmentVaccine Development
Developing a vaccine for HIV infection is a globalDeveloping a vaccine for HIV infe...
Challenges and RisksChallenges and Risks
Although the effort to develop an effectiveAlthough the effort to develop an effe...
ChallengeChallenge
 HIV-related stigma is increasinglyHIV-related stigma is increasingly
recognized as the single greates...
Human rightsHuman rights
• Freedom from discrimination is aFreedom from discrimination is a
fundamental human rightfundame...
QUESTIONSQUESTIONS
??????????????????????????
Thank youThank you
Aids  issues
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Aids issues

  1. 1. AIDS IssuesAIDS Issues ByBy Dr Mona AbosereaDr Mona Aboserea Prof. of Public HealthProf. of Public Health Zagazig universityZagazig university
  2. 2. HIVHIV Human Immunodeficiency VirusHuman Immunodeficiency Virus H = Infects onlyH = Infects only HHuman beingsuman beings I =I = IImmunodeficiency virus weakens themmunodeficiency virus weakens the immune system and increases the risk ofimmune system and increases the risk of infectioninfection V =V = VVirus that attacks the bodyirus that attacks the body
  3. 3. AIDSAIDS AAcquiredcquired IImmunemmune DDeficiencyeficiency SSyndromeyndrome AA == AAcquired, not inheritedcquired, not inherited II = Weakens the= Weakens the IImmune systemmmune system DD = Creates a= Creates a DDeficiency of CD4+ cellseficiency of CD4+ cells in the immune systemin the immune system SS == SSyndrome, or a group of illnessesyndrome, or a group of illnesses taking place at the same timetaking place at the same time
  4. 4. DR. S.K CHATURVEDIDR. S.K CHATURVEDI Transmission of HIVTransmission of HIV HIV is not transmitted byHIV is not transmitted by • Public bathsPublic baths • HandshakesHandshakes • Work or school contactWork or school contact • Using telephonesUsing telephones • Sharing cups, glasses,Sharing cups, glasses, plates, or other utensilsplates, or other utensils • Coughing, sneezingCoughing, sneezing • Insect bitesInsect bites • Touching, huggingTouching, hugging • Water, foodWater, food • KissingKissing ??????
  5. 5. Stages of HIV infectionStages of HIV infection
  6. 6. HIV infection occurs in 4 stages:HIV infection occurs in 4 stages: primary infection, clinicallyprimary infection, clinically asymptomatic stage, symptomatic HIVasymptomatic stage, symptomatic HIV infection, and progression from HIV toinfection, and progression from HIV to AIDS.AIDS.
  7. 7. Case Surveillance DefinitionsCase Surveillance Definitions The WHO system also is based onThe WHO system also is based on laboratory confirmation of HIV infection.laboratory confirmation of HIV infection. However, the WHO surveillance systemHowever, the WHO surveillance system consists of 4 clinical stages that correspond toconsists of 4 clinical stages that correspond to WHO antiretroviral treatment guidelines:WHO antiretroviral treatment guidelines: HIV infection – stage 1, no symptoms.HIV infection – stage 1, no symptoms. HIV infection – stage 2, mild symptoms.HIV infection – stage 2, mild symptoms. Advanced HIV disease – stage 3,Advanced HIV disease – stage 3, advanced symptoms.advanced symptoms. AIDS – stage 4, severe symptomsAIDS – stage 4, severe symptoms..
  8. 8. In addition, for children aged youngerIn addition, for children aged younger than 5 years, WHO suggests using thethan 5 years, WHO suggests using the percentage of total CD4+ Tpercentage of total CD4+ T lymphocytes rather than the absolutelymphocytes rather than the absolute CD4 count for accuracy.CD4 count for accuracy. The WHO staging system is designedThe WHO staging system is designed to assist in the clinical management ofto assist in the clinical management of HIV, especially where there are limitedHIV, especially where there are limited laboratory facilitieslaboratory facilities
  9. 9. What is HIV Incidence SurveillanceWhat is HIV Incidence Surveillance (HIS)?(HIS)? HIV incidence measures the number of new HIV infections in a population over a period of time. HIS estimates are based on data collected through routine case reporting and a newly developed biomarker. HIS is part of a national effort supported by the Centers for Disease Control and Prevention (CDC) to fully integrate incidence as a component of the HIV/AIDS surveillance system and will help target HIV treatment and prevention efforts.
