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OTITIS EXTERNA

Dr. Mohammed Shafeeq
Definition
●

It is a generalised condition of the skin in EAC
characterised by general oedema & erythema
which may be associated with itchy discomfort
with or without ear discharge.
External auditory canal - Anatomy
●

Bottom of concha to TM

●

24mm along posterior border

●

Divided into:
●

Outer/cartilaginous part

●

Inner/bony part

●

Outer part – upwards, backwards & medially

●

Inner part – downwards,forwards & medially
●

Cartilaginous part:
●

8mm, outer 1/3rd

●

Fissures of Santorini

●

Skin is thick with ceruminous & sebaceous glands

●

Hair is confined to this region
●

Bony part:
●

16mm, inner 2/3rd

●

Tympanic portion of temporal bone

●

Skin is thin, with thin layer of sq epithelium

●

Devoid of hair/ceruminous glands

●

Isthmus

●

Anterior recess

●

Foramen of Huschke
Pathogenesis
Clinical course of otitis externa can be divided
into:
●

Pre-inflammatory stage

●

Acute inflammatory stage

●

Chronic inflammatory stage
●

Pre-inflammatory stage:
protective lipid/acid balance is lost
stratum corneum – oedematous
blocks sebaceous/apocrine glands
-- aural fullness/itching

disruption of epithelial layer
-- invasion of pathogens
●

A/c inflammatory stage:
3 grades – mild / moderate / severe
Pre-inflammatory phase –> acute inflammation
progressive thickening exudate, increasing
oedema
oblitertion of lumen, increasing pain

severe stages – auricular changes & cervical
lymphadenopathy
●

C/c inflammatory stage:
resistant inflammations lasting > 3weeks
thickening of external canal skin
fibrous canal stenosis
Pre-disposing factors
●

Anatomical - narrow EAC
(hereditary/iatrogenic/exostoses), obstruction of
normal meatus (keratosis obturans/FB/hearing aids)

●

Dermatological - eczema,seborrhoeic dermatitis

●

Allergic – long term topical medications

●

Physiological – humidity, immunocompromised

●

●

Traumatic – skin maceration(swimming), ear
probing, laceration, radiotherapy
Microbiological – active COM, exposure to
P.aeruginosa or fungi
Microbiology
●

Pseudomonas species -- 50-65%

●

Other Gram negative organisms – 25-35%

●

Staphylococcus aureus – 15-30%

●

Streptococci – 9-15%
Classification (etiological basis)

●

INFECTIVE group
●

Bacterial
–
–
–

●

Fungal
–

●

Otomycosis

Viral
–
–

●

Localised otitis externa (furuncle)
Diffuse otitis externa
Malignant otitis externa

Herpes zoster oticus
Otitis externa haemmorhagica

REACTIVE group
●

Eczematous otitis externa

●

Seborrhoeic otitis externa

●

Neurodermatitis
Acute localised otitis externa
●

Infection of a hair follicle (furuncle)

●

begin as folliculitis-->small abscess/furuncle

●

Staphylococcus aureus

●

Lateral cartilaginous (outer 1/3rd) portion of EAC
Acute localised otitis externa (contd...)
●

Symptoms – severe pain/discharge/hearing
loss/aural fullness

●

O/E – tragal tenderness/oedematous EAC/enlarged,
tender preauricular LN

●

Furuncle in posterior meatal wall --> oedema over
mastoid --> obliteration of retroauricular groove
Acute localised otitis externa (contd...)

Treatment:
●

Early cases without abscess formation,
●

Systemic antibiotics

●

Topical antibiotics+corticosteroids

●

Analgesics/local hot fomentation/ear pack with
10% icthammol glycerine

●

If abscess has formed,
●
●

●

Incision & Drainage
Topical antibiotic ointment with/without oral antibiotics

Recurrent furunculosis
●

R/o diabetes, staphylococcal skin infection, nasal
vestibule harbouring staphylococci
Acute diffuse otitis externa
●

Swimmer's ear

●

Commonest form of otitis externa

●

Usual pathogens – Pseudomonas aeruginosa,
Staphylococcus aureus, Proteus mirabilis

●

Symptoms – pain/itching/aural fullness/hearing loss

●

O/E – tenderness/ narrow EAC with congested,
oedematous skin/ clear or purulent exudates
Acute diffuse otitis externa (contd...)
Treatment:
●

Ear toilet

●

Medicated wicks ●

●

Acidifying/antiseptic agents – gentian violet

●

●

Antibiotic-steroid prepration
Mild astingent – 8% aluminium acetate/3% silver nitrate

Antibiotics ●

●

●
●

Topical antibiotics – (neomycin/ciprofloxacin/ofloxacin)
with/without corticosteroids
Broad spectrum systemic antibiotics

Analgesics
Avoid water entry/avoid usind cotton buds/avoid digital
manipulation of ear canal
Chronic otitis externa
●

●

●

Low grade, diffuse infection of EAC persisting
for months/years
Pruritis, dry hypertrophic skin of EAC leading to
post inflammatory stenosis
Causes are bacterial/fungal infections, also
include skin conditions seborrhoeic dermatitis,
psoriasis, neurodermatitis, sensitization to an
topical ear drops
Chronic otitis externa (contd...)

