Major points from the document: - Real-time bidding (RTB) is growing rapidly, with the top 1,000 advertisers increasing their RTB spending from 17% to 23% of their plans over the last year. However, some brands remain on the sidelines. - Both major advertisers like Adobe, BMW, and 1-800-Flowers as well as publishers across premium and long-tail sites are increasingly using RTB, with some publishers deriving 20% or more of their inventory from RTB. - Ad networks are reinventing themselves through RTB, with some becoming "RTB first" networks and others using a hybrid model of direct deals and RTB.