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DR. MEENANK
1.

Definition

2.

Etiology

3.

Optics

4.

Classification

5.

Clinical varieties in detail

6.

Treatment
Definetion


Myopia ( short sight ) condition where parallel rays come to
focus in front of the sentient layer of retina when
accommodation is at rest



Muopia (Greek) = To close the eye
History


Kepler (1611), Plempius (1632) - lengthening of posterior part.



Donders (1866) est.. Pathological basis, and detail clinical
manifestation's
Etiology


Axial : most commonest




1mm = 3D

Curvatural : cornea thickness


causes astigmatism



1mm = 6D



eg : ectasies


conical cornea


lenticular curvature



eg : ant/post lenticonus – marked



Positional : dislocation of lens



Myopia due to excessive accommodation - spasm of
accommodation,
suspensory lig. Rupture


Index myopia : change in the R.I of the crystalline lens
eg : Nuclear Sclerosis,

Incipient Cataract,
Diabetes.


Buphthalmos : cong/ infantile glaucoma.

Defective development – A.P diameter
myopia not in ratio

enlarged and
Optics


Optical system – eye too powerful for axial length



Image of distant object on retina are circles of
diffusion form by divergent beam



Far point is finite pt in front of eye – object at far pt
focused without acc.



Angle of alpha –ve resulting in convergent squint


Accommodation- uncorrected- not
developed , as not needed for Nv.
Thus may develop exophoria,
convergence insufficiency and
presbyopia



Enlarged image is cause of nodal pt being far
away from retina
Classification
myopia

Congenital myopia
Simple (or)
Developmental
myopia
Pathological (or)
Degenerative myopia

Acquired myopia
Congenital myopia


Since birth



Diagnosed – 2 -3 yrs.



Associated – prematurity, birth defects,
congenital squint, and axial length



Unilateral or bilateral



Unilateral – manifest as anisometropia
diagnosed - after squint- amblyopia


Associated – cataract, microphthalmas, cong. Retinal
separation, megalo-cornea



Prognosis – early detection

no 6/6 uni-ocular
Simple Myopia


Physiological / developmental / school



Biological variation in development



Limited progression no disease



Factors associated :


Axial – A.P diameter (or) neurological



Curvatural – underdevelopment of eye ball



Diet – poor nutriention



Genetic influence – one (or) both parents
Physiological – A/S normal along
with normal fundus

Simple
Myopia
Intermittent –
early signs of
globe
enlargement
temporally

Sever category
of intermittent –
crescent with
super-traction
of disc
course
Born hyper
metropic

Emmetropic
• overshoot



Stabilized at
teens

Myopic
• 7-10 yrs

• -5D to -8D

symptom's :


Poor distance vision – beyond far point impaired



Asthenopic sympt – eye strain due to difference b/w convergence and
accommodation






Nv -No accommodation – convergence weakness – exophoria – suppression of
one eye
Nv –convergence – excessive accommodation – ciliary spasm

Physiological out-look – myopic child behavior


Signs



A.C. – deep



Pupil – large and sluggish



Fundus – normal





Eye – large and prominent

Error - -5.00 D to -8.00D

Diagnosis –visual acuity
subjective testing

retinoscopy
Pathological Myopia


Degenerative / progressive



2-3 %



More marked, high degree



Hereditary



Postnatal



Inc. progressive


Prevalence –
earlier and higher in females
higher – Asians, Arabs, Jews

lower – Africans, Caucasians
more in urban populations
Etiology


Results from rapid growth of eye out side its biological variation



2 theories
- Hereditary

- General growth

Genetic
factors
Retinal growth
Scleral
stretching

Increase in
axial length

Pathological myopia
• Degeneration – choroid, retinae,
vitreous


Symptoms



Muscae volitantes – deg. lig. Vitreous





Diminished Vn – progressive due to degeneration
Night blindness – high myopes with choroidi-retinal changes

Signs


Prominent, elongated(post), unilateral, stimulating exophthalmos



Cornea – large; A.C – deep; pupil – large, sluggish



Refractive error – by -4D/yr up to 20-30yrs


Fundus –


Generalized atrophy of choroid and retinae



Loss of RPE- fundus tugroid- prominent choroidal vessels



Choroid disappears – visible sclera – atrophic patch - post. Pole –
macula (common)



Foster – Fuchs's spots – rare, sudden, dark pig.
sub-retinal neovascularization and choroidal hx.



