Bill Faloon presents updates on human age-reversal research, including his announcement of two human trials testing potential age-reversal interventions in humans.
10. “The Science of Living Longer”
“No longer is it (aging)
being treated as a
dreadful inevitability but
instead as a puzzle that
can be solved---as a
disease with a cure.”
TIME-Special Edition - Fall 2019
12. “Can we live forever?”
January 28, 2019
Harvard Medical School geneticist Vadim Gladyshev:
“His research on 31 species has
identified around 1000 genes…
whose levels define how long
an organism will live for.2
1. https://www.chemistryworld.com/features/can-we-live-forever/3009999.article
2. Aging Cell, 2015, 14, 352 (DOI: 10.1111/acel.12283)
13. Can human mortality be hacked?
March 24, 2019
https://theweek.com/articles/830455/human-mortality-hacked
“...a growing number of
‘transhumanists’ are convinced that,
in time, human beings can be
transformed through bioengineering,
and that aging will be curable just
like any other malady.”
“A fringe group of scientists and
tech moguls think they're closing
in on the fountain of youth…”
14. “The Ever-Growing Reality That
We Might Be Able To Live Forever”
What once was science
fiction now looks more
like our near future.
Jan 2, 2019
Would you like
to live forever?
“
”“
https://melmagazine.com/en-us/story/the-ever-growing-reality-that-we-might-be-able-to-live-forever
15. CAN WE CHEAT AGING Dec. 13, 2018
All around the world, scientists are trying to beat the
most debilitating condition known to humans: ageing
http://www.bbc.com/future/story/20181211-how-science-and-medicine-could-cure-ageing
16. Huge Advances in Only 10 Years
No Way to Reverse Aging
Manhattan Beach Summit Attendees
November 2009
Many Potential Methods
2009 2019
20. Life Biosciences raised more than
$75 million to research treatments
for age-related decline.
March 4, 2019
https://www.fastcompany.com/90314848/pepsicos-top-scientist-is-joining-the-fight-to-help-you-live-forever
https://www.bloomberg.com/news/articles/2019-03-04/departing-pepsico-scientist-to-become-ceo-of-anti-aging-startup
Mehmood Khan, vice chairman
and chief scientific officer of
PepsiCo, announced he’s joining
Life Biosciences, a startup
dedicated to “age-reversal.”
21. Insilico Medicine Secures
$37M in Series B Funding
Alexander Zhavoronkov, Ph.D., is the Chief Executive
Officer of Insilico Medicine, Inc, a company applying
advances in artificial intelligence to drug discovery,
biomarker development and aging research.
Landmark AI paper resulted in a $37 million round
of additional funding from venture capitalists.
Total dedication to finding an aging cure.
https://insilico.com
Life Extension contributed $140K start-up funding for Insilico.
22. According to Juvenescence’s Greg Bailey
“We won’t be aging as fast or
poorly as our parents”
“I think the world is going to be shocked”
Juvenescence has now raised $165 million
to fund longevity projects with the goal of
extending human lifespans to 150 years.
“Science fiction has become science”
‘Extraordinary’ Breakthroughs In Anti-Aging
Research ‘Will Happen Faster Than People Think’
https://www.forbes.com/sites/robinseatonjefferson/2019/08/26/how-extraordinary-breakthroughs-in-anti-aging-research-will-happen-faster-than-people-think
27. Age-adjusted Prevalence of Obesity and Diagnosed Diabetes
Among US Adults
Diabetes
No Data < 14.0% 14.0%–17.9% 18.0%–21.9% 22.0%–25.9% > 26.0%
No Data < 4.5% 4.5%–5.9% 6.0%–7.4% 7.5%–8.9% > 9.0%
Age-Adjusted Prevalence of Obesity and
Diagnosed Diabetes Among US Adults
CDC’s Division of Diabetes Translation. United States Diabetes Surveillance System available at http://www.cdc.gov/diabetes/data
1994 2000 2015
Diabetes1994 20152000
Obesity
28. New Genetic Test Measures Lifelong Body Weight
Reveals Startling Link between Obesity and Cancer
It Is Worse Than Previously Thought!
59% higher risk of kidney cancer (revised up from 30%)
106% higher risk of endometrial cancer (revised up from 50%)
13% higher risk of ovarian cancer (revised up from 6%)
110% higher risk of esophageal cancer (revised up from 48%)
47% higher risk of pancreatic cancer (revised up from 10%)
44% higher risk of colorectal cancer (revised up from 5%)
What can Mendelian randomization tell us about causes of cancer? International Journal of Epidemiology. 2019;
48(3): 816-821https://academic.oup.com/ije/article-abstract/48/3/816/5539268?redirectedFrom=fulltext.
