earSight Innovations is developing new technologies that allow accurate measurement of the eye with the ability to move cataract surgery outcomes to a new level. Cataract surgery is the most commonly performed surgery in the world with over 20 million surgeries conducted annually.​

1. First Clinical Results in 30 Eyes with a Novel
Ocular Biometer for IOL Power Calculation
Arthur Cummings FRCS1,2, Gerard Kervick FRCOphth4, Diana Bogusevschi PhD2,
Andrew Nolan PhD2, Michael Mrochen PhD2,3
1 Wellington Eye Clinic, Dublin, Ireland
2 ClearSight Innovations, Dublin, Zurich
3 IROC Science to Innovation, Zurich
4 Mater Hospital, Cork
The authors (except for 4 )have a financial interest in ClearSight
Innovations

2. Background
• IOL Power Calculation and Refraction Prediction in unusual
eyes remain challenging – Toric IOL’s, Post-refractive surgery
eyes e.g. post-LASIK, post-RK.
• Accurate measurements of all ocular parameters combined
with ray-tracing is a potential solution for both normal and
unusual cases.

3. Purpose
• A novel device consisting of Purkinje imaging technique
combined with an optical coherence method is employed in a
feasibility study on IOL power calculation.
• The measured ocular parameters are compared with the
Standard of Care (SOC) device (OB820, WaveLight)
• This will assess its viability for refraction prediction.

4. Method: Device
• The novel biometry device provides accurate measurements of the following
parameters:
– Cornea:
• Anterior and Posterior Radii, Conic Constants and Astigmatism
– Lens Geometry:
• Anterior and Posterior Radii and Conic Constants.
– Thickness values:
– Central Corneal Thickness (CCT), Anterior Chamber Depth (ACD), Lens
Thickness (LT) and Axial Length (AL)

5. Method: Study Design
• 34 subjects were enrolled (Informed consent provided)
• All eyes underwent pupil dilation to at least 5 mm pupil diameter before
the eyes were measured with OB820, WaveLight (= Lenstar LS 900 from
Haag-Streit).
• Following that the eyes were measured with the novel ocular biometer
from ClearSight Innovations
• Comparison is performed between the two devices.

6. Patients
• Enrolled patients stratification:
– The grouping of eyes included:
• Normal, healthy – 10 eyes;
• Varying degrees of cataracts – 16 eyes;
• Pseudo-phakic – 14 eyes.
– Gender: 12 Male and 21 Female
– OD/OS: 18 Right and 18 Left
– Average Age of 59.9 years.

7. Results
• The novel ocular biometer was able to measure and reconstruct all eye elements.
• The comparisons with the SOC device showed high correlations:
Novel Biometer/ OB820
AL 0.991 (p < 0.05)
ACD 0.985 (p < 0.05)
LT 0.993 (p < 0.05)
RAC 0.983 (p < 0.05)
RPC N/A

8. Results
• It is shown that the novel device can be used for accurate IOL Power
Calculation and Refraction Prediction.
• The SOC device did not provide any measurements of the Posterior
Cornea or Radii of Anterior and Posterior Crystalline Lens, which prohibits
comparison.
• As refraction prediction is more sensitive to Radius of Anterior Cornea,
Axial Length and ACD, we will consider these to be the parameters of
interest.

9. Axial Length: Correlation and Bland-Altman
Mirricon II versus OB820

10. ACD: Correlation and Bland-Altman
Mirricon II versus OB820

11. Radius of Anterior Cornea: Correlation and Bland-Altman
Mirricon II versus OB820

12. Conclusions
• The novel biometry device is shown to provide comparable ocular
parameters to the OB820, WaveLight.
• It also has the capability of measuring additional elements, such as
Posterior Cornea, Anterior and Posterior Crystalline Lens geometries.
• The novel ocular biometer provides the possibility of more accurate ray-
tracing IOL prediction for both normal and unusual eyes.