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Antimicrobial Drug Resist.

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mohammed sediq
mohammed sediq
Gesundheit & MedizinTechnologie
1 von 31
RED SEA UNIVERSITY FACULTY OF MEDICINE
ANTIMICROBIAL DRUG RESISTANCE
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],INTRODUCTION:
~Gram –ve  chloramphinicol acetyl transferase against chloramphinicol . b)Microorganism alters its permeability to the drug eg tetracyclin and polymyxin . Streptococci have natural barrier to aminoglycosides . acer:
c)Microorganism develops an altered structural target eg:chromosomal resistance to aminoglycosides “30s ribosomal subunit’’ Erythromycin resistant organisms altere receptors in 50s ribosomal subunit. Penicillin resistance  change in penicillin binding protein “PBP”.
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Origins of the drug resistance ORIGINS Non genetic Genetic chromosomal Extrachromosomal
[object Object],[object Object],[object Object], 1  Non genetic origin:
[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object], 2  Genetic origin :
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Clinical importance of extrachromosomal resistance : ,[object Object],[object Object],[object Object]
The mechanisms of resistance : ,[object Object],[object Object]
Transformation: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Transduction: ,[object Object]
Conjugation (plasmid- mediated transfer): ,[object Object],[object Object]
Transposition: ,[object Object]
cross resistance : ,[object Object],[object Object],[object Object]
Limitation of drug resistance : ,[object Object],[object Object]
[object Object],[object Object]
Specific mechanisms of resistance ,[object Object],[object Object],[object Object],[object Object],[object Object]
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MRSA: ,[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],SYMPTOMS:
Diagnosis and treatment: ,[object Object],[object Object],[object Object],[object Object]
MRSA prevention: ,[object Object],[object Object]
FOR MORE DETAILS: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Web sites: ,[object Object],[object Object],[object Object],[object Object]
Preppared and presented by: ,[object Object],[object Object]
DON’T WORRY.. MEDICINE IS JUST LIKE THIS…!

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Antimicrobial Drug Resist.

  • 1. RED SEA UNIVERSITY FACULTY OF MEDICINE
  • 3.
  • 4. ~Gram –ve  chloramphinicol acetyl transferase against chloramphinicol . b)Microorganism alters its permeability to the drug eg tetracyclin and polymyxin . Streptococci have natural barrier to aminoglycosides . acer:
  • 5. c)Microorganism develops an altered structural target eg:chromosomal resistance to aminoglycosides “30s ribosomal subunit’’ Erythromycin resistant organisms altere receptors in 50s ribosomal subunit. Penicillin resistance  change in penicillin binding protein “PBP”.
  • 6.
  • 7. Origins of the drug resistance ORIGINS Non genetic Genetic chromosomal Extrachromosomal
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  • 31. DON’T WORRY.. MEDICINE IS JUST LIKE THIS…!