July 25, 2019
29. People with high BMI
and central obesity
have 3.5 times
increased dementia
risk.
Central Obesity (belly fat) Increases Dementia Risk
Central obesity and increased risk of dementia more than three decades later (PDF). Neurology 2008: 71, 1057-1064
30. RapamycinClinicalTrial
Dose: 5 mg/week of sirolimus (rapamycin)
Recruitment: Age Reversal Network volunteers
Subjects: 20 overweight individuals
initiated and 14 concluded
Side effects: 10% had minor canker sores that usually resolved
(No one stopped because of side effects)
31. California wildfires caused some to drop out
and high stress levels in those who continued.
Major Impediment
32. More data on this study will be sent
soon to RAADfest participants via email
Rapamycin Study Partial Results
Significant reductions in
visceral adipose tissue.
Non-smoke affected
subjects showed
indicatorsofage-reversal
Reduction
33. Reduced
Rapamycin (5 mg) once
weekly well tolerated
Initial Interpretations
High stress offsets
beneficial effects of this
regenerative technique.
More data on this study will be sent
soon to RAADfest participants via email
35. “Measuring population ageing: an analysis of the Global Burden of Disease Study 2017.” Lancet Public Health. 2019 Mar;4(3):e159-e167.
“At what age do you feel 65?”
In a startling revelation, 76-year-old people in
Japan and 46-year-old people in Papua New
Guinea have the same level of age-related
health problems as an average 65-year-old.
Available at: https://medicalxpress.com/news/2019-03-age.html. Accessed April 2, 2019.
March 8, 2019
36. “Measuring population ageing: an analysis of the Global Burden of Disease Study 2017.” Lancet Public Health. 2019 Mar;4(3):e159-e167.
Level of Age-Related Health Problems
Available at: https://medicalxpress.com/news/2019-03-age.html. Accessed April 2, 2019.
March 8, 2019
New Guinea: 46 year old = 65 year old
Japan: 76 year old = 65 year old
37. “Measuring population ageing: an analysis of the Global Burden of Disease Study 2017.” Lancet Public Health. 2019 Mar;4(3):e159-e167.
You Control Disease Risk and How Old You Feel!
Available at: https://medicalxpress.com/news/2019-03-age.html. Accessed April 2, 2019.
March 8, 2019
The Lancet Public Health showing marked
differences in the “age-related disease burden”
between countries...The United States ranked
54th on this list, between Algeria and Iran.
40. May 8, 2019
One of the biggest investment
opportunities over the next decade
will be in companies working to
delay human death, a market
expected to be worth at least $600
billion by 2025, according to
Bank of America analysts.
https://www.cnbc.com/2019/05/08/techs-next-big-disruption-could-be-delaying-death.html
Human life expectancy could pass 100 years
42. “There is now
compelling evidence
that the ageing
process is plastic and
that it is possible to
revive aged cells and
tissues”
“Turning back time with emerging
rejuvenation strategies”
Jan. 2019
Nature Cell Biology Volume 21, Pages 32-43 (January, 2019)
43. “Strategies to delay and potentially even reverse
the aging process have recently been developed”
Jan. 2019
44. A piece of non-coding DNA may hold the key to how humans could regenerate body parts.
Some animals can achieve
extraordinary feats of repair,
such as salamanders which
grow back legs, or geckos.
Scientists at Harvard University
uncovered the DNA switch that
controls genes for whole-body
regeneration.
Humans may soon have the
ability to regrow limbs.
Mar. 17, 2019
Harvard University uncovers DNA switch
that controls genes for whole-body regeneration
https://www.telegraph.co.uk/science/2019/03/14/harvard-university-uncovers-dna-switch-controls-genes-whole/
45. A new CRISPR/Cas9 therapy can
suppress aging, enhance health
and extend life span in mice,
opening door for better
understanding of aging in humans
Salk Institute researchers
have developed a new gene
therapy to help decelerate
the aging process.
From left: (front) Reyna Hernandez-Benitez, Hsin-
Kai Liao; (back) Pradeep Reddy, Mako Yamamoto,
Juan Carlos Izpisua Belmonte
Feb.2019PUTTING THE BRAKES ON AGING
https://www.salk.edu/news-release/putting-the-brakes-on-aging/
46. “Has this scientist finally found the fountain of youth?”
August
2019
Juan Carlos Izpisúa Belmonte, Gene Expression Laboratory at San Diego’s Salk Institute for Biological Studies
“It completely rejuvenates…If
you look inside, obviously, all the
organs, all the cells are younger.”
Salk Institute uses gene editing “age-reversal mixture”
to rejuvenate progeroid mice on verge of death.
