2. 2Barry Kidd 2010
DefinitionDefinition
Inadequate perfusion (oxygen supply) of tissues,Inadequate perfusion (oxygen supply) of tissues,
resulting in:resulting in:
Organ dysfunctionOrgan dysfunction
Cellular and organ damageCellular and organ damage
And if not quickly corrected…And if not quickly corrected…
DeathDeath
3. 3Barry Kidd 2010
Causes of Shock – a quick list:Causes of Shock – a quick list:
Heart AttackHeart Attack
AnaphylaxisAnaphylaxis
Loss of Circulating Blood Volume (bleeding ,Loss of Circulating Blood Volume (bleeding ,
burns, dehydration)burns, dehydration)
Venous Dilation (allergy, pain, drugs, heatVenous Dilation (allergy, pain, drugs, heat
stroke, infection)stroke, infection)
High or Low Body TemperatureHigh or Low Body Temperature
4. 4Barry Kidd 2010
Signs of ShockSigns of Shock
Pulse: Rapid, weak, threadyPulse: Rapid, weak, thready
TachycardiaTachycardia
RespirationsRespirations
Shallow, irregular, laboredShallow, irregular, labored
May be tachypnea (increased respiratory rate.)May be tachypnea (increased respiratory rate.)
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Signs of ShockSigns of Shock
Due to hypoperfusion:Due to hypoperfusion:
Decreased “mentation” - confused, sluggish, anxiousDecreased “mentation” - confused, sluggish, anxious
Skin cold, mottledSkin cold, mottled
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Emergency TreatmentEmergency Treatment
Evaluate vital signsEvaluate vital signs
BP, Respiration Rate, Pulse Oximeter, Temp.BP, Respiration Rate, Pulse Oximeter, Temp.
Control bleedingControl bleeding
Prevent loss of body heatPrevent loss of body heat
7. 7Barry Kidd 2010
Causes of Shock:Causes of Shock:
Classification (the real list)Classification (the real list)
Low Output Circulatory FailureLow Output Circulatory Failure
Hypovolemic shock (too little volume)Hypovolemic shock (too little volume)
Cardiogenic shock (pump failure)Cardiogenic shock (pump failure)
Obstructive shockObstructive shock
Distributive shock: Venous poolingDistributive shock: Venous pooling
High Output Circulatory FailureHigh Output Circulatory Failure
Distributive Shock: Sepsis, toxic shock,Distributive Shock: Sepsis, toxic shock,
anaphylaxis:anaphylaxis:
8. 8Barry Kidd 2010
Hypovolemic ShockHypovolemic Shock
CO reduced due to loss of intravascularCO reduced due to loss of intravascular
VOLUMEVOLUME
Reduced venous returnReduced venous return
CausesCauses
Most often, blood loss (hemorrhage)Most often, blood loss (hemorrhage)
DehydrationDehydration
BurnsBurns
Fluid lost into peritoneal cavity w/Fluid lost into peritoneal cavity w/
pancreatitispancreatitis
10. 10Barry Kidd 2010
Obstructive ShockObstructive Shock
CO reduced by vascular obstruction:CO reduced by vascular obstruction:
Obstruction of Venous return (vena cava syndromeObstruction of Venous return (vena cava syndrome
– usually neoplasms)– usually neoplasms)
Compression of the heart (pericardial tamponade*)Compression of the heart (pericardial tamponade*)
Outflow from heart (Massive pulmonary embolism,Outflow from heart (Massive pulmonary embolism,
aortic dissection)aortic dissection)
11. 11Barry Kidd 2010
Obstructive ShockObstructive Shock
CO reduced by vascular obstruction:CO reduced by vascular obstruction:
Obstruction of Venous return (vena cavaObstruction of Venous return (vena cava
syndrome – usually neoplasms)syndrome – usually neoplasms)
Compression of the heart (pericardialCompression of the heart (pericardial
tamponade*)tamponade*)
Outflow from heart (Massive pulmonaryOutflow from heart (Massive pulmonary
embolism, aortic dissection)embolism, aortic dissection)
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Pericardial TamponadePericardial Tamponade
Life threateningLife threatening
condition caused by fluidcondition caused by fluid
(blood, effusion fluid)(blood, effusion fluid)
under pressure aroundunder pressure around
the heart.the heart.