  10. 10. HIV and AIDSHIV and AIDS • When the immune system becomesWhen the immune system becomes weakened by HIV, the illnessweakened by HIV, the illness progresses to AIDSprogresses to AIDS • Some blood tests, symptoms orSome blood tests, symptoms or certain infections indicatecertain infections indicate progression of HIV to AIDSprogression of HIV to AIDS
  11. 11. Period of communicability:Period of communicability: So long the infected person is aliveSo long the infected person is alive Incubation period:Incubation period: Variable???Variable??? But 50% of those infected develop AIDSBut 50% of those infected develop AIDS about 10 years after infection.about 10 years after infection.
  12. 12. Clinical picture of AIDS:Clinical picture of AIDS: 11 -- Non-specific manifestations:Non-specific manifestations: e.g.e.g. lymphadenopathy, anorexia, chronic diarrhea, weightlymphadenopathy, anorexia, chronic diarrhea, weight loss, fever and fatigue.loss, fever and fatigue. 2 -2 - Specific indicator diseasesSpecific indicator diseases:: (a) Opportunistic infections such as pneumocystitis(a) Opportunistic infections such as pneumocystitis carenii pneumonia, chronic cryptosporidiosis,carenii pneumonia, chronic cryptosporidiosis, toxoplasmosis of CNS,etc.toxoplasmosis of CNS,etc. (b) Neurologic diseases as HIV dementia or sensory(b) Neurologic diseases as HIV dementia or sensory neuropathy.neuropathy. (c) Cancers as Kaposi sarcoma and Hodgkin's lymphoma.(c) Cancers as Kaposi sarcoma and Hodgkin's lymphoma. (d) Others e.g. pulmonary or extra-pulmonary T.B.(d) Others e.g. pulmonary or extra-pulmonary T.B.
  13. 13. Diagnosis of AIDS:Diagnosis of AIDS: 1 - Clinical picture.1 - Clinical picture. 2 - Laboratory diagnosis:2 - Laboratory diagnosis:  Serologic tests for HIV antibodiesSerologic tests for HIV antibodies e.g.e.g. ELISA, Western blot, IndirectELISA, Western blot, Indirect Immunofluorescence Assay.Immunofluorescence Assay.  PCR test to detect HIV antigen.PCR test to detect HIV antigen.
  14. 14. Desired Outcome of Routine HIVDesired Outcome of Routine HIV ScreeningScreening 1616
  15. 15. Health Consequences ofHealth Consequences of AIDS-related StigmaAIDS-related Stigma
  16. 16. What is Stigma?What is Stigma? 1)1) It's a mark of anIt's a mark of an enduringenduring condition orcondition or attributeattribute 2)2) The condition isThe condition is negatively valuednegatively valued byby societysociety As a consequence, those with theAs a consequence, those with the condition becomecondition become disadvantaged.disadvantaged.
  17. 17. StigmaStigma , prejudice, prejudice && discriminationdiscrimination Related but not synonymous:Related but not synonymous: PrejudicePrejudice: An attitude. An: An attitude. An individualindividual evaluation or judgment of a groupevaluation or judgment of a group DiscriminationDiscrimination:: AA behaviorbehavior. Refers to. Refers to treatment of individuals based on theirtreatment of individuals based on their membership in a group.membership in a group.