47. CRISPR-cas9 therapy delays aging
partially by removing Senescent Cells Feb. 18, 2018
Overall, the treated progeria mice had activity levels similar
to normal mice, and their life span increased by roughly 25 percent
Two months after delivery of the
(CRISPR) therapy, the mice were
stronger and more active, with
improved cardiovascular health.
They showed decreased
degeneration of a major arterial
blood vessel and delayed onset of
bradycardia - two issues commonly
observed in progeria and old age.
https://www.nature.com/articles/s41591-019-0343-4#article-info
These two mice are the same age
48. This is why we need to start
treating aging as a disease
By David A. Sinclair and Nir Barzilai
The next medical frontier is extending the human lifespan. But
changing the definition of aging is still a huge obstacle
Nir Barzilai, Ph.D.
Albert Einstein College of Medicine
Metformin Advocate
David Sinclair, Ph.D.
Harvard Medical School
NAD+ Advocate
December 31, 2018
51. A Conversation with ‘Forever Man’ Bill Faloon About Fending Off Aging
https://www.noozhawk.com/article/tam_hunt_conversation_about_aging_with_forever_man_bill_faloon_20181108
Bill Faloon is a man with a mission: to fend off aging. As long as possible, and maybe
even forever.
A recent Popular Science story called him “the forever man.” This is both because
Faloon wants to figure out how we can live forever and because he has been working
to resolve this problem for what can seem like forever — or at least since the 1970s,
which seems to most of us to be pretty much forever.
I met Faloon at this year’s RAADfest conference in San Diego, where he was
omnipresent. When he wasn’t on stage giving a talk or appearing on a panel, he was
mingling with attendees answering questions and generally offering wisdom where he
could. He talks a mile a minute with a soft intensity and keen intelligence.
53. “…If You Want It”
https://www.technologyreview.com/magazine/2019/09 September
2019
It’s so named because
“there is no upper limit
as to how long we will
attempt to enable study
participants to live.”
54. Still Shot from European Special on the “Forever Man”
December 2018
56. 1) Preserve general
health of neurons.
2) Brain’s primary
immune cells.
3) Clean-up toxins
around neurons.
https://www.nature.com/articles/d41586-018-04930-7
What are Microglial Cells?
57. “Young bone marrow transplantation preserves learning and memory in old mice”, Communications Biology (2019). DOI: 10.1038/s42003-019-0298-5
“Young bone marrow rejuvenates
aging mouse brains, study finds”
Transplanting the
of young
laboratory mice into old
mice prevented cognitive
decline in the old mice.
Available at:https://medicalxpress.com/news/2019-02-young-bone-marrow-rejuvenates-aging.html.
February 20, 2019
58. Information from one neuron flows to another neuron across a synapse
Neurons communicate with one another at synaptic junctions
Synapses: The point of connection between brain cells
59. “Young bone marrow rejuvenates
aging mouse brains, study finds”
Microglia in brains of old mice have fewer/shorter branches than young mice
Available at: https://medicalxpress.com/news/2019-02-young-bone-marrow-rejuvenates-aging.html.
Feb. 20, 2019
Synaptic branches of microglia of old mice who received bone marrow
transplants from young mice resembled those of young mice
60. Young Bone marrow transplants
restore exploratory activity in old mice
Feb. 20, 2019
“Remarkably, young
bone marrow
recipients, but not
old bone marrow
recipients, were
more active than
old control mice.”
https://www.nature.com/articles/s42003-019-0298-5/figures/1
61. “Young bone marrow rejuvenates
aging mouse brains, study finds”
Available at: https://medicalxpress.com/news/2019-02-young-bone-marrow-rejuvenates-aging.html.
Feb. 20, 2019
Young bone marrow
restores aged mouse brains!
62. PHILADELPHIA (CBS) — Could the secret to eternal youth be found in blood transfusions from young people?
Some claim that transfusions with “young blood” from teenagers can reverse the aging process.
Dec. 20, 2018
Controversial Treatment Transfuses Patients With
‘Young Blood’From Teenagers To Reverse Aging Process
63. Transfer
Research goes Mainstream
Johnson and Johnson signs $50 million deal with Stanford
University researchers to identify blood factors responsible for
age reversal in parabiosis studies:
"…it could mean new therapeutic approaches
for treating numerous diseases associated with
aging, including neural dysfunction and
dementias such as Alzheimer's disease.”
March 4, 2015
64. Stanford University scientists
previously showed that transfused
serum from 12-to-15-month age
mice into old mice reverses some
signs of brain aging.
Kathlyn J. Gan et al. Specific factors in blood from young but not old mice directly promote synapse
formation and NMDA-receptor recruitment, Proceedings of the National Academy of Sciences (2019).