Decreases CO byDecreases CO by
decreasing fillingdecreasing filling
Causes includeCauses include
pericarditis and MIpericarditis and MI
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Distributive ShockDistributive Shock
Maldistribution of flowMaldistribution of flow
Two Categories:Two Categories:
Low Output - Venous pooling due to loss ofLow Output - Venous pooling due to loss of
venous tonevenous tone
High Output Circulatory FailureHigh Output Circulatory Failure
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Venous PoolingVenous Pooling
A Low Output Circulatory FailureA Low Output Circulatory Failure
Often due to spinal shock or drug overdoseOften due to spinal shock or drug overdose
Behaves like hypovolemic shockBehaves like hypovolemic shock
CO severely reduced because blood is pooledCO severely reduced because blood is pooled
in peripheral veins, rather than returned toin peripheral veins, rather than returned to
heartheart
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Distributive Shock: High OutputDistributive Shock: High Output
Cardiac Output is normal or elevated;Cardiac Output is normal or elevated;
distribution inappropriatedistribution inappropriate
Shock is due to loss of vascular resistanceShock is due to loss of vascular resistance
Examples:Examples:
Sepsis, Toxic Shock:Sepsis, Toxic Shock:
Bacterial endotoxin triggers vasodilationBacterial endotoxin triggers vasodilation
AnaphylaxisAnaphylaxis
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Anaphylactic ShockAnaphylactic Shock
Histamine triggers vasodilation, increasedHistamine triggers vasodilation, increased
capillary permeabilitycapillary permeability
Can lead to low-output distributive shockCan lead to low-output distributive shock
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Physiological Response to ShockPhysiological Response to Shock
The pressure drop is compensated for byThe pressure drop is compensated for by
regulatory mechanismsregulatory mechanisms
This = “Nonprogressive” / “Compensated”This = “Nonprogressive” / “Compensated”
ShockShock
20. 20Barry Kidd 2010
Progressive ShockProgressive Shock
Compensatory mechanisms inadequate toCompensatory mechanisms inadequate to
compensate for loss of blood volumecompensate for loss of blood volume
Cardiac circulation compromisedCardiac circulation compromised decreaseddecreased
heart functionheart function decreased flowdecreased flow
Positive feedback cycle: Shock worsensPositive feedback cycle: Shock worsens lessless
compensationcompensation shock worsens…shock worsens…
Clotting in small vesselsClotting in small vessels
Vessels dilate and permeability increasesVessels dilate and permeability increases
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Irreversible ShockIrreversible Shock
Cardiac and other tissue irreversibly damagedCardiac and other tissue irreversibly damaged
Characterized by:Characterized by:
Decreasing cardiac functionDecreasing cardiac function
Progressive blood vessel dilationProgressive blood vessel dilation
Progressive increase in vessel permeabilityProgressive increase in vessel permeability
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Irreversible ShockIrreversible Shock
Cardiac and other tissues are irreversiblyCardiac and other tissues are irreversibly
damageddamaged
Characterized by:Characterized by:
Decreasing cardiac functionDecreasing cardiac function
Progressive blood vessel dilationProgressive blood vessel dilation
Progressive increase in vessel permeabilityProgressive increase in vessel permeability
24. 24Barry Kidd 2010
Physiology
Basic unit of life = cell
Cells get energy needed to stay
alive by reacting oxygen with
fuel (usually glucose)
No oxygen, no energy
No energy, no life
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Circulatory Shock
“Pathophysiologic state in which tissue perfusion is
totally inadequate to meet the oxygen or nutritional
needs of the cells”
Shock described as “momentary pause in the act of
death”
Shock is not a disease entity in itself, but a response to
some assault or injury the body has experienced
Whatever the initiating event, the cause of death in
irreversible shock is microcirculatory failure and the
subsequent depression of cellular metabolism
27. 27Barry Kidd 2010
What is needed to maintain
perfusion?
Pump
Pipes
Fluid
Heart
Blood Vessels
Blood