1. Pharm-Immuno 9-11 Cell Mediated Immunity Dr. Saber Hussein

8. Migration of naive and effector T cells Fig 6-3 HEV

10. E- & P-S ligand LFA-1

15. Activation of macrophages by T cells The illustration shows a CD4 + T cell recognizing class II MHC-associated peptides & activating the M  , but the same reaction may be elicited by a CD8 + T cell that recognizes class I MHC-displayed peptides derived from cytoplasmic microbial Ags Fig 6-7

18. Fig 6-9: T H 1/T H 2

21. Granule-associated killing mechanisms Granzymes

24. Evasion of cell-mediated immunity by microbes Fig 6-12

31. Affinity maturation in antibody responses Fig7-11

34. Fig 7-14 Fig 7-14

36. Fig 8-1 A Effector functions of Antibodies

39. Neutralization of microbes and toxins by antibodies B. Antibodies inhibit the spread of microbes from an infected cell to an adjacent uninfected cell. Fig8-2B

40. Neutralization of microbes and toxins by antibodies C. Antibodies block the binding of toxins to cells and thus inhibit the pathologic effects of the toxins Fig8-2C

41. Antibody-mediated opsonization and phagocytosis of microbes A. Antibodies of certain IgG subclasses bind to microbes and are then recognized by Fc receptors on phagocytes Signals from the Fc receptors promote the phagocytosis of the opsonized microbes and activate the phagocytes to destroy these microbes Fig 8-3A

42. Antibody-mediated opsonization and phagocytosis of microbes B. The different types of human Fc receptors, and their cellular distribution and functions, are listed Fig 8-3B

44. Antibody-dependent cellular cytotoxicity (ADCC) Antibodies of certain IgG subclasses bind to cells (e.g., infected cells), and the Fc regions of the bound antibodies are recognized by an Fc  receptor on NK cells The NK cells are activated and kill the antibody-coated cells Fig 8-4A

45. Antibody-dependent cellular cytotoxicity (ADCC) IgE antibodies bind to helminthic parasites , and the Fc regions of the bound antibodies are recognized by Fc  receptors on eosinophils . The eosinophils are activated to release their granule contents , which kill the parasites Fig 8-4B

47. Evasion of humoral immunity by microbes The principal mechanisms by which microbes evade humoral immunity are listed, with illustrative examples