1. Cindy Rondón Michelle Silvera Medicine Students University Pontificia Bolivariana 2011

2. NEOPLASIA Abnormal proliferation of cells in a tissue or organ Neoplasma Gastrointestinal Neoplasia Tumor No tumor Microsatellite Cromosomal Mosaic Variegate Instability Instability Aneuplody

25. Author Idea Yes No Ilanks S et al “ Karyoptypes of both lymphocites and fibroblast from the patient reveled a cytogenetic picture closely resembling that seen in cases of the mosaic variegate aneuplody syndrome caused by bialellic BUB1B mutation” X Kaplan KB et al, Musacchio A et al “ APC and BUBR1 are both implicated in regulation of mitosis” X

26. Author Idea Yes No Bohers E et al. “ Reduction in levels of full length BUBR1 protein first resulted in premature chromatide separation and then, when recued to less than 50% of the normal level, resulted in aneuplody” X Ilanks et al “ homozygocity for complete BUB1B has been postulated to be lethal in humans as well” X