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Ovarian  Cysts and Tumors
Ovaries ,[object Object],[object Object],[object Object]
Types of Ovarian Tumors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
10/04/11 template from www.brainybetty.com copyright 2006 Ovarian neoplasms may be primarily cystic, solid, or mixed. Some are benign, some are malignant. Some produce enough hormone to cause symptoms for the patient. Some examples of these shown below. Primarily Cystic Primarily Solid Mixed ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Ovarian  Cysts and Tumors ,[object Object],[object Object],[object Object],[object Object],[object Object]
10/04/11 template from www.brainybetty.com copyright 2006
Non-Neoplastic and Functional Cysts of ovary ,[object Object],[object Object],[object Object]
Ovarian Cysts ,[object Object],[object Object]
Follicular Cyst ,[object Object],[object Object],[object Object],[object Object]
Theca lutein cyst ,[object Object],[object Object]
 
[object Object],[object Object],[object Object],[object Object],[object Object],Ovarian Cancer  OVARIAN TUMOURS
Ovarian Cancer: Burden of suffering ,[object Object],[object Object],[object Object],[object Object],[object Object]
Risk Factors ,[object Object],[object Object],[object Object]
Risk Factors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Ovarian Tumors classification ,[object Object],[object Object],[object Object],[object Object],[object Object]
Downloaded from: Robbins & Cotran Pathologic Basis of Disease (on 28 April 2008 01:14 PM) © 2007 Elsevier
Ovarian Tumors ,[object Object],[object Object],[object Object],10/04/11 template from www.brainybetty.com copyright 2006
Ovarian Tumors ,[object Object],[object Object],[object Object],[object Object],10/04/11 template from www.brainybetty.com copyright 2006
Pathophysiology ,[object Object],[object Object],[object Object],10/04/11
10/04/11 template from www.brainybetty.com copyright 2006 Designation Definition Stage I Cancer limited to the ovaries IA Growth limited to one ovary, capsule intact, no malignant ascites, no tumor on external surface IB Growth limited to both ovaries, capsule intact, no malignant ascites, no tumor on external surface IC As for IA or IB but with surface growth, ruptured capsule (before or during surgery), positive washings, or malignant ascites Stage II Growth involving one or both ovaries with pelvic extension IIA Extension and/or metastases to the uterus and/or tubes IIB Extension to other pelvic organs IIC As for IIA or IIB but with surface growth, ruptured capsule (before or during surgery), positive washings, or malignant ascites Stage III Tumor involving one or both ovaries with peritoneal implants outside the pelvis and/or positive retroperitoneal or inguinal nodes; liver capsule involvement IIIA Tumor grossly limited to the true pelvis with negative nodes but microscopic seeding of abdominal peritoneal surfaces IIIB Abdominal peritoneal implants, but none exceeding 2 cm; nodes negative IIIC Abdominal peritoneal implants larger than 2 cm and/or positive retroperitoneal or inguinal nodes Stage IV Tumor involving one or both ovaries with distant metastases; pleural effusions must be demonstrated to harbor malignant cells; liver parenchymal involvement
Classification of Ovarian Tumors, Surface Epithelial Tumors  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
l-Epithelial Ovarian Cancer ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
A. Serous Tumors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Serous Tumors ,[object Object],[object Object],[object Object],[object Object],[object Object]
Serous Tumors ,[object Object],[object Object],[object Object],[object Object]
Serous Tumors ,[object Object],[object Object],[object Object],[object Object]
10/04/11 template from www.brainybetty.com copyright 2006 Psammoma bodies
Figure 22-39 A, Borderline serous cystadenoma opened to display a cyst cavity lined by delicate papillary tumor growths. B, Cystadenocarcinoma. The cyst is opened to reveal a large, bulky tumor mass.  Downloaded from: Robbins & Cotran Pathologic Basis of Disease (on 28 April 2008 01:14 PM) © 2007 Elsevier
