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HUMAN BODY

CIRCULATORY SYSTEM
COMPOSITION OF BLOOD
• RED CELLS
• WHITE CELLS
• PLATELETS
     floating in a liquid called
               PLASMA
COMPOSITION OF BLOOD
COMPOSITION OF BLOOD
RED BLOOD CELLS
• Biconcave discs
• No nuclei
• Spongy cytoplasm enclosed in an elastic cell
  membrane
• Red pigment called haemoglobin
• Are made by the red bone marrow of certain
  bones in the skeleton: ribs, vertebrae and
  breastbone
Red blood cells: hystology
Red bone marrow
HAEMOGLOBIN
Haemoglobin (Hb)
• Hb + O₂                    oxyhaemoglobin (OHb)

In places where the O₂ concentration is low, OHb breaks down
   and releases its O₂. Where??

• Oxygenated blood : contains mainly OHb.
• Deoxygenated blood : with little OHb.
Oxyhaemoglobin
Red blood cells
    After 4 months

   Hb         Iron

Bilirubin    Stored in the liver

  Bile
WHITE CELLS
• Different types
• Larger than red cells
• They have nuclei
• They are made in the same bone marrow that
  red cells
• The two more numerous types are:
        - Phagocytes
        - Lymphocytes
White blood cells
White blood cells
White blood cells: Phagocytes
• They collect at the site of an
  infection, engulfing (ingesting) and digesting
  harmful bacteria. They prevent the spread of
  infection through the body.
Phagocytes
White blood cells: Lymphocytes
Production of antibodies (proteins)
PLATELETS
They help to clot the blood
PLASMA
• Ions:
  sodium, potassium, calcium, chloride, hydroge
  n carbonate.
• Proteins: fibrinogen (clotting), albumin and
  globulins (antibodies).
• Food substances: aa, glucose and fats.
• Hormones
• Urea
Functions of the blood
• Homeostatic functions
• Transport
• Defence against infections
         - Clotting
         - White cells
Functions of blood: Transport
Substance                      From                 To
Oxygen                         Lungs                Whole body
Carbon dioxide                 Whole body           lungs
Urea                           liver                kidneys
Hormones                       glands               Target organs
Digested food                  intestine            Whole body
Heat (opening and closing of   Abdomen and muscle   Whole body
blood vessels)
Blood functions: DEFENCE AGAINST
             INFECTIONS
• WHITE CELLS:
      - Phagocytes: - at the sites of a wound
                       - in the blood capillaries
                       - in lymph nodes


              ingest harmful bacteria and stop them entering the
              general circulation

        - Lymphocytes: Production of antibodies

• CLOTTING
THE HEART
Human Heart
• 4 chambers:
                   - 2 atria (thin-walled)
                   - 2 ventricles (thick- walled)
•   Veins: deoxygenated blood except pulmonary vein
•   Arteries: Oxygenated blood except pulmonary artery
•   Valves: They stop blood flowing backwards.
•   Coronary arteries: They supply the heart muscle with
    food and oxygen.
Human heart
Valves of the heart
CONTROL OF THE HEART BEAT
• At rest: normal heart rate, 50-100 beats per
  minutes.
• During exercise: 200 beats/min
• The heart beat is initiated by the pacemaker, a
  small group of specialized muscles cells at the
  top of the right atrium.
Control of the heart beat
• Blood pressure ↑      ↓ heart rate



•   Blood pressure ↓
                         ↑ heart rate
• ↓ O₂ concentration
• ↑ CO₂ concentration
• Hormone adrenaline
THE CIRCULATION
CIRCULATION
BLOOD VESSELS
Blood vessels
              Function                      Structure of wall          Width of lumen
ARTERIES      Carry blood away from         Thick and strong,          Relatively narrow, it
              the heart                     containing muscles and     varies with heart beat, as
                                            elastic tissue.            it can stretch and recoil.
CAPILLARIES   supply all cells with their   Very thin, only one cell   Very narrow, just one cell
              requirements and take         thick.                     can pass through.
              away waste products.