DOI: 10.1073/pnas.1902672116
JUNE 3, 2019
65. Researchers find synapse-boosting factors in young blood
Available at: https://medicalxpress.com/news/2019-06-synapse-boosting-factors-young-blood.html. Accessed June 4, 2019.
June 4, 2019
Stanford University researchers used serum from
15-day old (very young) mice and discovered:
“ ”
67. Very Young Blood (serum) Regenerates
Synapses, Dendrites, Neurotransmitters
Available at: medicalxpress.com/news/2019-06-synapse-boosting-factors-young-blood.html. Accessed June 4, 2019.
June 4, 2019
“When two proteins (thrombospondin-4 and
SPARC-like protein-1) richer in younger
serum were applied to older serum…some of
the same rejuvenating effects took place.”
68. “Strikingly, recombinant THBS4 and
SPARCL1… may represent rejuvenation
factors that enhance synaptic connectivity
by increasing dendritic arborization, synapse
formation, and synaptic transmission.”
Kathlyn J. Gan et al. Specific factors in blood from young but not old mice directly promote synapse
formation and NMDA-receptor recruitment, Proceedings of the National Academy of Sciences (2019).
DOI: 10.1073/pnas.1902672116
JUNE 3, 2019
Human equivalent of a 15-day old mouse may be approximately one to two years.
71. “Some reports show that up to 50%
of patients with hip fracture die
within six months and many of those
who survive do not recover their
baseline independence and function.”
Negrete-Corona, J., J. C. Alvarado-Soriano, and L. A. Reyes-Santiago. "Hip fracture as risk factor for mortality
in patients over 65 years of age. Case-control study." Acta ortopedica mexicana 28, no. 6 (2014): 352-362.
https://www.ncbi.nlm.nih.gov/pubmed/26016287
“Hip Fracture Among Older Patients Is A Devastating Injury”
72. https://medicalxpress.com/news/2018-12-scientists-youth-factor-blood-cells.html
“Scientists identify ‘youth factor’ in
blood cells that speeds fracture repair”
Medical press Dec. 5, 2018
Duke Health researchers showed
introducing bone marrow stem cells
to a bone injury can expedite healing.
New study by same Duke-led team
has pinpointed “youth factor” inside
bone marrow stem cells that can have
a rejuvenating effect on tissue.
75. Adult stem cells lose ability to repopulate tissues with functional cells
Systemic deterioration occurs as functional cells degenerate/die
Khorraminejad-Shirazi M et al., Aging and stem cell therapy: AMPK as an applicable pharmacological target for
rejuvenation of aged stem cells and achieving higher efficacy in stem cell therapy. Hematol Oncol Stem Cell Ther (2017)
Boost cellular AMPK
Suppress excess mTORC1
Replenish NAD+ cell levels
Activate sirtuin proteins
How your stem cells may be renewed:
77. More than 90% of people over 65 years
of age have at least one chronic disease
Harsh Reality:
Goldman, Dana P., et al. "Substantial health and economic returns from delayed aging may warrant a new
focus for medical research." Health affairs 32, no. 10 (2013): 1698-1705.
79. Optimal Health
Level 2
Level 1
Before we can utilize
the latest technologies…
We must address the
first level foundation
toward optimal health - Hormones - Kidney function
- LDL/HDL - Vitamin D
- Blood Pressure - Glucose
- C-reactive protein - Homocysteine
- Insulin - Triglycerides
80. House of Optimal Health
- Hormones - Kidney function
- LDL/HDL - Vitamin D
- Blood Pressure - Glucose
- C-reactive protein - Homocysteine
- Insulin - Triglycerides
Level 2
Level 1
- Senolytics
- NAD+ Restoration
- mTOR-inhibition
- Umbilical Cord Blood/Plasma
- Umbilical Exosomes
- Mesenchymal Stem Cells - Mitochondria Restoration
- Very Young Plasma
Overlooking the Basics
Circumvents Rejuvenation
86. Anti-Cancer Properties of Senolytics May. 17, 2019
https://science.sciencemag.org/content/364/6441/636.full
“Indeed, elimination of senescent
cells with aging attenuates tumor
formation in mice, raising the
possibility that senolysis might be an
effective strategy to treat cancer.”
87. 8 Million Americans Suffer Chronic Heart Failure
Clinical trial urgently needed!
Pharmacologic and genetic removal of p16-positive
(senescent) cells in mice appears to ameliorate (or
improve) the level of age-induced fibrosis and
hypertrophy in senescent cardiac muscle cells, and
may support regeneration of cardiomyocytes…
What we learned from 2019 studies:
88. Senolytics May Reverse Heart Failure
Clinical trial urgently needed!