Cystoid degeneration at periphery


Advance cases – total retinal atrophy, central



Lattice degeneration/ snail track lesion


Optic disc


Myopic crescent – from elongation of disc

separation of retina and choroid from temp
may be annular


Super traction crescent – nasal retina extending over the disc –
blur margin



Posterior staphyloma – higher degree,

herniation of post. Pole – sudden kinking of vessels at margin as in
glaucoma


Vitreous – degeneration, PVD-Wiess reflex, liquefaction, opacities



Visual field – ring scotoma



Electo-retinograph – chorioretinol atrophy



Complications


retinal tears, detachment, Hx (high myopia)



vitreous detachment, degeneration



complicated cataract –↓ lenticular metabolism



Nuclear sclerosis – common, effects refraction



Choroidal Hx – sever Vn loss if in fovea



POAG – not common but seen
acquired

index – nuclear sclerosis, incipient cataract, diabetic myopia

Curvatural – true inc. in corneal curvature (or) lenticular

Positional – subluxation(ant) of lens

Consecutive – surgical overcorrection(cataract/ hypermetropia)

Pseudo-myopia – due to excessive accommodation and spasm of
accommodation
Space myopia – no stimulus for Nv, its variable, trouble in flying and in fog

Night/twilight – shift from photic to scotopic vn is associated with inc. sensitivity to
shorter wavelength viz myopic
Cholinergic – pilocarpine, echothiosulphate

Drug induced -

Steroid – show changes in crystalline lens
Sulplanamides – changes the refractive indices in media
Diagnosis
presentation

Simple – blurred Dv, constant/ transient, Nv
may be normal, co-existing condt.
Nocturnal – blurred Dv in dim illumination,
difficulty in driving
Pseudo myopia – transient Dv blur, inc after
near work
Degenerative - considerable Dv blur,
flashes/ floaters, Vn loss
Induced – transient Dv blur until drug effect,
pupils constricted – cholinergic antagonist
Ocular
examination

Visual acuity – both unaided Nv and Dv should
be measured-mean gives reduced V.A

Refraction – retinoscopy or and A.R. , but A.R
not qualitative
retinoscopy – diagnosis for nocturnal myopia
with cyclopegics
Ocular motility, binocular Vn, accommodation
– heterophoria, versions, accommodative
facility test
systemic and ocular health – IOP, SLB, postsegment


Special test


Fundus Photography



A and B scan



Visual field



Fasting blood sugars
Treatment


Optical Correction




Proper correction with concave lens for image to fall on retina

Myopia up to -6.00D


Children – full correction



Young adults – prevent over correction



Adults - ↓ 30 yrs. – full correction

↑ 30 yrs. – under corrected – ciliary muscles fail to
accommodate


Spectacle's



Contact lens



Economical, safe



Larger retinal image



Allow incorporation



Better Vn in Sr. myopia



Better correction of astigmatism



Better visual field



Less acco- near pt. blur in
presbyopia



Dec. prismatic effect



Rigid lens dec. progressive
myopia


Surgical Treatment


Incisional – Radial Keratotomy



Lamellar corneal refractive Sx



Non-freeze keratomileusis



Keratomileusis insitu





Freeze keratomileusis of Barraque for myopia

Automated lamellar keratoplasty

Laser-based corneal refractive Sx



Laser insitu keratomileusis (LASIK)



Custom Laser insitu keratomileusis (C-LASIK)





Photorefractive keratectomy (PRK)

Epithelial Laser insitu keratomileusis (E-LASIK)

Miscellaneous corneal refractive Sx



Intracorneal contact lens





Orthokeratology
Intra stromal corneal ring segment

Intra ocular refractive procedure's


Phakic refractive lens



Refractive lens exchange

obsolete
Radial keratotomy

Photorefractive
keratectomy

Intraocular refractive procedure's

LASIK


Radial keratotomy


Deep radial incisions (90% thickness) sparing central 4mm –
cornea flatter's on healing



Disadvantages – globe rupture, irregular astigmatism, glare,
bullous keratopathy
Photorefractive keratectomy (PRK)
First refractive procedure to use the excimer laser
 Max success in myopia
 Good for -2.00D to -6.00D
 Photoabalation of central optical zone of ant.
Corneal stroma


De-epithelialzation – photo
ablative

Ablation – 6mm for myopia

0.5.1.0mm more

Laser should be coaxial with
pupil

Prevent extreme drying or
wetting of cornea and residual
islands

Hand held ring for centration

Toric photoabalation

corneal curvature shifts as ant
stroma collapse and thins
Intrastromal PPk – double
NdYAG
Plasmamediated
photodistribution shock wave

