47. “ My doctor says that hormone replacement is dangerous and there’s no evidence that bioidentical hormones are safer!”
53. Premarin Conjugated Equine Estrogens (CEE) Estradiol-17 β Dihydroequilin-17β CEE contains at least 10 estrogens, only 3 are human . CEE contains 3x more Dihydroequilin than Estradiol . DHE has 10% higher binding affinity for est. receptors. DHE binds far less to SHBG and has a slower metabolic clearance The most abundant estrogen in CEE is Equilin sulfate . Kuhl H, Climacteric 2005;8(Suppl 1):3–63 Human Horse
54. Estradiol Ethinyl estradiol EE cannot be inactivated by normal oxidation! EE does not interact with estrogen receptor ! EE is 12,000-60,000 times more potent by weight! EE is much more thrombogenic than estradiol EE in Birth Control Pills Acetylene
55. Progesterone vs. Progestins Progesterone MPA (Provera ) Megestrol Every progestin has a different spectrum of androgenic, estrogenic, glucocorticoid , and progestational effects!
57. Testosterone Substitution Testosterone Methyltestosterone Methyltestosterone ( in Estratest ) aromatizes to an alien estrogen and increases risk of breast cancer , also causes liver damage and breast enlargement in bodybuilders Headlines: “Testosterone therapies increase risk of breast cancer.”
67. E3N-EPIC Study Bioidentical estradiol plus progesterone decreased the risk of breast cancer ! Int J Cancer. 2005 Apr 10;114(3):448-54. Cohort study 54,000 women 5.8 years f/u c/w WHI-- 16,000, 6 yr. f/u No Evidence that BHRT is safer?
68. ORDET Study Int. J. Cancer 112 (2004) (2), pp. 312–318. Higher progesterone= lower risk of breast cancer 6,000 women 5 yr. F/U