What We Learned in 2019:
“Pharmacological clearance of senescent
cells improves survival and recovery in aged
mice following acute myocardial infarction”1
1. https://onlinelibrary.wiley.com/doi/pdf/10.1111/acel.12945
90. “Aged‐senescent cells contribute to impaired heart regeneration.” Aging Cell; June 2019
Senescent Cells Damage Aging Hearts
“Aging leads to increased cellular
senescence and is associated with
decreased potency of tissue‐specific
stem/progenitor cells.”
“In aged subjects (>70 years old), over half
of cardiac progenitor cells are senescent…”
“Therapeutic approaches that eliminate senescent
cells may alleviate cardiac deterioration with aging
and restore the regenerative capacity of the heart.”
92. “Just a year ago I felt
immortal, wearing my
age with pride, even
joking about it.”
https://www.nytimes.com/2019/09/11/business/boone-pickens-dead.html
Who missed the longevity boat?
T. Boone Pickens (1928-2018)
Expiration date: Sept. 11, 2019
Net worth > $950 million
In 2016 T. Boone Pickens wrote:
One year later suffered series of
strokes and a fall. Dead at age 91.
102. Step 1: Join the
Vitality in Aging Longitudinal Study
(Sign up in RAADcity)
103. Open to Everyone!
Modeled on Framingham Heart Study
Long term and ongoing
No upper age threshold
No preset termination date
104. Began in 1948 with 5,209 adults from Framingham, Massachusetts
PriortoFraminghamlittlewas knownabout
hypertension/cardiovascularrisks
Doctors backthen didnotknow how toprevent heartattacks
Atherosclerosiswasthoughtanunavoidableaspectofnormalaging
Framingham Heart Study
Millions of Lives Saved
105. 3,000 medical papers published using
Framingham…now in its third generation
FraminghamHeartStudyissourceoftheterm“riskfactor”
Framingham Heart Study
Millions of Lives Saved
Framingham findings revealed role
of diet and other artery-clogging factors
106. Vitality in Aging Longitudinal Study
Become part of a team effort to defeat aging!
Identify “risk factors” causing you to age
Access biomarker tests at subsidized prices
Access interventions at discount prices
Test safety & efficacy of self-experimentation
Accelerate science of human age reversal
107. Long Term Funding Sources Will Be Needed
Human Age Reversal Project
Bill Faloon
Donations of Physicians’ Time
Funding Need: > $800,000
Donations Received to Date: $395,000
SOURCES OF FUNDING:
108. New charity to fund research with tax deductible donations:
Human Age Reversal Project
Make checks payable to:
Human Age Reversal Project
300 NE 20th St. #409
Boca Raton, FL 33431
Or donate online:
age-reversal.net/donate
109. I Refunded >$ 1 Million to Age Reversal Investors
100% of these monies refunded to investors
Initial attempts to raise $10-$25 Million for
age-reversal research raised over $1,000,000
This amount insufficient to fund viable commercial entity
110. Some tests only available to VIA Study Subjects!
Results help identify factors associated with rapid aging,
age-delay, or age-reversal…analogous to Framingham.
Longitudinal Study includes biomarkers (such as NAD+) visceral fat measure,
cognitive testing, comprehensive blood test, medical evaluation
Vitality in Aging Longitudinal Study
Commercial Prices
Longitudinal Study
>$4,000
$595
Age Management Diagnostics
Panels
113. Heart rate variability predicted first cardiovascular event
in populations without known cardiovascular disease
Low heart rate variability is associated
with approximately 40% increased risk
of a first cardiovascular event in
populations without known
cardiovascular disease.
Heart rate variability and first cardiovascular event in populations without known cardiovascular disease: meta-analysis and
dose–response meta-regression. EP Europace, Volume 15, Issue 5, May 2013, Pages 742–749,https://doi.org/10.1093/europace/eus341
Published: 30 January 2013
114. LowHeartRateVariabilityAssociatedwithHigherRiskofStroke
Decreased Nighttime Heart Rate Variability Is Associated With Increased Stroke Risk
Originally published 15 Sep 2011 https://doi.org/10.1161/STROKEAHA.110.607697
Stroke. 2011;42:3196–3201
Low HeartRateVariabilityassociated
with33%increasedstrokerisk.
Lower half of nighttime Heart
Rate Variability interval analysis
associated with 331% increased
stroke risk.
115. Heart rate variability as predictive factor for sudden cardiac death. Aging (Albany NY). 2018 Feb
23;10(2):166-177. https://www.ncbi.nlm.nih.gov/pubmed/29476045
Heart RateVariabilityCan PredictSudden Cardiac Death
Sudden cardiac death represents about
25% of deaths in clinical cardiology.
Low heart rate variability has been shown to be
independently predictive of increased mortality in
post-myocardial infarction (heart attack) patients
and heart failure patients.