Figure 22-40 Papillary serous cystadenoma revealing stromal papillae with a columnar epithelium. Downloaded from: Robbins & Cotran Pathologic Basis of Disease (on 28 April 2008 01:14 PM) © 2007 Elsevier
Figure 22-42 Papillary serous cystadenocarcinoma of the ovary with invasion of underlying stroma. Downloaded from: Robbins & Cotran Pathologic Basis of Disease (on 28 April 2008 01:14 PM) © 2007 Elsevier
Mucinous Tumors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Figure 22-44 A, A mucinous cystadenoma with its multicystic appearance and delicate septa. Note the presence of glistening mucin within the cysts. B, Columnar cell lining of mucinous cystadenoma. Downloaded from: Robbins & Cotran Pathologic Basis of Disease (on 28 April 2008 01:14 PM) © 2007 Elsevier
Brenner Tumor ,[object Object],[object Object]
Figure 22-46 A, Brenner tumor (right) associated with a benign cystic teratoma (left). B, Histologic detail of characteristic epithelial nests within the ovarian stroma. (Courtesy of Dr. M. Nucci, Brigham and Women's Hospital, Boston, MA.) Downloaded from: Robbins & Cotran Pathologic Basis of Disease (on 28 April 2008 01:14 PM) © 2007 Elsevier
10/04/11 template from www.brainybetty.com copyright 2006 Papillary adenocarcinoma, ovary
 
Sex Cord Tumors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
10/04/11 template from www.brainybetty.com copyright 2006
Sex Cord Tumors, Thecoma-Fibroma ,[object Object],[object Object],[object Object],[object Object]
Granulosa – theca cell tumor.
Sex Cord Tumors Sertoli - Leydig ,[object Object],[object Object],[object Object],[object Object]
  Sex cord tumor with annular tubules.
Germ Cell Tumors  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Germ Cell Tumors Dysgerminoma ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Embryonal carcinoma ,[object Object],[object Object],[object Object],[object Object]
Germ Cell Tumors Teratoma ,[object Object],[object Object],[object Object],[object Object],[object Object]
Figure 22-48 Opened mature cystic teratoma (dermoid cyst) of the ovary. Hair (bottom) and a mixture of tissues are evident. Downloaded from: Robbins & Cotran Pathologic Basis of Disease (on 28 April 2008 01:14 PM) © 2007 Elsevier
Downloaded from: Robbins & Cotran Pathologic Basis of Disease (on 28 April 2008 01:14 PM) © 2007 Elsevier
Endodermal Sinus (Yolk Sac) Tumor  ,[object Object],[object Object],[object Object]
Figure 22-52 A Schiller-Duval body in yolk sac carcinoma. Downloaded from: Robbins & Cotran Pathologic Basis of Disease (on 28 April 2008 01:14 PM) © 2007 Elsevier
Choriocarcinoma ,[object Object],[object Object],[object Object],[object Object]
10/04/11 template from www.brainybetty.com copyright 2006
Ovarian Tumors Metastatic Carcinoma ,[object Object],[object Object],[object Object]
Symptoms ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],10/04/11
Diagnostic tools ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Treatment ,[object Object],[object Object],[object Object]
Surgical treatment ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Chemotherapy and Radiation ,[object Object],[object Object],[object Object]
 

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Lect 3- overy cancer

  • 1. Ovarian Cysts and Tumors
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  • 6. 10/04/11 template from www.brainybetty.com copyright 2006
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  • 21. Downloaded from: Robbins & Cotran Pathologic Basis of Disease (on 28 April 2008 01:14 PM) © 2007 Elsevier