Complications – decentation
Corneal haze, infiltrates, ulcers
Night glare , halos
Delayed epi healing
Islands, Hx, IOP↑
Combination – Incisional & Ablative
Procedure
 LASIK





- Laser In Situ Keratomileusis

Microkeratome to make a corneal flap – excimer to ablate the
refractive error
adv – bilateral, PRK healing risks avoided, stable results
Dis-adv – flap related, striae, diffuse lamellar keratitis, under (or)
over correction


LASEK – LASER Epithelial Keratomileusis


Similar to PRK – epithelium is removed and replace post Sx



Alcohol to store the epithelium



For large pupils and thin corneas



For > -8.00 D



Adv – no risk of flap dislocation (LASIK)



Thin flap



Less chance of ectasia



Dis- adv – visual recovery slower than LASIK


Epi LASIK



Cleaves epi from bowmen's – structural integrity maintained





Newer version of LASEK- advantage on LASIK
More thin flap, less haze, faster recovery

Custom LASIK


Customized for each eye



Less halos and glare, More chance of 6/6



Wave front aberrometer - corneal topography



Ablation – flexible laser system
Intra ocular refractive Sx


Refractive lens exchange


Existing cataract and cornea unfit for refractive Sx



For -16.00D to -30.00D



PCO reduced



Accommodation retained thrgh ‘hinges’


Phakic IOLs


Patients not qualified for refractive Sx



Ant / Post chamber lens with out removing crystalline lens



Made of plastic (or) silicone
Patient history and examination

Supplement
al testing

Management flow
chart
Simple
myopia

Correction
Infants and
toddlers – no
correction < 3D
Pre-school/earlyschool – correct if
>1-2D
Adolescent's/adult
s – correct
significantly

Control

plus lens for Nv
Rigid contact
lens
Visual hygiene

Assessment and diagnosis

Patient counseling and education

Treatment and management

Nocturnal
myopia

Reduction

Corneal
modification
– refractive
Sx

Pseudomyopia

Myopia
correction
for night
time seeing
only

Reduction of
accommodative
response – vision
therapy, plus lens
for Nv,
cycloplegic
agents, visual
hygiene

Degenerative
myopia

Induced
myopia

Identificatio
n and
treatment of
causative
agent
Correction
and
manageme
nt of retinal
changes
If a man is called to be a street sweeper, he
should sweep street so well that all the host

of heaven and earth will pause to say, here
lived a great street sweeper who did his job
well.
- Martin Luther King, Jr.