  18. 18. Why is AIDS so highlyWhy is AIDS so highly stigmatized?stigmatized? Stigma is more intense when the conditionStigma is more intense when the condition is:is: 1) Perceived as lethal and incurable1) Perceived as lethal and incurable 2) Perceived to be the responsibility of the2) Perceived to be the responsibility of the bearerbearer
  19. 19. Effects of stigmaEffects of stigma Social isolationSocial isolation Limited rights and reduced access toLimited rights and reduced access to servicesservices HIV/AIDS related stigma fuels new HIVHIV/AIDS related stigma fuels new HIV infectionsinfections Secondary stigmaSecondary stigma (stigma by association)(stigma by association)
  20. 20. Consequences of AIDS-relatedConsequences of AIDS-related stigma and discriminationstigma and discrimination It causes human suffering due to:It causes human suffering due to:  Loss of employmentLoss of employment  Loss of housingLoss of housing  Rejection by familyRejection by family  Rejected by communityRejected by community  Denied schoolingDenied schooling  Denied marriageDenied marriage  Restrictions on movement -> QuarantineRestrictions on movement -> Quarantine  Physical and verbal abuse and threatsPhysical and verbal abuse and threats andand  Interferes with AIDS prevention and treatmentInterferes with AIDS prevention and treatment servicesservices
  21. 21. Stigma in service deliveryStigma in service delivery • Discourages access to ANC servicesDiscourages access to ANC services • Prevents access to counselling , HIV testingPrevents access to counselling , HIV testing • Discourages disclosure of HIV test results toDiscourages disclosure of HIV test results to partner(s)partner(s) • Discourages acceptance of any health careDiscourages acceptance of any health care interventionsinterventions • Inhibits use of safer infant-feeding practicesInhibits use of safer infant-feeding practices • Confers secondary stigmatisation on the childConfers secondary stigmatisation on the child
  22. 22. Health Consequences of AIDS StigmaHealth Consequences of AIDS Stigma  PreventionPrevention - afraid to access prevention services and- afraid to access prevention services and be identified as member of "at risk" group.be identified as member of "at risk" group. - afraid to disclose positive sero status to sex partner- afraid to disclose positive sero status to sex partner  Treatment -Treatment - afraid to disclose status to health careafraid to disclose status to health care staff and not wanting to be seen at "AIDS clinic"staff and not wanting to be seen at "AIDS clinic"  ResearchResearch - not wanting to identify as member of- not wanting to identify as member of stigmatized group. Concerns of loss of confidentialitystigmatized group. Concerns of loss of confidentiality  CareCare - unwilling to provide care for sick family- unwilling to provide care for sick family member. Unwilling to go into AIDS treatment fieldmember. Unwilling to go into AIDS treatment field  Mental healthMental health consequences for PWAs: High rates ofconsequences for PWAs: High rates of depression and suicide.depression and suicide.
  23. 23. Addressing stigmaAddressing stigma • Interventions addressing HIV-relatedInterventions addressing HIV-related stigma can take place at all levels:stigma can take place at all levels: NationalNational Community and social/culturalCommunity and social/cultural Health care site/facilityHealth care site/facility IndividualIndividual
  24. 24. Stigma avoidance strategies included:Stigma avoidance strategies included: 1) stating or implying that they had a1) stating or implying that they had a different disease, such as TB;different disease, such as TB; 2) adopting a “don’t ask, don’t tell” status;2) adopting a “don’t ask, don’t tell” status; 3) lying outright about their HIV status;3) lying outright about their HIV status; 4) seeking treatment at a hospital far away4) seeking treatment at a hospital far away from home; andfrom home; and 5) refusing to explain written medical5) refusing to explain written medical documents to illiterate family members.documents to illiterate family members.
  25. 25. Interviewed at baseline, six-Interviewed at baseline, six- month follow-up, and twelve-month follow-up, and twelve- month follow-up visits aboutmonth follow-up visits about their experiences withtheir experiences with medication and living with HIVmedication and living with HIV
  26. 26. So what can we do to reduceSo what can we do to reduce AIDS-related stigma?AIDS-related stigma?
  27. 27. Reducing AIDS stigmaReducing AIDS stigma Targeting at multiple levelsTargeting at multiple levels PolicyPolicy:: Law and policy reforms neededLaw and policy reforms needed globally to prohibit discrimination of PWAs andglobally to prohibit discrimination of PWAs and to protect those who are most vulnerable (e.g.to protect those who are most vulnerable (e.g. sexual partners, substance abusers, ethnic andsexual partners, substance abusers, ethnic and racial minorities).racial minorities). SocialSocial: Community-based programs, including: Community-based programs, including media (as appropriate in each setting). Workmedia (as appropriate in each setting). Work through local NGOsthrough local NGOs InstitutionalInstitutional: Military, schools, prisons,: Military, schools, prisons, hospitals, and religious institutions and leaders.hospitals, and religious institutions and leaders.