Treatment:
GOAL – prevent stenosis & restore normal skin in EAC
●

Frequent inspection & debridment of EAC

●

Antibiotic-corticosteroid topical applications

●

●

EAC can be painted with gentian violet/ triamcinolone/
nystatin
Treat underlying causes – seborrhoea, psoriasis,
neurodermatitis
Chronic otitis externa (contd...)

Surgical treatment:
In case of medical treatment failure with canal stenosis
●

Canalplasty with skin grafting – restore canal patency
and hearing
Procedure:

➔

Abnormal skin is removed entirely

➔

Denuded canal is enlarged using diamond bur

➔

➔

➔

➔

Split thickness graft is harvested from medial surface of
upper arm with a dermatome
Graft placed on exposed suface
'rosebud' type of packing is done over skin graft and left for
2 weeks
Crusting may occur for several weeks, requires removal till
complete healing
Chronic otitis externa (contd...)

Preventive measures:
●

●

Patients instructed not to use cotton swabs or
any other objects to canal
Swimmers instructed to use ear plugs and
advised to use alcohol-vinegar (1:1) drops after
swimming
Malignant (necrotizing) otitis externa
●

Progressive, lethal infection of EAC,
surrounding tissue and skull base

●

Elderly diabetic/ immunocompromised pts.

●

Pseudomonas aeruginosa
Malignant otitis externa (contd...)

Pathophysiology:
●

●

Infection begins in EAC --> cellulitis, chondritis,
osteitis, osteomyelitis
May spread to osseus auditory canal & skull
base through fissures of Santorini -->
replacement of compact bone with granulation
tissue

●

Facial N paalysis – stylomastoid foramen involvement

●

CN IX, X, XI palsies - jugular foramen involvement

●

Jugular V thrombosis-->lateral sinus thrombosis
Malignant otitis externa (contd...)
●

Symptoms:
purulent discharge/excruciating pain/facial N palsy/
CN IX,X,XI palsy

●

O/E:
granulation tissue in floor of EAC at bony-cartilaginous
junction is typical otoscopic finding

●

Investigations:
C&S of discharge
CT scan
Gallium scan
Malignant otitis externa (contd...)

Treatment:
●

Hospitilization

●

Control of diabetes

●

Antibiotics ●

Aminoglycosides + penicillin/cephalosporins

●

Quinolones

●

Daily debridement of EAC

●

Surgery ●
●

Debridement of devitalised tissue/bone
Mastoidectomy with facial N decompression /
subtotal petrosectomy
Fungal otitis externa (Otomycosis)
●

Fungal infection of EAC

●

Aspergillus niger – black headed filamented growth
Aspergillus fumigatus – brown
Candida albicans – white/creamy deposits

●

Secondary fungal infection may be seen in pts
using topical antibiotics for otitis externa/ middle
ear suppuration
Fungal otitis externa (contd...)
●

Symptoms:
pruritis/ pain or discomfort in ear/ watery
discharge with musty odour/ ear block

●

O/E:
erythematous canal with black/grey/white
fungal mass – 'wet piece of filter paper'
Fungal otitis externa (contd...)

Treatment:
●

Ear toilet

●

Antifungal agents – nystatin/clotrimazole

●

2% salicylic acid

●

Ear must be kept dry

●

●

Secondary bacterial infections – antibiotic +
steroid prepration
Oral antifungals – refractory to topical agents
Herpes zoster oticus
●
●

●
●

●

HSV – most frequent virus to affect EAC
HSV stay dominant in sensory ganglia –
reactivates in decreased immunocompetence
Blisters/vesicles on auricle, EAC, TM
Blisters – short lived, rupture, dry & heal
spontaneously
May develop CN VII, VIII palsy
Herpes zoster oticus (contd...)
●

●

'Ramsay Hunt Syndrome' – clinical syndrome
with facial N palsy with or without hearing loss
and dizziness owing to herpes zoster
Treatment:
Self limiting, primarily supportive
Antivirals (acyclovir) & steroids can be used
Otitis externa haemmorhagica
●

Formation of haemmorhagic bullae on TM and
deep meatus

●

Viral / seen in influenza epidemics

●

Severe ear pain / blood stain discharge

●

Treatment:
Analgesics
Antibiotics – secondary infections
Complications – Otitis Externa
●