The cost/benefit relationship between heart rate variability
and sudden cardiac death in general population groups is
currently considered only modest by mainstream medicine.
Heart rate variability measures important for aging population groups
116. HEART RATE
VARIABILITY
“Heart rate variability is simply a
measure of the variation in time
between each heartbeat.”
https://www.health.harvard.edu/blog/heart-rate-variability-new-way-track-well-2017112212789
“This variation is controlled by a
primitive part of the nervous system
called the autonomic nervous system.”
ANewWaytoTrackWellBeing
Nov 22, 2017
118. Vitality in Aging Longitudinal Study
Morpheus wrist band
Standard clinical tests
Age Management Blood Test Panel
NAD+ and Omega-3 Index
Bioimpedance measure of visceral fat
Cognitive tests
Initial medical exam
Commercial cost: >$4,000 RAADfest attendee: $595
More tests if funding is secured.
119. If future funding is raised from donations, investments
and/or government grants…participants who join the
Vitality in Aging Longitudinal Study now may receive
no additional expenses for continued participation.
Hidden Potential Benefit
120. This could translate into FREE long-term access to advanced
diagnostics. As new interventions are discovered, new
intervention studies will commence, ideally recruiting subjects
from VIA Longitudinal Study participants.
Hidden Potential Benefit
121. Blood Test Panel Only Option
Age Management Blood Test Panel
Omega-3 Index
Morpheus wrist band
Standard clinical tests
NAD+
Bioimpedance measure of visceral fat
Cognitive tests
Initial medical evaluation
Commercial cost: >$3,000 RAADfest attendee: $395
122. Open to Everyone!
Step 1 - Enroll in VIA Longitudinal Study at RAADcity
Step 2 - Baseline Blood/Diagnostic Panels at RAADcity
Step 3 - Use test results to adjust your longevity program
Step 4 - Retest to measure age reversal efficacy
Step 5 - Adjust interventions based on retest results
Modeled after Framingham Heart Study, i.e. long term and ongoing…
124. Statistically Significant + Meaningful
Age Reversal in 12 Months
Outcome Objectives:
$530,000 + donated/discounted services
Human Age Reversal Project
Vitality in Aging Interventions Trial
Study Cost:
Major Funding Provided by:
125. Step #1: VIA Longitudinal Study
Results will help determine if you qualify for:
Step #2: VIA Interventions Trial
HowtoParticipate
in TheseClinicalTrials:
127. Step #1: VIA Longitudinal Study
Step #2: VIA Interventions Trial
You pay (at deep-discounted prices) for
lab tests and interventions.
(Everyone should enroll in this study)
Human Age Reversal Project pays
for lab tests and medical interventions.
(30-50 people selected for this study)
130. Trial Parameters
> Open label (no placebo group)
> 50 healthy people aged 50-75 years
Initial Phase
Recruitment/Baseline Testing:
October 3rd 2019 – December 15th 2019
Vitality in Aging Intervention Trial
133. 12% Calorie Reduction Improves Biological Age Scores by 1.5 Years
2018 Published Human study measures 8 Aging Biomarkers
Change in the Rate of Biological Aging in Response to Caloric Restriction: CALERIE Biobank Analysis, J Gerontol A Biol Sci Med Sci. 2018 Jan; 73(1): 4-10.
137. Boosting AMPK activity with:
Metformin has been shown to reduce all-cause mortality in humans.
Salicylate (this is not aspirin) can potently boosts AMPK.
1) Indirectly with metformin
2) Directly with salicylate
138. Inhibit mTOR
Rapamycin inhibits mTOR and has been
shown to increase lifespan in animals.
Rapamycin reduces cancer risk by 40%
in human kidney transplant patients.
New research finds rapamycin reduces
visceral fat in non-transplant patients.
Turn back mTOR
Turn back the clock
139.
140. July 9, 2018
NAD+ Restores Cellular DNA Repair
►NAD+ depletion turns off
DNA repair enzymes.
►Increase NAD+ with
nicotinamide riboside.
Boost NAD+ Blood Levels
141. July 9, 2018
Increase NAD+ / Reduce NADH
►Aging results in reduced NAD+
and higher relative levels of
NADH, which creates cellular
imbalances.
►The NAD+/NADH ratio will be
tested after using beta-lapachone.
Restore NAD+/NADH Ratio
142. Autophagy is another mechanism by which caloric
restriction has been shown to extend mean and
maximal lifespan in model organisms (yeast, fruit
flies, nematodes, mice, rats, and large animals).
Several CR mimetics induce autophagy, including
glucosamine, metformin, and rapamycin.
Autophagy triggers “self cleaning” programs in
the body that selectively remove old
mitochondria (mitophagy), damaged proteins,
oxidized lipids, and even damaged cells.