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Myopia refractive error

  • 3. Definetion  Myopia ( short sight ) condition where parallel rays come to focus in front of the sentient layer of retina when accommodation is at rest  Muopia (Greek) = To close the eye
  • 4. History  Kepler (1611), Plempius (1632) - lengthening of posterior part.  Donders (1866) est.. Pathological basis, and detail clinical manifestation's
  • 5. Etiology  Axial : most commonest   1mm = 3D Curvatural : cornea thickness  causes astigmatism  1mm = 6D  eg : ectasies  conical cornea
  • 6.  lenticular curvature  eg : ant/post lenticonus – marked  Positional : dislocation of lens  Myopia due to excessive accommodation - spasm of accommodation, suspensory lig. Rupture
  • 7.  Index myopia : change in the R.I of the crystalline lens eg : Nuclear Sclerosis, Incipient Cataract, Diabetes.
  • 8.  Buphthalmos : cong/ infantile glaucoma. Defective development – A.P diameter myopia not in ratio enlarged and
  • 9. Optics  Optical system – eye too powerful for axial length  Image of distant object on retina are circles of diffusion form by divergent beam  Far point is finite pt in front of eye – object at far pt focused without acc.  Angle of alpha –ve resulting in convergent squint
  • 10.  Accommodation- uncorrected- not developed , as not needed for Nv. Thus may develop exophoria, convergence insufficiency and presbyopia  Enlarged image is cause of nodal pt being far away from retina
  • 13. Congenital myopia  Since birth  Diagnosed – 2 -3 yrs.  Associated – prematurity, birth defects, congenital squint, and axial length  Unilateral or bilateral  Unilateral – manifest as anisometropia diagnosed - after squint- amblyopia
  • 14.  Associated – cataract, microphthalmas, cong. Retinal separation, megalo-cornea  Prognosis – early detection no 6/6 uni-ocular
  • 15. Simple Myopia  Physiological / developmental / school  Biological variation in development  Limited progression no disease  Factors associated :  Axial – A.P diameter (or) neurological  Curvatural – underdevelopment of eye ball  Diet – poor nutriention  Genetic influence – one (or) both parents
  • 16. Physiological – A/S normal along with normal fundus Simple Myopia Intermittent – early signs of globe enlargement temporally Sever category of intermittent – crescent with super-traction of disc
  • 17. course Born hyper metropic Emmetropic • overshoot  Stabilized at teens Myopic • 7-10 yrs • -5D to -8D symptom's :  Poor distance vision – beyond far point impaired  Asthenopic sympt – eye strain due to difference b/w convergence and accommodation    Nv -No accommodation – convergence weakness – exophoria – suppression of one eye Nv –convergence – excessive accommodation – ciliary spasm Physiological out-look – myopic child behavior
  • 18.  Signs   A.C. – deep  Pupil – large and sluggish  Fundus – normal   Eye – large and prominent Error - -5.00 D to -8.00D Diagnosis –visual acuity subjective testing retinoscopy
  • 19. Pathological Myopia  Degenerative / progressive  2-3 %  More marked, high degree  Hereditary  Postnatal  Inc. progressive
  • 20.  Prevalence – earlier and higher in females higher – Asians, Arabs, Jews lower – Africans, Caucasians more in urban populations
  • 21. Etiology  Results from rapid growth of eye out side its biological variation  2 theories - Hereditary - General growth Genetic factors Retinal growth Scleral stretching Increase in axial length Pathological myopia • Degeneration – choroid, retinae, vitreous
  • 22.  Symptoms   Muscae volitantes – deg. lig. Vitreous   Diminished Vn – progressive due to degeneration Night blindness – high myopes with choroidi-retinal changes Signs  Prominent, elongated(post), unilateral, stimulating exophthalmos  Cornea – large; A.C – deep; pupil – large, sluggish  Refractive error – by -4D/yr up to 20-30yrs
  • 23.  Fundus –  Generalized atrophy of choroid and retinae  Loss of RPE- fundus tugroid- prominent choroidal vessels  Choroid disappears – visible sclera – atrophic patch - post. Pole – macula (common)  Foster – Fuchs's spots – rare, sudden, dark pig. sub-retinal neovascularization and choroidal hx.  Cystoid degeneration at periphery
  • 24.  Advance cases – total retinal atrophy, central  Lattice degeneration/ snail track lesion
  • 25.  Optic disc  Myopic crescent – from elongation of disc separation of retina and choroid from temp may be annular  Super traction crescent – nasal retina extending over the disc – blur margin  Posterior staphyloma – higher degree, herniation of post. Pole – sudden kinking of vessels at margin as in glaucoma
  • 26.  Vitreous – degeneration, PVD-Wiess reflex, liquefaction, opacities  Visual field – ring scotoma  Electo-retinograph – chorioretinol atrophy  Complications  retinal tears, detachment, Hx (high myopia)  vitreous detachment, degeneration  complicated cataract –↓ lenticular metabolism  Nuclear sclerosis – common, effects refraction  Choroidal Hx – sever Vn loss if in fovea  POAG – not common but seen
  • 27. acquired index – nuclear sclerosis, incipient cataract, diabetic myopia Curvatural – true inc. in corneal curvature (or) lenticular Positional – subluxation(ant) of lens Consecutive – surgical overcorrection(cataract/ hypermetropia) Pseudo-myopia – due to excessive accommodation and spasm of accommodation Space myopia – no stimulus for Nv, its variable, trouble in flying and in fog Night/twilight – shift from photic to scotopic vn is associated with inc. sensitivity to shorter wavelength viz myopic Cholinergic – pilocarpine, echothiosulphate Drug induced - Steroid – show changes in crystalline lens Sulplanamides – changes the refractive indices in media