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  • 25. 10/04/11 template from www.brainybetty.com copyright 2006 Designation Definition Stage I Cancer limited to the ovaries IA Growth limited to one ovary, capsule intact, no malignant ascites, no tumor on external surface IB Growth limited to both ovaries, capsule intact, no malignant ascites, no tumor on external surface IC As for IA or IB but with surface growth, ruptured capsule (before or during surgery), positive washings, or malignant ascites Stage II Growth involving one or both ovaries with pelvic extension IIA Extension and/or metastases to the uterus and/or tubes IIB Extension to other pelvic organs IIC As for IIA or IIB but with surface growth, ruptured capsule (before or during surgery), positive washings, or malignant ascites Stage III Tumor involving one or both ovaries with peritoneal implants outside the pelvis and/or positive retroperitoneal or inguinal nodes; liver capsule involvement IIIA Tumor grossly limited to the true pelvis with negative nodes but microscopic seeding of abdominal peritoneal surfaces IIIB Abdominal peritoneal implants, but none exceeding 2 cm; nodes negative IIIC Abdominal peritoneal implants larger than 2 cm and/or positive retroperitoneal or inguinal nodes Stage IV Tumor involving one or both ovaries with distant metastases; pleural effusions must be demonstrated to harbor malignant cells; liver parenchymal involvement
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  • 34. 10/04/11 template from www.brainybetty.com copyright 2006 Psammoma bodies
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  • 37. Figure 22-39 A, Borderline serous cystadenoma opened to display a cyst cavity lined by delicate papillary tumor growths. B, Cystadenocarcinoma. The cyst is opened to reveal a large, bulky tumor mass. Downloaded from: Robbins & Cotran Pathologic Basis of Disease (on 28 April 2008 01:14 PM) © 2007 Elsevier
  • 38. Figure 22-40 Papillary serous cystadenoma revealing stromal papillae with a columnar epithelium. Downloaded from: Robbins & Cotran Pathologic Basis of Disease (on 28 April 2008 01:14 PM) © 2007 Elsevier
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  • 40. Figure 22-42 Papillary serous cystadenocarcinoma of the ovary with invasion of underlying stroma. Downloaded from: Robbins & Cotran Pathologic Basis of Disease (on 28 April 2008 01:14 PM) © 2007 Elsevier
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  • 44. Figure 22-44 A, A mucinous cystadenoma with its multicystic appearance and delicate septa. Note the presence of glistening mucin within the cysts. B, Columnar cell lining of mucinous cystadenoma. Downloaded from: Robbins & Cotran Pathologic Basis of Disease (on 28 April 2008 01:14 PM) © 2007 Elsevier
  • 45.
  • 46. Figure 22-46 A, Brenner tumor (right) associated with a benign cystic teratoma (left). B, Histologic detail of characteristic epithelial nests within the ovarian stroma. (Courtesy of Dr. M. Nucci, Brigham and Women's Hospital, Boston, MA.) Downloaded from: Robbins & Cotran Pathologic Basis of Disease (on 28 April 2008 01:14 PM) © 2007 Elsevier
  • 47. 10/04/11 template from www.brainybetty.com copyright 2006 Papillary adenocarcinoma, ovary
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  • 51. 10/04/11 template from www.brainybetty.com copyright 2006
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  • 53. Granulosa – theca cell tumor.
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  • 55.   Sex cord tumor with annular tubules.
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  • 62. Figure 22-48 Opened mature cystic teratoma (dermoid cyst) of the ovary. Hair (bottom) and a mixture of tissues are evident. Downloaded from: Robbins & Cotran Pathologic Basis of Disease (on 28 April 2008 01:14 PM) © 2007 Elsevier
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  • 64. Downloaded from: Robbins & Cotran Pathologic Basis of Disease (on 28 April 2008 01:14 PM) © 2007 Elsevier
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  • 66. Figure 22-52 A Schiller-Duval body in yolk sac carcinoma. Downloaded from: Robbins & Cotran Pathologic Basis of Disease (on 28 April 2008 01:14 PM) © 2007 Elsevier
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  • 68. 10/04/11 template from www.brainybetty.com copyright 2006
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