144. Vitality in Aging Interventions Trial
Senolytics
Selective removal of senescent cells
Intervention #2
145. Selective removal of senescent cells - Age-related accumulation
of senescent cells contributes to atherosclerosis, aging of the
eye (cataracts, AMD), osteoporosis, skin and brain aging,
Kirkland and colleagues at Mayo Clinic show that senescent cells
are selectively eliminated by “senolytic” drugs.
Senolytic Cocktail of:
Senolytics
1) Dasatinib
2) Quercetin
3) Fisetin
147. 1) Fish oil: Boost omega-3 index > 10%
Reduce and Resolve Chronic Inflammation
2) Resolvins: Return tissues to health
Inflammaging major cause of aging and contributes to the global
loss of Sirt1 function. We intend to use omega-3 fatty acids and
other fatty acids to increase resolvins, protectins, and maresins
with a target of a minimum of 10% omega-3 index.
151. “TheroleofDNA methylationin epigeneticsofaging”
Epigenetics, especially DNA methylation,
plays a mechanistic role in aging.
Epigenetic clocks are best biomarkers for
predicting human mortality.
DNAmethylationinfluencedbymetformin,caloric
restriction and rapamycin treatment in mice.
This may reverse/prevent 20% to 40% of the
age-related changes in DNA methylation.
Pharmacol Ther. 2019 March; 195:172-185. doi:10.1016/j.pharmthera.2018.11.001
153. LS/tandemmassspectrometrybasedtesting
Quantitativeb-galactosidasestaining,p16INK4a,etc)
Neurovision – Mayo Clinic CD38
Johns Hopkins
Aging Biomarker Tests
Vitality in Aging Interventions Trial
More Accurate FlowFISH-
Based Telomere Length Tests
Newer DNA
Methylation Age Tests
NAD+, NAD/NADH ratio,
and NAD+ metabolite tests
Cell Senescence Tests
Univ of British Columbia/UCLA Galactosidasestaining,p16INK4a,skinpunch
NanoSomiX
Exosome tests for predicting
Alzheimer’s disease 10 years
prior to onset of memory loss
Age Management Panel
Comprehensive blood
biomarkers with Levine
Biological Age Calculator
155. Healthy Subjects in order to Measure Meaningful Age Reversal in 12 Months
Strict Inclusion Criteria for Study Subjects
Vitality in Aging Interventions Trial
Exercise
(10,000 step equivalent each day)
Healthy diet patterns
(no junk foods)
Restful sleep patterns
(no benzodiazepines)
Body Mass Index: 18-24
(no significant central fat mass)
No serious
preexisting disorders
No prescription narcotics
or recreational drugs
Target LDL below 80 mg/dl
Omega-3 Index > 8%
(achievablewithhighdosefishoil)
156. (Need website for donations)
Human Age Reversal Project
$395,000
Donated Funds Allocated for the VIA Intervention Trial:
Goal: Statistically Significant +
Meaningful Age Reversal
$???
age-reversal.net/donate
158. (Sign up in RAADclinic)
Vitality in Aging Longitudinal Study
Step 1: Join
159. Long Term Funding Sources Will Be Needed
Human Age Reversal Project
Bill Faloon
Donations of Physicians’ Time
Funding Need: > $800,000
Donations Received to Date: $395,000
SOURCES OF FUNDING:
160. New charity to fund research with tax deductible donations:
Human Age Reversal Project
Make checks payable to:
Human Age Reversal Project
300 NE 20th St. #409
Boca Raton, FL 33431
Or donate online:
age-reversal.net/donate
161. Some tests only available to VIA Study Subjects!
Results help identify factors associated with rapid aging,
age-delay, or age-reversal…analogous to Framingham.
Longitudinal Study includes biomarkers (such as NAD+) visceral fat measure,
cognitive testing, comprehensive blood test, medical evaluation
Vitality in Aging Longitudinal Study
Commercial Prices
Longitudinal Study
>$4,000
$595
Age Management Diagnostics
Panels
168. Consumer value of participating in VIA Longitudinal Study: ~ $4,000
VIA Longitudinal Study also includes for $595:
Morpheus Wrist Band:
Heart Rate Variability, Sleep , Physical Activity
Bioimpedance: Body Fat/Muscle Mass Scan
Cognitive Testing
Health Evaluations
169. Open to Everyone!
Step 1 - Enroll in VIA Longitudinal Study at RAADfest
Step 2 - Baseline Blood/Diagnostic Panels at RAADcity
Step 3 - Use test results to adjust your longevity program
Step 4 - Retest to measure age reversal efficacy
Step 5 - Adjust interventions based on retest results
Modeled after Framingham Heart Study, i.e. long term and ongoing…
170. Blood Test Panel Only Option
Age Management Blood Test Panel
Omega-3 Index
Morpheus wrist band
Standard clinical tests
NAD+
Bioimpedance measure of visceral fat
Cognitive tests
Initial medical evaluation
Commercial cost: >$3,000 RAADfest attendee: $395
171. Initial Vitality in Aging (VIA) Study Sites
JamesWatson,MD
351RollingOaksDrive,Suite203
ThousandOaks,California91361
(805)497-8411
RichardGaines,MD
3785N.FederalHighway,STE150
BocaRaton,Florida33431
(561)931-2430
172. Initial Vitality in Aging (VIA) Study Sites
John Sturges,MD
2170WestIronwoodCenterDrive#A
Coeur d’ Alene, Idaho 83814
(208)665-5596
173. Friday morning at 8 a.m.
Saturday morning at 8 a.m.
and
(Sunday morning 8 a.m. if needed)
To enroll in the VIA studies, you should attend
the informed consent lecture at RAADcity:
or
or
177. Lifespans
not limited by
senescence
Neocortex Connects-
Converts to the Cloud
Years 2030 2050
Stair Step Approach to Infinite Longevity
Singularity + A.I. enables
limitless self-improvement.
178. Hotel magnate Barron Hilton died
of natural causes at the age of 91.
He left about 97% of his estate to
Conrad N. Hilton Foundation, which
expects to grow its endowment
from $2.9 billion to $6.3 billion
www.foxbusiness.com/business-leaders/barron-hilton-fortune-estate-foundation
Who missed the longevity boat?
Barron Hilton (1927-2019)
Expiration date: Sept. 19, 2019
Net worth > $2.9 billion
Paris Hilton Barron Hilton
179. Too Wealthy to Die at Age 65
Paul Allen, Chairman of the Seattle
Seahawks co-founded Microsoft in 1975.
Diagnosed and treated for non-Hodgkin
lymphoma in 2009. Cancer returned in
2018. He died from septic shock.
Paul Allen was philanthropist and
donated to medical research…
but did NOT make it his priority!
https://www.nytimes.com/2018/10/15/obituaries/paul-allen-dead.html
Paul Allen (1953-2018)
Net worth > $26.1 billion
Expiration date: Oct. 15, 2018
180. Too Wealthy to Die at Age 58
Blake Nordstrom, company co-president,
dies unexpectedly at 58 from lymphoma.
At the time, he described his
condition as "treatable" and said he
planned to "continue to work
throughout this process as normal."
https://www.cnn.com/2019/01/02/business/blake-nordstrom-obit/
Blake Nordstrom(1961-2019)
Net worth > $1.5 billion
Expiration date: Jan. 2, 2019
181. Who Missed the Longevity Boat
Robert "Bob" McNair, billionaire
founder and owner of the
Houston Texans died at age 81.
He battled squamous cell
skin cancer and then
leukemia for about 20 years.
https://www.forbes.com/profile/robert-mcnair/#130c78d9251a
RobertMcNair (1937-2018)
Net worth ~ $3.8 billion
Expiration date: Nov. 23, 2018
Wealthy And Famous
That Expired In 2018
182. Who Missed the Longevity Boat
Herb Kelleher, the eccentric
founder of Southwest Airlines
who helped revolutionize
low-cost air travel in 1971.
Died at age 87.
https://www.cnn.com/2019/01/03/business/southwest-airlines-founder-herb-kelleher-obit
Herb Kelleher(1931-2019)
Net worth ~ $2.5 billion
Expiration date: Jan. 3, 2019
Wealthy And Famous
That Expired In 2019
183. “Just a year ago I felt
immortal, wearing my
age with pride, even
joking about it.”
https://www.nytimes.com/2019/09/11/business/boone-pickens-dead.html
Who missed the longevity boat?
T. Boone Pickens (1928-2018)
Expiration date: Sept. 11, 2019
Net worth > $950 million
In 2016 T. Boone Pickens wrote:
One year later suffered series of
strokes and a fall. Dead at age 91.
184. T. Boone Pickens Largely Funded $260 Million
Oklahoma State University Stadium
(He made many other charitable donations to biomedical research)
185. Fund research with tax deductible donations:
Human Age Reversal Project
Make checks payable to:
Human Age Reversal Project
300 NE 20th St. #409
Boca Raton, FL 33431
Or donate online:
age-reversal.net/donate
190. Fund research with tax deductible donations:
Human Age Reversal Project
Make checks payable to:
Human Age Reversal Project
300 NE 20th St. #409
Boca Raton, FL 33431
Or donate online:
age-reversal.net/donate
191. William Faloon
How Enrolling in Clinical
Trials Can Save Your Life
Friday, October 4rd 2019
RAADcity Stage
10:30 am