VEINS         Return blood to the heart     Quite thin, containing     Wide, contains valves
                                            less muscle and elastic
                                            tissue.
Arteries, veins: hystology
ATHEROMA and THROMBOSIS
CORONARY HEART DISEASES
Possible causes of coronary heart
              diseases
• SMOKING

• FATTY DIET

• STRESS

• LACK OF EXERCISE

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Powerpoint circulatory system core

  • 2. COMPOSITION OF BLOOD • RED CELLS • WHITE CELLS • PLATELETS floating in a liquid called PLASMA
  • 5. RED BLOOD CELLS • Biconcave discs • No nuclei • Spongy cytoplasm enclosed in an elastic cell membrane • Red pigment called haemoglobin • Are made by the red bone marrow of certain bones in the skeleton: ribs, vertebrae and breastbone
  • 6. Red blood cells: hystology
  • 9. Haemoglobin (Hb) • Hb + O₂ oxyhaemoglobin (OHb) In places where the O₂ concentration is low, OHb breaks down and releases its O₂. Where?? • Oxygenated blood : contains mainly OHb. • Deoxygenated blood : with little OHb.
  • 11. Red blood cells After 4 months Hb Iron Bilirubin Stored in the liver Bile
  • 12. WHITE CELLS • Different types • Larger than red cells • They have nuclei • They are made in the same bone marrow that red cells • The two more numerous types are: - Phagocytes - Lymphocytes
  • 15. White blood cells: Phagocytes • They collect at the site of an infection, engulfing (ingesting) and digesting harmful bacteria. They prevent the spread of infection through the body.
  • 17. White blood cells: Lymphocytes Production of antibodies (proteins)
  • 18. PLATELETS They help to clot the blood
  • 19. PLASMA • Ions: sodium, potassium, calcium, chloride, hydroge n carbonate. • Proteins: fibrinogen (clotting), albumin and globulins (antibodies). • Food substances: aa, glucose and fats. • Hormones • Urea
  • 20.
  • 21. Functions of the blood • Homeostatic functions • Transport • Defence against infections - Clotting - White cells
  • 22. Functions of blood: Transport Substance From To Oxygen Lungs Whole body Carbon dioxide Whole body lungs Urea liver kidneys Hormones glands Target organs Digested food intestine Whole body Heat (opening and closing of Abdomen and muscle Whole body blood vessels)
  • 23. Blood functions: DEFENCE AGAINST INFECTIONS • WHITE CELLS: - Phagocytes: - at the sites of a wound - in the blood capillaries - in lymph nodes ingest harmful bacteria and stop them entering the general circulation - Lymphocytes: Production of antibodies • CLOTTING
  • 25. Human Heart • 4 chambers: - 2 atria (thin-walled) - 2 ventricles (thick- walled) • Veins: deoxygenated blood except pulmonary vein • Arteries: Oxygenated blood except pulmonary artery • Valves: They stop blood flowing backwards. • Coronary arteries: They supply the heart muscle with food and oxygen.
  • 27. Valves of the heart
  • 28. CONTROL OF THE HEART BEAT • At rest: normal heart rate, 50-100 beats per minutes. • During exercise: 200 beats/min • The heart beat is initiated by the pacemaker, a small group of specialized muscles cells at the top of the right atrium.
  • 29. Control of the heart beat • Blood pressure ↑ ↓ heart rate • Blood pressure ↓ ↑ heart rate • ↓ O₂ concentration • ↑ CO₂ concentration • Hormone adrenaline
  • 33. Blood vessels Function Structure of wall Width of lumen ARTERIES Carry blood away from Thick and strong, Relatively narrow, it the heart containing muscles and varies with heart beat, as elastic tissue. it can stretch and recoil. CAPILLARIES supply all cells with their Very thin, only one cell Very narrow, just one cell requirements and take thick. can pass through. away waste products. VEINS Return blood to the heart Quite thin, containing Wide, contains valves less muscle and elastic tissue.
  • 37. Possible causes of coronary heart diseases • SMOKING • FATTY DIET • STRESS • LACK OF EXERCISE