  28. 28. FamiliesFamilies - provide support and education in whatever- provide support and education in whatever venue that is possiblevenue that is possible Mobilize and supportMobilize and support positive peoplepositive people and encourageand encourage their involvement in activities and advocacytheir involvement in activities and advocacy CouplesCouples - in whatever setting that couples can be- in whatever setting that couples can be reached, including testing and counselingreached, including testing and counseling IndividualsIndividuals - during healthcare visits, testing and- during healthcare visits, testing and counseling and other appropriate venuescounseling and other appropriate venues RecruitRecruit Opinion LeadersOpinion Leaders - educate and involve them- educate and involve them Reducing AIDS stigmaReducing AIDS stigma
  29. 29. Reducing stigmaReducing stigma Content of messagesContent of messages Content needs to be tailored, based on:Content needs to be tailored, based on: – Cultural context and normsCultural context and norms – Prevalent health beliefsPrevalent health beliefs – Local lawsLocal laws – Setting-specific stigma dynamicsSetting-specific stigma dynamics Specific infection fearsSpecific infection fears Pre-existing prejudices toward marginalized groupsPre-existing prejudices toward marginalized groups Multiple stigmas?Multiple stigmas? Look for strengths as well as for challengesLook for strengths as well as for challenges in each cultural settingin each cultural setting
  30. 30. Prevention of HIV TransmissionPrevention of HIV Transmission Strategies to prevent HIV transmissionStrategies to prevent HIV transmission Personal strategiesPersonal strategies Public health strategiesPublic health strategies  Safe practices: no risk of HIV transmissionSafe practices: no risk of HIV transmission  Risk reduction: reduces but does notRisk reduction: reduces but does not eliminate riskeliminate risk
  31. 31. a) Measures for casesa) Measures for cases 1 -1 - Case findingCase finding: screening of high risk: screening of high risk groups e.g. male homosexuals, i.v. druggroups e.g. male homosexuals, i.v. drug abusers, sexual partners of infectedabusers, sexual partners of infected persons, patients taking repeated bloodpersons, patients taking repeated blood transfusion as haemophilics.transfusion as haemophilics. 2 -2 - NotificationNotification: is obligatory to local health: is obligatory to local health authority and WHO.authority and WHO. 3 -3 - Isolation:Isolation: Isolation of the HIV-positiveIsolation of the HIV-positive person isperson is unnecessary, ineffective andunnecessary, ineffective and unjustified.unjustified.
  32. 32. 44 - Concurrent disinfection- Concurrent disinfection: of equipment: of equipment contaminated with blood or body fluids and withcontaminated with blood or body fluids and with excretions and secretions visibly contaminatedexcretions and secretions visibly contaminated with blood and body fluids.with blood and body fluids. 5 -5 - Treatment:Treatment:  Treatment of opportunistic diseases thatTreatment of opportunistic diseases that complicated HIV infection.complicated HIV infection.  Antiretroviral treatment: it is complex, involvingAntiretroviral treatment: it is complex, involving a combination of drugs as resistance willa combination of drugs as resistance will rapidly appear if a single drug is used. Therapidly appear if a single drug is used. The drugs are toxic and treatment must be lifelong.drugs are toxic and treatment must be lifelong. A successful treatment is not a cure, although itA successful treatment is not a cure, although it results in suppression of viral replication.results in suppression of viral replication.
  33. 33. b) Measures for contacts:b) Measures for contacts: 1 - Notification of contacts and source1 - Notification of contacts and source of infection:of infection: The infected patientThe infected patient should ensure notification of sexual andshould ensure notification of sexual and needle sharing partners wheneverneedle sharing partners whenever possible.possible. 2 -2 - Screening of contactsScreening of contacts for HIVfor HIV infection.infection. 3 - Health education.3 - Health education. 4 - No vaccination or4 - No vaccination or chemoprophylaxis.chemoprophylaxis.