Cellulitis/ Perichondritis/ Chondritis

●

Medial canal fibrosis

●

Tympanic membrane perforation

●

Malignant otitis externa
Thank you

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Otitis externa

  • 2. Definition ● It is a generalised condition of the skin in EAC characterised by general oedema & erythema which may be associated with itchy discomfort with or without ear discharge.
  • 3. External auditory canal - Anatomy ● Bottom of concha to TM ● 24mm along posterior border ● Divided into: ● Outer/cartilaginous part ● Inner/bony part ● Outer part – upwards, backwards & medially ● Inner part – downwards,forwards & medially
  • 4. ● Cartilaginous part: ● 8mm, outer 1/3rd ● Fissures of Santorini ● Skin is thick with ceruminous & sebaceous glands ● Hair is confined to this region
  • 5. ● Bony part: ● 16mm, inner 2/3rd ● Tympanic portion of temporal bone ● Skin is thin, with thin layer of sq epithelium ● Devoid of hair/ceruminous glands ● Isthmus ● Anterior recess ● Foramen of Huschke
  • 6. Pathogenesis Clinical course of otitis externa can be divided into: ● Pre-inflammatory stage ● Acute inflammatory stage ● Chronic inflammatory stage
  • 7. ● Pre-inflammatory stage: protective lipid/acid balance is lost stratum corneum – oedematous blocks sebaceous/apocrine glands -- aural fullness/itching disruption of epithelial layer -- invasion of pathogens
  • 8. ● A/c inflammatory stage: 3 grades – mild / moderate / severe Pre-inflammatory phase –> acute inflammation progressive thickening exudate, increasing oedema oblitertion of lumen, increasing pain severe stages – auricular changes & cervical lymphadenopathy
  • 9. ● C/c inflammatory stage: resistant inflammations lasting > 3weeks thickening of external canal skin fibrous canal stenosis
  • 10. Pre-disposing factors ● Anatomical - narrow EAC (hereditary/iatrogenic/exostoses), obstruction of normal meatus (keratosis obturans/FB/hearing aids) ● Dermatological - eczema,seborrhoeic dermatitis ● Allergic – long term topical medications ● Physiological – humidity, immunocompromised ● ● Traumatic – skin maceration(swimming), ear probing, laceration, radiotherapy Microbiological – active COM, exposure to P.aeruginosa or fungi
  • 11. Microbiology ● Pseudomonas species -- 50-65% ● Other Gram negative organisms – 25-35% ● Staphylococcus aureus – 15-30% ● Streptococci – 9-15%
  • 12. Classification (etiological basis) ● INFECTIVE group ● Bacterial – – – ● Fungal – ● Otomycosis Viral – – ● Localised otitis externa (furuncle) Diffuse otitis externa Malignant otitis externa Herpes zoster oticus Otitis externa haemmorhagica REACTIVE group ● Eczematous otitis externa ● Seborrhoeic otitis externa ● Neurodermatitis
  • 13. Acute localised otitis externa ● Infection of a hair follicle (furuncle) ● begin as folliculitis-->small abscess/furuncle ● Staphylococcus aureus ● Lateral cartilaginous (outer 1/3rd) portion of EAC
  • 14. Acute localised otitis externa (contd...) ● Symptoms – severe pain/discharge/hearing loss/aural fullness ● O/E – tragal tenderness/oedematous EAC/enlarged, tender preauricular LN ● Furuncle in posterior meatal wall --> oedema over mastoid --> obliteration of retroauricular groove
  • 15. Acute localised otitis externa (contd...) Treatment: ● Early cases without abscess formation, ● Systemic antibiotics ● Topical antibiotics+corticosteroids ● Analgesics/local hot fomentation/ear pack with 10% icthammol glycerine ● If abscess has formed, ● ● ● Incision & Drainage Topical antibiotic ointment with/without oral antibiotics Recurrent furunculosis ● R/o diabetes, staphylococcal skin infection, nasal vestibule harbouring staphylococci
  • 16. Acute diffuse otitis externa ● Swimmer's ear ● Commonest form of otitis externa ● Usual pathogens – Pseudomonas aeruginosa, Staphylococcus aureus, Proteus mirabilis ● Symptoms – pain/itching/aural fullness/hearing loss ● O/E – tenderness/ narrow EAC with congested, oedematous skin/ clear or purulent exudates
  • 17. Acute diffuse otitis externa (contd...) Treatment: ● Ear toilet ● Medicated wicks ● ● Acidifying/antiseptic agents – gentian violet ● ● Antibiotic-steroid prepration Mild astingent – 8% aluminium acetate/3% silver nitrate Antibiotics ● ● ● ● Topical antibiotics – (neomycin/ciprofloxacin/ofloxacin) with/without corticosteroids Broad spectrum systemic antibiotics Analgesics Avoid water entry/avoid usind cotton buds/avoid digital manipulation of ear canal
