The document outlines the Monroe Doctrine, which declared the Americas off-limits to future European colonization and stated the United States' opposition to European powers interfering with independent countries in North or South America. It established the principles of noncolonization and nonintervention in the Americas by European nations and helped keep European powers out of the United States and protect Latin American nations from European intervention. The doctrine had lasting impacts on foreign policy and relations between the United States and European powers over the 19th and early 20th centuries.