Replication

1. MOLECULAR SWITCH THAT
REGULATES DNA REPLICATION AND
TRACKING DNA
Maria Isabel Maya Naranjo
Molecular Biology

2. FOLDING

3. FOLDING

4. INTRODUCTION
• Replication process:
duplication of DNA.
• Replication mistakes can
result in diseases, thats
why sciencists are
investigating

5. SCIENTISTS
IDENTIFY
MOLECULAR
SWITCH THAT
REGULATES DNA
REPLICATION
AND
TRANSCRIPTION
February 12, 2015
Rowan University, Science

6. SCIENTISTS IDENTIFY MOLECULAR SWITCH
THAT REGULATES DNA REPLICATION AND
TRANSCRIPTION
• Mitochondria
contributes with a
small number of
genes essential for
celular respiration
and energy
generation.
•Transcription and
replication colliding was
prevented by the
scientists.

7. SCIENTISTS IDENTIFY MOLECULAR
SWITCH THAT REGULATES DNA
REPLICATION AND TRANSCRIPTION
• The key player that effectively switches on or
off trasncription or replication is TEFM
(mitochondrial transcription elongation factor)
• TEFM also has an unexpected anti-termination
activity.

8. SCIENTISTS IDENTIFY MOLECULAR
SWITCH THAT REGULATES DNA
REPLICATION AND TRANSCRIPTION

9. OBSERVATION
• I think that all this progess might be good
because of the medical utilities, but we should
know how to use them correctly. With
mitocondrial DNA, if we are able to prevent
colliding in those processes they have done a
great job until now, but we should still
investigate

10. TRACKING DNA HELPS SCIENTISTS
TRACE ORIGINS OF GENETIC ERRORS
January 27, 2015
Medical Research Council,
the journal Nature.

11. TRACKING DNA HELPS SCIENTISTS
TRACE ORIGINS OF GENETIC ERRORS
• They looked out the way
mutations can be
introduced in our DNA
• Some of the genetic
switches that control when
genes are activated are
likely to be hotspots for
DNA flaws, or mutations, to
develop.

12. TRACKING DNA HELPS SCIENTISTS
TRACE ORIGINS OF GENETIC ERRORS
• Polymerases are involved in this replication
process .
• A small but significant fraction of the finished
DNA is left-over scaffold.

13. TRACKING DNA HELPS SCIENTISTS
TRACE ORIGINS OF GENETIC ERRORS
• These scaffold sections, and the mistakes they
contain, become trapped in the DNA.
• This tends to occur at points in the important
regulatory switches.
• These sites are therefore more likely than
other regions to have trapped scaffold DNA
and its associated errors.

14. OBSERVATION
• In this study they showed someting positive in
my opinión, because of they are trying to look
the way to cure genetic diseases. If they find a
mutation that allows our body to increase its
effectivity they could use it to privilege us.

15. MEDICAL UTILITY

16. MEDICAL UTILITY
• Therapies for cancer.
• Developmental processes related to
fertility and aging.
• TEFM prevents from mutation, controls transcription
and replication. POTENCIAL TARGET FOR NEW DRUG
THERAPIES.
SCIENTISTS IDENTIFY
MOLECULAR SWITCH
THAT REGULATES DNA
REPLICATION AND
TRANSCRIPTION

17. MEDICAL UTILITY
TRACKING DNA HELPS SCIENTISTS TRACE
ORIGINS OF GENETIC ERRORS
• Hunt for disease causing mutations, specially
interpret regions of the genome that do not
code por proteins.

18. BIBLIOGRAPHY
• “Elps scientists trace origins of genetic errors."
University of Edinburgh, 2015 .[Internet] 2015 Jan.
[fecha de acceso: febrero 13 de 2015 ]. Disponible en:
<www.sciencedaily.com/releases/2015/01/150127111
416.htm>.
• Scientist indentify molecular switch that regulatesDNA
replication and transcription . Rowan University, 2015
Feb. [Fecha de acceso : febrero 13 de 2015]. Disponible
en : http://www.newswise.com/articles/scientists-
identify-molecular-switch-that-regulates-dna-
replication-and-transcription#.VN4fzviat6A.email

19. THANKS