  • 18. Chronic otitis externa ● ● ● Low grade, diffuse infection of EAC persisting for months/years Pruritis, dry hypertrophic skin of EAC leading to post inflammatory stenosis Causes are bacterial/fungal infections, also include skin conditions seborrhoeic dermatitis, psoriasis, neurodermatitis, sensitization to an topical ear drops
  • 19. Chronic otitis externa (contd...) Treatment: GOAL – prevent stenosis & restore normal skin in EAC ● Frequent inspection & debridment of EAC ● Antibiotic-corticosteroid topical applications ● ● EAC can be painted with gentian violet/ triamcinolone/ nystatin Treat underlying causes – seborrhoea, psoriasis, neurodermatitis
  • 20. Chronic otitis externa (contd...) Surgical treatment: In case of medical treatment failure with canal stenosis ● Canalplasty with skin grafting – restore canal patency and hearing Procedure: ➔ Abnormal skin is removed entirely ➔ Denuded canal is enlarged using diamond bur ➔ ➔ ➔ ➔ Split thickness graft is harvested from medial surface of upper arm with a dermatome Graft placed on exposed suface 'rosebud' type of packing is done over skin graft and left for 2 weeks Crusting may occur for several weeks, requires removal till complete healing
  • 21. Chronic otitis externa (contd...) Preventive measures: ● ● Patients instructed not to use cotton swabs or any other objects to canal Swimmers instructed to use ear plugs and advised to use alcohol-vinegar (1:1) drops after swimming
  • 22. Malignant (necrotizing) otitis externa ● Progressive, lethal infection of EAC, surrounding tissue and skull base ● Elderly diabetic/ immunocompromised pts. ● Pseudomonas aeruginosa
  • 23. Malignant otitis externa (contd...) Pathophysiology: ● ● Infection begins in EAC --> cellulitis, chondritis, osteitis, osteomyelitis May spread to osseus auditory canal & skull base through fissures of Santorini --> replacement of compact bone with granulation tissue ● Facial N paalysis – stylomastoid foramen involvement ● CN IX, X, XI palsies - jugular foramen involvement ● Jugular V thrombosis-->lateral sinus thrombosis
  • 24. Malignant otitis externa (contd...) ● Symptoms: purulent discharge/excruciating pain/facial N palsy/ CN IX,X,XI palsy ● O/E: granulation tissue in floor of EAC at bony-cartilaginous junction is typical otoscopic finding ● Investigations: C&S of discharge CT scan Gallium scan
  • 25. Malignant otitis externa (contd...) Treatment: ● Hospitilization ● Control of diabetes ● Antibiotics ● Aminoglycosides + penicillin/cephalosporins ● Quinolones ● Daily debridement of EAC ● Surgery ● ● Debridement of devitalised tissue/bone Mastoidectomy with facial N decompression / subtotal petrosectomy
  • 26. Fungal otitis externa (Otomycosis) ● Fungal infection of EAC ● Aspergillus niger – black headed filamented growth Aspergillus fumigatus – brown Candida albicans – white/creamy deposits ● Secondary fungal infection may be seen in pts using topical antibiotics for otitis externa/ middle ear suppuration
  • 27. Fungal otitis externa (contd...) ● Symptoms: pruritis/ pain or discomfort in ear/ watery discharge with musty odour/ ear block ● O/E: erythematous canal with black/grey/white fungal mass – 'wet piece of filter paper'
  • 28. Fungal otitis externa (contd...) Treatment: ● Ear toilet ● Antifungal agents – nystatin/clotrimazole ● 2% salicylic acid ● Ear must be kept dry ● ● Secondary bacterial infections – antibiotic + steroid prepration Oral antifungals – refractory to topical agents
  • 29. Herpes zoster oticus ● ● ● ● ● HSV – most frequent virus to affect EAC HSV stay dominant in sensory ganglia – reactivates in decreased immunocompetence Blisters/vesicles on auricle, EAC, TM Blisters – short lived, rupture, dry & heal spontaneously May develop CN VII, VIII palsy
  • 30. Herpes zoster oticus (contd...) ● ● 'Ramsay Hunt Syndrome' – clinical syndrome with facial N palsy with or without hearing loss and dizziness owing to herpes zoster Treatment: Self limiting, primarily supportive Antivirals (acyclovir) & steroids can be used
  • 31. Otitis externa haemmorhagica ● Formation of haemmorhagic bullae on TM and deep meatus ● Viral / seen in influenza epidemics ● Severe ear pain / blood stain discharge ● Treatment: Analgesics Antibiotics – secondary infections
  • 32. Complications – Otitis Externa ● Cellulitis/ Perichondritis/ Chondritis ● Medial canal fibrosis ● Tympanic membrane perforation ● Malignant otitis externa