  34. 34. Prevention of HIV TransmissionPrevention of HIV Transmission Public health strategies to prevent HIVPublic health strategies to prevent HIV transmission:transmission: Screen all blood and blood productsScreen all blood and blood products Follow universal precautionsFollow universal precautions Educate in safer sex practicesEducate in safer sex practices Identify and treat STIs/other infectionsIdentify and treat STIs/other infections Provide referral for treatment of drugProvide referral for treatment of drug dependencedependence Apply the comprehensive care approach toApply the comprehensive care approach to prevent vertical transmission of HIVprevent vertical transmission of HIV
  35. 35. We should stress onWe should stress on
  36. 36. HIV patients Health care providers Improve their awareness & KNOWELEDGE about AIDS GOOD COMMUNICATION WITH these patients: Good doctor patient relationship Change their negative attitude about AIDS Fair & justice in dealing with pts IMPROVING THEIR HEALTHY PRACTICE Especially early seeking medical advice And avoid reluctance or delay when feeling any sign or symptoms regarding HIV No discrimination And proper health education programs To minimize stigma & shyness Proper counselling & consultation
  37. 37. Vaccine DevelopmentVaccine Development Developing a vaccine for HIV infection is a globalDeveloping a vaccine for HIV infection is a global priority because of the vast public health need and thepriority because of the vast public health need and the lack of an alternative approach to prevent or controllack of an alternative approach to prevent or control infection adequately.infection adequately. Development of any vaccine requires a careful,Development of any vaccine requires a careful, systematic approach from basic scientific testingsystematic approach from basic scientific testing through definitive clinical trials with human participants.through definitive clinical trials with human participants. HIV is a global epidemic with staggering economic andHIV is a global epidemic with staggering economic and social costs, and vaccine trials are among the mostsocial costs, and vaccine trials are among the most challenging research to date.challenging research to date. Given the number of people infected, increasing healthGiven the number of people infected, increasing health care costs, and the increasing prevalence of AIDScare costs, and the increasing prevalence of AIDS among people in third-world countries, it is critical that aamong people in third-world countries, it is critical that a vaccine be developed.vaccine be developed.
  38. 38. Challenges and RisksChallenges and Risks Although the effort to develop an effectiveAlthough the effort to develop an effective vaccine against HIV has been unprecedentedvaccine against HIV has been unprecedented in modern science, there have beenin modern science, there have been formidable challenges with respect toformidable challenges with respect to the diversity and complexity of viral antigens.the diversity and complexity of viral antigens. The long incubation period between infectionThe long incubation period between infection and disease symptoms andand disease symptoms and an incomplete understanding of the immunean incomplete understanding of the immune response to the virus are only a fewresponse to the virus are only a few challenges that plague researchers.challenges that plague researchers.
  39. 39. ChallengeChallenge  HIV-related stigma is increasinglyHIV-related stigma is increasingly recognized as the single greatestrecognized as the single greatest challenge to slowing the spread ofchallenge to slowing the spread of HIV/AIDSHIV/AIDS  HIV/AIDSHIV/AIDS –– a threefold epidemica threefold epidemic • Stigma, discrimination, and denialStigma, discrimination, and denial
  40. 40. Human rightsHuman rights • Freedom from discrimination is aFreedom from discrimination is a fundamental human rightfundamental human right • Discrimination on the basis of HIV/AIDSDiscrimination on the basis of HIV/AIDS status, actual or presumed, is prohibitedstatus, actual or presumed, is prohibited by existing human rights standardsby existing human rights standards • Discrimination against persons living withDiscrimination against persons living with HIV/AIDS, or those thought to be infected,HIV/AIDS, or those thought to be infected, is a clear human rights violationis a clear human rights violation
  41. 41. QUESTIONSQUESTIONS ??????????????????????????
  42. 42. Thank youThank you

AIDS STIGMA

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