  • 28. Diagnosis presentation Simple – blurred Dv, constant/ transient, Nv may be normal, co-existing condt. Nocturnal – blurred Dv in dim illumination, difficulty in driving Pseudo myopia – transient Dv blur, inc after near work Degenerative - considerable Dv blur, flashes/ floaters, Vn loss Induced – transient Dv blur until drug effect, pupils constricted – cholinergic antagonist
  • 29. Ocular examination Visual acuity – both unaided Nv and Dv should be measured-mean gives reduced V.A Refraction – retinoscopy or and A.R. , but A.R not qualitative retinoscopy – diagnosis for nocturnal myopia with cyclopegics Ocular motility, binocular Vn, accommodation – heterophoria, versions, accommodative facility test systemic and ocular health – IOP, SLB, postsegment
  • 30.  Special test  Fundus Photography  A and B scan  Visual field  Fasting blood sugars
  • 31. Treatment  Optical Correction   Proper correction with concave lens for image to fall on retina Myopia up to -6.00D  Children – full correction  Young adults – prevent over correction  Adults - ↓ 30 yrs. – full correction ↑ 30 yrs. – under corrected – ciliary muscles fail to accommodate
  • 32.  Spectacle's  Contact lens  Economical, safe  Larger retinal image  Allow incorporation  Better Vn in Sr. myopia  Better correction of astigmatism  Better visual field  Less acco- near pt. blur in presbyopia  Dec. prismatic effect  Rigid lens dec. progressive myopia
  • 33.  Surgical Treatment  Incisional – Radial Keratotomy  Lamellar corneal refractive Sx   Non-freeze keratomileusis  Keratomileusis insitu   Freeze keratomileusis of Barraque for myopia Automated lamellar keratoplasty Laser-based corneal refractive Sx   Laser insitu keratomileusis (LASIK)  Custom Laser insitu keratomileusis (C-LASIK)   Photorefractive keratectomy (PRK) Epithelial Laser insitu keratomileusis (E-LASIK) Miscellaneous corneal refractive Sx   Intracorneal contact lens   Orthokeratology Intra stromal corneal ring segment Intra ocular refractive procedure's  Phakic refractive lens  Refractive lens exchange obsolete
  • 35.  Radial keratotomy  Deep radial incisions (90% thickness) sparing central 4mm – cornea flatter's on healing  Disadvantages – globe rupture, irregular astigmatism, glare, bullous keratopathy
  • 36. Photorefractive keratectomy (PRK) First refractive procedure to use the excimer laser  Max success in myopia  Good for -2.00D to -6.00D  Photoabalation of central optical zone of ant. Corneal stroma  De-epithelialzation – photo ablative Ablation – 6mm for myopia 0.5.1.0mm more Laser should be coaxial with pupil Prevent extreme drying or wetting of cornea and residual islands Hand held ring for centration Toric photoabalation corneal curvature shifts as ant stroma collapse and thins Intrastromal PPk – double NdYAG Plasmamediated photodistribution shock wave Complications – decentation Corneal haze, infiltrates, ulcers Night glare , halos Delayed epi healing Islands, Hx, IOP↑
  • 37. Combination – Incisional & Ablative Procedure  LASIK    - Laser In Situ Keratomileusis Microkeratome to make a corneal flap – excimer to ablate the refractive error adv – bilateral, PRK healing risks avoided, stable results Dis-adv – flap related, striae, diffuse lamellar keratitis, under (or) over correction
  • 38.  LASEK – LASER Epithelial Keratomileusis  Similar to PRK – epithelium is removed and replace post Sx  Alcohol to store the epithelium  For large pupils and thin corneas  For > -8.00 D  Adv – no risk of flap dislocation (LASIK)  Thin flap  Less chance of ectasia  Dis- adv – visual recovery slower than LASIK
  • 39.  Epi LASIK   Cleaves epi from bowmen's – structural integrity maintained   Newer version of LASEK- advantage on LASIK More thin flap, less haze, faster recovery Custom LASIK  Customized for each eye  Less halos and glare, More chance of 6/6  Wave front aberrometer - corneal topography  Ablation – flexible laser system
  • 40. Intra ocular refractive Sx  Refractive lens exchange  Existing cataract and cornea unfit for refractive Sx  For -16.00D to -30.00D  PCO reduced  Accommodation retained thrgh ‘hinges’
  • 41.  Phakic IOLs  Patients not qualified for refractive Sx  Ant / Post chamber lens with out removing crystalline lens  Made of plastic (or) silicone
  • 42. Patient history and examination Supplement al testing Management flow chart Simple myopia Correction Infants and toddlers – no correction < 3D Pre-school/earlyschool – correct if >1-2D Adolescent's/adult s – correct significantly Control plus lens for Nv Rigid contact lens Visual hygiene Assessment and diagnosis Patient counseling and education Treatment and management Nocturnal myopia Reduction Corneal modification – refractive Sx Pseudomyopia Myopia correction for night time seeing only Reduction of accommodative response – vision therapy, plus lens for Nv, cycloplegic agents, visual hygiene Degenerative myopia Induced myopia Identificatio n and treatment of causative agent Correction and manageme nt of retinal changes
  • 43. If a man is called to be a street sweeper, he should sweep street so well that all the host of heaven and earth will pause to say, here lived a great street sweeper who did his job well. - Martin Luther King, Jr.